Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Effects of closed-end and open-end vasectomies on rat’s testis
1
10
FA
Hossein
Nikzad
nikzad_h@kaums.ac.ir
Y
Homayoun
Naderian
N
Mohammad
Pourahmadi
N
Background: Vasectomy is one of the most effective tools of population control. Controversies are arisen with respect to the effects of vasectomy on testis and the process of spermatogenesis, thus the present study was carried out to determine the effects of closed-end and open-end vasectomies on rat’s testis in Kashan University in 2000.Materials and methods: For this experimental study, 20 Sprague Dawely rats were randomly selected. They were 8-12 weeks old and assigned in two groups of closed-end and open-end vasectomies. For the first group (closed-end) right vas deferens underwent closed-end operation and vas deferens of the left side underwent Sham operation, however for the other group (open-end) right and left vas deferens underwent open-end and Sham operations, respectively. 4 months later, their testes were removed and their weight, volume and macroscopic appearance were determined. Then, microscopic changes including histologic changes, seminoferous ducts, interstitial tissue, number of spermatogonia, number and type of spermatocytes, etc were all recorded. T-test was used for data analysis.Results : Histologic studies revealed that testicular tissue was normal in control group but have changes in the case group. In injured ducts detachment of immature cells from epithelium, epithelial vacuolization, thickening and folding of periductal membrane, and removal of germ cells were prominent changes. Quantitative evaluation of normal ducts revealed that there was significant differences between groups regarding: number of spermatogonia, spermatocyte, round spermatid, long spermatid, the proportion of long spermatid to sertoli, ductal diameter, and volume and weight of testis. Conclusion : There was no significant difference between the closed- and open-end vasectomies, however both affect the testicular tissue. Effects of increased hydrostatic pressure were less prominent in closed-end technique. Further studies with special attention on increased antisperm antibody , and seminoferous ductal structure wit0.h ultrastructure and immunochemistry are strongly suggested.
Closed-end vasectomy, Open-end vasectomy, Testis, spermatogenesis, rat
http://feyz.kaums.ac.ir/article-1-288-en.html
http://feyz.kaums.ac.ir/article-1-288-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Awareness in neurolept anesthesia
11
15
FA
Mohammad Bagher
Zeynali
Y
Farhad
Heshmati
N
Hossein
Talavat
N
Background: Awareness is a common problem of general anesthesia. The overall prevalence of awareness was reported 1-10%. The present study was conducted to determine the effects of neurolept anesthesia on awareness. Materials and methods: This double blind clinical trial was performed on sixty 25-40-year old individuals undertaking spinal surgery. All of whom belonged to class I-ASA. Patients received 10 mg of Diazepam over the night before operation and 7ml/kg of ringer solution was administered in the operating room. For the first group (Group A) neurolept anesthesia started with induction (talamonale 0.1ml/kg, thiopental 5mg/kg, and pancuronium 0.1mg/kg), maintained with N2O-fentanyl (50 μ g/30 min). For the second group (Group B) induction was started with fentanyl 1.5μg/kg, thiopenthal 5mg/kg, pancuronioum 0.1mg/kg) and maintained with halothane 0.6%, N2O-fentanyl 50μg/30 min. A tape player was used during the procedure and patient’s awareness was measured using the pain sensation and music recall following the procedure in recovery room and 24 hour after anesthesia. Results: Voice was heard by 10 and 3.3% of patients in the neurolept and control group, respectively (NS). Type of anesthesia had no effect on blood pressure and heart rate.Conclusion: Neurolept anesthesia accompanied by minor changes in patients’ awareness, thus this can be safely used as a safe technique with more advantage in poor risk patients and those who need wake up test during surgery.
