Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Ameliorative effect of lithium chloride on working and spatial memory deficit in a PTZ-induced seizure model
110
117
FA
Marzieh
Yazdani
Department of Physiology, Faculty of Sciences, Fars Science and Research Branch, Islamic Azad University, Fars, I. R. Iran.
N
Mohammad Amin
Edalatmanesh
Department of Physiology, Faculty of Sciences, Shiraz Branch, Islamic Azad University, Shiraz, I. R. Iran.
amin.edalatmanesh@gmail.com
Y
Samaneh
Rafiei
Department of Exercise Physiology, Kish International Campus, Tehran University, Kish, I. R. Iran.
N
Background: The repetitive seizure attacks lead to widespread neuronal damage and cognitive deficit, e.g. memory and learning impairment. The single or repeated administration of pentylenetetrazole (PTZ) can induce seizure in rat. This study evaluates the neuroprotective effect of lithium chloride (LiCl) on PTZ-induced working and spatial memory deficit.
Materials and Methods: To induce the PTZ-kindling model, repeated doses of PTZ (40mg/kg/BW/ip) were injected for 5 consecutive days. After observing five stages of seizure, the PTZ+Li20, PTZ+Li40 and PTZ+Li80 groups received 20, 40 and 80 mg/kg/BW of LiCl, respectively and the PTZ+Saline group, received Saline for 14 days. The Morris water maze (MWM) and Y maze tests were conducted in order to investigate the spatial and working memory.
Results: Compared to Control group, the PTZ+Saline group showed a decrease in alteration behavior in Y maze and an increase in latency time and distance to hidden platform in MWM. LiCl-treated rats, especially in the lowest dose, showed a significant higher alteration behavior in Y maze and the lower latency time and distance to hidden platform in MWM than the PTZ+Saline group.
Conclusion: The neuroprotective effects of LiCl can ameliorate the spatial and working memory impairment in a PTZ-kindling model.
Seizure, Cognitive disorders, Lithium, Rat
http://feyz.kaums.ac.ir/article-1-3339-en.html
http://feyz.kaums.ac.ir/article-1-3339-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Effect of crocin on inhibitory avoidance memory, balance and explorative behaviours following cisplatin administration in rat
118
125
FA
Zohreh
Ghotbeddin
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran.
z.ghotbeddin@scu.ac.ir
Y
Seyyed Reza
Fatemi-Tabatabaei
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran.
N
Mohamad Reza
Tabandeh
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran.
N
Mohsen
Mirzabeigi
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran.
N
Nima
Badripour
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran.
N
Rezvan
Amiri
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, I. R. Iran.
N
Background: A lot of studies indicate that cancer chemotherapy results in memory and motor impairment immediately following therapy. On the other side, crocin as the chemical constituent isolated from the Saffron is effective on memory and motor impairement. In this study, the effect of crocin on memory and motor impairment induced by cisplatin injection was studied in adult male rats.
Materials and Methods: In this study, male Wistar rats (n=50) were divided into 5 groups: Control, Sham, Cisplatin (2 mg/kg/week for 21 days), Crocin (30 mg/kg for 21 days) and Cisplatin+Crocin. Sham group was administrated with Saline. Then, inhibitory avoidance memory, balance and exploratory behaviors were assessed by shuttle box, rotarod and open field apparatus, respectively.
Results: Crocin improved memory impairment induced by cisplatin (P<0.01). Cisplatin also impaired balance in rotarod test. Rearing frequency and total distance traveled in open field test were significantly decreased (P<0.001 and P<0.05, respectively) compared to Control group.
Conclusion: We conclude that crocin injection following the use of anticancer drugs (e.g. cisplatin) might have a protective effect against the cisplatin-induced impairement in cognitive function, balance and explorative behavior.
Crocin, Cisplatin, Passive avoidance memory, Motor activity, Rat
http://feyz.kaums.ac.ir/article-1-3345-en.html
http://feyz.kaums.ac.ir/article-1-3345-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Cytotoxic and antioxidant effect of chrysin on neonate mouse spermatogenic stem cells
126
133
FA
Mehran
Pordel
Department of Biology, Mashhad Branch, Islamic Azad University, I. R. Iran.
