@article{ author = {Ghorbanian, Mohammad Taghi and Tarihi, Taghi and MesbahNamin, Sayed Ali Reza and Naghdi, Naser}, title = {Evaluating the effect of deprenyl on the differentiation of bone marrow stromal cells into dopamine producing neurons}, abstract ={Background : Bone marrow strormal cells (BMSCs) can be used as a valuable cells source for auto- graft in clinical applications involving regeneration of the central nervous system. BMSCs are adult stem cells with the potential of differentiation into other types of cells. Research has proved the effectiveness of deprenyl in the treatment of neurodegenerative process of parkinson and also the trophic effect on the neural cells in vitro. Deprenyl has proven as inhibitor of monoamine oxidase B (MAO B), resulting in an enhancement of the dopamine level. In the present study the effects of deprenyl on BMSCs is evaluated. Materials and Methods: to evaluate the differentiated capability of BMSCs into the neuroid cells, the dopamine level and activity of tyrosine hydroxylase antibody were assessed by high performance liquid chromatography (HPLC) and immunocytochemistry, respectively. Also, the real time polymerase chain reaction (RT-PCR) was used for the study of the expression of brain derived neurotrophic factor (BDNF) gene in BMSCs. Data were analyzed by one way-ANOVA and post hoc Tukey's test. Results : Molecular study indicated that the expression of the BDNF gene was increased in deprenyl-induced cells. Also, the immunocytochemical study of tyrosine hydroxylase and HPLC demonstrated that the deprenyl with concentration of 10-8 M has the potential of inducting the differentiation of BMSCs into dopaminergic cells and synthesis and secretion of dopamine.}, Keywords = {Bone marrow stromal cells, Deprenyl, Dopamine, High performance liquid Chromatography}, volume = {12}, Number = {3}, pages = {1-6}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-659-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-659-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Sohrabi, Davoud and Alipour, Mohsen and Gholami, Mohammad Rez}, title = {The effect of sodium benzoate on testicular tissue, gonadotropins and thyroid hormones level in adult (Balb/C) mice}, abstract ={Background : Sodium benzoate is used as a disinfectant agent against some microorganisms in food. The toxic effect of this chemical has been shown in some studies. The aim of this study was to evaluate the effects of sodium benzoate on testicular tissue, gonadotropins and thyroid hormones level in adult (Balb/C) mice. Materials and Methods: In this experimental study, 18 adult male mice (Balb/C, 10-12 weeks) were divided into three equal groups. Two groups of mice were given sodium benzoate 140 mg/kg/day and 280 mg/kg/day for 60 days respectively. The control animals received tap water. Post-anesthetic blood sampling from left ventricle was used for hormonal measurements. After scarification, the testes were removed and fixed for morphologic studies. Data were analyzed by student t-test. Results: No significant difference was evident concerning weight loss between the control and case groups. The testosterone level was significantly decreased in the case groups (P<0.0001). Also FSH, LH, T3 and T4 levels was significantly decreased in the high dose against the control group (P<0.0001 for FSH, LH & p<0.001 for T3, T4) however, TSH was considerably increased in the high dose and control groups (P<0.001). Ultrastructural study of testicular tissue showed the picnotic nature of germinal cells nuclei and plenty of distended vascular in cytoplasm. Conclusion: Sodium benzoate decreases plasma level of the testosterone, gonadotrophins, T3 and T4. Thus, it is recommended to replace it with other preservatives in drugs and foods.}, Keywords = {Sodium benzoate, Testis, Gonadotropins, Thyroid hormones}, volume = {12}, Number = {3}, pages = {7-11}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-665-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-665-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Niazmand, Saeid and ErfanianAhmadpour, Mahmoud and Hajzade, Mousalreza and Khoshnood, Esmat}, title = {The effects of aqueous-ethanol extract of Achillea wilhelmsii on gastric acid secretion at basal, vagotomized and vagal-stimulated conditions}, abstract ={Background: It has been shown that Achillea wilhelmsii, a plant used in traditional medicine to treat gastrointestinal disorders, has the antibacterial, antioxidant and antispasmodic effects. However, the effects of Achillea wilhelmsii on gastric acid secretion have not been detected yet. Materials and Methods: Twenty four male Wistar rats (200-250 g) were randomly divided into two groups (case and control). After anesthesia by sodium thiopental (50 mg/kg, ip) tracheostomy, laparatomy and gastrodeodenostomy were performed for each rat. Gastric secretions were collected through a tube inserted in the stomach and extended toward duodenum. Using the maceration method, different doses of the extract (0.5, 1, 2 mg/kg) were prepared in a volume of 1 ml. The same amount of normal saline was used in control group. Two samples