Neurolept anesthesia, Awareness
http://feyz.kaums.ac.ir/article-1-289-en.html
http://feyz.kaums.ac.ir/article-1-289-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Mallampati and thyromental tests to predict difficult intubation
16
21
FA
Samad
Nourizad
sa.noorizad@kaums.ac.ir
Y
Mehrdad
Mahdian
N
Hamid Reza
Sayyedi
N
Background : With respect to the frequency of difficult intubation and its known complications, the present study was conducted in Matini hospital in Kashan to determine the value of predictive tests. Materials and methods : This descriptive study was carried out on 379 patients referring for surgery. During the first preoperation visit Mallampati test was achieved and patients were categorized in either I to IV classes. Then the thyromental distance was measured. Induction was managed by sodium thiopental 5mg/kg and succinile choline 1.5mg/kg, then laryngoscopic view was determined according to the Cormack classification. Those who were classified as grade III or IV in Mallampati test or had thyromental distance of less than 6cm were considered as at risk patients for intubation. Those who fell in Cormack III of IV classification were considered as difficult intubation. Finally, sensitivity, specificity, positive and negative predictive values of these tests were calculated. Results : The study population included 179 males and 200 females with the mean age of 45.1±22.4 years. Of 379 patients, 29 (7.7%) were revealed to have difficult intubation. Positive and negative predictive values of Mallampati test was 12% and 93%, respectively, however, these values were 9.8% and 92.7% for Thyromental test. Conclusion : With respect to the low sensitivity and PPV of Thyromental and Mallampati tests, they are of limited value for detection of difficult intubation
Difficult intubation, Mallampati test, Thyromental test
http://feyz.kaums.ac.ir/article-1-285-en.html
http://feyz.kaums.ac.ir/article-1-285-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
A stereological study of the effect of locally administered growth hormone on the microstructure of the tibial growth plate in immature rabbits
22
30
FA
Yadollah
Mashayekhi
Y
M
Read
N
P
Sibbons
N
C.V
Howard
N
Background: The mechanism of growth hormone (GH) effects on growth plate (GP) and its chondrocytes is of utmost importance, thus we have investigated the microstructure of proximal tibial GP of rabbits with designed-based stereological methods. Material and methods: In this experimental study, the tissue came from a study into longitudinal growth using minipumps surgically implanted into the right upper tibial GP of 9 weeks old rabbits, administering GH at 10 and 100 μ g/day for a period of 21 days. Saline only administered and non-operated groups served as controls. The following stereological parameters were investigated: GP volume and height chondrocyte volume, surface and number densities. These direct measurements lead to estimate of chondrocyte total volume, surface and number mean chondrocyte volume and surface in the number-weighted distribution. Data were analyzed using t-test and single factor ANOVA, then if there was any significant difference, Dunnett’s multiple comparison test was performed. Results: No significant differences were found between the right and left tibial and saline and control groups in the total quantities. The GP volume and height and chondrocyte total volume showed no significant differences between the treatment and control groups. Conclusion: GH acts on rabbit proximal tibial GP by inducing chondrocyte hyperplasia but not hypertrophy. The operative procedure of implanting a minipump had no detectable effect on any of the parameters measured. GH had an effect on the local cytostructure of the GP on the treated side.
Growth hormone, Growth plate, stereologic study
http://feyz.kaums.ac.ir/article-1-279-en.html
http://feyz.kaums.ac.ir/article-1-279-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Patternof Staphylococcous Aureus susceptibility and resistance to antibiotics in Kashan
31
36
FA
Ghoalm Reza
Shajari
shajari_gh@kaums.ac.ir
Y
Rezvan
Moniri
N
Background: S.aureus related infections are prevalent and their resistance to routine antibiotics made their management a little difficult. The present study was corrected pit to determine the pattern of S.aureus susceptibility and resistance to antibiotics in clinic [6 month period in 1998 in Kashan].Materials and Methods: For this descriptive study, 7 subjects whose cultures were positive for S.aureus, included. Samples were cultured on standard, media standard techniques. Antibiotics resistance was achieved by disk diffusion method.Results: Of 76 samples the antibiotic resistance profile was as below: Oxacillin 96.1%, cloxacillin 63.2%, cephalotin 23.7% and vancomycin 18.4%. Conclusion: S.aureus is relatively resistance to oxacillin and cloxacillin in Kashan. Fourteen analytical studies are strongly recommended with special attention an age, sex and previous drug regimen.