N
Javad
Baharara
Research Center of Applied Biology, Mashhad Branch, Islamic Azad University, Mashhad, I. R. Iran.
baharara@yahoo.com
Y
Elaheh
Amini
Department of Cellular and Molecular Biology, Faculty of Biological Sciences, Kharazmi University, Tehran, I. R. Iran.
N
Background: So far, many plants have been used for the treatment of infertility. Several studies have revealed that chrysin (as an active metabolite) improves animals' reproduction. Therefore, the objective of this study was to evaluate the effect of chrysin on Balb/C mice spermatogenic stem cells.
Materials and Methods: In this in vitro experimental study Balb/C neonate spermatogonia stem cells cultured in DMEM-F12 medium were treated with various concentrations of chrysin (2.5, 5, 10, 20, 40 µg/ml) for 6 and 12 days. Then the cytotoxicity was assessed using MTT, Akredin orange/Propodium Idid, DAPI and antioxidant concentration DCF-DA tests.
Results: Chrysin showed no remarkable cytoxicity in concentrations less than 5 µg/ml. While, after 6 days the viability of cells treated with chrysin 10, 20 and 40 µg/ml was decreased to 30, 45 and 56 % (P<0.05 and P<0.001, respectiely); after 12 days the viability of cells was decreased to 44, 56 and 65 % (P<0.05, P<0.01 and P<0.001, respectiely). DCF-DA results revealed a 80 % antioxidant capacity of chrysin in 5 and 2.5µg/ml concentrations.
Conclusion: Lower concentrations of chrysin has protective effect on Balb/C mice spermatogenic through improving cell viability, decreasing cells apoptosis and inhibiting free radicals.
Chrysin, Antioxidant, Cytotoxicity, Infertility, Spermatogenic stem cells
http://feyz.kaums.ac.ir/article-1-3346-en.html
http://feyz.kaums.ac.ir/article-1-3346-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Molecular and genotyping identification of Echinococcus granulosus from camel and dog isolates in Isfahan, Iran (2015-2016)
134
141
FA
Mohsen
Arbabi
Department of Parasitology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I. R. Iran.
arbabi4.mohsen@yahoo.com
Y
Nader
Pestechian
Department of Parasitology, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran.
N
Hadi
Tavasol Khamseh
Student Research Committee, Kashan University of Medical Sciences, Isfahan, I. R. Iran
N
Hosein
Hooshyar
Department of Parasitology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I. R. Iran
N
Mehdi
Delavari
Department of Parasitology, Faculty of Medicine, Kashan University of Medical Sciences, Kashan, I. R. Iran
N
Background: Hydatidosis is one of the most important zoonotic parasitic disease worldwide caused by Echinococcus granulosus. Given the importance of parasite genotyping in disease control, this study was aimed to evaluate the genetic variation of the camel and dog isolates in Isfahan.
Material and Methods: This cross-sectional study was done on infected livers and lungs of camels with hydatid cyst (n=51) during 2015-2016, collected from Zarinshahr and Najafabad industrial abattoir and 200 adult E. granulosus worms collected from stray dogs in different geographical regions of Isfahan for the molecular identification of mitochondrial genes (CO1, ND1). The DNA of protoscolices and adult worms were extracted, the PCR and sequencing were done using specific primers. Pairwise sequence alignment was used to identify the genetic similarity between the sequences and the registered ones in Gen bank using Clustalw2 software.
Results: The PCR and sequencing of CO1 and ND1 genes on dog and camel samples showed different E. granulosus genotypes, including the common sheep strain (G1), bovid strain(G3) and camel strain (G6) in Isfahan region. The most frequent strains were the common sheep strain (G1). The genetic similarity between both ND1 and CO1 isolates taken from camel, dog and the isolates registered in Gene bank were 30.25-100% and 27.47-100% for camel and dog, respectively.
Conclusion: Mitochondrial ND1 and CO1 genes are proper molecular markers for identifying the genetic variation of the camel and dog E. granulosus. The dominant strain of the worm in Isfahan, is the same as the other parts of the country, i.e., the G1 genotype (the most common sheep strain) belonged to the G1- G1 E. granulosus complex.