of the gastric secretion were collected by 15 minute intervals. The total titrable acid was measured by a titrator. The data were analyzed using unpaired t-test and the results were reported with a significance level of 0.05. Results: The extract significantly inhibited the basal acid secretion in a dose-dependent manner. A concentration of 2 mg/kg of the extract showed a stimulatory effect on acid secretion. Vagotomy prevented the inhibitory effect of extract on gastric acid secretion. There was no difference between the effects of extract on control and stimulated vague group. Conclusion: The results indicated the inhibitory effect of extract on basal acid secretion. The comparison of extract effect on basal acid secretion at basal and vagotomized conditions showed that the inhibitory effect of the extract was mediated by the inhibition of gastric vagal activity. The extract could not inhibit the stimulated gastric acid secretion.}, Keywords = {Achillea wilhelmsii, Gastric acid, Vagotomy, Vagus nerve}, volume = {12}, Number = {3}, pages = {12-16}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-666-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-666-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Belaran, Maryam and Moazedi, Ahmad Ali and Hemmaty, Ali Asghar and Rasekh, Abdorahm}, title = {A comparison of the effect of intraperitoneal injection of glucose on spatial learning and memory of young and aged rats}, abstract ={Background: Despite controversy, the memory enhancing effect of glucose has been suggested in different learning methods. It seems that the age of animal is important in this practice. The present study evaluated the effects of glucose on spatial learning of young and aged rats. Materials and Methods: In this experimental study, rats in the case group received 500 mg/kg glucose 10 minutes before daily training. Subjects in the sham group received the same amount of saline. Animals were introduced to a Y-maze apparatus for the active avoidance task. Data were analyzed using one way analysis of variance and student t-test. Results: The results showed that glucose significantly improved the learning process in both young and aged rats (P< 0.05 and P< 0.01 respectively). However, the statistical comparison of the young and aged rats showed that the memory improvement following glucose administration was better in aged rather than in the young group (p<0.01). Conclusion: Pretraining glucose administration improved learning in young and aged rats. Glucose may alter the neuronal metabolism, activity or neurotransmitter synthesis.}, Keywords = {Spatial learning, Glucose, Y-maze, Active avoidance task, Rat}, volume = {12}, Number = {3}, pages = {17-24}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-667-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-667-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Neshat, Mehrdad and KhayatNouri, Mir Hadi and Mousavi, Ghafour}, title = {Effect of simvastatin on renal function and impairment following to the unilateral urethral obstruction in rat}, abstract ={Background: Obstructive uropathy indicates any possible obstruction in urinary flow. At the end stage, obstruction cause changes in the renal function. Competitive HMG-CoA reductase inhibitors, like simvastatin, decrease serum lipid level. It is shown that statines have organ protective effects following different impairments. The aim of this study was the evaluation of simvastatin effect on renal function and impairment following unilateral urethral obstruction in rat.Materials and Methods: In this experimental study 50 adult male rats (Sprague-Dawley), subjected to unilateral urethral obstruction (UUO), were divided randomly into five groups including control, UUO, UUO/SIM (simvastatin), Sham-operated and sham/SIM group. The control group received the drug solvent for 15 days. In UUO group, animals received the drug solvent postoperatively. Animals in UUO/SIM group received simvastatin (2 mg/kg/twice a day) for 15 days (starting one day before operation). Sham and sham/SIM groups were subjected to surgery without urethral obstruction. Blood samples were collected on day 0, 3, 7 and 14 after surgery to measure creatinine, urea and cholesterol levels of the serum. Rats were sacrificed for histopathological evaluation on day 14. Using one-way ANOVA analysis, Tukey's post hoc and student t-test, data were analyzed.Result: The evaluation of biochemical parameters showed that, compared to control the group, the level of creatinine, urea and cholesterol in the UUO group were significantly increased 7 and 14 day postoperative (P<0.05). However, these parameters were decreased in the simvastatin group (P<0.05). Histopathological evaluation showed renal interstitial fibrosis, tubular epithelial necrosis, interstitial infiltration of mononuclear cells, periglomerular sclerosis, subcapsular fibrosis and glomerulosclerosis in the UUO group. Simvastatin administration during urethral obstruction in the UUO/SIM group declined the obstruction induced urethral lesions and the changes of interstitial tissue. There was no significant difference between the control and sham groups.Conclusion: Our findings showed that the urethral obstruction decreased renal function and caused severe impairment in renal tissue. Simvastatin decreased the tissue lesions induced by the obstruction of urethra. Of course, the protective effects of simvastatin in humans need more research.