@article{ author = {Heidarian, Esfandiar and Haghighi, Bahram}, title = {Identification of essential histidine residues at the active site of rat liver plasma membrane phosphatidate phosphohydrolase}, abstract ={Background: Phosphatidate phosphohydrolase enzyme (PAP) catalyzes the transformation of phosphatidic acid to Pi and diacylglycerol. Two different forms of PAP have been reported in rat hepatocytes PAP1 which participates in the synthesis of phospholipids and triacylglycerols, and PAP2 which involved in lipid signaling transduction. PAP2 has two isoforms namely PAP2a and PAP2b. In this study the role of essential histidine residues in PAP2b was assessed.Material and Methods: The rat liver plasma membrane was solved using n-octyle glucoside and PAP2b purified during several chromatography steps. The kinetics parameters were assessed based on surface kinetic dilution model. Discontinuous gel electrophoresis (SDS-PAGE) was performed on purified enzyme in order to evaluate its purity and to measure the molecular weight of the enzyme subunit in gel 10%. The number of mol histidine residues modified per mol enzyme was determined based on the formation of N-carbetoxy histidine. Results: The specific activity of purified enzyme was 7350mU/mg protein. PAP2b showed only a single band on SDS-PAGE with a mass weight of 33.8 kDa by electrophoresis. The PAP2b was inactivated by DEPC. The inhibition was competitive with respect to phosphatidate and the maximum 6 moles of histidine residues were modified per mole PAP2b.Conclusion: The data have shown that the incubation of PAP2b by DEPC plus phosphatidate can prevent the inhibitory effect of DEPC on enzyme activity. Our findings also revealed the role of histidine in the active site of PAP2b .This enzyme is likely to have a similar hydrolysis catalytic mechanism as its super family through a phosphohistidine intermediate.}, Keywords = {Diethylpyrocarbonate, Histidine, Phosphatidic acid, Phosphatidate phosphohydrolase}, volume = {12}, Number = {2}, pages = {1-8}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-631-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-631-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Omidi, Abdollah and MohammadKhani, Parvane and Poorshahbaz, Parviz and Dolatshahi, Abbas}, title = {Efficacy of combined Cognitive Behavior Therapy and Mindfulness Based Cognitive Therapy in patients with Major Depressive Disorder}, abstract ={Background: Efficacy of Mindfulness Based Cognitive Therapy and Traditional Cognitive Behavior Therapy in reduction of psychiatric symptoms of patients with Major Depressive Disorder in 2007 is considered in this study.Materials and Methods: This clinical-experimental study was carried out on 90 patients randomly selected from 160 cases referr ing to Tehran University Consulting Centers, Shahed University and Saba Rehabilitation Clinic and met DSM-IV criteria for Major Depressive Disorder. They were divided into 3 equal groups including CBT (Cognitive Behavior Therapy), MBCT (Mindfulness Based Cognitive Therapy)] with CBT, and TAU (Treatment As Usual). The first and second groups received psychological treatment while the third ones received medications. They were between 18 and 45 years old with two depression episodes and evaluated through the Structured Clinical Interview for DSM-IV (SCID) and self–report by Brief Symptom Inventory (BSI), in two pre and post tests. Data were analyzed by t-test, and Co-variance analysis.Results: MBCT with CBT and CBT groups have significantly reduced psychiatric symptoms and psychological distress. The combined method has effects similar with traditional CBT therapy.Conclusion: Elements from MBCT and CBT in comparison to CBT made treatment more effective.}, Keywords = {Cognitive-Behavior Therapy, Major Depressive Disorder, Mindfulness, Based Cognitive Therapy}, volume = {12}, Number = {2}, pages = {9-14}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-632-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-632-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Heiydari, Saeide and Salahshorian, Asiye and Rafie, Forough and Hoseini, Fateme}, title = {Correlation of perceived social support and size of social network with quality of life dimension in cancer patients}, abstract ={Background: Cancer represents a stressful life with negative consequences requiring social support for patients. This study describes the correlation between perceived social support and network with quality of life in cancer patients. Material and Methods: A descriptive-co relational design with continuos sampling method was performed and 220 patients in Firoozgar & Hazrat Rasool hospital and Emam Khomeini cancer Institute. Data obtained through social support questionnaires (SSQ) and the Ferrans and Powers quality of life index- cancer version (QLI-CV) and analyzed using SPSS version 13, Pearson correlation, Onaway Anova and Kruskal- Wallis tests. Results: The mean scores for perceived social support and quality of life were (136.44 and 18.22 respectively) which most of them received moderate to high social support