Echinococcus granulosus, Camel, Dog, PCR, Sequencing, Strain
http://feyz.kaums.ac.ir/article-1-3347-en.html
http://feyz.kaums.ac.ir/article-1-3347-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Effect of interval exercise with iron supplementation on aerobic power and some hematologic indexes among the 15-18 years old boys
142
148
FA
Fatemeh
Omidali
Department of Physical Education‚ Ayatollah Boroujerdi University, Boroujerd, I. R. Iran.
omidali.fatemeh@yahoo.com
Y
Masoud
Hamzeloo
N
Background: Aerobic fitness is an index of pulmonary, cardiovascular function and haematological components and relevant to the delivery of oxygen. The aim of present study was to evaluate the effect of interval exercise with iron supplementation on aerobic power and some hematologic indexes among the15-18 years old boys.
Materials and Methods: In this quasi-experimental study, 30 students (mean age 17.1±84.16) were participated in an exercise program (6 weeks, 3 sessions per week). The participants were randomly divided into three groups: Control; Exercise and exercise+ iron supplementation groups. Iron supplementation group was administered a daily supplement of iron tablet. Using a before-after design, bulk-field test and blood sampling the data were analyzed.
Results: The results showed no significant difference among the groups. However, using a 6-week training program in Exercise and Exercise+ Iron supplementation group compared to the Conrol showed a significant difference for aerobic power; ferritin; transferrin and iron. No significant change was seen for hemoglobin, hematocrit and red blood cells. While in exercise group, interval exercise caused a significant increase in aerobic power (P=0.009), this was not the case for red blood indexes.
Conclusions: Interval exercises along with iron supplementation caused an increase in aerobic power and some hematologic indexes.
Exercise‚ Hematologic index‚ Iron
http://feyz.kaums.ac.ir/article-1-3352-en.html
http://feyz.kaums.ac.ir/article-1-3352-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Correlation between the cardiorespiratory endurance, dynamic postural control and thoracic kyphosis angle among the students
149
156
FA
Farzaneh
Saki
Department of Sport Injuries and Corrective Exercise, Faculty Sport Sciences, Bu-Ali Sina University, Hamedan, I. R. Iran.
f_saki@basu.ac.ir
Y
Parisa
Sedaghati
N
Masoumeh
Baghban
N
Background: Any deviation in the normal spinal alignment can alter the cardiorespiratory endurance and the posture control. The aim of present study was to investigate the correlation between cardiorespiratory endurance, dynamic postural control and kyphosis angle among the students.
Materials and Methods: This cross-sectional study was carried out on students (n=100; 48 girls and 52 boys) selected randomly according to inclusion criteria. Cardiorespiratory endurance, postural control and kyphosis angle were assessed using shuttle run test, Y balance test and flexible ruler, respectively. Normal distribution of the data was assessed using the Kolmogorov–Smirnov test. Data were analyzed using Pearson correlation product moment and linear regression (P≤0.05).
Results: The results showed a significant negative correlation between the cardiorespiratory endurance and kyphosis angle (P=0.012, r=-0.3.3). In addition, a significant negative correlation was observed between the dynamic postural control and kyphosis angle (P=0.003, r=-0.254).
Conclusion: According to our findings it seems mandatory for health and school's, sport coaches to screen the student's spinal deformities and evaluate its associated complications (e.g. decreased cardiorespiratory endurance and postural balance).
Cardiorespiratory endurance, Postural control, Kyphosis
http://feyz.kaums.ac.ir/article-1-3353-en.html
http://feyz.kaums.ac.ir/article-1-3353-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Serum copper and iron levels in idiopathic tinnitus
157
161
FA
Hamid Reza
Abtahi
N
Farank
Yazdkhasti
Department of E.N.T, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, I. R. Iran.
fayaz.fy@gmail.com
Y
Background: Tinnitus is a multi-factorial disorder. Many oxidative pathologies in different loci of auditory pathway can cause it. In this regard oxidative processes result in an imbalance in the trace elements in ear incorporated into the structure of enzymes responsible for antioxidant protection. Therefore, the present study is aimed to compare the concentration of iron (Fe) and cupper (Cu) as the trace elements in the serum of patients with tinnitus and the healthy subjects.
