@article{ author = {Amiri, Sara and Azadmanesh, Kayhan and Naghdi, Nasser}, title = {The maintenance effect of β-amyloid injection in the CA1 region of hippocampus on learning and spatial memory in adult male rats}, abstract ={Background: Alzheimer’s disease is one of the most common neurodegenerative diseases that lead to the progressive loss of mental, behavioral and learning abilities. The aim of this study was to investigate the maintenance effect of β-amyloid1-42 (Aβ) injection in the CA1 region of hippocampus on learning and spatial memory of adult male rats using the Morris water maze test. Materials and Methods: In this study, 42 adult male Wistar rats were randomly divided into control (intact), sham (Aβ solvent) and Aβ-injected groups (5 μg/μl). The β-amyloid and its solvent were bilaterally injected into the CA1 region of rats' hippocampus. The first recipient group of Aβ and its solvent after 6, the second group after 11 and the third groups after 31 days were trained by the Morris water maze test. Results: During 4 training days and also in probe and visible tests, there was no significant difference between control and sham groups. The results of the learning steps in Aβ groups showed that traveled distance and escape latency to find the hidden platform was significantly increased compared with the sham groups, but there was no significant difference in the probe and visible tests between these groups. Conclusion: It seems that long exposure to Aβ can lead to more memory and learning loss in animals with Alzheimer.}, Keywords = {Alzheimer, β-Amyloid, Hippocampus, Spatial Learning memory, Rat}, volume = {22}, Number = {1}, pages = {1-14}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3205-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3205-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Shariati, Seyed Hamid and ShalizarJalali, Ali and Esmaeilnejad, Bijan and Mazaheri-Khameneh, Rami}, title = {Histological analysis of testiculopathy induced by experimental babesiosis in mouse}, abstract ={Background: The babesias are the second common blood parasites in mammalian after trypanosomes and babesiosis as an emerging zoonotic disease has caused great concern. The aim of this study was to examine testicular histological alterations following experimental babesiosis induction by Babesia bigemina in mouse. Materials and Methods: In this experimental study, 24 adult male mice were randomly divided into four equal groups including untreated control, sham (receiving 2.0 ml normal saline intraperitoneally at the time of babesiosis induction), splenectomy and experimental babesiosis. Groups Experimental babesiosis was induced in splenectomized mice through 2.0 ml intraperitoneal injection of the infected heparinized blood sample belonging to a cow with confirmed B. bigemina infection. All animals were euthanized after 5 days and testicular histology was evaluated following confirmation of infection using microscopic and molecular analyses. Results: The experimental babesiosis caused a significant reduction in the cross-sectional area, quality, maturation and number of seminiferous tubules cross-sections as well as severe testicular morphological alterations such as distinct hypospermatogenesis and spermatogenic maturation arrest compared to control, sham and splenectomy groups. Conclusion: Findings of this study show that B. bigemina infection can lead to testicular damage in mice probably through microcirculatory disruption and blood flow reduction.}, Keywords = {Histology, Testis, Mouse, Babesia bigemina}, volume = {22}, Number = {1}, pages = {15-24}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3428-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3428-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {MohammadPourZehab, Maryam and Shariati-Sharifi, Fariborz and Jamshidian, Abbas and Hajinezhad, Mohammad Rez}, title = {The effect of Syrian mesquite (Prosopis farcta) seed extract on thioacetamide-induced oxidative stress in rats}, abstract ={Background: This experimental study aimed at investigating the effect of Prosopis farcta seeds hydro-alcoholic extract on thioacetamide-induced oxidative stress in rats. Materials and Methods: In this study, 30 adult male rats were randomly divided into three groups: healthy control, positive control, and P. farcta- treated group received thioacetamide. The healthy control rats received normal saline orally. The positive control rats received thioacetamide (50 mg/kg IP) for three times at one-day interval (oxidative stress induction). The P. farcta seed extract (100 mg/kg) was administered orally for 21 days. At the end of the experiment, blood samples were taken from the rats' heart to separate serum and the serum catalase (CAT) and superoxide dismutase (SOD) activities were determined. After euthanasia, liver and kidney were separated to determine malondialdehyde (MDA) levels. Results: The activities of CAT and SOD were significantly lower in the thioacetamide- intoxicated group compared to those in the healthy control group (P<0.001). The treatment with P. farcta seed extract significantly increased the activities of these enzymes compared to the positive control group (P<0.001). Moreover, after three weeks of oral treatment, the P. farcta seed extract significantly reduced the liver MDA concentrations compared with the positive control rats (P<0.05). Conclusion: It can be concluded that P. farcta seed hydro-alcoholic extract can protect against thioacetamide-induced oxidative stress.}, Keywords = {Thioacetamide, Liver, Prosopis farcta, Rats }, volume = {22}, Number = {1}, pages = {25-30}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3337-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3337-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Movagharnia, Rabee and Baghbani-Arani, Fahimeh and SadatShandiz, Seyed Ataollah}, title = {Cytotoxicity effects of green synthesized silver nanoparticles on human colon cancer (HT29) cells}, abstract ={Background: Nowadays, investigations on the role of nanoparticles for diagnosis, and treatment of cancers are being increased. This study aimed at examining the cytotoxic effect of green synthesized silver nanoparticles (AgNPs) on human colon cancer (HT29) and normal (HEK293) cells using the Artemisa tournefortiana extract. Materials and Methods: In the current study, the green synthesis of AgNPs was conducted using the A. tournefortiana extract. Then, the characterization of fabricated AgNPs was performed by ultraviolet-visible (UV-vis) spectroscopy, X-ray diffraction (XRD), and transmission electron microscopy (TEM) methods. The HT29 and HEK293 cell lines were treated with different concentrations of synthesized AgNPs for 24 hours and the viability of cells and half-maximal inhibitory concentration) IC50( were calculated by the MTT assay. Results: The fabricated AgNPs showed the characteristic surface plasmon resonance peak at around 425 nm. The crystallographic shapes from the XRD and TEM tests showed that the AgNPs were mostly spherical in shape, having an average diameter of 22 nm. The MTT results revealed that AgNPs significantly decreased the viability of cells in dose-and time-dependent manner. The IC50 values of nanoparticles for HT29 and HEK293 cell lines, during the 24 hours, were 40.71 and 61.38 mg/mL, respectively. Conclusion: According to the results of the current study, the green fabricated AgNPs can have a more cytotoxic effect on colon cancer cells compared to the normal cells. Thus, they can be considered as a promising strategy for the treatment of colon cancer.}, Keywords = { Green synthesis, Silver nanoparticles, MTT, Colon cancer}, volume = {22}, Number = {1}, pages = {31-38}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3196-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3196-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Abdi, Ahmad and Aohajeriravani, Oro}, title = {The effect of Punica granatum L. along with aerobic training on resistin, serum adiponectin and insulin resistance in women with type 2 diabetes}, abstract ={Background: Factors secreted from adipocytes, such as resistin and adiponectin can affect peripheral insulin resistance and type 2 diabetes. Physical activity and pomegranate, which has both anti-inflammatory and antioxidant properties can affect resistin and adiponectin. The aim of this study was to examine the effect of Punica granatum L. along with aerobic training on serum resistin, adiponectin and insulin resistance in women with type 2 diabetes. Materials and Methods: In this study, 33 diabetic women with type 2 diabetes were selected from Babol city and were randomly divided into four groups (control, P. granatum L., training and P. granatum L.+ training). The training groups participated in an aerobic training for six weeks, three sessions a week (60% to 75% of the reserved heart rate and for 25 to 45 min). The control groups of P. granatum L. and P. granatum L. + training were fed 150 mL of P. granatum L. for six weeks (at about 18 p.m). Two days before and after the protocol, blood samples were taken. Results: The results showed that there was no significant difference in the serum resistin levels among the three experimental groups. Also, the results showed a significant difference between adiponectin levels and insulin resistance in four groups. Conclusions: It seems that aerobic training and P. granatum L. and combination of both can have anti-inflammatory and antioxidant effects on reduction of adiponectin and insulin resistance in women with type 2 diabetes.}, Keywords = {Aerobic exercise, Punica granatum L., Resistin, Adiponectin, Type 2 diabetes}, volume = {22}, Number = {1}, pages = {39-47}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3369-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3369-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Ansar, Akram and Alirezaei, Pedram and Daneshyar, Sajjad and Sharafi, Bita and Torabian, Saadat}, title = {Comparison of efficacy and tolerability of tretinoin gel 0.05% with adapalene gel 0.1% in treating mild to moderate acne vulgaris}, abstract ={Background: Acne vulgaris is an inflammatory skin disease. Topical retinoids with significant anti-inflammatory properties are used for treatment of acne. The common side effect of topical retinoids is local irritation. The aim of this study was to compare the efficacy and tolerability of tretinoin 0.05% and adapalene 0.1% in patients with mild to moderate acne vulgaris. Materials and Methods: This randomized double-blind clinical trial was conducted on 50 patients referred to the dermatology clinic of Farshchian hospital in Hamadan city with mild to moderate facial acne. The patients were divided into two groups; the first group received tretinoin gel 0.05% and the second group adapalene gel 0.1%. The severity of acne was measured by Global Acne Grading System (GAGS) and tolerability was evaluated at the beginning of the trial, and 4 and 12 weeks thereafter in both groups. Results: The mean GAGS score at the beginning of the study was 49.56 (SD=12.24) in the adapalene group and 47.76 (SD=11.34) in the tretinoin group (P=0.592). This score dropped to 35.00 (SD=11.13) in the adapalene and 25.28 (SD=8.17) in the tretinoin group in week 4 (P= 0.001). A further GAGS score decline was observed in week 12 (25.08±9.00 in the adapalene and 12.12±4.71 in the tretinoin group (P<0.001)). Regarding tolerability, there was no significant difference between the two groups at the end of weeks 4 and 12 (P=1.00 and P=0.747, respectively). Conclusions: Adapalene 0.1% and tretinoin 0.05% are both effective and safe in treatment of mild to moderate acne vulgaris, although the tretinoin gel shows more efficacy in reducing the GAGS score.­ Both treatments are equally tolerated.}, Keywords = {Acne vulgaris, Tretinoin, Adapalene}, volume = {22}, Number = {1}, pages = {48-56}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3236-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3236-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mokhtari, Fatemeh and Esfarjani, Fahimeh and Kargar-Fard, Mehdi}, title = {The effect of aerobic exercise and barley β-glucan on blood glucose, body composition and blood pressure of diabetic women}, abstract ={Background: The incidence of type 2 diabetes increases with aging, unhealthy diets, obesity and sedentary lifestyles. The aim of this study was to investigate the combinational effect of a 12-week aerobic exercise and barley β-glucan (BBG) on blood glucose, body composition and blood pressure in women with type 2 diabetes. Materials and Methods: In this semi-experimental study, 24 women with the mean age of 49 years and a blood glucose level of 110-280 mg/dl were purposefully selected and  randomly divided into three groups: a) group of aerobic exercise with diet (n=8), b) diet group (n=8) c) control group (n=8). The diet group consumed one barley bread, containing 4 g of β glucan, each day for 12 weeks. The group of aerobic exercise, who was on diet, participated in a progressive walking program with the intensity of %60-70% of maximal heart rate in addition to diet program (barley bread). Blood glucose, weight, fat percentage, and systolic and diastolic blood pressure levels were measured in pre-and post-training. Results: Results showed a significant decrease in the blood glucose level in the experimental groups compared to the control group, while no major changes were observed in body composition and blood pressure. Conclusion: It seems that the combined program (aerobic training with diet) or consumption of β-glucan alone can decrease blood glucose in patients with diabetes.}, Keywords = {Aerobic exercise, Type 2 diabetes, Blood glucose, Body fat percentage, Barley β-glucan}, volume = {22}, Number = {1}, pages = {57-66}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3208-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3208-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Sarlak, Parisa and Sedaghati, Parisa and Saki, Farzaneh}, title = {Comparing the effect of short-term detraining on athletic performance of elite competitive children and adolescent swimmers}, abstract ={Background: Optimum functioning of the competitive swimmers depends on the adaptations in power and strength of superficial, upper and lower limbs and interaction with core stabilizing muscles of the body. The aim of this study was to compare the effect of   short periods of detraining on exercise performance of elite competitive children and adolescents swimmers. Materials and Methods: In this prospective cohort study, 48 female participants with a history of more than 2 years (Damash Team) of professional exercise at Alborz province were selected based on available sampling and were assigned into 2 equal groups of children and adolescents based on their age. During the two periods, dependent variables, endurance of the trunk flexors, lateralis and flexors of the trunk, strength of the trunk muscles, dynamic balance and the performance of the swimmers (50 and 100 m) were evaluated. Results: Comparison of the results for swimming speed (50 m) showed a significant difference between the adolescent and children groups (P=0.001). In addition, total endurance of trunk muscles, power of trunk muscles and the dynamic balance in adolescents showed a significant difference (P=0.01), but the dynamic balance and swimming speed (50 and 100 m) were significant only in the children group (P=0.001). Conclusion: A 25-day detraining period results in a considerable alteration in the trunk muscle function, balance, and exercise performance of the competitive swimmers, especially among the children.}, Keywords = {Endurance, Detraining, Muscle strength, Elite, Athletes}, volume = {22}, Number = {1}, pages = {67-74}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3403-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3403-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Keshavarz-Norouzpour, Masoumeh and Bolhassani, Azam and Sari, Soyar}, title = {Polymorphism analysis of the CTLA-4 (rs231775) gene as a marker of inhibitor development in Iranian patients with hemophilia A}, abstract ={Background: Development of factor VIII (FVIII) inhibitor is the main problem of replacement therapy in patients with hemophilia A. Recently, the correlation of polymorphisms of some genes involved in immune system has been determined with inhibitor development. The reports showed that cytotoxic T lymphocyte antigen-4 (CTLA-4) plays an important role in regulating T cell activation and thus, CTLA-4 gene polymorphism is related to genetic susceptibility to various autoimmune diseases. This study aimed at investigating the correlation between polymorphism of CTLA-4 gene and inhibitor development in Iranian hemophilia A patients for the first time. Materials and Methods: In this case-control study, the genomic DNA was extracted from blood samples of 55 inhibitor positive and 45 inhibitor negative hemophilia A patients. Then, the genotyping of the CTLA-4 gene was performed using the Tetra Primer ARMS PCR. Moreover, the validation of single nucleotide polymorphisms (SNPs) in the CTLA-4 gene was determined by DNA sequencing. On the other hand, the role of HCV infection was determined in inhibitor-positive and inhibitor-negative HA patients. Results: Results showed that no statistically significant difference was observed between the genotypic and allelic frequencies with the presence of inhibitors (P>0.05). Moreover, a significant correlation was observed between HCV infections and development of inhibitors (P<0.05). Conclusion: The CTLA-4 gene polymorphism does not play a role for inhibiting coagulation factor in Iranian patients with hemophilia type A.}, Keywords = {Hemophilia A, Inhibitor, CTLA-4, Tetra ARMS PCR}, volume = {22}, Number = {1}, pages = {75-82}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3414-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3414-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Amiri, Arezoo and HajiGhasemKashani, Maryam and Ghorbanian, Mohammad Taghi}, title = {The study of neurotrophic factor genes expression of human adipose stem cells cultured in serum-containing and serum-free media}, abstract ={Background: Fetal bovine serum (FBS) is immunogenic for human and may transmit infection in the case of transplantation. So, this study aimed to compare the proliferation and survival rates of human adipose stem cells (hASCs), and their neurotropic factor genes expression in serum-containing and serum-free media. Materials and Methods: In this experimental study, stem cells were extracted from the abdominal subcutaneous adipose tissue of 15 cesarean women and cultured in α-MEM containing 10% of FBS or serum-free medium. The stemness of fourth passage of the cells was confirmed using the flow cytometry method, and their differentiation into adipocytes and osteocytes was also confirmed. Cell proliferation and survival were assessed using hemocytometry and MTT [3- (4,5-Dimethyltiazol-2-yl) -2,5-Diphenyltetrazolium bromide] methods, respectively. In addition, the expression of neurotrophic factor genes was analyzed by the real-time polymerase chain reaction method. Results: The cells had positive response to CD44, CD73, CD90, and CD105 markers, while they responded negatively to CD34 and CD45 markers and had the ability to differentiate into adipocytes and osteocytes. The survival and proliferation of the cells cultured in the serum-based medium for 48 hours were significantly increased compared to those cultured in the serum-free medium. Moreover, serum resulted in a significant increase in BDNF and NT-3 genes expression, compared to the cells cultured in the serum-free medium. Conclusions: More suitable cells can be provided for transplantation with serum deletion and culture medium optimization. The results can be matched to find an appropriate replacement for FBS.