Staphylococcous aureus, Antibiotic resistance
http://feyz.kaums.ac.ir/article-1-291-en.html
http://feyz.kaums.ac.ir/article-1-291-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Effects of neurosurgery on hemodynamic parameters
37
42
FA
Hamid Reza
Sayedi
seiadiarani_hr@kaums.ac.ir
Y
Samad
Nourizad
N
Esmaeil
Fakharian
N
Sayed Gholam Abbas
Moosavi
N
Mehrdad
Mahdian
N
Background: General anesthesia could be accompanied by changes in hemodynamic parameters (arterial blood pressure, heart rate, rhythm, central venous pressure, and venous blood pressure) that would result in altered intracranial pressure. In deep anesthesia the brain perfusion is dependent on blood pressure. The present study was conducted to determine the effects of neurosurgery on hemodynamic parameters in Naghavi Hospital in Kashan. Materials and methods: This quasi-experimental study was performed on 112 patients. Systolic and diastolic blood pressure, and cardiac rhythm and rate were measured. Then the influence of sex, age, type of operation, duration of surgery and patient’s position on aforementioned parameters were evaluated. Results: The study population included 70 males and 42 females, most of whom aged ≥ 40 years. Hemodynamic changes were more apparent among males. Meanwhile, age of ≥ 40 years, spinal surgery, prone position, and operations of more than 2-hour duration were associated with greater hemodynamic changes. Changes in systolic and diastolic blood pressure during induction was significantly differed regarding the duration of operation and patient’s position. Conclusion: Hemodynamic changes are common in neurosurgical operations. These are different according to the type and duration of surgery and patient’s position. Further studies are highly recommended.
Systolic blood pressure, Diastolic blood pressure, Heart rate, Cardiac rhythm
http://feyz.kaums.ac.ir/article-1-290-en.html
http://feyz.kaums.ac.ir/article-1-290-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Seroepidemiology of hepatitis B and C in blood donors in Kashan, 1996-2001
43
50
FA
Hasan
Afzali
afzali_h@kaums.ac.ir
Y
Abbas
Taghavi Ardakani
N
Gholam Reza
Vali
N
Background: Hepatitis B and C viruses are the most common causes of viral hepatitis, chronic hepatic disorders and cirrhosis. Since the true profile of hepatitis B and C was unknown in Kashan, the present study was performed on blood donors in Kashan during a 6-year period, 1996-2001.Materials and methods : For this descriptive study, all blood donors were included. Having their inclusion criteria fulfilled, they were asked for another 7cc venous blood before the cannula removed. HBSAg and HCVAb were determined using ELISA technique. Results : Of 43731 blood donors, 273 (0.6%) were HBSAg positive. The prevalence of hepatitis B was revealed to be 0.49-0.82. Meanwhile, 477 subjects (1.1%) were AntiHCV positive, thus the prevalence was 0.38-1.71. Conclusion : With respect to the prevalence of hepatitis C, this should be considered as a social health problem in Kashan. Fortunately, hepatitis B was controlled during the recent decade due to vaccination, observing health issues and improved monitoring of blood products.
Seroepidemiology, Hepatitis B, Hepatitis C
http://feyz.kaums.ac.ir/article-1-281-en.html
http://feyz.kaums.ac.ir/article-1-281-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
One year follow up of side to side arterio-venous fistula with ligation of venous distal limb in hemodialytic patients
51
55
FA
Sayed Saeid
Mortaz
Y
Hamid Reza
Taheri
N
Mohammad Reza
Jalali Nadoushan
N
Background: It is essential to have a proper vessel route to do hemodialysis that is done by applying A-V fistula. In the current study complications and patency rate of side to side anastomosis with distal limb venous ligation have been evaluated during one year follow up. Materials and methods: This study was carried out on 62 randomized CRF patients who received AVF by side to side anastomosis and patency rate of this technique were evaluated in six months and one year periods. Results: Complications were reported in 12.9%, the vast majority of which were mild and none of them needed reoperation. The patency rate revealed to be 93.56%. Conclusion: AVF by side to side anastomosis with distal venous limb ligation can have low complication and high patency rate. However, a longer time follow up and comparing with other techniques are needed for more accurate conclusions.