Materials and Methods: This cross-sectional study was conducted on patients with idiopathic tinnitus (n=55) and the healthy volunteers (n=47) referred to the ENT clinic of Alzahra hospital (Isfahan, Iran) during 2014-2015. Among the healthy participants 47 age- and sex-matched cases were selected based on convenient sampling. The concentration of Fe and Cu were measured by flame atomic absorption spectroscopy.
Results: There was a significant decrease in mean serum Cu level in patients with tinnitus (112.48±27.59) compared to the control group (139.52±14.24), (P<0.001). Moreover there were no statistically significant differences between the mean serum Fe in patients with tinnitus (95.68±35.97) and control group (103.95±53/68), (P=0.38).
Conclusion: In the present study, a relationship was seen between the serum Cu level and the occurrence of tinnitus. Given the notion that trace elements are among the antioxidant micronutrients, defining such a cause-and-effect relationship between trace elements and tinnitus may shed some light on the treatment of the disease, which requires more studies.
Tinnitus, Copper, Iron
http://feyz.kaums.ac.ir/article-1-3355-en.html
http://feyz.kaums.ac.ir/article-1-3355-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Antibacterial activity of acetic and lactic acid against Listeria monocytogenes and their effect on the intracellular constituent release
162
169
FA
Zoleikha
Shiravani
Department of Food Hygiene and Quality Control, Faculty of Veterinary Medicine, Urmia University, Urmia, I. R. Iran.
z.shiravani682@yahoo.com
Y
Javad
Aliakbarlu
N
Hosein
Tajik
N
Background: Organic acids (e.g. acetic and lactic acid) have been used in foods as natural preservatives. Acetic acid and its salts are used in foods as antimicrobial and acidulant agents. The aim of this study was to evaluate the antibacterial activity of acetic and lactic acids against the Listeria monocytogenes.
Materials and Methods: This experimental study was conducted at the Department of Food Hygiene (Faculty of Veterinary Medicine, Urmia University) during autumn 2015. The antibacterial effects of acetic and lactic acid against Listeria monocytogenes were determined using minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and cell constituents release methods. The concentration ranges of acetic and lactic acid (0.0195-10 and 0.043-22.2 μl/ml, respectively) were used to determine the MIC of acids.
Results: Based on the results, acetic and lactic acid inhibited the growth of Listeria monocytogenes and acetic acid had stronger effect against the the bacterium. The MIC values for acetic acid and lactic acid were 2.5 and 5 μl/ml, respectively. Cell constituents release showed that acetic and lactic acids are able to lyze the bacterial cell.
Conclusion: Acetic and lactic acids were effective in inhibiting the growth of Listeria monocytogenes and the antibacterial effect of acetic acid was stronger than that lactic acid. These acids can be used in foods in combination with other preservatives to inhibit the food borne pathogens and food spoilage microorganisms.
Acetic acid, Lactic acid, Antibacterial, Listeria monocytogenes
http://feyz.kaums.ac.ir/article-1-3341-en.html
http://feyz.kaums.ac.ir/article-1-3341-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Role of mindfulness, psychological flexibility and integrative self-knowledge on psychological well-being among the university students
170
177
FA
Mehdi
Imani
N
Javad
Karimi
N
Mahdieh
Behbahani
Student Research Committee, Kashan University of Medical Sciences, Kashan, I. R. Iran.
psy.m.behbahani@gmail.com
Y
Abdollah
Omidi
N
Background: Studies has shown the effect on environmental conditions on psychological well-being. In this regard, psychological characteristics have an important role. This study aimed to investigate the role of mindfulness, psychological flexibility and integrative self -knowledge amonge the university students.