}, Keywords = {Human adipose stem cells, Neurotrophic factors, Proliferation, Survival, Serum}, volume = {22}, Number = {1}, pages = {83-93}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3342-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3342-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Zahiri-Sarvari, Sanaz and Daneshmandi, Hasan and Rahnama, Nader and Akoochakiyan, Mahdieh}, title = {The effect of weight and duration of carrying backpack on forward head, kyphoses and lordoses in 14-18 year-old girls}, abstract ={Background: In recent years, the weight of school backpack has become a growing concern and carrying the heavy backpack causes postural deformity. The aim of this study was to investigate the effect weight and duration of carrying backpacks on forward head, kyphoses and lordoses in 14-18 year-old girls. Materials and Methods: In this prospective cohort study, 262 girls with the mean age 15.5±1.1 years, height 160±6 cm, weight 56.4±12.5 kg, backpack weight 3.98±1.3 kg, and duration of carrying 17.5±8.5 min were randomly selected. Then, 45 healthy girls (mean age, 15.8 years) were voluntarily selected and randomly divided into three groups based on basic measurements including the weight of backpack 3.5, 4.8 and 6.1 kg in 16, 21 and 27 minutes, walking on the treadmill with 1.6 meters per second. The forward head, kyphoses, and lordoses were measured before and after walking on treadmill. Results: Results showed that carrying backpacks more than 3.5 kg in 16 min increased the kyphoses angle (P=0.048). Moreover, the results showed that carrying backpacks with any weight significantly increased lumbar lordoses angles. However, no significant difference was observed in changes of forward head posture among the three groups. Conclusion: Carrying heavy backpacks can increase kyphoses in girls. So, they should avoid carrying backpacks 6% heavier than their weight for more than 16 minutes.}, Keywords = {Backpack, Student, Forward head, Kyphoses, Lordoses}, volume = {22}, Number = {1}, pages = {94-102}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3111-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3111-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {KamaliSabeti, Arghavan and Daneshyar, Fahimeh and Yazdanfar, Hamid and KamaliSabeti, Arti}, title = {Comparison of the conformity rate of dental age based on Demirjian and Nolla methods with chronological age in 5-16 year old children in Hamedan city}, abstract ={Background: Considering the different results of dental age estimation tests for different populations and lack of sufficient studies on the Iranian race, this study was designed to compare the conformity rate of Demirjian and Nolla methods in dental age estimation. Materials and Methods: In the present cross-sectional study, 185 panoramic radiographs were assessed using patients' medical documents of pediatric and orthodontic departments. The maturation of each mandible left side permanent teeth except the third molars was categorized as A-H in Demirjian and 0-10 in the Nolla method. Results: The mean age of the participants was 9.6±2.8 years. For both genders, the Nolla and Demirjian methods had underestimation and overestimation, respectively, compared to chronological age. Pearson correlation coefficients for chronological age in the Nolla and Demirjian methods were (Pmale=0.982, Pfemale=0.985) and (Pmale=0.987, Pfemale=0.988), respectively. The difference between chronological age and dental age in the Nolla method ranged from -0.02 to 0.77 and -0.1 to 0.70 for boys and girls, respectively and ranged from 0.02 to 0.76 and 0.05 to 0.9 similarly in the Demirjian method. Conclusion: The Demirjian and Nolla methods are always associated with an overestimation and underestimation respectively compared to chronological age. Considering the difference between chronological age and dental age in the two methods, the average of differences in the Nolla method was lower compared to Demirjian. So, the Nolla method has more accurate estimation of chronological age. Therefore, in the present study, the Nolla method is more preferable than the Demirjian method.}, Keywords = {Dental age estimation, Chronology, Methods, Pediatric dentistry}, volume = {22}, Number = {1}, pages = {103-111}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3434-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3434-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mazoochi, Tahere and Ehteram, Mohamm}, title = {Apoptosis in the ovary and follicular atresia}, abstract ={Background: In the ovary, growing follicles develop from a pool of primordial follicles constituted early in life. The majority of ovarian follicles undergo atresia.  Follicular atresia is an important and negative process during the development of ovarian follicles. Cell apoptosis is believed to be involved in this process. This article is an overview of some researches on apoptosis in the ovaries and the factors involved in it. Materials and Methods: In this review article, the PubMed, Scopus, Embase, Current Content, and IranMedex databases were searched using keywords such as "apoptosis" and "ovary". The full-text articles published between 1997 and 2017 in English or Persian were included in the study. The genes involved in ovarian apoptosis and factors controlling follicle atresia and their role in ovarian follicular reserve and fertility were investigated. Results: Although follicular atresia occurs at all stages of follicular development, it has been shown that this process is dependent on the developmental stage and a large part of it is observed in the transitional stage between the preantral follicles and the antrum formation. Different paracrine and autocrine factors control the cell death of the ovary. Conclusion: Ovarian cells receive conflicting signals for survival and death, and it seems that the reason for determining the fate of cells in different stages of follicular development is the interaction between different signals.}, Keywords = {Ovary, Atresia, Apoptosis, Follicle}, volume = {22}, Number = {1}, pages = {112-119}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3514-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3514-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Davoudi-Farimani, Samane and Khayatzadeh, Jina and Homayouni-Tabrizi, Masou}, title = {The effect of copper oxide nanoparticles on the expression of the USP9Y gene in rat testicles}, abstract ={ Background: The increasing use of nanoparticles has raised concerns about the risks of nanoparticle release to the environment, which has adverse effects on fertility. Disruption of the expression of the USP9Y (Ubiquitin Specific Protease 9 Y chromosome) gene may cause azoospermia or oligospermia in the testes. The aim of this study was to investigate the effect of copper oxide nanoparticles on the expression of the USP9Y gene in rat testicles. Materials and Methods: In this experimental study, 24 adult male Wistar rats were divided into three treatment groups and one control group. The treatment groups received different concentrations of copper oxide nanoparticles (0.25, 0.50 and 0.75 mg/kg) and the control group received normal saline intraperitoneally for 14 days. Then, the testicles were removed and the size and diameter of the small and large testicles were measured. Finally, the expression of the USP9Y gene was investigated by the real-time PCR method. Results: After 14 days exposure to copper oxide nanoparticles, the rats' body weight, weight and diameter of the testicles, and the USP9Y gene expression were reduced dose-dependently in all three treatment groups. Conclusion: It seems that exposure to copper oxide nanoparticles may have a negative effect on fertility by reducing the expression of some genes associated with fertility of the male rats, and also by reducing the weight and size of the testes.}, Keywords = {Oxidative nanoparticles, USP9Y gene, Testicle, Infertility, Rat}, volume = {22}, Number = {2}, pages = {120-127}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3383-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3383-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Hasani, Sephdeh and Habibian, Masoumeh}, title = {The effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of old female rats}, abstract ={Background: The aging process is associated with a progressive deterioration of tissues and organs. Apoptotic cell death has been known as a possible causal factor in age-related pathologies. Therefore, this study was conducted to assess the effect of regular high-intensity interval exercise on some apoptotic factors in the brain tissue of aged female rats. Materials and Methods: In this experimental study, 14 aged female Wistar rats were selected and randomly divided into two equal groups (n=7) of control and exercise. The animals performed 10 bouts of 1-min high-intensity treadmill running (20–34 m·min–1), separated by 2 min of rest, for 3 days a week for 8 weeks. The rats were killed 48 h after the last treatment and their brain Bax and Bcl-2 levels were evaluated by the ELISA method. Results: The results showed that an 8-week, high-intensity interval exercise decreased brain Bax levels in aged rats (P<0.05). However, a significant increase was observed in the levels of brain Bcl-2 in the exercise group (P<0.05). Conclusion: It seems that a high-intensity exercise may mediate part of its protective effect against aging-induced apoptosis, by increasing brain Bcl-2 and suppressing Bax levels in brain.}, Keywords = { Apoptotic, Brain, High-intensity interval training}, volume = {22}, Number = {2}, pages = {128-133}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3437-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3437-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Fashi, Mohamad and AghaAlinejad, Hamid and Eskandari, Arezoo}, title = {The effect of aerobic exercise after exposure to black carbon particulate matter 2.5 on expression of NF-κB and TNF-α genes in the lung tissue of male rats}, abstract ={Background: The aim of the present study was to investigate the effect of aerobic exercise after exposure to black carbon particulate matter 2.5 (PM 2.5) on expression of NF-κB, and TNF-α genes in the lung tissue of male rats. Materials and Methods: Twenty-four male Wistar rats (mean weight, 279.29±26.97 g) were randomly divided into four equal groups: 1) control (without any intervention), 2) without aerobic exercise and with exposure to PM2.5 black carbon, 3) aerobic exercise without exposure to black carbon, and 4) aerobic exercise after exposure to PM2.5 black carbon. The aerobic exercise protocol was performed at 50% the maximal speed of each group for 4 weeks 15 minutes after exposure to black carbon particles in the chamber. Animals were sacrificed 24 hours after the last training session and exposure to black carbon particles. The expression of NF-κB and TNF-α genes were analyzed in the lung tissue of rats by the real-time PCR. Results: A significant difference was found in the NF-κB expression between the group 1 and other groups and also there was a significant difference in the TNF-α expression between the group 2 and group 3 after exposure to black carbon in the lung tissue of male rats. Conclusion: The findings show that aerobic exercise after exposure to the black carbon particles (PM2.5) is associated with adjustment in lung inflammatory factors. It seems that these changes in part are associated with a lower risk of inflammatory pulmonary disease.  }, Keywords = {Inflammation, Black carbon, Aerobic exercise, NF-κB, TNF-α}, volume = {22}, Number = {2}, pages = {134-142}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3480-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3480-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Ziaolhagh, Sayyed Javad and Khojasteh, Leila and Ziaolhagh, Sayyed Saeid and Yahyaei, Behrooz}, title = {The effect of boldenone anabolic steroid, and endurance and resistance training on liver damage markers in rats}, abstract ={Background: This study aimed at investigating the effect of boldenone, and endurance and resistance training on liver damage in rats. Materials and Methods: In this study, 70 male Wistar rats aged 12 weeks (weight, 228±7 g) were randomly divided into 10 equal groups: control, sham, boldenone (2 mg/kg), boldenone (5 mg/kg), resistance training, resistance training-boldenone (2 mg/kg), resistance training-boldenone (5 mg/kg), endurance training, endurance training-boldenone (2 mg/kg) and endurance training-boldenone (5 mg/kg) groups. The resistance training program included an 8-week climb from the ladder, three times a week and each session 3 sets with 5 repetitions and the endurance training program was 8-week running on treadmills, 3 days a week, every day 30 minutes at a speed of 12 meters per minute. The injection was performed in the biceps femoris muscle once a week. After anesthesia, autopsy was performed and the liver tissue was isolated for histological studies. Results: The most liver tissue damage was observed in the boldenone group without training; so that the vacuolar degeneration more than 66% and the presence of 1-3 necrotic cells was very important. In resistance training and high-dose boldenone resistance training, liver damage was also observed as vacuolar degeneration. In the endurance training-boldenone inflammation group, increased kupffer cells and mild vacuolar degeneration were observed. Histological studies showed that endurance training reduced the vacuolar degeneration and inflammation and did not increase kupffer cells. Conclusion: It seems that boldenone can cause damage to liver and endurance training compared with resistance training may cause more reduction in liver damage, especially reduction in the vacuolar degeneration and inflammation induced by boldenone.}, Keywords = {Boldenone anabolic steroid, Endurance and resistance training, Liver damage, Rat}, volume = {22}, Number = {2}, pages = {143-152}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3477-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3477-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Kheirandish, Rezvan and Ranjbar, Rohollah and Habibi, Abdolhami}, title = {The effect of selected Pilates exercises on some respiratory parameters of obese sedentary women}, abstract ={Background: Obesity has adverse effects on respiratory mechanisms and is considered as a risk factor for respiratory problems. The aim of the present study was to investigate the effect of the selected Pilates exercise program on some respiratory parameters of obese sedentary women. Materials and Methods: In this randomized experimental study with pre- and post-test design, 24 inactive obese women (with the mean age 38.4±8.61 years and BMI 35.6±2.95 kg/m2) were randomly divided into two groups of exercise (n=15) and control (n=9). The experimental group participated in a Pilates training program) 8 weeks, 3 times per week), while the control group did not participate in any training program. Some respiratory parameters were measured before and after the training program by a spirometer. Results: The results showed that Pilates training increased vital capacity (IVC) by 10%, inspiratory reserve volume (IRV) by 19%, expiratory reserve volume (ERV) by 51% , tidal volume (VT) by 29%, peak expiratory flow (PEF) by 88%, peak  inspiratory flow (PIF) by 28%, maximum expiratory flow 25 (MEF25) by 55%, maximum expiratory flow 50 (MEF50) by 63%,  maximum expiratory flow 75 (MEF75) by 89%, maximum expiratory flow 75-85 (MEF75-85) by  93% , which this increase was not significant in the IRV and VT indexes. Conclusion: It seems that Pilates exercises can increase the performance of the respiratory muscles in obese sedentary women and improve lung function by increasing some respiratory parameters.}, Keywords = { Pilates, Obesity, Respiratory indexes}, volume = {22}, Number = {2}, pages = {153-161}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3483-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3483-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Vahdatpoor, Halime and Shakeryan, Sai}, title = {Liver enzyme changes following the consumption of ginger and eccentric exercise in overweight girls}, abstract ={Background: The aim of this study was to examine the effect of two weeks ginger supplement on some liver enzymes including aspartate aminotransferase (AST), alkaline phosphatase (ALP), and alanine aminotransferase (ALT) following eccentric activity in overweight girls. Materials and Methods: In this semi-experimental study, 28 overweight female students were randomly divided into two complementary (n=14) and placebo (n=14) groups. The supplement group consumed 2 grams of ginger powder daily for two weeks. The exercise protocol consisted of two sessions of exhausting activity (negative slope on treadmill, one session before and one session after two weeks of supplementation) with an initial speed of 4 km/h and an initial gradient of 2%. Blood samples were measured in four stages before and immediately after the exercise in two steps before and after the use of ginger supplement to measure changes in liver enzymes. Results: The results showed that eccentric activity increased the AST, ALP and ALT levels. Also, there was no significant difference in the AST, ALP and ALT levels between the supplement and placebo groups after two weeks of ginger supplementation (P≥0.05). Conclusion: It seems that the use of ginger had a small effect in the improvement of liver enzyme serum levels. Therefore, the intensity and duration of the effective exercise, especially when consuming ginger, needs to be further investigated}, Keywords = {Eccentric exercise, Ginger, Liver enzymes, Overweight}, volume = {22}, Number = {2}, pages = {162-168}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3515-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3515-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mohseni, Negin and Ghorbian, Saei}, title = {Study of the association between Dicer (rs3742330 A>G) and Drosha (rs10719 C>T) gene polymorphisms and the risk of recurrent pregnancy loss}, abstract ={Background: Drosha and Dicer are important molecules that play critical regulatory roles in the biogenesis of micro-RNA. Genetic polymorphism in the Drosha and Dicer can cause defect on the embryo implantation and lead to the recurrent abortion. The aim of this study was to evaluate an association between Drosha and Dicer gene polymorphisms and the risk of recurrent pregnancy loss (RPL). Materials and Methods: This case-control study was performed on 100 women with RPL (with unknown reasons) and 100 women with a successful pregnancy (one alive child) and no abortion history referred to Imam Khomeini Hospital in Ardebil city during 2015-2017. The frequencies of these polymorphisms were evaluated using the PCR-RFLP method. Results: Results showed no statistically significant difference in the genotype frequency of the Dicer gene polymorphism between the case and control groups (P>0.05). On the other hand, a statistically significant difference was found in the genotype frequency of the Drosha gene polymorphism between the groups (P<0.05). Conclusion: It seems that the Drosha gene polymorphism can be a predisposing genetic factor for RPL, whereas the Dicer gene polymorphism cannot be considered as a risk factor for predisposing RPL in the studied population.