from their meddle-size social network (4.17). Also, statistically, significant relations were found between age and marital status and perceived social support with the quality of life and diagnosis duration, type of treatment and economical condition (P<0.001) while there was not any relation between the quality of life and type of cancer. A significant positive correlation was found between perceived social support and quality of life (r=0.446, p<0.001) especially the family dimensions and size of social network(r=0.200, p<0.001), also quality of life and the size of social network(r=0.246, p<0.05). Conclusions : The results of this study give insights into the importance of perceived social support for promotion of the quality of life in cancer patients. Oncology nurse are recommended to apply findings to enhance the social networks of cancer patients and give them appropriate support. So that, further researches are recommended in this issue. }, Keywords = {Cancer, Perceived social support, Quality of life}, volume = {12}, Number = {2}, pages = {15-22}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-633-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-633-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Miranzadeh, Mohammad Bagher and Mostafaei, Gholam Rez}, title = {Assessing the effect of chemical coagulation and lime addition in upgrading the quality of effluents of stabilization ponds of Kashan University of Medical Sciences}, abstract ={}, Keywords = {Lime, Quality control, Reuse, Sewage, Stabilization pond}, volume = {12}, Number = {2}, pages = {23-27}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-634-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-634-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Shahabodin, Mohammad Esmaeil and PourAmir, Mahdi and PourAmir, Ali Akbar and Rasaie, Mohammad Javad and Parastouee, Karim}, title = {Evaluating protective effect of grape seed suspension on glucose, insulin and serum total antioxidant levels after alloxan injection in rat}, abstract ={}, Keywords = {Black grape seeds (shahani), Alloxan, Glucose, Insulin, Serum total antioxidant level}, volume = {12}, Number = {2}, pages = {28-33}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-635-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-635-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {BabaieAsl, Fayeze and Kheradmand, Motahare and Jafarian, Roghaye}, title = {Effect of duration of subcutaneous heparin injection on its subsequent pain}, abstract ={Background: High incidence of site-pain associated with subcutaneous heparin therapy has been reported. In spite of the use of different methods to decrease pain after subcutaneous heparin injection, the effect of duration of injection on its subsequent pain has not been studied enough. Therefore, this study was carried out to compare the duration of 10 and 30 seconds subcutaneous heparin injections. Materials and Methods : This semi-experimental study was conducted on 80 patients treating with subcutaneous heparin in medical-surgical wards of Babol Shahid Beheshti Hospital. Heparin was injected randomly to either right or left hand with a 12 hour interval during 10 seconds as control and 30 seconds as study technique. After each injection, patients reported the site-pain (from zero-ten) by VAS (Visual Analogue Scale) instrument, immediately and in sitting position. Data(Patient's pain score in 10 and 30 Seconds injection per gender, age group and type of disease) were analyzed using SPSS Version 15 and Wilcox on, Mann-Whitney and Kruskal -Wallis tests. Results: Severity of pain in control group was 2.10 ± 1.40 and in study group 1.65 ± 1.39 . The difference was significant (P<0.0 1 ). In comparison of the two techniques with demographic characteristics, in 10 second injection, the obtained pain from control group was significantly more than case group among female patients, those in medical wards and patients in 40-60 years range (P<0.0 0 , P<0.0 3, P<0.0 0 respectively) . Conclusion: This Study results indicated that increasing the duration of subcutaneous heparin injection could significantly decrease the patient's pain. To reduce the subsequent physical and psychological stresses of patients and increase the patient's trust to health care providers and nurses, injection of heparin in 30-seconds is recommended. }, Keywords = {Heparin, Pain, Injection duration, Subcutaneous injection}, volume = {12}, Number = {2}, pages = {34-38}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-636-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-636-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {MousaviBuiki, Noushin and Mahmoudzadeh, Hossein and Movafegh, Ali}, title = {Studying the effect of dextromethorphane on cholecystectomy postoperative pain}, abstract ={Background: Considering undesirable postoperative pain in recovery phase and many side effects of narcotics, the preemptive analgesic effect of oral dextromethorphane on cholecystectomized patients was studied in this study.Material and Methods: In this double blind, randomized, clinical trial