Material and Methods: This cross-sectional study was performed on the students of Kashan university of medical sciences (n=300) and based on quota sampling, a number of students (n=241) were selected based on the faculty and the major of the study. The administered tools were Ryff scale of psychological well-being (RSPWB-18), mindfulness (MAAS), acceptance and actions (AAQ-II) questionnaires and integrative self-knowledge scale (ISKS). Finally the data were analyzed using correlation and stepwise regression.
Results: Pearson correlation disclosed a positive and considerable relation between mindfulness, integrative self-knowledge, psychological flexibility and psychological well-being. In addition, the findings showed significant role of mindfulness, integrative self-knowledge and psychological flexibility to predict the psychological well-being of the students; so these variables can predict 21% of psychological wellbeing changes.
Conclusion: This study disclosed that the mindfulness, psychological flexibility and integrative self -knowledge can in part specify the variance of psychological well-being.
Psychological flexibility, Psychological well-being, Students, Mindfulness, Integrative self-knowledge
http://feyz.kaums.ac.ir/article-1-3356-en.html
http://feyz.kaums.ac.ir/article-1-3356-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
The correlation between alexithymia and anxiety, depression in asthma
178
187
FA
Fatemeh
Rezaei
Department of Psychology, Faculty of Literature and Humanities, Lorestan University, Khoramabad, I. R. Iran.
rezaeipsyc@gmail.com
Y
Fatemeh
Karimi
N
Afroz
Afshari
N
Nasrin
Hosseini-Ramaghani
N
Background: Alexithymia is a personality trait characterized by the inability to identify and describe emotions. Only few researches have studied the correlation between alexithymia and health factors in psychosomatic disorders. This study aimed to determine the correlation between alexithymia and anxiety, depression in asthmatic patients.
Materials and Methods: This cross-sectional study was conducted on all asthmatic patients referred to Khorram Abad medical centers. Among them 100 cases were chosen using the convenience sampling. The tools were Alexithymia Scale )TAS-20( along with Hospital Anxiety and Depression Scale )HADS(. The data were analyzed using Pearson correlation and Multivariate Regression.
Results: A significant positive relationship was seen between aalexithymia, its factors and anxiety/depression. In addition, multiple multivariate regression analysis showed that difficulty in identifying feelings and describing feelings can predict the anxiety and depression.
Conclusion: Findings showed that difficulty in identifying and describing emotions as two factors of Alexithymia in asthmatic patients can predict the depression and anxiety. So, considering the emotional aspects of asthma, effective approaches should be taken into account in the treatment of these patients' mental health problems.
Asthma, Alexithymia, Anxiety, Depression
http://feyz.kaums.ac.ir/article-1-3357-en.html
http://feyz.kaums.ac.ir/article-1-3357-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Antibiotic susceptibility pattern and the prevalence of Staphylococcus aureus isolated from skin and soft tissue in Tehran Razi skin hospital (2014-15)
188
196
FA
Zeynab
Fagheei-Aghmiyuni
N
Ahmad
Khorshidi
N
Tahereh
Soori
N
Rezvan
Moniri
Anatomical Research Center, Kashan University of Medical Sciences, Kashan, I. R. Iran.
moniri@kaums.ac.ir
Y
Seyyed Gholam Abbas
Mousavi
N
Background: Staphylococcus aureus (S. aureus) is the most common cause of skin and soft tissue infections. This study aimed to determine the prevalence of S. aureus isolated from skin and soft tissue and antibiotic susceptibility pattern among the patient hospitalized in Razi skin hospital (Tehran-Iran).
Materials and Methods: This cross-sectional study was conducted on patients (n=400) with skin and soft tissue infections in Razi skin hospital. Sterilized swabs were used to collect the skin infection samples. S. aureus isolates were confirmed using biochemical tests (gram staining, catalase, coagulase, DNase test and manitol fermentation tests).
Result: 51.3 %( 205 out of 400) of isolates were S. aureus. Ninety six (46.8%) of isolates were methicillin and penicillin-resistant S. aureus. All of the isolates showed sensitivity to vancomycin, linezolid. 98% of the isolates were susceptible to daptomycin. One-hundred sixteen (56.6%) isolates were multi- drug resistant.