}, Keywords = {Recurrent abortion, Polymorphism, Drosha, Dicer}, volume = {22}, Number = {2}, pages = {169-176}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3444-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3444-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Zanjani, Zahra and Shaiiri, Mohammad Rez}, title = {The relationship between disgust propensity and disgust sensitivity with contamination/washing obsessive-compulsive symptoms in students}, abstract ={Background: There is increasing attention for the role of disgust in psychopathology, especially contamination/washing obsessive-compulsive symptoms by Western researchers in recent decades. There has not been much attention paid to this disorder in Iran. This study aimed at determining the role of disgust propensity and disgust sensitivity in predicting contamination/washing obsessive-compulsive symptoms. Materials and Methods: In this analytical descriptive study, 295 students were selected from Shahed University by the cluster sampling method. The participants completed the demographic questionnaire, Padua Inventory (PI, contamination subscale) and Disgust Propensity and Sensitivity Scale-Revised (DPSS-R). Results: The results of Pearson correlation showed that there was a positive and significant relationship between the disgust propensity and the disgust sensitivity with contamination/washing obsessive-compulsive symptoms and this relationship was stronger in women (0.41-0.42) than in men (0.23-0.24). The results of regression analysis showed that disgust propensity (β=0.34, P<0.001) and disgust sensitivity (β=0.17, P<0.001) could predict the contamination/washing obsessive-compulsive symptoms (R=0.45, R2=0.20). Disgust propensity had a stronger predictive role (R2=0.16, P<0.001). However, age could not predict contamination/washing obsessive-compulsive symptoms. Conclusion: The present study provides support for the role of disgust in the prediction of contamination/washing obsessive-compulsive symptoms and it can be used for early diagnosis and timely treatment of this disorder.}, Keywords = {Disgust propensity, Disgust sensitivity, contamination/washing obsessive compulsive symptoms, Student}, volume = {22}, Number = {2}, pages = {177-184}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3472-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3472-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Maghbooli, Nastaran and Mohammadi, Mohammad Ali and Naderian, Mohammad Reza and Jamali, Raik}, title = {The utility of Helicobacter pylori eradication in improving functional dyspepsia in adult population in Iran}, abstract ={Background: This review aimed at investigating the effectiveness of Helicobacter pylori eradication in improving the symptoms of patients with functional dyspepsia in Iranian adult population. Materials and Methods: This study was a systematic review. Data were collected from the Medline database by searching some keywords including "Helicobacter pylori", "eradication", "effectiveness", "dyspepsia", and "Iran". After obtaining the full text of articles, the critical review was performed based on article titles and abstracts. For each article, information regarding benefits, side effects and efficacy was identified. Then, scenarios were extracted according to the mentioned data. Results: From a total of 28 reviewed papers, 6 were systematic reviews (with the level of evidence 1a), 18 articles were randomized interventional trials (with the level of evidence 1b) and 4 articles were longitudinal studies (with the level of evidence 2b). Most studies reported improvement in symptoms, although some of them did not report the statistically significant difference. After extracting data related to the scenarios from the articles, they were rated regarding the clinical advantage and the ability to localize each scenario. Conclusion: Considering the results of analyzing the articles and extracted scenarios, Helicobacter pylori eradication is recommended in Iranian adult patients with functional dyspepsia, normal upper gastrointestinal endoscopy, and documented Helicobacter pylori infection.}, Keywords = {Helicobacter pylori, Functional dyspepsia, Iran}, volume = {22}, Number = {2}, pages = {185-191}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3505-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3505-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Hosseinian, Masoumeh and Noury, Robabeh and Moghadasin, Maryam and Esalatmanesh, Sophi}, title = {Study of the mediating role of mental health and motives for substance use in the relationship between adjustment to university and cigarette and water-pipe use among the students}, abstract ={Background: The prevalence of cigarette and water-pipe smoking is gradually increasing among the students in Iran. Considering the psychosocial consequences of smoking, this study aimed at examining the mediating role of mental health and motives to drug abuse in the relationship between adjustment to university and cigarette and water-pipe smoking among students. Materials and Methods: This correlational study with a structural equation modeling approach was conducted on 634 students selected from Kashan universities by cluster sampling. Data were collected using the Student Adaptation to College Questionnaire (SACQ), Substance Use Motives questionnaires, Young Risk Behavior Scale (YRBS), and General Health Questionnaire (GHQ-28). Results: The study model had good fit indices (X2=1.42, DF=5, P=0.92, AGFI=0.99, CFI=0.99, NFI=0.99, GFI=0.99, RMSE=0.019).The results of the study showed that there was a reverse and meaningful relationship between individual-emotional adjustment and attachment to university with mental health and substance use motives (P<0.05). Moreover, there was a direct and meaningful relationship between mental health and substance use motives with cigarette use and also between substance use motives and water-pipe use. Conclusion: Findings show decrease in the two dimensions of adjustment to university and individual-emotional adjustment, which can lead to mental health problems. Coping motives for cigarette smoking and enhancement motives for water-pipe smoking may increase the probability of cigarette and water pipe smoking in students. Implementing different smoking prevention programs and screening the students' mental health, especially students with mental disorders, are recommended.}, Keywords = {Adjustment to university, Mental health, Motivations to drug use, Cigarette, Water-pipe, Students}, volume = {22}, Number = {2}, pages = {192-205}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3527-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3527-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Einabadi, Masoume and Abdolerahmani, Fahimeh and YousefiMashoof, Rasoul and Vazini, Hossein and shakerimoghaddam, ali and Khaledi, Azad and Piroozmand, Ahmad and Karami, Pezhm}, title = {Study of drug resistance of Staphylococcus aurous and Pseudomonas aeruginosa strains isolated from environmental samples of Hamadan educational hospitals in 2017 using disk diffusion and minimum inhibitory concentration}, abstract ={Background: Staphylococcus aureus and Pseudomonas aeruginosa are the most important bacteria causing the nosocomial infections, which are resistant to most of the antibiotics. The aim of this study was to evaluate the drug resistance of S. aureus and P. aeruginosa strains isolated from environmental samples of Hamedan educational hospitals using disk diffusion and minimum inhibitory concentration (MIC) methods. Materials and Methods: In this descriptive cross-sectional study, 400 samples were collected from Hamedan educational hospitals. To assess the antibiotic susceptibility of 10 common antibiotics, the agar dilution (Kirby-Bauer) method was used. Also, to determine the MIC of S. aureus and P. aeruginosa, vancomycin and ciprofloxacin antibiotics were used. Results: From a total of 400 samples, 39 (9.7%) isolates were P. aeruginosa and 28 (7%) were S. aureus. Staphylococcus aureus showed the highest resistance to ofloxacin (82.1%) and the highest drug resistance to P. aeruginosa was related to meropenem (82%). Also, the highest MIC and maximum bactericidal concentration (MBC) for S. aureus to vancomycin were 128 and 256, respectively. In P. aeruginosa, the highest MIC and MBC to ciprofloxacin were 128 and 256, respectively. Conclusion: Staphylococcus aureus and P. aeruginosa showed the highest resistance to ofloxacin and meropenem, respectively. Considering the rapid increase of antibiotic resistance, accurate evaluation of the antibiotic resistance pattern of the bacteria is required.}, Keywords = { Antibiotic resistance, Staphylococcus aureus, Pseudomonas aeruginosa}, volume = {22}, Number = {2}, pages = {206-213}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3496-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3496-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Moghanni, Marzieh and Dashtgard, Ali and Barzegari-Esfeden, Zohreh}, title = {Prevalence of extended spectrum β-Lactamase producing Escherichia coli among hospitalized and outpatient children in Shohada Hospital in Qaen during 2017-2018}, abstract ={Background: Antibiotic resistance in pathogens, especially Escherichia coli, has become a major treatment issue. One of the most common resistance mechanisms is the production of extended spectrum beta-lactamase (ESBL) enzymes. Given the importance of the ESBL-producing bacteria, it is necessary to determine their prevalence in each region. The aim of this study was to determine the prevalence of ESBL-producing E. coli in pediatric hospitalized patients and outpatients in Shohada Hospital in Qaen city. Materials and Methods: This descriptive cross-sectional study was conducted on 223 samples of E. coli obtained from two groups of hospitalized patients and outpatients in Shohada Hospital in Qaen city. To confirm the E. coli strains, selective culture media and biochemical tests were used. The antibiotic susceptibility of the strains was determined by the disk diffusion method, and detection of the ESBL phenotype strains was performed by the combined disk method. Results: The prevalence of ESBL-producing E. coli was 30%. Also, the prevalence rates of ESBL-producing E. coli in hospitalized patients and outpatients were 50% and 24.4%, respectively. The ESBL strains showed the highest resistance to ceftriaxone, cefexime, cefazolin and cefotaxime antibiotics, and the least resistance to nitrofurantoin and amikacin. Conclusion: The findings show a higher prevalence of ESBL-producing E. coli in hospitalized patients compared to outpatients, which indicates a wide spread of antibiotic-resistant strains in hospitals. Therefore, continuous monitoring and rapid identification of these strains can play an important role in preventing the spread of ESBL genes.}, Keywords = {Escherichia coli, Antibiotic resistance, Extended spectrum beta-lactamases}, volume = {22}, Number = {2}, pages = {214-221}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3522-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3522-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Bahmanabadi, Rashin and Khalili, Mohammad Bagher and Bakhshi, Bita and SoltanDallal, Mohammad Mehdi}, title = {Evaluation of the prevalence of typical and atypical enteropathogenic Escherichia coli isolated from stool specimens of patients with diarrhea admitted to Tehran Children\'s Hospital by the PCR Method}, abstract ={Background: Infectious diarrheal diseases are a major cause of death in community, especially in children. Enteropathogenic Escherichia coli (EPEC) are considered as a major cause of children's diarrhea in developing countries. The aim of this study was to evaluate the prevalence of both typical Enteropathogenic (tEPEC) and atypical Enteropathogenic (aEPEC) E. coli isolated from patients admitted to the children's hospital in Tehran by the PCR method. Materials and Methods: In this cross-sectional study, a total of 157 children diarrheal samples were collected from February 2016 to August 2017 and were sent to the microbiology department in the School of Public Health in Tehran University of Medical Sciences for testing. The identification of isolates was performed by conventional biochemical tests. The typical and atypical E. coli isolates were identified for the presence of eae, sxt1, sxt2 genes, and bfp A by the PCR method. The drug resistance patterns of isolated EPEC were tested by the agar disk diffusion method. The antibiotics used were amoxicillin-clavulanic, ampicillin, gentamicin, trimethoprim- sulfamethoxazole, ciprofloxacin, cefepim, Nitrofurantoin and imipenem. Results: Out of 101 E. coli isolates, 7 were identified as EPEC. All the isolated strains carried eae but not stx1, stx2, and bfp A genes. Also, 100% of the isolates were resistant to amoxicillin-clavulanic and ampicillin. Conclusion: A high prevalence of EPEC in children can be considered as a threat to the children's health. In this study, all the isolates were aEPEC.}, Keywords = {Escherichia coli Enteropathogenic, Typical, Atypical, Children, Diarrhea, PCR}, volume = {22}, Number = {2}, pages = {222-229}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3417-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3417-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Bagheri, Samaneh and Heidari, Azhdar and Alinaghipour, Azam and Banitaba, Seyyed Mojtaba and Salami, Mahmou}, title = {The effect of probiotics mixture on learning and spatial memory in kindled rats}, abstract ={Background: Repeated seizure attacks lead to extensive neuronal damage and cognitive impairment such as memory loss and learning. Probiotics are shown to have some protective actions against neurological disorders. The present study aimed to examine the effect of probiotics on learning, memory and the nitric oxide level in kindled rats. Materials and Methods: In this experimental study, 40 male rats were randomly divided into five groups: control, kindled with penthylenetetrazole (PTZ), kindled and valproic acid (VPA), kindled after probiotic treatment (probiotic + PTZ), and kindled before probiotic treatment (PTZ + probiotic). The animals were treated by a mixture of probiotics for 4 weeks. Chemical kindling was induced by intraperitoneal injection of PTZ (35 mg/kg) every 48 hours for 24 days. The learning and spatial memory were evaluated by the Morris water maze. The serum nitric oxide level was assessed by the Miranda method. Results: No significant difference was observed between the control and VPA groups in terms of memory, learning and serum levels of nitric oxide. Learning (P<0.001) and spatial memory (P<0.05) phenomena were improved in the probiotic supplemented groups compared to the PTZ group. Also, serum nitric oxide levels were reduced in the probiotic supplemented groups (P<0.05). Conclusion: Probiotic supplementation reduces the level of nitric oxide and improves the learning and memory process.}, Keywords = {Probiotics, Spatial memory, Chemical kindling, Rat}, volume = {22}, Number = {3}, pages = {230-238}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3589-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3589-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {AsadiMotlagh, Masoumeh and Pakpour, Bahareh and Navaian, Maji}, title = {The effect of 5-HT3 receptor agonist of the ventral hippocampus on amnesia induced by ethanol in mice}, abstract ={Background: The aim of this study was to investigate the effect of 5-HT3 receptor agonist in the CA1 hippocampus area on demolition of ethanol-induced memory. Materials and Methods: This study was conducted on 96 NMRI mice. Ethanol was injected intraperitoneally, while 5-HT3 receptor agonist (MCHL) was injected intra-CA1. To assess the memory, a single-trial step-down passive avoidance apparatus was used. Results: Results showed that pre-training injection of ethanol (1mg/kg), and MCHL (0.5 ng/mouse) decreased a passive avoidance memory in the adult mice. Also, a non- effective dose of MCHL (0.005 ng/mouse) with a non- effective dose of ethanol (0.01mg/kg) induced amnesia. Also, the results showed that injection of different doses of MCHL (0.5, 0.05, and 0.005 ng/mouse) combined with an effective dose of ethanol (1mg/kg) could retrieve damaged memory by ethanol. Conclusion: Findings of this study showed that the CA1 region of the hippocampus has an important role in amnesia induced by serotonin and serotonin CA1 5-HT3 receptor agonists have interaction with ethanol.}, Keywords = {5-HT3, Ethanol, Passive avoidance memory, Hippocapus, Mice}, volume = {22}, Number = {3}, pages = {239-247}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3538-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3538-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Hosseini, Seyyed Ali and Ahmadi, Mozhgan and Sharifi, Anahita and Shadmehri, Saeideh and Zar, Abdossaleh}, title = {The effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic rats}, abstract ={Background: Diabetes is a chronic disease which can lead to increased levels of leptin and lipid profile. The aim of this study was to examine the effect of resistance training and genistein on leptin and lipid profile of streptozotocin-induced diabetic rats. Materials and Methods: In this experimental study, 56 diabetic rats were divided into 7 groups of 8 rats including control, resistance training, 30 mg/kg genistein consumption, 10 mg/kg genistein consumption, resistance training and 30 mg/kg genistein consumption, resistance training and 10 mg/kg genistein consumption, and sham. The training groups performed a resistance training program for 8 weeks and 5 sessions per week. Results: Resistance training had a significant effect on reduction of leptin, triglyceride, cholesterol and very-low-density lipoprotein (VLDL) (P≤0.05). Genistein consumption had a significant effect on reduction of leptin and increased high-density lipoprotein (HDL) levels (P≤0.05) and had no effect on reduction of triglyceride, cholesterol, LDL and very low-density lipoprotein (VLDL) (P≥0.05). Resistance training along with genistein consumption had an interactional effect on reduction of leptin, triglyceride, cholesterol, LDL, and VLDL and increased HDL (P≤0.05). Also, 10 mg/kg and 30 mg/kg genistein consumption had similar effects on reduction of leptin and increased HDL levels in diabetic rats (P≥0.05). Conclusion: Resistance training along with genistein consumption has interactional effects on leptin and lipid reduction in streptozotocin-induced diabetic rats.