Hemodialysis, Arteriovenous fistula, side to side anastomosis, patency
http://feyz.kaums.ac.ir/article-1-286-en.html
http://feyz.kaums.ac.ir/article-1-286-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Surveying the association between asbestos exposure and pulmonary tuberculosis
56
62
FA
Siminokht
Shoaie
Y
Shokrollah
Mohammadi Mahmoodabadi
N
Asbestos, Exposure, Pulmonary Tuberculosis
http://feyz.kaums.ac.ir/article-1-292-en.html
http://feyz.kaums.ac.ir/article-1-292-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Frequency and etiology of intracranial hemorrhage in neonates admitted in Kashan hospitals, 1996-2000
63
68
FA
Ziba
Mosayebi
mosaieby_z@kaums.ac.ir
Y
Amir Hossein
Movahedian
N
Mohsen
Khezri
N
Background: Intracranial hemorrhage (ICH) is an important cause of mortality and neurologic sequels in the neonatal period. As there is little information about the prevalence and etiologies of neonatal I.C.H. in Kashan, the present study was carried out on neonates admitted in Kashan hospitals during a 4-year period, 1996-2000. Material and methods: This retrospective study was conducted on 2755 neonates. Having the diagnosis confirmed, initial data including gestational age, sex, clinical manifestations, mode of delivery, maternal risk factors, type and cause of hemorrhage were collected from medical records and results were analyzed. Results: Of 62 cases of ICH, 42 were in preterm and 20 were in full term neonates. The most common etiology of ICH in preterm and term neonate was asphyxia and trauma, respectively. The most common type of ICH in preterm was intraventricular hemorrhage versus subdural hemorrhage in full terms. There was no significant relationship between ICH and sex or mode of delivery. Decreased More reflex was the most common clinical finding and preeclampsia was the most important maternal risk factor in ICH. Conclusion: Considering the frequency of ICH in preterm neonates (27 times more than full terms neonates) and asphyxia as the most common etiology, further attempts should be employed to prevent preterm deliveries and occurrence of asphyxia.
Intracranial hemorrhage, Asphyxia, Trauma, Prematurity, Full term neonates
http://feyz.kaums.ac.ir/article-1-287-en.html
http://feyz.kaums.ac.ir/article-1-287-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
study of the infants’ growth from birth to 2 years in rural community of Babol
69
78
FA
Karimallah
Hajian
Y
Abbas
Alipour
N
Narges
Habibian
N
Parvin
Sajjadi
N
Background: Evaluating the process of child’s growth monitoring is of utmost importance to detect malnourishment. The present study was conducted with the aim of determining the trend of infant growth from birth to 2 years in the rural community of Babol and compare this with NCHS. Materials and methods: This exiting data type study was conducted on monitoring growth system in Babol rural communities, which were covered by health centers. 429 children with their birth between 1994 to 1996 were selected through a cluster sampling technique. The percentiles of height and weight were calculated and compared with NCHS standard. Results: Results have revealed that the weight of 67.5% of infants was between 50th and 97th NCHS standard at 1 month. This figure was reduced by increasing the age to 45.2% at 6 month, 42.6% at 12 month and 44.2% at 24 month. Girls’ growth profile showed a 5-20% reduction as compared to boys. Results also showed that the reduction of height in comparison with standard, was began at age 1 to 3 month. The 50th percentile of height was close to the NCHS, but after 3 month it deviates from NCHS. A significant difference was observed between 50th percentiles of height and weight with NCHS (p< 0.05). Conclusion: The results indicated that Iranian infants’ growth can not be evaluated with NCHS standard. It is necessary to provide national and local charts of the growth for Iranian children.
Height, Weight, NCHS standard, malnourishment
http://feyz.kaums.ac.ir/article-1-284-en.html
http://feyz.kaums.ac.ir/article-1-284-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Cutaneous lesions of the groin area and its related factors, Razi hospital, Tehran
79
83
FA
Masoume
Barzegari
Y
Haede
Ghani Nejad
N
Reza
Taghavi Ardakani
N
Ali
Dadban
N
Background: The traditional classification of dermatologic diseases is based on etiology and clinical appearance, however, regional approach could be an appropriate alternatrive in clinical or research affairs. The present study was conducted in a dermatologic clinic in Razi hospital, Tehran to determine the frequency of cutaneous lesions of groin area and proposed the importance of a regional approach.Materials and methods : This cross sectional study was performed on 3401 patients referring consecutively. Diagnosis was made by clinical and paraclinical studies, if necessary biopsy was also taken. Meanwhile, sex, age and body mass index were all recorded. Results: Of 3401 patients, 3.9% had cutaneous lesions of groin area. Dermatophytosis, erythrasma, and seborrheic dermatitis were reported in 17.2, 14.9, and 14.9% of individuals. Lesions had shown significant differences according to the sex, and type of lesions.Conclusion : Cutaneous lesions of groin area are relatively common. Further regional approach studies are strongly recommended.