on 44 patients in Shari’ati Hospital, Tehran University of Medical Sciences, 22 patients received placebo and 22 received 45 mg oral dextromethorphane 2 hours pre-operation. The anesthesia method was the same in both groups. Visual analog scale (VAS) for pain was recorded for each group in 1, 6 and 24 hours. Used morphine amount was recorded. As dextromethorphane causes drowsiness the patient's alertness was also recorded with Ramsey scores post- operation. Data were analyzed using t-test, Chi-square, and Mann-Whitney-U-tests.Results: Mean postoperative pain intensity was 9.55 in case and 8.33 in control group respectively. This was statistically significant but limited only in the first postoperative hour. No difference was observed in 6th, 24th hour pain, sedation, and alertness between the groups.Conclusion: Premedication with 45 mg oral dextromethorphane decreases post operative pain in first hour, so it can be used as an alternative analgesic drug along with narcotics.}, Keywords = {Analgesia, Dextromethorphan, Pain, Postoperative, Premedication}, volume = {12}, Number = {2}, pages = {39-43}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-637-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-637-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Razi, Ebrahim and Rayegan, Fariba and Barekat, Sayed Majid and Mousavi, Sayed Gholam Abbas}, title = {Evaluating the correlation of pulmonary artery pressure with respiratory and biochemical indexes in COPD hospitalized patients at Kashan Shahid Beheshti Hospital in 2005-2006}, abstract ={Background: Pulmonary hypertension (PH) is the most common complication and important intervention factors in chronic obstructive pulmonary disease (COPD) patients. It is presented by right-sided heart failure, hepatic congestion, hypoxemia, ascites and peripheral edema. This study was conducted to assess the correlation of pulmonary artery pressure with hematological and respiratory indexes in COPD patients. Materials and Methods: This cross sectional study was carried out on 81 hospitalized COPD patients in Shahid Beheshti Hospital in Kashan during 2005-2006. The increase of pulmonary artery pressure (PAP) by transthorasic echocardiography (TE), force expiratory volume in first second (FEV 1) by spirometry, PaO2 and PaCO2, with arterial blood gas analyzer (ABG), hemoglobin (Hb), alanine aminotransferase (ALT), aspirate aminotransferase (AST), erythrocyte sedimentation rate (ESR), and serum albumin with blood samples were determined. Pulmonary hypertension was defined as increasing the mean of pulmonary artery pressure grater than 25 mm/Hg. The relationship between PAP and other parameters was evaluated by Pearson analyzing test and correlation index. Results: Among 81 patients with COPD, 77 subjects (95.1 %) had pulmonary hypertension (PAP> 25 mm Hg). In this study the mean s± SD of studied parameters were as: age= 69 ± 9.2 yrs, FEV1 =38.1 ± 13.1% predicted, PaO2 =54.6 ± 13.1 mm Hg, PaCO2 =52.5 ± 10.5 mm Hg, Hb=41.58 ± 1.8 g/dl), AST =39.9 ± 70.5 IU/l, ALT = 39.7 ± 74.02 IU/l, serum albumin= 3.8 ± 0.49 g/dl, and ESR=6.6 ± 9.1.There was not significant correlation between PAP and the other parameters. Conclusions: According to the echocardiography results PAP>25 mm/Hg was found in most COPD hospitalized patients, having no correlation with the respiratory and biochemical indexes. So, to predict PAP, routine echocardiography for COPD patients, instead of the mentioned indices, is recommended.}, Keywords = {Chronic obstructive pulmonary disease, Echocardiography, Pulmonary artery pressure, Pulmonary hypertention, Spirometry}, volume = {12}, Number = {2}, pages = {44-49}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-638-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-638-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Alavi, Sayed Mohammad and Alavi, Leil}, title = {The Effect of Co-Trimoxazole in treatment of Toxoplasmosis Lymphadenitis}, abstract ={Background: Lymphadenitis is one of the clinical signs of toxoplasmosis. Co-Trimoxazole (CTM) has a good therapeutic effect on ocular and cerebral infection of T.gondii. Since this infection is epidemic in Ahvaz and due to lack of study of therapeutic effect of CTM on Toxoplasmosis Lymphadenitis (TLA), this study was carried out to determine the therapeutic effects of CTM on TLA in Ahvaz from 2005-2007. Methods and Methods: Forty six patients with TLA were enrolled in this controlled clinical trial study. Diagnosis was based on clinical examination, serological tests (chemiluminisent) and histo-pathological examinations. Palpable lymph node, IgM>8 IU and follicular hyperplasia were defined as positive findings. The patients were randomly divided into 2 groups of 23.The test group was treated by CTM (48 mg/kg/day divided in 2 dosages) for 1 month. The control group was only observed for 1 month. The patients were followed up by physical and serological examination in month 1, 3 and 6. No palpable lymph node and IgM<6 IU were found as clinical and serological response. The data were analyzed in SPSS software using x2 test.Results: At the end of treatment, clinical response was observed in 15 patients (65.2%) from the test group and 5 (21.7%) patients from the control group. Serological response in the test group and the control group were 52.2% and 13% respectively. There was a significant difference in therapeutic effect between two groups (p0.05).Conclusion: CTM displays a good therapeutic effect on TLA and may be used in the selected patients who need treatment.