}, Keywords = {Diabetes, Resistance training, Genistein, Leptin, Lipid profile}, volume = {22}, Number = {3}, pages = {248-257}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3502-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3502-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mesdaghinia, Azam and Khazaee, Paria and Heydari, Azhdar}, title = {The effect of cyclooxygenase-2 inhibition on pentylenetetrazole-induced seizure threshold in mice}, abstract ={Background: Previous studies have shown the protective effect of cyclooxygenase (COX) enzyme in development of convulsions. However, involvement of COX-2 in the pathogenesis of epilepsy is not yet well-known. The present study was designed to investigate the effect of celecoxib and nimesulide (selective COX-2 inhibitors) on pentylenetetrazole (PTZ)-induced clonic seizure threshold in mice. Materials and Methods: In this study, white male mice were randomly divided into 13 groups including control groups, solvent (Tween 80) and eleven experimental groups which received celecoxib (2.5, 5 and 10 mg/kg), nimesulide (2.5, 5 and 10 mg/kg), diazepam (0.1, 0.5 and 5 mg/kg), and combination of non-effective dose of diazepam with celecoxib or nimesulide. Pentylenetetrazol-induced clonic seizure threshold was assessed in all groups. Results: Nimesulide (2.5 and 5 mg/kg), celecoxib (2.5 and 5 mg/kg), and diazepam (0.5 and 5 mg/kg) significantly increased the PTZ-induced seizure threshold compared with the solvent group (P<0.05). Also, only combination of sub-effective dose of diazepam (0.1 mg/kg) with celecoxib (2.5 mg/kg) showed a significant protective effect against PTZ-induced seizure threshold (P<0.01). Conclusion: Findings of the current study show the possible role of COX-2 isoenzyme in the pathophysiology of epilepsy. It is possible that some COX-2 inhibitors such as celecoxib act through GABAergic neurons and reduce excitability by increasing GABA release. Also, the difference between the effects of celecoxib and nimesulide can be attributed to the effect of these two compounds on COX-1 and COX-2 expression.}, Keywords = {Seizure, Pentylenetetrazole, Cyclooxygenase-2, GABA }, volume = {22}, Number = {3}, pages = {258-266}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3599-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3599-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Sadat-Hoseini, Saied Kamal and DabidiRoshan, Valiollah}, title = {The effect of six weeks of voluntary wheel running exercise on hepatic superoxide dismutase levels and apoptosis-inducing factor after doxorubicin administration in aging model rats}, abstract ={Background: In the last decade, cancer incidence increases progressively with age and older patients cannot participate in treatment programs due to the special physical condition and side effects of anti-tumor drugs. Therefore, the aim of this study was to examine the effect of six-week voluntary wheel running exercise on doxorubicin (DOX)-induced hepatotoxicity in aging model rats. Materials and Methods: Thirty-two Wistar male rats were randomly assigned to exercise and control groups with 4 subgroups. All subjects received a daily injection of D-galactose for nine weeks (100 mg/kg/day, intraperitoneally). The training protocol included six weeks of voluntary wheel running exercise. Doxorubicin was administrated intraperitoneally (1mg/kg/day) for 15 days. Superoxide dismutase (SOD) and apoptosis-inducing factor (AIF) levels were measured after liver tissue homogenization by enzyme-linked immunosorbent assay (ELISA) method. Results: Administration of cumulative dose of DOX caused no significant decrease in SOD and AIF levels (P=0.797, and P=0.869, respectively). Six weeks of voluntary wheel running exercise led to insignificant decrease in SOD and insignificant increase in AIF in comparison to the  control group (P=0.377, and P=0.948, respectively). Conclusion: According to the results of the present study, the six-week voluntary wheel running exercise has no significant effect on DOX-induced hepatotoxicity in aging model rats.}, Keywords = {Voluntary exercise, Doxorubicin, Hepatic toxicity, Oxidative stress, Apoptosis}, volume = {22}, Number = {3}, pages = {267-273}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3153-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3153-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rafieirad, Maryam and Valipour-Chahardah-Charic, Saee}, title = {Evaluation of the simultaneous effect of zinc oxide nanoparticles and vitamin C on oxidative stress in rat cerebellum}, abstract ={Background: In recent years, the potential effects of nanoscale materials on the central nervous system have become even more noticeable. The cerebellum is one of the areas of the brain with high absorption of zinc. The aim of this study was to investigate the effects of zinc oxide nanoparticles (NPs) on oxidative stress indices in rat cerebellum in the presence and absence of vitamin C. Materials and Methods: In this experimental study, male Wistar rats (250-200g) were divided into the following groups (n=7): a normal saline group (control), three groups that received different doses of zinc oxide NPs (1.25, 2.5 and 5 mg/kg), three groups that received different doses of vitamin ­C (30, 60 and 120 mg/kg) and three groups that received 1.25, 2.5 and 5 mg/kg of zinc oxide NPs combined with 30 mg/kg of vitamin­ C. Half an hour after receiving the medication, the rats were anesthetized and then their cerebellum was removed and the malondialdehyde (MDA) and thiol groups of the cerebellum region were measured. Results: The MDA level decreased significantly in the groups received 5mg/kg of zinc oxide NPs, in the groups received different doses of vitamin­ C, and in the groups received different doses of zinc oxide NPs combined with 30 mg/kg vitamin­ C compared with the saline group. Total thiol concentration did not change significantly in the different study groups compared to the control group. Conclusion: Zinc oxide NPs alone or in combination with vitamin C has a reduced effect on oxidative stress in the rat cerebellum.}, Keywords = {Zinc oxide NPs, Malondialdehyde, Thiol, Vitamin C, Rats}, volume = {22}, Number = {3}, pages = {274-282}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3525-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3525-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Edalatmanesh, Mohammad Amin and Sheikholeslami, Mahtab and Rafiei, Samaneh}, title = {Evaluation of brain-derived neurotrophic factor expression and spatial memory after valproic acid administration in animal model of hippocampal degeneration}, abstract ={Background: Hippocampal neurodegeneration caused the incidence of cognitive deficits, along with a possible decrease of neurotrophins. Valproic acid (VPA) is a histone deacetylase inhibitor, which could protect the nervous system from neuronal degeneration through neurotrophic modifications. This study aimed to investigate the effect of different doses of VPA on a hippocampal brain-derived neurotrophic factor (BDNF) level, CA1 area of hippocampal histopathology, and spatial memory assessment in animal models of hippocampal degeneration. Materials and Methods: To induce hippocampal degeneration, rats were injected intraperitoneally with trimethyltin (TMT). Three test groups (TMT+VPA) received 100, 200 and 400 mg/kg of VPA, respectively, and the TMT+Saline group received normal saline for 14 days after TMT intoxication. To investigate the spatial memory, the Morris water maze was used. Then, the BDNF hippocampal level was evaluated using the ELISA technique and histopathological evaluation of hippocampus was also done. Results: Valproic acid decreased the distance and latency time to arrive the hidden platform in learning blocks and increased the spent time in the target quadrant in a probe test following TMT intoxication. Also, the BDNF hippocampal level and amelioration of cell damage in the CA1 area of the hippocampus significantly increased in VPA-treated groups compared with the TMT+Saline group. Conclusion: Valproic acid has neuroprotective effects, which can decrease cognitive deficits due to TMT intoxication in rats.}, Keywords = {Brain-derived neurotrophic factor, Trimethyltin, Valproic acid, Spatial memory, Hippocampus, Rat }, volume = {22}, Number = {3}, pages = {283-291}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3487-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3487-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Taheri, Ali and Ghaffari, Mgmostafa and Bavi, Zeinab and Sohili, Fariborz}, title = {Cytotoxic effect of the extract of seaweed Sargassum glaucescens against breast (MCF-7) and colorectal (HT-29) cancer cell lines}, abstract ={Background: Seaweed is one of the natural resources with a wide range of secondary metabolites, which has cytotoxic properties. The present study aimed to investigate the cytotoxic effect of seaweed Sargassum glaucescens collected from Chabahar seashores against colorectal and breast cancer cells. Materials and Methods: The cytotoxicity of methanol, chloroform, ethyl-acetate and hexane extracts of the seaweed at different concentrations (125, 250, 500 and 1000 μg/ml) against cancer cells of MCF-7 and HT-29 was evaluated by MTT and trypan blue methods. The DNA fragmentation of cells was also investigated by the electrophoresis method. Results: The percentage of live cells was decreased by increasing the concentration of the extracts. The concentration of 1000 μg/ml of methanol extract showed the highest effect compared to the control and also lower concentrations of the extract (P<0.05). The LC50 of the methanol extracts of colorectal and breast cancer cells were 630.8±16.37 and 774.01±28.07 µg/ml, respectively. Also, the algal methanol extract was able to fragment the DNA of cancer cells and to induce apoptosis compared with the control samples. Conclusion: The cytotoxic effect of the seaweed extract can be the beginning of further studies to achieve cancer treatment. Also, after pre-clinical and clinical studies, these extracts can be used in the food and pharmaceutical industries.}, Keywords = {Cytotoxicity, Marine algae Sargassum glaucescens, Apoptosis, Breast cancer cell, Colorectal cancer cell}, volume = {22}, Number = {3}, pages = {292-301}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3454-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3454-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rasad, Hamid and Entezari, Mohammad and Mahaki, Behzad and Nurany, Maryam and Pahlavani, Naseh}, title = {The effect of honey consumption on lipid profiles in healthy individuals: A randomized clinical trial}, abstract ={Background: It has been indicated in several studies that honey consumption has beneficial effects on risk factors for cardiovascular disease. This study aimed at examining the effect of honey intake compared with sucrose on lipid profiles in young healthy people. Materials and Methods: This randomized, single-blinded, clinical trial was performed on 60 healthy subjects with the age range of 18 to 30 years. Subjects were randomly divided into honey and sucrose groups. The honey group received 70 g honey per day and sucrose group received 70 g sucrose per day for one month. Lipid profiles of the participants were measured using the enzyme kit and compared in both groups (honey and sucrose) at the beginning and at the end of the intervention. Results:  Results showed that there was no significant difference in the mean of the baseline FBS, SBP, and DBP between the honey and sucrose groups (P>0.3). From baseline to four weeks, honey reduced the levels of total cholesterol, TG, and LDL but sucrose intake increased these levels (P<0.3). Also, honey consumption increased HDL but sucrose intake decreased it (P<0.001). We adjusted confounding variables including age, physical activity and some nutrient intakes in all of these analyses. Conclusion: Honey consumption, unlike sucrose, can decrease total cholesterol, TG, and LDL and also can increase HDL in healthy people. Background: It has been indicated in several studies that honey consumption has beneficial effects on risk factors for cardiovascular disease. This study aimed at examining the effect of honey intake compared with sucrose on lipid profiles in young healthy people. Materials and Methods: This randomized, single-blinded, clinical trial was performed on 60 healthy subjects with the age range of 18 to 30 years. Subjects were randomly divided into honey and sucrose groups. The honey group received 70 g honey per day and sucrose group received 70 g sucrose per day for one month. Lipid profiles of the participants were measured using the enzyme kit and compared in both groups (honey and sucrose) at the beginning and at the end of the intervention. Results:  Results showed that there was no significant difference in the mean of the baseline FBS, SBP, and DBP between the honey and sucrose groups (P>0.3). From baseline to four weeks, honey reduced the levels of total cholesterol, TG, and LDL but sucrose intake increased these levels (P<0.3). Also, honey consumption increased HDL but sucrose intake decreased it (P<0.001). We adjusted confounding variables including age, physical activity and some nutrient intakes in all of these analyses. Conclusion: Honey consumption, unlike sucrose, can decrease total cholesterol, TG, and LDL and also can increase HDL in healthy people.}, Keywords = {Honey, Sucrose, Total Cholesterol, Triacylglycerol, High-density lipoprotein, Low-density lipoprotein }, volume = {22}, Number = {3}, pages = {302-308}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3490-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3490-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Yalfani, Ali and mokhtari, marzieh and gandomi, farzaneh}, title = {The effect of eight weeks of Aquatic therapy with patella taping on pain, motor function and unstable balance in women with the patellofemoral pain syndrome}, abstract ={Background: Patellofemoral pain syndrome (PFPS) is the most common knee musculoskeletal disorder in active persons. The aim of this study was to compare the effects of three aquatic therapy methods on pain, function and unstable balance in women with PFPS. Materials and Methods: In this study, 45 women with PFPS were selected and randomly divided into three groups: aquatic therapy, aquatic therapy with temporary patella taping and aquatic therapy with permanent patella taping. Before and after eight weeks, the factors of pain, function, and balance were assessed by the VAS scale, Kujala questionnaire and the Biodex balance system SD, respectively. Results: There was no significant difference between the averages of pre-test and post-test of pain, function and balance among the groups. The results of t-test showed significant differences between pre-tests and post-tests of factors in three groups; in this regard, pain reduction (P=0.0001) and increase in function (P=0.0001) were significant in three groups. Unstable balance in the level 4, for the temporary taping group in two directions ((POA=0.0001(, and (PAP=0.0001)) and also balance in the level 8, for the temporary taping group in two directions ((POA=0.0001 (and (PML=0.0001)) showed significant improvement. Conclusions: It can be concluded that it is not necessary to use patella tapping with aquatic therapy as an additional cost. Only the experts who seek to increase their patients' balance can improve their patients’ unstable balance by temporarily patella taping.}, Keywords = {Patellofemoral pain syndrome, Aquatic therapy, Tapping, Balance}, volume = {22}, Number = {3}, pages = {309-317}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3460-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3460-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Khajehlandi, Mojdeh and Janbozorgi, Maryam}, title = {Comparison of the effect of one session of resistance training with and without blood-flow restriction of arm on changes in serum levels of growth hormone and lactate in athlete females}, abstract ={Background:­ Exercise  trainings with blood-flow restriction have been effective in improving various physical factors and can be a unique and beneficial method in the field of medicine. Therefore, the current study aimed to compare the effects of one session of resistance training with and without blood-flow restriction of arm on changes in serum levels of growth hormone and lactate in athlete females. Materials and Methods: To perform the current clinical trial, 30 basketball players aged 23-30 years were randomly divided into three groups: traditional resistance training (intensity of 80% 1RM), resistance training with blood-flow restriction (intensity of 30% 1RM) and control group. Training started with one set of 30 repetitions and ended with two sets up to fatigue with the rest time of 30 seconds. Blood samples were taken  before  and immediately after completing exercise training. Results: Post-test findings indicated a significant increase in the serum levels of growth hormone in two training groups compared to pre-test, but the amount of  lactate ion in all three groups significantly reduced compared to the pre-test (P<0.05). Also, growth hormone levels in groups with and without blood-flow restriction increased significantly compared to the control group (P=0.001 and P=0.026, respectively). conclusion: The pattern of growth hormone and lactate changes in both groups, with and without blood-flow restriction are similar to each other. It seems that for those who are not able to lift heavy weight, low intensity resistance training with blood-flow restriction can be replaced with traditional high-intensity training.}, Keywords = {Resistance training, Athlete females, Blood-flow restriction, Lactate, Growth hormone }, volume = {22}, Number = {3}, pages = {318-324}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3493-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3493-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Abdorahimi-Noshad, Leila and Sabzi, Elnaz and Sharifi, Ghonche and Moradi, Kobra and Sheikh-Hasani, Nafiseh}, title = {Comparison of personality traits and resiliency in patients with AIDS and normal people}, abstract ={Background: AIDS is one of the chronic and debilitating infectious diseases. The aim of this study was to investigate personality traits and resiliency in patients with AIDS and normal people. Materials and Methods: In this causal-comparative study, 30 patients with AIDS referred to the Behavioral Counseling Center of Imam Khomeini Hospital and Tehran Valfajr Health Center (in 2017) were selected by the accessible sampling method. Then, the normal group was selected among those referred to the health centers of Tehran Province by matching the variables of age, education, gender, employment and marriage status. The two groups were evaluated by the Big-Five Personality Inventory of Costa and McCrae (NEO-FFI) and Connor and Davidson resilience (CD-RISC) questionnaires. Results: The results of the current study showed no significant difference in the personality traits including "Extroversion", "Openness to Experience" and "Conscientiousness" between the two groups of AIDS and normal people (P>0.05). Also, people with AIDS obtained significantly higher scores in personality traits such as "Neuroticism" (P<0.05) and lower scores in "Agreeableness and resiliency" (P<0.05) compared to the normal people. Conclusion: People with AIDS had higher levels of neuroticism and lower levels of agreeableness and resiliency compared with normal people. It is recommended that these factors be considered in designing educational programs for AIDS patients.