}, Keywords = {Simvastatin, Unilateral urethral obstruction, Renal function, Rat}, volume = {12}, Number = {3}, pages = {25-32}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-668-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-668-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Safavy, Sayed Esmaeil and KhayatNouri, Mir Hadi and Sharooz, Rasoul}, title = {Study of the apoptosis in adult rat testicular tissue following unilateral experimental cryptorchidism}, abstract ={Background: Cryptorchidism is caused following any failure in the descending scrotum at the birth and is one cause of the infertility in the human and some animal species. In most mammalian species, the temperature of testis is a few degrees lower than the abdominal cavity which is necessary for the maintenance of normal spermatogenesis. The aim of the present study was to investigate the process of apoptosis in testicular tissue of adult rat following unilateral experimental cryptorchidism. Materials and Methods: Adult male Wistar rats (200-250 g) were divided into 15 groups, each containing 8 animals. Experimental unilateral cryptorchidism was carried out in 7 groups using the fixation of right testis to the abdominal wall. In seven groups the testes were assessed 1, 3, 6, 10, 15, 30 and 60 days postoperative. In another seven groups, as sham, the testis was displaced from scrotum to the abdominal cavity. Then the testis was returned to the scrotum. One group, as the control, bore with no procedure. Following the sampling of the testicular tissue and the later fixation the testes were studied for apoptosis. Results: The tunnel staining identified that the experimental cryptorchidism induces apoptosis in germinal cells of testicular tissue. Peak of the apopetotic cell numbers were observed in third and sixth day postoperative. There was no significant difference between the sham and control groups. Conclusion: Our results showed that the experimental cryptorchidism induced apoptosis in testicular tissue. The peak of cell death is three days postoperative then it gradually the decreases with elapsing time. This effect was probably the result of thermal and oxidative stress in testicular cells.}, Keywords = {Cryptorchidism, Apoptosis, Testis, Adult rat}, volume = {12}, Number = {3}, pages = {33-39}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-669-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-669-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {EmadiBaigi, Mojtaba and Soheili, Zahra Soheila and Samei, Shahram}, title = {Evaluating the expression of Snail genes in prostate cancer}, abstract ={Background: Prostate cancer (PCa) is the second most common malignancy in men worldwide. Because it is known that the inappropriate activation of necessary process for fetal development in adult has the potency of leading to pathological conditions, the hypothesis has been raised that the reactivation of some aspects of the embryonic epithelial-mesenchymal transition (EMT) program could underlie the mechanism of tumour invasion. Snail and slug are zinc-finger proteins acting primarily as the survival factors and inducers of cell motion. In the present study, the expression of snail genes in prostate cancer was evaluated. Materials and Methods: In the present case-control study, the whole RNA content was extracted from the normal and prostate cancerous tissues and used for cDNA synthesis. Due to Snail genes some limitations of obtaining complete normal samples in the control group, samples from open prostatectomy were used. To quantify the expression of snail genes, the synthesized cDNA was amplified by Real-Time PCR. Data were analyzed using student t- test. Results: Our data showed that both genes were expressed in normal and cancerous tissues and there was no significant difference in the gene expression between normal and cancerous tissues (P = 0.35 and P = 0.06 for snail and slug genes, respectively). Conclusion: The observed heterogeneity could reflect the dynamic and reversible nature of EMT during progression and metastasis of prostate tumours.}, Keywords = {Prostate cancer, EMT, Snail genes, Real-time PCR}, volume = {12}, Number = {3}, pages = {40-46}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-670-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-670-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Esalatmanesh, Kamal and Soleimani, Zahra and Arj, Abbas and Akbari, Hossein and Salesi, Mansour}, title = {Diagnostic value of ELISA (IgG and IgM) test in brucellosis patients in Kashan during 2004}, abstract ={Background: Brucellosis is an important common disease with many complications. Early diagnosis of the disease is very important. The present study was designed to compare the diagnostic value of ELISA test (IgM, IgG) with serologic agglutination tests (Wright and Coombs Wright) in brucellosis patients in Kashan during 2004. Materials and Methods: This case control study was conducted on 31 brucellosis patients. Using 5 cc venous blood, the ELISA, Wright and Coombs Wright tests were performed before and 3 months after the treatment. The results were analyzed concerning the determination of specificity and sensitivity of the tests.  