Groin area, Cutaneous lesions
http://feyz.kaums.ac.ir/article-1-294-en.html
http://feyz.kaums.ac.ir/article-1-294-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Congenital anomalies and consanguineous marriage
84
88
FA
Amir Hossein
Movahedian
movahedian_eh@kaums.ac.ir
Y
Ziba
Mosayebi
N
Saeid
Yousefian
N
Tahere
Mazouchi
N
Background: Consanguineous marriage is one of the most important etiology of morbidity and anomaly in neonates and children, for which annually thousands of neonates and children sacrifice. This study was performed in Shabihkhani hospital in Kashan to determine the prevalence of congenital anomalies among consanguineous marriages. Material and methods: All neonates born in Shabihkhani hospital in 2000-01 were included and initial data including sex, gestational age, type of delivery, prenatal care, drug history, special disease in mother, type of anomaly, history of still birth or anomaly in previous pregnancy were recorded. Type of anomaly in the first 24 hours was distinguished for further classification. Paraclinic tests and consultations were also used. Results: Of 3529 neonates, 768 (21/8%) were born of a consanguineous marriage and the remaining 2761 (78.2%) from non-consanguineous marriage. Totally, 109(3.08%) deliveries were led to neonate’s anomaly, of these 7.03% were in the consanguineous marriage group (72.3% in first-cousin marriage and 27.7% in second-cousin marriage) and 2% in the other group. Conclusion: The prevalence of consanguineous marriage in our study was relatively high and the rate of neonate anomaly of consanguineous marriage was more than what expected. Obviously, in case of consanguineous marriage, the rate of anomaly clearly increased.
Congenital anomaly, Consanguineous marriage, First-cousin marriage, Second-cousin marriage
http://feyz.kaums.ac.ir/article-1-293-en.html
http://feyz.kaums.ac.ir/article-1-293-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Isolation of a Steroidal Alkaloid From Buxus hyrcana
89
92
FA
Abdolmajid
Ayatollahi
Y
Hossein
Komeilizadeh
N
Background: Buxus hyrcana is species of Buxus genus. Buxus specien are known an The are of sterois alkaloids with biologic activity. They are widely Ysed in Traditicnal Medicine to Treat rhematism gout, skin diseases and Malaria nesistant to common therapies . therapies. The present study was carries out to extract steroid alkaloids from Buxus hyrcana gathered in uoshahr, Iran, and assessed its phytochemical chara cteristicsMaterials and Methods: For This exploratory study, The plant was dried regardless of exte heat or light. Then was powdered and ulraclecl using metharel. Turllur experiments enealed thal the produst contained alkaloids, and flavonoids. To txtract alkaloids , The product was exposed to Hcl s so thal ets PH reached 2. then chlorofcrn was osed to divide The chlovofornic phase contained non – alkaloids, wheras the olter phase contained and ets PH was reached Q By means of arncniurn , Finally chloroform wan wed for extraction During The Column chranatography of the chloro formic phase, an unpurified material was esolated that finally purified by thin loyer chromatography. Results: The purified material had The following characteristics: UV absorption, Melting point of 170-173 ° C . molecular formula of And molecular mass of 385 Meanuhile, The presence of ketonic, alcoholic and amin groups as cyclopropanic cyclen wene all Cenfirmed.
http://feyz.kaums.ac.ir/article-1-282-en.html
http://feyz.kaums.ac.ir/article-1-282-en.pdf
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
6
3
2002
10
1
Case Report: Anaplastic cervical cancer in a virgin girl
93
98
FA
Maryam
Afrakhteh
Y
Jafar
Nasouhi
N
Atsa
Mahdavi
N
Anaplastic cervical cancer in a virgin girl without any known risk factor, is rare. With respect to its rarity, severity and prognosis, we introduce a case referred to Shohada hospital in Tehran, in 1378. The case, a 31 years old virgin girl with acute urinary retention, anemia, fever and abnormal uterine bleeding was admitted. Many times, she expelled vaginally some tissues with pathologic report of highly malignant neoplasm of unknown cellular origin. Regarding clinical and paraclinical data, the patient underwent radical hysterectomy (Wertheim) and pelvic lymph node dissection. Pathologic report was highly malignant anaplastic neoplasm with massive lymphatic invasion to cervix. The operation followed by chemotherapy and radiotherapy. Five months later, the patient managed by chemoradiation, because of recurrence of tumor in para-aortic lymph nodes. Finally nine months following the first diagnosis, she expired from uremia. In conclusion, supposing unknown risk factors for cancer of cervix, probability of this cancer in virgins should be considered. Early detection of cervical cancer in this group who are apparently without any known risk factors, is of utmost importance.
Cervical cancer, Virgin girl, Anaplastic cancer
http://feyz.kaums.ac.ir/article-1-280-en.html
http://feyz.kaums.ac.ir/article-1-280-en.pdf