}, Keywords = {AIDS, Resilience, Personality traits}, volume = {22}, Number = {3}, pages = {325-332}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3456-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3456-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Hadadi, Mohammadreza and Sherafati, Reza and Delavari, Mahdi and Arbabi, Mohsen and Gilasi, Hamidreza and Abed, Alirez}, title = {Evaluation of anti-Neospora caninum antibody presence in cow\'s milk in Kashan}, abstract ={Background: Neosuporosis is caused by a parasitic protozoan called Neospora caninum. This parasite can infect different species of domestic and wild animals. Some studies have reported the possibility of human infection with this parasite. The aim of this study was to evaluate the anti-Neospora caninum antibody in raw milk of cattle in Kashan city. Materials and Methods: In this study, 187 milk samples were collected from two industrial farms in Kashan. The breed of all cows was Holstein. Before sampling, the livestock information such as age, race, history of abortion and stillbirth, the daily milk yield was recorded in the prepared forms. Fat of the samples was separated by centrifuge and lactoserums were collected. To determine anti-Neospora caninum antibody in milk samples, an indirect ELISA kit was used. Results: Results showed that 18.8% (CI=18.18±5.53) of the samples were infected with Neospora caninum. No significant relationship was found between the infection with this protozoa and milk production and age of the cows (P=0.84). Also, the results showed that there was no significant relationship between abortion and infection with Neospora. Conclusion: Considering the contamination rate of cow's milk in Kashan, the implementation of control programs in livestock has great importance. Also, considering the possibility of human infection with Neospora, the need for attention to these control programs is more and more evident.}, Keywords = {Neospora caninum, Cow's milk, Iran}, volume = {22}, Number = {3}, pages = {333-338}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3588-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3588-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Esmaili, Zahra and Heydari, Azhdar}, title = {The effect of chronic caffeine intake on pentylenetetrazole (PTZ)-induced seizure threshold and nitric oxide metabolites in mice}, abstract ={Background: Long-term caffeine intake decreases seizure susceptibility and has protective effect. This protective effect of caffeine may be due to the blockade of A2A adenosine receptors. Considering that activation of adenosine A2A receptors elevates nitric oxide production, the aim of the present study was to investigate the effect of chronic caffeine intake on the pentylenetetrazole (PTZ)-induced seizure threshold and measurement of nitric oxide metabolites levels in mice. Materials and Methods: In this study, NMRI male mice (weighing 25-30 g) were divided into 3 groups including one control and two experimental groups (n=9 in each group). PTZ- induced clonic seizure was measured following oral intake of caffeine in experimental groups (100 and 300 mg/L in the drinking water) or only tap water in the control group for 90 days. Measurement of nitric oxide metabolites in the brain tissues was done at the end of the experiments using the Greiss method. Results: The chronic caffeine intake at concentrations of 100 and 300 mg/L in the drinking water for 90 days did not change the seizure threshold. On the other hand, both concentrations of caffeine significantly decreased nitric oxide metabolites levels compared to the control group (P<0.05). Conclusion: The results of this study confirmed and extended previous studies that chronic caffeine intake has no effect on seizure. Reduced levels of nitric oxide metabolites and resultant decreased neuronal excitability may be the main protective mechanism of the chronic caffeine intake. Blockade of the A2A adenosine receptors following the chronic caffeine intake may be involved in decreased levels of nitric oxide metabolites.}, Keywords = {Caffeine, Seizure, Pentylenetetrazole, Nitric oxide, Adenosine receptor}, volume = {22}, Number = {4}, pages = {339-345}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3617-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3617-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Kazemi, Maryam and Ghavipanjeh, Gholamreza and Shahaboddin, Mohammad Esmaeil and Banitaba-Bidgoli, Seyyed Mojtab}, title = {The effect of hydro-alchoholic exteract of (Matricaria recutita L.) on pentylenetetrazole-induced seizure and its relationship with nitric oxide in mice}, abstract ={Background: Matricaria recutit (MAT) has a series of flavonoid compounds with benzodiazepine-like properties. So, it may be effective in the treatment of epilepsy and seizures. This study aimed at examining the effect of intraperitoneal injection of the hydro-alcoholic extract of Matricaria recutita on seizures induced by pentylenetetrazole (PTZ) in mice. Materials and Methods: In this study, 56 male mice (25-30 g) were divided into seven groups (n=8): 1-control (saline), 2-control (PTZ), 3-MAT (50mg/kg), 4-MAT (100 mg/kg), 5- MAT (200 mg/kg), 6- diazepam (1mg/kg) and 7- MAT (50 mg/kg)+diazepam (0.25 mg/kg). After 10 days of treatment in different groups, the PTZ-induced seizure threshold was assessed and nitric oxide (NOX) metabolites in the brain tissue were measured by the Greiss method. Results: The chamomile hydro-alcoholic extract (200 mg/kg), and diazepam (1 mg/kg) significantly increased the seizure threshold (P<0.001). The chamomile hydro-alcoholic extract (50, and 100 mg/kg) did not show anticonvulsant activity. The concentrations of NOX in the diazepam (1 mg/kg), MAT 100 mg/kg, and MAT 200 mg/kg groups were significantly lower than those in the control (PTZ) group and co-administration of MAT (50 mg/kg) with diazepam (0.25) decreased the NOX concentration. The hydro-alcoholic extract of MAT (50 mg/kg) had no significant effect on the NOX concentration. Conclusion: According to the results of this study, the chamomile hydro-alcoholic extract has an inhibitory effect on the PTZ-induced seizure and NOX in male mice.}, Keywords = {Epilepsy, Seizure, Matricaria recutita L., Nitric oxide, Mice}, volume = {22}, Number = {4}, pages = {346-354}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3620-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3620-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {RanjbarZeidabadi, hamed and Kheirkhah, Babak}, title = {Molecular isolation of a human papilloma virus from blood serum in patients with leukemia in Kerman}, abstract ={Background: Cancer is the second common cause of death in developed countries. Viruses are one of the most important environmental factors which increase the risk of developing cancer. The aim of this study was to identify the human papilloma virus (HPV) in patients with the blood cancer. Materials and Methods: In this case-control study, blood serum samples were collected from 35 patients with Chronic lymphocytic leukemia (CLL) and 25 patients with Acute lymphoblastic leukemi (ALL) from Kerman medical centers. Thirty healthy individuals were considered as a control group. After DNA extraction from the serum samples, the polymerase chain reaction (PCR) was performed to detect HPV. Results: The specific sequence of HPV was observed in 15 samples (25%) of the patients’ serum. Out of this number, five samples (14.25%) of the 35 patients had CLL and 10 samples (40%) of 25 patients had ALL. Also, no positive sample was found in the serum of the patients of the control group. Out of the 15 patients suffering from HPV, seven (46.62%) and three (19.98%) had HPV16 and HPV18, respectively and five samples (33.4%) were of other types of HPV. Conclusion: This study showed that the PCR method with specific primers of Papilloma Virus 16 and 18 is a suitable and accurate method for detecting human papillomavirus.  }, Keywords = {Cancer, Human papilloma virus, CLL, ALL}, volume = {22}, Number = {4}, pages = {355-361}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3600-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3600-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Davoodi, Seyed Hani and Vahidian-Rezazadeh, Majid and Fanaei, Hame}, title = {The effect of endurance and resistance exercises and consumption of hydro-alcoholic extract of nettle on the changes in weight and plasma levels of nesfatin-1 in type 1 diabetic rats}, abstract ={Background: Diabetes mellitus is one of the most common metabolic diseases and nettle is a plant that has been introduced as an anti-diabetes medication. Nesfatin-1 is an adipokine secreted from an adipose tissue and involved in the mechanism for glucose metabolism. This study aimed at examining the effect of an 8-week endurance and resistance training program along with the consumption of the hydro-alcoholic extract of nettle on plasma levels of nesfatin-1 in type 1 diabetic rats. Materials and Methods: In this study, Wistar rats were divided into four groups and diabetes was induced in them by streptozotocin. The nettle extract (1mg/kg) was intraperitoneally injected daily in the "nettle", "endurance+nettle" and "resistance+nettle" groups. The "endurance+nettle" group swam in water for eight weeks, five sessions per week, and each session from 60 to 120 minutes. The "resistance+nettle" group began the exercise with 50, 75, 90, and 100 percent weight on the designed ladder, and then they gradually increased their record. Blood samples were taken directly from the hearts of the animals at the end of the 8th week. Results: Weight loss was observed in all groups after 8 weeks. The least amount of weights in the "control", "nettle" and "resistance+nettle" groups were significantly lower than those in the beginning of the study (P<0.001). The results showed a significant increase in nesfatin-1 in the "nettle" group compared to the "control" group (P<0.01). Also, this increase was observed in the "endurance+nettle" and "resistance+nettle" groups compared to the "control" group (P<0.001). Conclusion: Consumption of the nettle extract with exercise can increase the plasma nesfatin-1, which can be effective in controlling diabetes and preventing weight loss due to this disease.}, Keywords = {Aerobic exercise, Resistance exercise, Hydro-alcoholic extract of nettle, Nesfatin-1, Rat, Type 1 diabetes}, volume = {22}, Number = {4}, pages = {362-369}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3586-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3586-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Hosseini, Masoumeh and BagheriAfsariehee, Mohammad Rez}, title = {The effect of high intensity interval training and Aloe Vera consumption on resistin and insulin resistance index in diabetic rat}, abstract ={Background: Diabetes mellitus is a disorder in the metabolism of sugars, fats and proteins in the body, leading to hyperglycemia and hyperlipidemia. Resistin is an adipocytokine associated with diabetes. This study aimed at investigating the effect of high intensity interval training and Aloe Vera consumption on resistin and the insulin resistance index in diabetic rats. Materials and Methods: In this experimental study, 32 male Wistar streptozotocin-(STZ) diabetic rats were randomly divided into four groups including the control, training, supplementation and training + supplementation. The training program included 8 weeks, five sessions per week, and each session with 6-12 periods of two minutes activity at 90% maximum speed and one minute rest (10 m/min). The Aloe Vera gel (300 mg/kg) was given as gavage in the supplementation recipient groups, 5 days a week for 8 weeks. Results: The results showed that the insulin levels and insulin resistance index increased and resistin decreased significantly in the experimental groups (P<0.001). Fasting glucose increased in the training group, but decreased in the supplementation and training+ supplementation groups (P>0.05). Conclusion: It seems that combination of high intensity interval training and the use of Aloe Vera can have a positive effect on diabetes control by reducing resistin and glucose and increasing insulin levels.}, Keywords = {Aloe Vera, Resistin, Interval training, Diabetes mellitus, Insulin resistance, Rat}, volume = {22}, Number = {4}, pages = {370-378}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3557-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3557-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rezaei, Fahimeh and Nezhadali, Masoumeh and Hedayati, Mehdi}, title = {Association of adiponectin rs17300539 gene polymorphism with a non-alcoholic fatty liver disease in an Iranian population}, abstract ={Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disorder, resulting from exceeding fat cumulating in the liver .Adiponectin, a protein secreted from the adipose tissue, reduces liver inflammation. In this study, the relationship between adiponectin rs17300539 gene polymorphism and a non-alcoholic fatty liver disease was investigated. Materials and Methods: This case-control study was conducted on 80 subjects with NAFLD and 80 healthy subjects. The determination of polymorphism rs17300539 of adiponectin gene was performed by the PCR-RFLP method and electrophoresis technique. The plasma levels of adiponectin and insulin hormones were measured by an enzyme-linked immunosorbent assay (ELISA) kit. Results: The results showed that there was no significant difference in allele frequencies between the two groups of the case and control (P>0.05). The body mass index (BMI) in genotype GA carriers was higher than that of genotype GG carriers (P<0.05). Moreover, the diastolic blood pressure in the male patients carrying the genotype GA was higher than that in the genotype GG carriers (P<0.05). In the female patients carrying the genotype GA, the AST and triglyceride levels were higher than the GG female carriers (P<0.05).  Conclusion: It seems that the allele G can be beneficial in reducing the side-effects of the non-alcoholic fatty liver disease.}, Keywords = { Non-alcoholic fatty liver, Adiponectin, Polymorphism, Adipose tissue }, volume = {22}, Number = {4}, pages = {379-386}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3463-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3463-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Abasi, Salar and Nikseresht, Mahmou}, title = {Comparison of serum apelin levels and maximal oxygen consumption in active and inactive obese men}, abstract ={Backgrounds: Apelin is an adipokine that may play a significant role in regulating energy metabolism. Obesity and physical activity are factors that affect the concentration of apelin, but it is not known which one is more prominent. Thus, the aim of this study was to compare the serum levels of apelin-13 and the maximal oxygen consumption (VO2max) in men who are inactive normal-weight, active and inactive obese. Materials and Methods: Forty-five healthy men (age range, 34-46 years) were assigned to one of the following groups. 1) active-obese: body mass index (BMI)=28-33.9 kg/m2, 3-5 score in the physical activity rate questionnaire (PAR-Q) and n=16; 2) inactive-obese: BMI = 28-33.9 kg/m2, 1 in PAR-Q and n=18; 3) inactive normal-weight: BMI=18.5-24.9 kg/m2, 1 in PAR-Q and n=11. Blood samples were collected from the subjects in a fasting state; then, the serum level of apelin-13 was measured by the ELISA method. The VO2max was estimated by the non-exercise method and based on the PAR-Q. Results: One-way ANOVA showed that there was no significant difference in the serum levels of apelin-13 between the groups (P=0.73). It was found that VO2max was significantly lower in the inactive-obese group compared to the other groups (P≤0.001); however, no significant difference was noted between the active-obese and inactive normal-weight groups (P=0.14). Conclusion: Findings of this study show that the moderate physical activity and type 1 obesity could not be effective in apelin-13 concentration. In addition, it can be suggested that the obesity and physical activity indices have the same reciprocal effects in maximal oxygen consumption.}, Keywords = {Apelin-13 peptide, Body mass index, VO2max, Physical fitness}, volume = {22}, Number = {4}, pages = {387-393}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3516-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3516-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Zahmatkesh, Marjan and Shabani, Rami}, title = {The effect of concurrent aerobic and resistance exercises on glucose homeostasis and serum HS-CRP in overweight and obese anxious adolescent girls}, abstract ={Background: Obesity disturbs glucose homeostasis and inflammatory markers. The aim of this study was to examine the effect of a concurrent aerobic and resistance training on glucose homeostasis and high-sensitive serum C-reactive protein (HS-CRP) in overweight and obese anxious adolescent girls. Materials and Methods: This clinical trial study was performed on 30 overweight and obese anxious adolescent girls. The subjects were randomly divided into experimental and control groups. Participants in the experimental group performed an aerobic exercise training program consisted of 3 sessions per week and each session of 90 minutes for 8 weeks. Glucose, insulin, HS-CRP and anxiety were measured before and after 8 weeks of the exercise program. Results: The results showed that 8 weeks of the concurrent exercise caused a significant decrease in glucose (P=0.02), insulin (P=0.02), insulin resistance (P=0.05) and anxiety (P=0.02) compared with the control group. However, there was no significant difference in HS-CRP (P>0.05). Conclusion: The concurrent aerobic and resistance exercises can be used to improve the blood glucose homeostasis and decrease anxiety in overweight and obese adolescent girls.}, Keywords = {Aerobic exercise, Resistance training, Anxiety, C-reactive protein, Obesity, Insulin resistance }, volume = {22}, Number = {4}, pages = {394-403}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3539-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3539-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Afshari, Behrooz and Omidi, Abdollah and Sehat, Mojtab}, title = {The effect of dialectical behavior therapy on executive function in patients with a bipolar disorder}, abstract ={Background: Bipolar disorder is a debilitating psychiatric disorder characterized by recurrent depression, manic and hippomanic episodes. The effect of a dialectical behavior therapy on executive functions in bipolar disorders has not been addressed so far. The aim of this study was to determine the effect of the dialectical behavior therapy on executive function in the bipolar disorder. Materials and Methods: Sixty patients with a bipolar disorder were randomly assigned to the intervention (the dialectical behavior therapy combined with medication) and control (only medication) groups. The questionnaires and tests were used at baseline, after 12 weeks intervention, and three months after the intervention. Participants in the intervention group received twelve 90-min sessions of the standard dialectical behavior therapy for the bipolar disorder. Results: The results showed that the intervention group had a lower score in mania, and depression. Also, the intervention group had a higher score in executive functions after three months intervention and three months follow-up. Conclusion: The dialectical behavior therapy in combination with medication can lead to reduce manic and depression symptoms, and improve performance of the patients in planning and problem-solving.