Results: The sensitivity of ELISA for IgM and IgG was 100%. Specificity of the test was 63.3% and 72.7% respectively. Also, while the positive predictive value of both tests was 100% the negative predictive values were 83.6% and 86.9% respectively.  Conclusion: Regarding the sensitivity and specificity the ELISA test could be considered as a reliable and appropriate test in diagnosis of brucellosis}, Keywords = {Brucellosis, Coombs Wright, ELISA, Wright}, volume = {12}, Number = {3}, pages = {47-50}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-671-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-671-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Honarmand, Azim and Safavi, Mohammad Rez}, title = {Evaluating the efficacy of infection probability score, APACHE II and APACHE III in the determination of the need for mechanical ventilation and duration of it in patients with respiratory failure}, abstract ={Background: Although the predictive criteria for duration of mechanical ventilation may help to evaluate the right time of disconnecting a patient from the ventilator, the efficacy of the APACHE ( Acute physiology, Age and Chronic Health Evaluation) or IPS (Infection Probability Score) systems in the prediction of the need to ventilator and its duration needs further evaluation. The study was performed in Alzahra Medical Center of Isfahan in 2006 – 2007 to evaluate the efficacy of the predicting power needing intubation (NI), mechanical ventilation (NMV), and duration of MV. Materials and Methods: One hundred eighty critically ill patients were included in this evaluative diagnostic study. On admission day in the ICU, patients' data were collected to compare the APACHE II and III, and IPS scores. The necessity of mechanical ventilation and its duration were recorded for each patient. Sensitivity, specificity, area under the curve and corrected prediction of outcome for each cut-off point were calculated for three scores. Results: The best cut-off points for prediction of NI were 50 for APACHE III, 12 for APACHE II and 12 for IPS. The Youden index had best cut-off points for APACHE III=0.62, APACHE II=0.36 and IPS=0.4. The area under the Receiver Operating Characteristic (ROC) curve was 0.63, 0.77 and 0.83 for APACHE III, APACHE II and IPS respectively. There were statistical differences between APACHE III , APACHE II and IPS in terms of Youden index and the area under the ROC curve (P<0.05). For the prediction of NMV, APACHE III yield significantly better results in the area under the ROC curve and Youden index than those of APACHE II or IPS (p<0.05). In the prediction of more than 5 days respiratory support under MV none of the three scoring systems could provide a good discrimination. Conclusion: To predict for NI or NMV, the APACHE III had better accuracy than the APACHE II or IPS. Concerning estimation of the requirement of mechanical ventilation in critically ill patients although the APACHE III showed to be sufficiently accurate the sensitivity and calibration of the scoring systems should be improved.}, Keywords = {APACHE II, III, IPS, Mechanical ventilation, Intubation, ROC}, volume = {12}, Number = {3}, pages = {51-57}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-672-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-672-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Hemmaty, Mohammad and Binesh, Elahe and KhajeKaramAldini, Mehangiz and Zibaei, Saei}, title = {Identification of helicobacter pylori in the milk of sheep and goat using incubation and PCR methods in Mashhad suburb}, abstract ={Background: Helicobacter pylori (HP) is identified as the most common gastrointestinal (GI) infection agent in the world. According to some findings shepherd's Helicobacterial infection is due to their contacts to sheep. Considering the controversy, the transmission of HP from the milk of small ruminates to humans and the possibility of the Zenotic nature of the disease has not proven yet. Thus, recognition of the routes of transmission of bacterium to human is vital. Materials and Methods : Using random clustering, 100 samples (81 sheep and 19 goat's samples) were taken from 20 villages of Mashhad suburb during two years. A questionnaire regarding the health status of the shepherds and their family from the point of view GI discomfort was taken. All taken samples were incubated on two specific HP media, HPSPA (Helicobacter pylori Special Peptone Agar) and Columbia Agar including antibiotics. Following centrifugation, DNA extraction was carried out on all precipitated samples. The specific Urease C gene of HP was traced through polymerase-chain reaction (PCR). Results: Considering the negative results of both PCR and isolation tests, neither culture media nor PCR could prove the existence of HP gene or the Urease C gene for the specific HP in samples. Information showed that 20% of shepherds and 25% of their families and also 10% of both are complaining of GI discomfort, without any clear relation to HP. Conclusion: The results showed that two incubation procedures could not detect HP or its gene, Urease C. Probably, the reason could be due to some multifactorial agents, essential for the determination of the strategy of prevention and health. Possibility of transmission of the agent from the small ruminants and milk to humans needs further investigation.