}, Keywords = {Toxoplasmosis, Lymphadenitis, Trimethoprim-sulfamethoxazole combination}, volume = {12}, Number = {2}, pages = {50-54}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-639-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-639-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Salarvand, Shahin and Abedi, Heidar Ali}, title = {Causes and motivations of elderly home residency from residents\' point of view}, abstract ={Background: As the population ages, a greater demand for long-term care is expected. Admitting older people to care unit and residential home has been identified as the most significant relocation. Studying risk factors resulting in entrance to the elderly home and developing programs to delay or prevent of them are important. Materials and Methods: This is a qualitative phenomenological study using purposive sampling of elderly residents of private and state nursing homes in Isfahan continuing until data saturation encountered, e.g when sample size became 10 participants. They were between 66-85 years old (3 men, 7 women). Data were collected by interviewer, and through field notes. Colaizzi's method was used for data analysis. The rigor of present study was based on transferability and credibility. Results: Two themes of voluntary and compulsory entry were found. Voluntary entry sub themes were entered with previous agreement, due to financial and family problems, compulsory entry sub themes were entered with cheating, and in unconscious condition, each with specific sub concepts. Conclusion: Several elders have resided voluntarily for taking care or getting ride of family problems and the rest have resided compulsorily with family care giver agreement. The ability of families, friends, neighbors and other community- based caregivers to provide support should be strengthened.}, Keywords = {Aged, Homes for the aged, Motivation}, volume = {12}, Number = {2}, pages = {55-61}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-640-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-640-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} } @article{ author = {Ebadi, Sayed Ali Reza and Zamani, Batol and Dehghani, Nahid and Arbabi, Mohsen and Mousavi, Sayed Gholam Abbas}, title = {Evaluating the prevalence of osteomalacia and its relevant factors in idiopathic low back pain patients referring to Kashan specialty medical clinics in 2005-2006}, abstract ={Background: Chronic low back pain (LBP) is an extremely common problem in society. The prevalence of this disease is different in countries. Due to the importance of LBP and vitamin D key role in its manifestation, this research was done to determine the prevalence of osteomalacia and the relevant factors in idiopathic low back pain patients at Kashan in 2005-2006. Materials & Methods: This cross sectional study was carried out on 100 patients diagnosed with LBP referring to Kashan specialty medical clinics. The second etiology of LBP was ruled out through history, physical examination and imaging methods. A biochemical assay of serum calcium, phosphate, alkaline phosphates (ALP), parathyroid hormone (PTH), 25-hydroxy vitamin D level, and 24 hours urine calcium were considered. Serum 25-hydroxy vitamin D test was used to confirm the osteomalacia diagnosis. Patients information including age, gender, vitamin D consumption, sun light exposure time periods and vitamin D deficiency (mild, moderate, severe) were also considered. The data were analyzed using statistical tests x2 and t-test. Results: The average (12% male and 88% female) patient age was 41.2±6. Fifty percent of patients were diagnosed by osteomalacia of which 42(84%) were females and 8 (16%) males. Fifty four percent of osteomalacia patients had not been exposed to the sun light effectively while they had consumption of vitamin D. The most and least prevalence of osteomalacia were found in age range of 40-49 years old and under 20 years old, respectively. The mean of 25 hydroxy-vitamin D in patients with osteomalacia was 10.5ng/ml and 58.5 ng/ml in others (p<0.0001). Vitamin D deficiency was reported mild in 50%, moderate in 24%, and severe in 26% of patients. Conclusion: Due to the high prevalence of vitamin D deficiency in LBP patients, using different methods like food fortification and patient education to have enough sun light exposure are recommended.  }, Keywords = {Idiopathic low back pain, Osteomalacia, Sun light, Vitamin D deficiency}, volume = {12}, Number = {2}, pages = {62-66}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-641-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-641-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2008} }