}, Keywords = {Bipolar disorder, Dialectical behavior therapy, Executive function}, volume = {22}, Number = {4}, pages = {404-410}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3618-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3618-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Zanjani, Zahra and MoghbeliHanzaii, Masumeh and Mohsenabadi, Hami}, title = {The relationship of depression, distress tolerance and difficulty in emotional regulation with addiction to cell-phone use in students of Kashan University}, abstract ={Background: Cell phone plays an essential role in communications throughout the world. This question has been raised whether the over use of the cell-phone could lead to addiction. Addiction to cell phone use is characterized by the overuse and preoccupation with the mobile phone. So, the aim of this study was to investigate the relationship of depression, distress tolerance and difficulty in emotional regulation with addiction to cell-phone use in students of Kashan University. Materials and Methods: In this analytical-descriptive study, 200 students of Kashan University in the academic year 2016-2017 were selected by the cluster sampling method. The research tools included the cell-phone over-use scale (COS, 2007(, Beck depression inventory (BDI), difficulty in emotion regulation scale (DERS), and distress tolerance scale (DTS). Results: The results of the regression analysis showed that depression, distress tolerance and difficulty in emotional regulation explained more than 33% of the changes in addiction to cell-phone use. Also, there was a significant correlation between depression and addiction to cell-phone use (r=0.22, P<0.05). In addition, there was a significant correlation between distress tolerance (r=-0.47, P<0.05) and difficulty in emotion regulation (r=0.50, P<0.05) with cell-phone addiction in Kashan University students. Conclusion: According to the results of this study, addiction to cell-phone use can be predicted by three variables of depression, distress tolerance, and difficulty in emotion regulation. The difficulty in emotion regulation played a stronger role in this prediction.}, Keywords = {Addiction to cell phone use, Depression, Distress tolerance, Emotion regulation}, volume = {22}, Number = {4}, pages = {411-420}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3563-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3563-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Raigan, Fariba and Taghadosi, Mohsen and Sepahi, Narges and Khaki, Mohamm}, title = {Evaluation of sleep disorder and its effective factors in patients with an ischemic heart disease in the CCU ward of Kashan Shahid-Beheshti Hospital during 2017-2018}, abstract ={Background: Complaints of sleep disorders are common in ischemic heart patients, even after taking sleeping drugs. Evaluation of the causes of sleep disorders and modifying these factors that lead to the progression of patients' treatment is very important. Therefore, this study aimed at investigating sleep disorders and their effective factors in cardiac ischemic patients admitted to the cardiac care unit (CCU) with the use of sleeping drugs. Materials and Methods: This descriptive analytical study was conducted on 250 patients in the CCU ward of Kashan Shahid Beheshti Hospital, during 2017-2018, using the random sampling method. Data were collected by a specific questionnaire with 0.90 validity and 0.76 reliability. Results: In total, 80.4% of the patients reported a degree of sleep disorders. The most common problems were observed subsequently in the onset and duration of sleep, sleep disorders due to environmental factors, daily dysfunction, sleep disorder due to heart disease, and respiratory problems during sleep. Among the environmental factors, there was a significant relationship between sleep disorders and lack of a comfortable bed condition (OR=20.42), continuous illumination of the lights (OR=19.05), feeling of hot or cold (OR=15.44), feeling of the unpleasant odor (OR=13.60), and high levels of noise in the ward (OR=12.22). Conclusion: According to the results of this study, paying more attention to these patients, comprehensive review of them, and the establishment of a care plan for the improvement of sleep conditions are necessary in hospitalized patients.}, Keywords = {Ischemic heart disease, Factors affecting sleep disorders, Sleep disorders questionnaire, CCU}, volume = {22}, Number = {4}, pages = {421-428}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3499-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3499-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Ghoreishi, Fatemeh sadat and Assarian, Fatemeh}, title = {A case report of pedophilia symptoms in a patient with bipolar disorder}, abstract ={Background: Pedophilia is a paraphilia subtype and it is rarely reported as hypersexuality manifestation in bipolar patients. Various studies have evaluated the co-occurrence of paraphilia disorders with bipolar disorders. Since the prognosis and treatment of pedophilia as a disorder and pedophilia as just a sign are completely different, the present case report is of particular importance. Case Report: The reported case was a 45-year-old man with pedophilia referred to the psychiatric center. The examination revealed that the patient was suffering from the bipolar disorder. In mania phases, he developed pedophilia behaviors and such behaviors were completely resolved with the control of the bipolar disorder through drug therapy. Conclusion: Pedophilia can be a symptom associated with mood disorders; therefore, it is important to be considered in the prognosis and treatment of such form of pedophilia.}, Keywords = { Bipolar disorder, Pedophilia, Case report}, volume = {22}, Number = {4}, pages = {429-432}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3603-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3603-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Khalaji, Naser and Rasmi, Yousef and Sadeghi, Fahimeh}, title = {The effect of curcumin on biochemical and hematological indices of red blood cells during and after taking ecstasy in male Wistar rats}, abstract ={Background: The using of ecstasy pills or 3, 4-methylenedioxymethamphetamine (MDMA) has severe damage to various systems of the body, including blood cells. In this study, we investigated the protective effect of curcumin (turmeric extract) on red blood cells and its hematological and biochemical indices with and after taking ecstasy. Materials and Methods: In this experimental study, 40 adult male rats were divided into five groups: group1; control without MDMA and Curcumin, group 2; received MDMA, group 3; received MDMA and curcumin, group 4; received MDMA for 15 days, then 15 days later, no drug injection and group 5; received MDMA for 15 days, then injection of curcumin for 15 days later. The blood samples were collected and then, blood smears were prepared to assess morphology of red bleed cells mean values morphology of red blood cells. Results: The mean of red blood cell levels were significantly lower in MDMA recipient groups than in the control group. By using curcumin during and after taking ecstasy the level of red blood cells and hemoglobin were significantly decreased compared with that in the control group. Also, red blood cells were significantly decreased in the curcumin recipient groups compared with the MDMA groups. The total bilirubin levels in 2 and 4 groups which received MDMA alone, as well as in 3 and 5 groups received MDMA with curcumin were significantly higher than those in the control group. Conclusion: The effect of curcumin during and after taking ecstasy is likely due to a high digestive absorption of MDMA by curcumin or non-metabolizing of MDMA when using curcumin.}, Keywords = {Addiction, Ecstasy, Red blood cells, Billirubin, Curcumin}, volume = {22}, Number = {5}, pages = {433-441}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3580-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3580-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Ranjbar, Tooba and Asghari-Moghaddam, Nastaran and Mohammadgholi, Azadeh}, title = {Investigating the effect of biosynthetic nano-silver on HDAC8 expression in lung cancer A549 cell line}, abstract ={Background: Currently nanoparticles have encouraged a broad range of investigations in cancer therapy and diagnosis. The gene HDAC8 is responsible for repression of transcription in cells and it has been shown that its expression increases in lung cancer. The aim of this study was to determine the effect of nanoparticles synthesized by the eucalyptus extract on the expression of the HDAC8 gene in lung cancer A549 cell line. Materials and Methods: In this experimental study, green synthesis of silver nanoparticles was performed using the extract of Eucalyptus camaldulensis. In order to evaluate the half maximal inhibitory concentration (IC50), cultured A549 cells were treated by different concentrations of synthesized nanoparticles and the MTT assay was performed. Finally, the HDAC8 expression change of cells treated with the half maximal inhibitory concentration was determined by real-time PCR. Results: Results from the MTT assay revealed that the obtained nanoparticles decreased the viability of cells in concentration-dependent manner. The IC50 value of silver nanoparticles in 24 hours against A549 cells was 2 μg/ml. Also, the HDAC8 expression showed a 9-fold decrease in the treated cells. Conclusion: According to the results, nano-silver particles produced by the eucalyptus extract can cause apoptosis by decreasing the HDAC8 expression. Hence, they can be considered as an agent with promising aspects to treat lung cancer.}, Keywords = { Silver nanoparticles, Eucalyptus extract, Lung cancer, Cell line A549, HDAC8}, volume = {22}, Number = {5}, pages = {442-449}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3529-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3529-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Hosseini, Sayed Mojtaba and Fallahmohammadi, Zia and Talebi, Vahi}, title = {The effect of regular interval training on histochemical symptoms and cytokine and neurotrophic levels of brain tissue of the Lewis rats in experimental model of multiple sclerosis}, abstract ={Background: Multiple sclerosis is an inflammatory and chronic disease of the central nervous system. Regarding the possible effects of exercise in preventing this disease, the aim of this study was to investigate the effect of 6 weeks of high intensity interval training on TNF-α, IL-10 and BDNF levels in rat brain tissue of the experimental autoimmune encephalomyelitis (EAE) model. Materials and Methods: In this experimental study, 25 Lewis female rats, 6 weeks old, were randomly divided into 5 groups. Interval training was performed for 6 weeks and 5 days a week. An interval training program was conducted in the second week and during 6 weeks of training in each session including 10 repetitions of 1 minute. The EAE model was induced at the end of the sixth week of exercise. TNF-α, BDNF and IL-10 were measured in the brain tissue. Results: The results of coloring showed that the amount of inflammation of the nerve tissue decreased in the interval training groups. Interval training in Lewis female rats with experimental autoimmune encephalomyelitis showed a significant decrease in TNF-α (P=0.001), but did not significantly change the IL-10 (P=0.07) and BDNF (P=0.54) levels. In addition, trained rats showed delayed clinical symptoms. Conclusions: It seems that interval exercises with the duration and severity of the present study protocol may delay the incidence and severity of clinical symptoms and thus increase cellular protection in Lewis rats against the onset of experimental autoimmune encephalomyelitis.}, Keywords = {Cytokine, Experimental autoimmune encephalomyelitis, Interleukin 10, BDNF, TNF-α}, volume = {22}, Number = {5}, pages = {450-457}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3597-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3597-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Shadmehri, Saeedeh and Ahmadi, Mozhgan and Abbassi-Daloii, Asieh and Ziaolhagh, Seyed Javad and Yahyaei, Behrooz}, title = {Motor coordination and structural changes of hippocampus tissue in response to eight weeks of aerobic training and Ritalin consumption in hyperactive rats}, abstract ={Background: Changes in the structure of the hippocampus play a role in the development of attention deficit hyperactivity disorder (ADHD). The aim of this study was to evaluate the motor coordination and structural changes of the hippocampus tissue in response to an 8-week aerobic training program and Ritalin consumption in hyperactive rats. Materials and Methods: In this experimental study, 33 Wistar rats weighing 180-220g were randomly divided into 5 groups: 1) healthy control, 2) hyperactivity, 3) hyperactivity-aerobic training, 4) hyperactivity- Ritalin, and 5) hyperactivity-aerobic training-Ritalin and respond positively to the open field test. To induce ADHD in the rats, they were injected 10 mg/kg of L-NAME for 8 weeks (6 days per week) based on the weight of the rats. The drug group received 1 mg oral Ritalin per kg weight of rats daily for 8 weeks. The rats performed aerobic training 30 minutes a day and 7 days a week for 8 weeks. Results: The results showed that aerobic training and Ritalin consumption had no significant effect on weight (P=0.877) but had a significant effect on motor coordination (P=0.001) in hyperactive rats. In rats with the hyperactivity disorder, there was a slight change in the tissue and cellular structure, necrosis and tissue hyperemia as well as piconosis of the hippocampus tissue. Treadmill training along with Ritalin consumption reduced the tissue and cellular damage, necrosis, and also piconosis of the hippocampus tissue. Conclusion: Attention deficit hyperactivity disorder can cause the structural damage of the hippocampus tissue and treadmill exercises with Ritalin consumption may improve the damage to the hippocampal structure.}, Keywords = {Keywords: Hyperactive, Aerobic training, Ritalin, Hippocampus, Motor coordination, Wistar rats}, volume = {22}, Number = {5}, pages = {458-468}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3565-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3565-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mahdian, Hossein and Farzanegi, Parvin and Farzaneh-Hessari, Ami}, title = {The effect of combined therapy with resveratrol, and continuous and interval exercises on levels of apoptotic biomarkers in heart tissue of male rats with non-alcoholic fatty liver}, abstract ={Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. This study aimed at evaluating the effects of therapy with resveratrol supplementation alone or in combination with exercise trainings on cardiomyocytes apoptosis in a heart tissue of rats with NAFLD. Materials and Methods: In this experimental study, a total of 56 male Wistar rats were divided into control and seven experimental NAFLD groups including, patient, saline, resveratrol (RSV), continuous exercise, interval exercise, continuous exercise+RSV, and interval exercise+RSV. Apoptosis biomarkers, including Bax and Bcl2 levels, were measured in the heart of all groups using specific ELISA kits. Results: The Bax levels in the heart tissue of the patient and saline groups were 29.95±5.83 and 28.37±5.83 ng/mg/protein, respectively, which were significantly higher than those in other groups (P<0.0001), while the Bcl2 concentration was significantly decreased (P<0.0001). The mean ratios of Bax/Bcl2 in the patient (23.02±7.65) and saline (20.43±5.29) groups were significantly higher than those in the other groups (P<0.001). Resveratrol supplementation alone or in combination with exercise trainings significantly decreased the cardiac Bax content, but significantly increased the cardiac Bcl2 level (P<0.001). Conclusion: Non-alcoholic fatty liver disease is associated with increased apoptotic biomarkers in heart cells. Although resveratrol alone has an anti-apoptotic properties, combined therapy with interval and continuous trainings can be more effective.}, Keywords = {Apoptosis, Non-alcoholic fatty liver, Interval and continuous training, Resveratrol}, volume = {22}, Number = {5}, pages = {469-477}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3594-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3594-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rezaeinezhad, Najmeh and Ghanbari-Niaki, Abbas and Alizadeh, Rostam}, title = {The effect of circuit resistance training with different intensities on the agouti-related protein, insulin and glucose plasma levels in young men}, abstract ={Background: Agouti-related protein (AgRP) is a signaling peptide that affects feeding behavior, energy homeostasis, and the stimulation of the hypothalamic–pituitary–adrenal axis. The aim of the present study was to investigate the effect of a 6-week circuit-resistance training course (10 exercises at 20%, 40%, 60%, and 80% of 1RM) at different intensities on the levels of plasma AgRP, plasma insulin, and glucose. Materials and Methods: The participants in this experimental study included 45 dormitory male students, aged 20-24 years, with the mean weight of 70.61±3.76 kg, mean age of 21.55±0.17 years, and mean height of 174.84±1.15 cm. They were randomly divided into five groups, each with nine members (i.e., one control group and four experimental groups at 20%, 40%, 60%, and 80% of 1RM). The experimental groups performed the circuit-resistance training exercises at the specified intensities; in contrast, the control group performed no regular training during the course of the study. The blood samples were collected from the venous vein 48 hours before and after the training session (three hours after normal breakfast). Results: The results showed no significant differences between the groups in terms of the AgRP (P=0.399) and glucose levels (P=0.270); however, the difference related to the insulin levels was observed to be significant (P=0.013). Conclusion: According to the results of this study, a larger reduction in the AgRP levels is associated with high intensities of resistance training (i.e., at 80% of 1RM). Therefore, training intensity could be regarded as an influential factor in reducing the appetite and controlling obesity among young men.}, Keywords = {Circuit-resistance training, Agouti-related protein, Normal breakfast, Training intensity }, volume = {22}, Number = {5}, pages = {478-486}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3575-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3575-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Moulaie, Somaye and Mirzaie, Amir and Aliasgari, Elahe}, title = {Antibacterial and anticancer activities of silver nanoparticles fabricated by the Artemisia scoparia extract against lung cancer cell line (A549)}, abstract ={Background: In recent years, due to an increase in prevalence of cancer, there is a need to find new ways to control this disease. The aim of this study was to evaluate antibacterial and anti-cancer activities of silver nanoparticles (AgNPs) fabricated by Artemisia scoparia extract gainst lung cancer cell line (A549). Materials and Methods: In this experimental study, AgNPs was synthesized and ccharacterization of fabricated AgNPs was performed by scanning and transmission electron microscopy (SEM, TEM) methods. Subsequently, antibacterial activity of synthesized AgNPs was determined using the minimum inhibitory concentration (MIC) method. Moreover, cell toxicity of AgNPs against A549 cell line in 3.125-100 µg/mL concentrations was performed using the MTT method. The gene expression of Bax and Bcl2 was measured using the real-time PCR. Results: The results of SEM and TEM showed that the synthesized AgNPs had 33.40 nm average size. The MIC results demonstrated that the AgNPs had a significant antibacterial activity. In addition, the MTT results showed that AgNPs had dose-dependent cell toxicity. The real-time PCR results revealed that the Bax and Bcl2 gene expression were up-regulated (2.34±0.34) and down-regulated (0.43±0.61), respectively (P<0.05). Conclusion: According to the results of this study, the AgNPs had antibacterial and anticancer activities and it can be used as a drug candidate.