}, Keywords = {Helicobacter pylori, Sheep milk, PCR, Isolation}, volume = {12}, Number = {3}, pages = {58-62}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-673-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-673-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Soleimani, Ali Reza and Mianesaz, Elahe and Tamadon, Mohammad Reza and Mousavi, Sayed Gholam Abbas}, title = {Evaluation of the relationship between diabetes mellitus and kidney transplantation}, abstract ={Background: Best choice for end stage renal disease (ESRD) is replacement therapy and kidney transplantation. Pre/post transplantation diabetes mellitus (DM) has adverse effects on both the patient and new kidney. In this study the effects of DM before and after the transplantation were compared with complications and outcomes of the procedure in kidney transplanted patients during 2002- 2007. Materials and Methods: In this historical cohort study patients were divided into 3 groups: group I with DM before graft, group II with DM after the transplantation and group III left non diabetic. All information were evaluated based on the delayed function of graft (DGF), rejection possibility, systemic infections, cancer, relapse of renal disease, cardiovascular disease and subsequent death. Results: One hundred five patients were included in this study (35 in each group). Mean age of the group I, II and III were 47, 47.3, and 47.1 respectively. Also, the incidence of outcomes and complications was 82.9%, 57.1% and 22.9% respectively. The one year survival of transplanted kidneys in each group was 68.5%, 77.1% and 91.4% and the one year survival of patients was 82.8%, 88.5% and 97.1% respectively. Conclusion: The prevalence of post transplantation diabetes mellitus (PTDM) in this research was 21%. The rate of complications and death in pre transplantation DM patients was higher than that in PTDM patients. Also, this rate was the lowest in non diabetic patients. In conclusion, due to the adverse effects of DM or PTDM, the accurate follow up of patients in terms of blood sugar monitoring and complications is suggested.}, Keywords = {Kidney transplantation, Diabetes mellitus, PTDM}, volume = {12}, Number = {3}, pages = {63-67}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-674-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-674-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Dehghani, Rohollah and DinparastJadid, Navid and Shahbazzadeh, Dalavar and Bigdelli, Shahl}, title = {Surveying the scorpion sting agents at Khuzestan (a province of Iran) in 2004}, abstract ={Background: Seven scorpion species have been reported as human envenoming in Iran. The accurate identification of scorpion sting agents can best help the treatment. This identification also discloses the pathophysiological basis of symptoms and gives the rational for first aids implementation. The study was performed to identify the agents of scorpion sting in Khuzestan. Materials and Methods: This descriptive research was conducted on 418 scarified scorpions, preserved Ethyl alcohol (70%). The census sampling was performed and the appropriate species were assigned using all morphological criteria by key identification stereo microscopy . The results of scorpion stungs were recorded on a data sheet, classified and compared based on their species and families. Results: Results showed that, 7 scorpion stungs belonged to Buthidae and Hemiscorpidae families. The recognized scorpion species during this study were as follows: Family Buthidae:Mesobuthus eupeus(91, 21.7%), Androctonus crassicauda (120, 28.7%), Compsobuthus matthiessenis (86,20.6%), Orthochirus scrobiculosus(1, 0.5%), Buthotus(Hotentotta) saulcyi (14,3.35%), Buthotus(Hotentotta) schach (1,0.25%)  Family Hemiscorpidae: (24.9%) Hemiscorpious lepturus Among 23096 scorpion stungs, the highest and lowest occurrences were in Masjed Suleiman (20.7%) and Dehdez (0.44%) respectively. Conclusion: This is the first report from Iran, introducing the Compsobuthus matthiesseni as the major and Orthochirus scrobiculosus and Buthotus schach as the minor sting agents. Prevention, control and treatment plan, teaching the healthcare providers and informing the community regarding the new species are suggested. }, Keywords = {Agents, Khuzestan, Scorpion sting, Species}, volume = {12}, Number = {3}, pages = {68-74}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-664-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-664-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} }