Conclusion: More than half of the skin and soft tissue infections were caused by S.aureus. More than 46 percent of the isolates were methicillin resistant. The highest resistance to penicillin was observed.
Staphylococcus aureus, Skin and soft tissue infection (SSTI), Antibiotic susceptibility pattern, MRSA
http://feyz.kaums.ac.ir/article-1-3359-en.html
http://feyz.kaums.ac.ir/article-1-3359-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Factors affecting the outcome of community-acquired pneumonia among the patients hospitalized in Beheshti hospital (Kashan-Iran)
197
205
FA
Mansoreh
Momen–Heravi
N
Reza
Razzaghi
Infectious Research Center, Kashan University of Medical Sciences, Kashan, I. R. Iran.
rezarazzaghi33@yahoo.com
Y
Seyyed Gholam Abbas
Mousavi
N
Somayeh
Zamani-Fard
N
Background: Community-acquired pneumonia (CAP) is a common infectious disease with high morbidity and mortality. The goal of this study was to evaluate the factors affecting the outcome of pneumonia among the Beheshti hospital patients.
Materials and Methods: This cohort study was done on pneumonia patients (n=140) in Kashan Beheshti hospital during 2014-2015. A questionnaire consisting the demographic, clinical and paraclinical findings and outcomes was filled-out.
Results: Eighty three (59.3%) out of 140 patients were male and 57(40.7%) women. The majority of cases were ≥50 years old (mean age 60.02±1.70) .There was a history of diabetes in 54(38.6%) .The most common signs and symptoms were coughing and the lung rales. The ninty-one and 9% of the cases were improved and complicated condition, respectively. The complication were: pleural effusion (77%), empiyema (15%) and abscess (8%).There was positive CRP (100%); increased ESR (82%) and leukocytosis (80%). While, there was no statistical association between the sex, age and clinical symptoms with the disease complication and outcome, there was a significant correlation between the first BS, HbA1C, CRP, duration of hospitalization, radiographic pattern and diabetes with disease outcome.
Conclusion: Considering the association between the diabetes in one side and some factors (outcome of pneumonia, duration of hospitalization, history of pneumonia, times of admission, BS at admission, HbA1c, bilateral involvement, leukocytosis, increased ESR, CRP and CURB 65, the diabetes should be considered as an important factor affecting the pneumonia outcome. The managed control of diabetes can improve the pneumonia outcome.
Pneumonia, Community acquired, Outcome
http://feyz.kaums.ac.ir/article-1-3358-en.html
http://feyz.kaums.ac.ir/article-1-3358-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
21
2
2017
6
1
Presenting a case of Ganglioneuroma with abdominal pain in a five year old boy
206
210
FA
Ramin
Haghighi
N
Negar
Dadpour
N
Seyyed Hasan
Seyed-Sharifi
Student Research Committee, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, I. R. Iran.
Hsharifi368@yahoo.com
Y
Background: Ganglioneuroma as a neuroblastoma-family tumor is a rare case with a ganglion cell origin. In most cases, ganglioneuroma is found in the mediastinal and retroperitoneal incidentally and may be presented with nonspecific symptoms. Here, we reported a 5-year-old boy with a retroperitoneal ganglioneuroma referred with abdominal pain.
Case Report: The case was a 5 years old boy with abdominal pain started one month ego, the pain is not generalized in a specific abdominal area. Patient in the physical examination had tenderness and mass in the right side of the abdomen. Laboratory tests, except for urine analysis, were normal. Imaging assessment reported one huge mass in the right side of retroperitoneal cavity. According to the patient's condition was decided to perform laparotomy. The pathological examination of the samples confirmed the ganglioneuroma.
Conclusion: For a case manifested with pain and the abdominal and retroperitoneal mass are established in his/her imaging. The ganglioneuroma should be considered as a differential diagnosis. The treatment and the final diagnosis of the anglioneuroma are accomplished through complete surgical resection of the lesion and histology.
Ganglioneuroma, Retroperitoneal, Mediastinal, Abdominal mass, Child
http://feyz.kaums.ac.ir/article-1-3340-en.html
http://feyz.kaums.ac.ir/article-1-3340-en.pdf