}, Keywords = {Green synthesis, Silver nanoparticle, Lung cancer, Artemisia scoparia }, volume = {22}, Number = {5}, pages = {487-496}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3546-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3546-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Nikseresht, Mahmoud and Taherikalani, Abdolhossei}, title = {Cytokines response during a month of detraining in trained and overweight men}, abstract ={Background: Training-induced physiological adaptations reduced during detraining, but researches are limited about the comparison of the effects of detraining after different types of training. Thus, the aim of this study was to compare the effects of one month detraining on cytokines concentrations in aerobic- (AT) and resistance trained (RT) and overweight men. Materials and Methods: In this quasi-experimental study, 19 trained men (25-38 years) were assigned to RT (n=10) and AT (n=9) groups, based on the types of training. The groups were matched by the physical activity level, age and body mass index. The subjects avoided to perform any exercises for a month. All subjects were taken blood samples to measure serum levels of interleukin (IL)-10, IL-17A, and IL-20 before and after the detraining period. Results: After 4 weeks of detraining, body fat percentage and waist circumference increased significantly in the AT and RT groups, while the maximal oxygen consumption in these groups was significantly decreased (for all variables, P<0.05). The concentration of IL-17A (P=0.049) showed a significant increase only in the RT group; however, no significant differences were noted for IL-10 and IL-20 concentrations in response to the detraining period in both groups (both, P>0.05). Conclusion: It seems that the negative effects caused by one month of detraining are more prominent in the RT group (increase in IL-17A).}, Keywords = {Interleukin-17, Maximal oxygen consumption, Cessation of training, Active men}, volume = {22}, Number = {5}, pages = {497-502}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3572-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3572-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Shiravand, Fatemeh and Ranjbar, Roohollah and Ghanbarzadeh, Mohsen and Hosseinzadeh, Masoumeh}, title = {The effect of melatonin on aerobic capacity and time of exhaustion during a sub-maximum activity in girl students of physical education}, abstract ={Background: Preservation and storage of muscle glycogen is the most important factor limiting the success of individuals in performing the following activities. It has been shown that melatonin supplementation before exercise can maintain glycogen stores. This study aimed to investigate the effect of melatonin consumption (6 mg) on the time of exhaustion during a submaximal-activity and also the maximum oxygen consumption during an increasing activity in physical education girl students of Shahid Chamran University of Ahvaz. Materials and Methods: In this clinical trial study, 13 girls with the mean age of 21.5±1.29 years, the mean weight of 58.36±2.69 kg and vo2max 39.08±4.17 mg/kg/min were participated and received melatonin (6 mg) and placebo (starch capsules) in two complementary steps. Supplements were administered acutely 30 minutes before the exercise. Each test was repeated in placebo and supplement conditions. To ensure the elimination of exercise and supplement impact, the interval of 5 to 7 days was considered between the two tests. The sub-maximal and progressive protocols respectively included running below the maximum intensity (70% of the heart rate reserve) to exhaustion and the Bruce's test on the treadmill. Results: The results showed that consumption of 6 mg melatonin significantly increased the time to reach exhaustion (P=0.01) and the maximum oxygen consumption (P=0.002). Conclusion: It appears that trained girls can use 6 mg of melatonin supplement 30 minutes before starting the exercise to improve endurance performance and aerobic capacity.}, Keywords = {Aerobic power, Time of exhaustion, Melatonin, Maximum oxygen consumption}, volume = {22}, Number = {5}, pages = {503-510}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3552-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3552-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Emad-Momtaz, Hossein and Sharif, Amin Alsadat}, title = {Comparing the effects of 8 weeks and 12 weeks of corticosteroid therapy on serum 25-hydroxyvitamin D levels in children with nephrotic syndrome in the recovery phase}, abstract ={Background: Nephrotic syndrome is a relatively common problem in childhood that can be caused by various diseases. These patients are susceptible to osteoporosis due to the nature of the disease and the complication of steroid therapy. Therefore, the aim of this study was to compare serum 25-hydroxyvitamin D levels in children with nephrotic syndrome in the recovery phase and under the two different treatment regimens. Materials and Methods: This clinical trial study was performed on 68 children with primary nephrotic syndrome referred to the Nephrology Clinic of Besat Hospital in Hamedan in 2014. Thirty-four patients were treated for 8 weeks and 34 patients were treated for 12 weeks. The two groups were matched for age and sex. At the end of the treatment, serum 25-hydroxyvitamin D levels were measured and compared in the two groups and the rate of relapse was also assessed. Results: There was no significant difference between the two groups in age and sex. The mean of vitamin D levels in the 8-week treatment group was significantly higher than the other group (21.61±11.39 and 16.18±9.79, respectively), and this difference was statistically significant (P=0.039). Absence of relapse was 47.1% in the 8-week treatment group and 73.5% in the 12-week treatment group, this difference was also statistically significant (P= 0.026). Conclusion: The recurrence rate was significantly lower in the 12-week treatment compared to the 8-week treatment. However, vitamin D levels significantly decreased in this treatment group compared to the other group.}, Keywords = {Children, Nephrotic syndrome, Steroids, 25-Hydroxyvitamin D }, volume = {22}, Number = {5}, pages = {511-516}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3406-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3406-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Firozi-Niyaki, Maryam and Barari, Ali Reza and Abbassi-Daloii, Asieh}, title = {The effect of endurance training and taxol consumption on cyclooxygenase-2 and prostaglandin E2 levels in the liver tissue of mice with cervical cancer}, abstract ={Background: Herbs have a strong anti-cancer effect. Also, exercise is one of several lifestyle factors known to lower the risk of developing cancer. The aim of this study was to investigate the effect of endurance training and taxol on cyclooxygenase-2 and prostaglandin E2 in the liver tissue of mice with cervical cancer. Materials and Methods: In this experimental study, 35 female C57 mice were randomly divided into 5 groups (n=7 in each group): control (healthy), control (cancer), complement (cancer), training-supplementary (cancer) and training (cancer). The implantation of cancerous tumors was performed under the skin of the upper pelvis. The training group completed the endurance training protocol, which included 3 sessions per week, 50 minutes per session, at a speed of 14-18 m/s for six weeks. A dose of 60 mg/kg/day of pure taxol was injected intra peritoneally. The dependent variables of this study were measured 24 hours after the last training session by ELISA. Results: The results showed that the use of taxol and endurance training reduced the levels of cyclooxygenase-2 and prostaglandin E2 in the liver tissues of C57 mice with cervical cancer. Conclusion: Induction of the cancerous tissue in mice with cervical cancer increases the levels of cyclooxygenase-2 and prostaglandin E2 and endurance training along with taxol may reduce these levels.}, Keywords = {Cervical cancer, Taxol, Endurance training, Cyclooxygenase-2, Prostaglandin E2}, volume = {22}, Number = {5}, pages = {517-524}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3537-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3537-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Jafarpour, Seyed Masoud and Aliasgharzade, Akbar and Moradi, Habibollah and Mohseni, Mehr}, title = {Measurement of outdoor and indoor natural gamma background radiation and risk of cancer in residents of Kashan during 2016-2017}, abstract ={Background: Natural gamma background radiation can cause ionization in vital molecules such as DNA and can have destructive effects on human health. Measurement of these radiations is very important because they increase incidence of cancers and genetic damages. The aim of this study was to measure the dose rate, annual effective dose and incidence of cancer risk in Kashan city, north of Isfahan Province.   Materials and Methods: In this cross-sectional study, measurements were performed using the dosimeter of the Radiation Alert Monitor 5 Model during daylight in outdoor and indoor in five geographical regions of Kashan city (north, south, east, west and center) and in four different seasons of the year. In each geographic region, measurements were carried out at three consecutive days in the middle of each season in ten random points. Then, the annual effective dose and excess lifetime cancer risk were calculated.   Results: The mean dose rates were 155±34 nSv/h and 186±34 nSv/h in outdoor and indoor, respectively. There was no significant difference between the mean dose rate in different seasons and different geographical regions. Furthermore, the annual effective dose was found to be 1.10 mSv while the estimated excess lifetime cancer risk was 4.16×10-3.  Conclusion: The annual effective dose arising from natural gamma background radiation (1.10 mSv) in Kashan city is much higher than the worlds' average (0.48 mSv) and the values obtained in most cities in Iran.}, Keywords = {Background radiation, Iran, Radiation effects, Gamma rays, Incidence of cancer risk}, volume = {22}, Number = {5}, pages = {525-531}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3571-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3571-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Banafsheh, Hamidreza and Mesdaghinia, Azam and Ghoreishi, Fatemeh Sadat and Gilasi, Hamidreza and Kashani, Zohreh and Gholami, Mostafa and Ghaderi, Amir}, title = {The survey of pattern of abusing and causes of addiction tendency among women undergoing methadone maintenance treatment in Kashan city during 2017-2018}, abstract ={Background: The current prevalence rates indicate an increasing trend of substance abuse among women. This study aimed at determining the pattern of consumption and causative factors for tendency to drug abuse in woman referred to addiction treatment centers. Materials and Methods: In this descriptive cross-sectional study, the study population was all women referred to addiction treatment centers of Kashan during 2017-2018. The research instrument was a demographic information questionnaire, causes of drug abuse tendency and structured clinical interviews with the Diagnostic and Statistical Manual of Psychiatric Disorders (SCID) to assess the substance abuse disorder. Results: The mean age and onset age of drug abuse were 40±10.3 and 25±6.4 years, respectively. Opium was the most common abused drug (81%) and smoking was the most cited method for drug abuse. Ten percent of the patients had a history of injection. The main causes of drug tendency from the perspective of the patients were addict family (77%), easy access to drugs (64%), as well as depression and disappointment (56%). Conclusion: The pattern of drug abuse among women undergoing the method one maintenance treatment in Kashan is traditional on the basis of the opium derivatives. The addict family was the main cause of drug abuse. Therefore, it would be necessary to pay more attention to the family of the patients as vulnerable groups in planning and to provide training on the causes of drug abuse tendency and preventive measures.}, Keywords = {Addiction, Women, Pattern of consumption, Causes of addiction tendency}, volume = {22}, Number = {5}, pages = {532-538}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3581-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3581-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Moghaddasi, Reza and Moazedi, Ahmad Ali and Ghotbeddin, Zohreh and Akhond, Mohammad Rez}, title = {The effect of electrical low-frequency stimulation on balance and locomotor activity in adult male rats during epileptogenesis of dorsal hippocampal}, abstract ={Background: Epilepsy is the third world neurological disorder. Epileptic focus causes motor impairment by sending projections to different areas of the brain such as areas which are related to movement control. Regarding the inhibitory effect of low-frequency electrical stimulation (LFS) on seizure wave's transmission, this study aimed at examining the effect of LFS during the epileptogenesis of dorsal hippocampal on balance and locomotor activity in adult male rats using the kindling method. Materials and Methods: Fifty rats were randomly divided into 5 groups: Control, Sham, Kindled, LFS and KLFS. Animals in the kindled group were stimulated rapidly by daily stimulation of dorsal hippocampus (1 ms pulse duration at 50Hz for 3 seconds). Animals in the sham and control groups did not receive any stimulation. In the LFS groups, four LFS packages at a frequency of 1 Hz were applied daily. At the end of stimulation, motor activity and balance were assessed by open-field and rotarod tests. Results: Frequency of rearing and grooming in the Kindled group significantly increased compared to the control group (P<0.05). Balance in the Kindled group was significantly decreased (P<0.05). LFS induction during hippocampal kindling did not show any significant difference in any of the mentioned parameters with the control group. Conclusion: In summary, applying low-frequency electrical stimulation during hippocampal kindling can reduce the motor activity and improve balance.}, Keywords = {Kindling, Low-frequency electrical stimulation, Balance, Motor activity, Rotarod, Open field, Rat}, volume = {22}, Number = {6}, pages = {538-546}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3654-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3654-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Akbari, Maryam and Moradi, Lida and AbbassiDaloii, Asieh}, title = {The effect of endurance training and Ziziphus jujube extract consumption on apoptosis of cardiac tissue in male Wistar rats}, abstract ={Background: Apoptosis is a highly regulated process that ensures the tissue and cellular homeostasis. This study aimed at investigating the effect of endurance training and the Ziziphus jujube extract consumption on apoptosis of cardiac tissue in male Wistar rats. Materials and Methods: In this experimental study, 32 male Wistar rats aged 8-12 weeks (weighing 195 mg±7.94) were randomly divided into four groups: control, jujube extract, endurance training and endurance training-jujube extract. A moderate endurance training program was conducted for eight weeks and five sessions per week. Rats were received a daily dose of 600 mg/kg of the extract orally. The gene expression of anexin-5 and caspase-3 in cardiac tissue was measured by the real-time PCR. Results: The results showed that there was a significant difference in the mean weight of the heart tissue of male Wistar rats among different groups (P<0.001). Changes in anexin-5 expression of the cardiac tissue in training-supplementation group were significantly lower than those in the control group (P<0.012). Also, the results showed that changes in caspase-3 expression of the cardiac tissue in supplementation (P<0.001), training (P<0.013) and training-supplementation (P<0.0001) groups were significantly lower than the changes in the control group (P<0.012). Conclusion: According to the findings of this study, it seems that endurance training and jujube extract consumption can have an interactive effect in reducing apoptosis of the cardiac tissue.  }, Keywords = {Exercise, Apoptosis, Ziziphus Jujube extract, Cardiac tissue, Rats}, volume = {22}, Number = {6}, pages = {547-554}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3625-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3625-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rami, Mohammad and Habibi, Abdolhamid and Khajehlandi, Mojdeh}, title = {The effect of moderate intensity exercise on the activity of catalase enzyme and malondialdehyde in hippocampus area of diabetic male Wistar rats}, abstract ={Background: Diabetes mellitus exacerbates oxidative stress and reduces the antioxidant defense system activity. As the brain has a high sensitivity to oxidative stress due to physiological and biochemical reasons and scientific evidence suggests the effect of regular exercise on reducing brain sensitivity to brain damage under pathophysiological conditions. Therefore, this study aimed at investigating the effect of moderate intensity exercise training on the activity of catalase enzyme and malondialdehyde in hippocampus area of diabetic male Wistar rats. Materials and Methods: Twenty-four male rats (245±9.4 g) aged 10 weeks were divided into four groups (diabetic training, diabetic control, healthy training and healthy control). The rats of the diabetic group were diabetic by intraperitoneal injection of streptozotocin (STZ). The exercise program included 6 weeks of moderate intensity exercise. At the end of six weeks, the hippocampal tissue samples were extracted 24 hours after the last training session and the activity of catalase enzyme and malondialdehyde was evaluated. Results: After the endurance training, the catalase levels in both diabetic training group (161.24±7.74) compared to the diabetic control group (148.55±8.05) and healthy training group (408.85±2.3) compared to the healthy control group (283.44±9.33) were significantly increased (P<0.05). Also, the level of malondialdehyde in the diabetic training group (9.65±1.75) was significantly decreased compared to the control diabetic group (13.23±1.01) (P>0.05). Conclusion: It can be concluded that endurance training may be effective to increase the antioxidant role of catalase enzyme and reduce the amount of malondialdehyde in the hippocampus tissue of diabetic rats.   }, Keywords = {Exercise, Catalase, Malondialdehyde, Hippocampus}, volume = {22}, Number = {6}, pages = {555-563}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3633-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3633-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rafiei, Samaneh and Edalatmanesh, Mohammad Ami}, title = {The effect of swimming training, Gallic acid and high-fat diet on the serum levels of sex hormones in rats with polycystic ovary syndrome}, abstract ={Background: Polycystic ovary syndrome (PCOS) is characterized by hormonal-metabolic disorders, obesity, oxidative stress and ovulatory dysfunction. The aim of this study was to investigate the effect of four weeks of swimming training and Gallic acid (GA) administration on the serum level of sex hormones in rats with a polycystic ovary syndrome (PCOS) under the standard and high-fat diet. Materials and Methods: In this experimental study, 72 virgin female Sprague-Dawley rats were randomly divided into the nine groups: Control, PCOS,  PCOS+HF (high fat diet), PCOS+EX (swimming training), PCOS+EX+HF (swimming training and high fat dietary), PCOS+GA (GA treatment), PCOS+GA+HF (GA treatment with high fat diet), PCOS+EX+GA (GA treatment and swimming training), PCOS+EX+GA+HF (GA treatment and swimming training with a high-fat diet). PCOS was induced with 1mg/kg letrozole and GA (100mg/kg, 4weeks) was administrated orally for 28 days. Then, the serum levels of LH, FSH, β-estradiol, progesterone and testosterone were measured using the ELISA method. Results: In the PCOS group, the progesterone level decreased and LH, FSH, β-estradiol and testosterone levels significantly increased compared to the control group (P<0.05). Treatment with GA or swimming training ameliorated the serum levels of these hormones. However, high fat diets reduced the ameliorative effect of GA and swimming training on the sex hormones in different groups. Conclusion: Gallic acid administration and swimming training can reduce dysregulation of sex hormones due to the PCOS in rats, but a high-fat diet increases PCOS pathogenesis.}, Keywords = {Polycystic ovary syndrome, Exercise training, Gallic acid, high-fat diet, Sex hormones}, volume = {22}, Number = {6}, pages = {564-572}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3533-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3533-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mousavi, Smatalsadat and Fallahmohammadi, Ziya and HajizadehMoghaddam, Akbar}, title = {Evaluating the protective effect of 6 weeks resistance training and vitamin D intake on brain neuro-inflammatory factors in female rats with experimental autoimmune encephalomyelitis}, abstract ={Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease and is associated with reduced physical capacity. The aim of this study was to examine the protective effect of a 6-week resistance training program and vitamin D intake on the brain neuro-inflammatory factors in female Lewis rats with experimental autoimmune encephalomyelitis (EAE). Materials and Methods: In this experimental study, four-week-old female Lewis rats (n=48) were randomly divided into 8 groups. Resistance training protocol was performed for 6 weeks and 5 days a week. A training program was started with a load equal to 50% of the body weight of the rat. Animals in the first two sessions performed 8 to 10 repetitions (climbing the ladder) at 2-minute breaks. The rats were immunized with the guinea pig's spit and complete adjuvant. The EAE model was induced at the end of the sixth week of the exercise. Rats received 5 μg of vitamin D3 in 150 μl of sesame oil per kilogram of their body weight via intraperitoneal injection once every two days for 2 weeks. Results: The results showed that six weeks of resistance training with vitamin D had no significant effect on granulocyte-monocyte growth factor, nuclear transcription factor kB and transforming growth factor beta (P>0.05). However, Interleukin-17 values showed a significant difference in all three levels of training (P=0.000), supplements (P=0.045), and interactive training and supplementation (P=0.043). Conclusion: The inadequacy of the training period (frequency and intensity of exercise) and the dose rate of vitamin D3 can be one of the possible causes of ineffectiveness of the present intervention.}, Keywords = {Resistance training, Neuro-inflammatory factors, Vitamin D, Multiple sclerosis}, volume = {22}, Number = {6}, pages = {573-580}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3658-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3658-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Golfam, Leila and Heydari, Azhdar and Ardjmand, Abolfazl}, title = {The effect of pre- and post-natal nitrate exposure on inhibitory avoidance memory in mice}, abstract ={Background: Nitric oxide (NO) is directly involved in mechanisms responsible for fetal neurogenesis and development. It has also been shown that NO can impair or improve learning and memory in different models. There is evidence that administration of nitrate can produce NO. This study aimed at examining the effect of pre- and post-natal nitrate exposure on inhibitory avoidance memory in mice and measuring the NO metabolites herein. Materials and Methods: In this experimental study, 28 pregnant mice were divided into 4 groups: 1) Control group (whose mothers received only drinking water during the pregnancy and post-natal), 2) Treatment Group (whose mothers received sodium nitrate (100 mg / l) in drinking water during the pregnancy and post-natal until the 6th and 11th day after birth). During a two-day session (training and test) the learning and memory of animals (30 days after receiving sodium nitrate) were studied in a step down apparatus. The latency time for coming down from the platform in the test day (S) was used as a criterion for memory. The nitrate oxide metabolites in brain tissue were measured by Miranda method. The nitrite to nitrate recovery and total nitrite measurements were performed using Griess reagents with a spectrophotometer. Results: The oral administration of sodium nitrate (100 mg/L) during pregnancy and lactation until 11 days after birth improved the avoidance memory compared to the control group (P<0.05). Also, sodium nitrate did not change the NO metabolites during those time periods. Conclusion: The oral sodium nitrate in pregnancy and lactation period improves mice avoidance memory without an alternation in nitric oxide metabolites.}, Keywords = { Nitrate, Avoidance memory, Mice, Nitric oxide, Pregnancy, Lactation}, volume = {22}, Number = {6}, pages = {581-588}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3673-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3673-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Ghodratpour, Fatemeh and Baghbani-Arani, Fahimeh and SadatShandiz, Seyed Ataolah}, title = {Cytotoxic effects of Zn oxide nanoparticles against breast cancer T47D cells and NM23 gene expression}, abstract ={Background: Breast cancer is the second leading cause of cancer-related death worldwide among women. Nowadays, nanoparticles are interested as anti-cancer factors in studies related to cancer therapy. Therefore, the present study aimed to explore cytotoxic effects of zinc oxide nanoparticles (ZnONPs) and to evaluate NM23 gene expression in T47D breast cancer cells. Materials and Methods: The cancerous T47D and normal HEK293 cell lines were treated with different concentration of ZnONPs for 24 hours and the cytotoxicity activity of ZnONPs was analyzed by the MTT assay. Then, the NM23 gene expression was evaluated using the real-time PCR method. Results: According to MTT results, the ZnONPs significantly decreased the viability of T47D cells in dose-dependent manner. Also, the results revealed that the mRNA level of NM23 was up-regulated (7.8-fold) in cells treated with ZnONPs. Conclusion: ZnONPs can destroy cancerous T47D cells compared to normal HEK293 cells. Furthermore, it seems that ZnONPs can modulate metastasis by enhancing the NM23 gene expression level in breast cancer T47D cells. Thus, ZnONPs can be considered as a promising strategy for the treatment of breast cancer.}, Keywords = {Breast cancer, ZnONPs, T47D, NM23}, volume = {22}, Number = {6}, pages = {589-594}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3663-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3663-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Pourvatan, Neda and Khazaei-Koohpar, Zeinab}, title = {Investigation of exon 4 mutations of phenylalanine hydroxylase gene in phenylketonuria patients in Guilan Province using PCR-sequencing}, abstract ={Background: Phenylketonuria (PKU) is a heterogeneous and autosomal recessive metabolic disorder that is mainly caused by mutations in the hepatic phenylalanine hydroxylase (PAH) gene. Distribution pattern of mutations in the PAH gene are specific to each population. To date, no reports of phenylketonuria molecular analysis have been found in this population. The aim of this study was to identify PAH mutations within exon 4 in PKU patients in Guilan Province and compare it with the studies in other parts of Iran. Materials and Methods: In this cross-sectional and descriptive study, 25 unrelated PKU patients (age range, 1-21 years) were identified from different regions of Guilan Province during a one-year period. After collecting blood samples and DNA extraction, the DNA fragments containing the exon 4 of the PAH gene and its flanking intronic sequences were amplified and sequenced. Results: In this study, IVS4+5G>T mutation (10%) was identified. This mutation was found in two homozygous PKU patients and one heterozygous patient; they had mPKU and cPKU phenotypes, respectively and their parents were third degree relatives. In addition, IVS4+47C>T (28%) and IVS3-22C>T (8%) polymorphisms were also detected. Conclusion: Investigation of mutations in the PAH gene can be a useful tool for molecular detection of the PKU disease and carrier detection in this population. Moreover, the other 12 remaining exons need to be analyzed to obtain the full spectrum of mutations of this gene among the PKU patients in Guilan Province.}, Keywords = {Guilan Province, PKU, PAH, mutation, exon4. .PCR-Sequencing.}, volume = {22}, Number = {6}, pages = {595-601}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3666-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3666-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rezaei, Zeinab and RasoliAzad, Mourad and Mehrzad, Fatemeh and Farhad, Majid and Azad-Miveh, Zahr}, title = {The effect of dialectical behavioral therapy on craving and depression in methadone patients}, abstract ={Background: Methadone maintenance treatment (MMT) is a common medication for opioid dependence disorder. Despite the positive results, this therapy has many physical and psychological effects. The aim of this study was to determine the effectiveness of a dialectical behavioral therapy (DBT) on craving and depression in people under the methadone maintenance therapy. Materials and Methods: This is a randomized, controlled clinical trial with intervention (DBT) and control (MMT) groups. Initial diagnostic evaluations were performed by psychiatrist and clinician at a clinical interview. Fifty men referred to methadone treatment clinic were randomly assigned to the two groups (intervention and control). Data were collected through demographic information questionnaire, craving scale, depression questionnaire, treatment validity questionnaire, and treatment alliance questionnaire for pre-test, post-test and follow up. Results: The results showed that the scores of the intervention group were significantly reduced in comparison with the control group in craving and depression after 4 months of intervention and 2 months follow-up (P<0.01). Conclusion: The combination of the methadone therapy and dialectical behavior therapy can be useful in reducing craving and psychological problems of opiate dependent people. Considering the emphasis on a dialectical behavioral therapy on emotional regulation as the main mechanism for change, this treatment can be a useful therapy for other psychological disorders that are involved with emotional problems.}, Keywords = {Methadone maintenance therapy, Dialectical behavior therapy, Craving, Depression}, volume = {22}, Number = {6}, pages = {602-609}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3723-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3723-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Afshar, Mohammad and Sabbagi, Ensieh}, title = {The effect of educational package on recurrence and severity of bleeding in patients with epistaxis}, abstract ={Background: Epitasis is a disorder that affects about 60% of the population, and the lack of treatment of this disorder causes a lot of problems for the patient. Therefore, this study aimed at examining the effect of the educational package on reducing the recurrence and severity of bleeding in patients with epistaxis. Materials and Methods: This clinical trial study was performed on 60 patients with epistaxis referred to Matini Hospital, Kashan, Iran. Patients were randomly assigned into two equal groups of intervention and control (n=30, each group). In addition to routine care services, patients in the intervention group received an educational package including face to face education and educational pamphlets. Patients in the control group only received routine care services. After one month of training, at the end of the 4th, 8th and 12th weeks, the intensity and recurrence of epistaxis were evaluated. Results: Sixty percent of the patients in the intervention group and 66.7% of the control group were female and the rest were male. The mean age of the subjects in the intervention group was 50.8±19.39 and in the control group was 47.51±19.19 years. The frequency rates of recurrence of nasal bleeding during the first four weeks in the intervention and control groups were 20% and 46.7%, respectively (P=0.03), whereas in the 8th week, 6.7 and 16.7 percent (P=0.43) and in the 12th week were 0 and 6.7 in intervention and control groups (P=0.49). Also, the severity of bleeding was lower in the first week (P=0.07) than in the eighth week (P=0.37) and twelfth (P=0.35). Conclusion: A short-time education through face-to-face and pamphlet can reduce recurrence of epistaxis while having a modest effect on severity of bleeding.  }, Keywords = {Severity of bleeding, Recurrence of bleeding, Educational package, Epistaxis}, volume = {22}, Number = {6}, pages = {610-616}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3684-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3684-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mirzaii-Fini, Fatemeh and Dowlati, Mohammad Ali and DehghaniAshkezari, Mahmood and Kouchaki, Ebrahim}, title = {Investigating the association of Val/Met polymorphism of the BDNF gene with the incidence of disease in patients with Alzheimer and comparison with healthy elderly people in Iran}, abstract ={Background: Alzheimer's disease is the most common cause of dementia in the elderly and the genetic and environmental factors interfere with its creation. The BDNF gene is responsible for producing a brain-derived neuronal factor. In this disease, the valine66methionine polymorphism and nucleotide changes of 196 (G>A) BDNF are genetic risk factors .This polymorphism has not been investigated in patients with Alzheimer's disease in Iran. This study aimed to provide appropriate information on the prognosis of the disease and the ability to get it. Materials and Methods: In this case-control study, 73 patients with Alzheimer's disease and 100 healthy controls were evaluated. Blood samples were taken from the subjects and DNA was extracted. After quantitative and qualitative DNA analysis, PCR-RFLP was performed and the results of both groups were analyzed and compared. Results: Fourteen patients and seven controls had polymorphisms of BDNF gene. Fifty-nine patients had normal allele, 8 patients with heterozygote allele and 6 patients had methionine/methionine allele. In the controls, 93 patients had normal allele, 5 with heterozygote allele and 2 had methionine/methionine allele. Conclusion: The findings of this study indicate that the increase in valine/methionine polymorphism in the BDNF gene in Alzheimer's patients compared to the control group can express the role of this polymorphism in this disease. Also, patients with this polymorphism had a worse clinical status than patients without this polymorphism. Therefore, evaluation of this polymorphism can provide appropriate information about the patient's condition.}, Keywords = {Alzheimer's disease, BDNF gene, Polymorphism, Valine/methionine}, volume = {22}, Number = {6}, pages = {617-623}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3672-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3672-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Sattari, ُShiva and Ahmadizadeh, Changiz}, title = {The study of expression of PTEN and AKT1 genes in co-culturing of HT29 colon cancer cell line with Streptococcus thermophilus}, abstract ={Background: Colon cancer is one of the most common cancers in the world. Probiotics are viable and useful microorganisms that have an effective role in controlling cancer by influencing the digestive enzymes of animals and humans, inhibition of cancerous agents in the body and in vitro conditions, suppression of lotions, and cancer-inducing compounds and tumors in experimental animals. The present study was conducted to investigate the PTEN/ AKT1 cellular signaling pathway in adjacent cultures of Streptococcus thermophilus with HT29 colon cancer cells. Materials and Methods: Bacterial culture, supernatant and bacterial extract were prepared and the cells were treated with these materials. Cell necrosis was evaluated by the MTT method. Also, the expression of PTEN and AKT1 genes in HT29 cell line was investigated using the real-time PCR. Results: The results showed that the thermophiles bacterium reduced the expression of AKT1 genes, and increased the expression of PTEN and led the cancerous cells toward apoptosis. The MTT test showed that the concentration of OD=0.05 had the highest mortality in 4 hours. Conclusion: Thermophiles bacteria can be used to create a novel therapeutic effect with high impact, low side effects, harmless biological effect and lower costs. Also, it can be used as an extra treatment appropriate to the body's natural flora for the treatment and prevention of colon cancer.}, Keywords = {Probiotic, Colon cancer, HT29 cell}, volume = {22}, Number = {6}, pages = {624-631}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3648-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3648-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Afshari, Behrooz and Zanjani, Zahr}, title = {Evaluation of executive and cognitive functions in bipolar patients and their family members}, abstract ={Background:  Bipolar disorder is a debilitating psychiatric disorder characterized by recurrent depression, manic, and hypomanic episodes. Examination and comparison of executive and cognitive functions in bipolar patients and their family members has not been addressed in Iran so far. The aim of the present study was to examine executive and cognitive functions in bipolar patients and their family members. Materials and Methods: In this cross-sectional study, 50 patients with bipolar disorder, 50 of their family members, and 50 healthy controls were included. The Young Mania Rating Scale, Beck Depression Inventory, Tower of London task, Wisconsin Card Sorting Task, Trail Making Test, Ruler Drop method, Four- Choice task, and general intelligence test were used to examine executive and cognitive functions of the participants. Results: Executive and cognitive functions in patients with a bipolar disorder were significantly lower than those in the other groups (P<0.01), but there was no significant difference in executive and cognitive functions between family members of the patients and healthy controls. Conclusion: According to the results of the present study, executive and cognitive functions have been destroyed in patients with bipolar disorder, but their family members have normal executive and cognitive functions.}, Keywords = {Executive function, Cognitive function, Bipolar disorder}, volume = {22}, Number = {6}, pages = {632-639}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3652-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3652-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} }