@article{ author = {Moghaddasi, Reza and Moazedi, Ahmad Ali and Ghotbeddin, Zohreh and Akhond, Mohammad Rez}, title = {The effect of electrical low-frequency stimulation on balance and locomotor activity in adult male rats during epileptogenesis of dorsal hippocampal}, abstract ={Background: Epilepsy is the third world neurological disorder. Epileptic focus causes motor impairment by sending projections to different areas of the brain such as areas which are related to movement control. Regarding the inhibitory effect of low-frequency electrical stimulation (LFS) on seizure wave's transmission, this study aimed at examining the effect of LFS during the epileptogenesis of dorsal hippocampal on balance and locomotor activity in adult male rats using the kindling method. Materials and Methods: Fifty rats were randomly divided into 5 groups: Control, Sham, Kindled, LFS and KLFS. Animals in the kindled group were stimulated rapidly by daily stimulation of dorsal hippocampus (1 ms pulse duration at 50Hz for 3 seconds). Animals in the sham and control groups did not receive any stimulation. In the LFS groups, four LFS packages at a frequency of 1 Hz were applied daily. At the end of stimulation, motor activity and balance were assessed by open-field and rotarod tests. Results: Frequency of rearing and grooming in the Kindled group significantly increased compared to the control group (P<0.05). Balance in the Kindled group was significantly decreased (P<0.05). LFS induction during hippocampal kindling did not show any significant difference in any of the mentioned parameters with the control group. Conclusion: In summary, applying low-frequency electrical stimulation during hippocampal kindling can reduce the motor activity and improve balance.}, Keywords = {Kindling, Low-frequency electrical stimulation, Balance, Motor activity, Rotarod, Open field, Rat}, volume = {22}, Number = {6}, pages = {538-546}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3654-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3654-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Akbari, Maryam and Moradi, Lida and AbbassiDaloii, Asieh}, title = {The effect of endurance training and Ziziphus jujube extract consumption on apoptosis of cardiac tissue in male Wistar rats}, abstract ={Background: Apoptosis is a highly regulated process that ensures the tissue and cellular homeostasis. This study aimed at investigating the effect of endurance training and the Ziziphus jujube extract consumption on apoptosis of cardiac tissue in male Wistar rats. Materials and Methods: In this experimental study, 32 male Wistar rats aged 8-12 weeks (weighing 195 mg±7.94) were randomly divided into four groups: control, jujube extract, endurance training and endurance training-jujube extract. A moderate endurance training program was conducted for eight weeks and five sessions per week. Rats were received a daily dose of 600 mg/kg of the extract orally. The gene expression of anexin-5 and caspase-3 in cardiac tissue was measured by the real-time PCR. Results: The results showed that there was a significant difference in the mean weight of the heart tissue of male Wistar rats among different groups (P<0.001). Changes in anexin-5 expression of the cardiac tissue in training-supplementation group were significantly lower than those in the control group (P<0.012). Also, the results showed that changes in caspase-3 expression of the cardiac tissue in supplementation (P<0.001), training (P<0.013) and training-supplementation (P<0.0001) groups were significantly lower than the changes in the control group (P<0.012). Conclusion: According to the findings of this study, it seems that endurance training and jujube extract consumption can have an interactive effect in reducing apoptosis of the cardiac tissue.  }, Keywords = {Exercise, Apoptosis, Ziziphus Jujube extract, Cardiac tissue, Rats}, volume = {22}, Number = {6}, pages = {547-554}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3625-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3625-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rami, Mohammad and Habibi, Abdolhamid and Khajehlandi, Mojdeh}, title = {The effect of moderate intensity exercise on the activity of catalase enzyme and malondialdehyde in hippocampus area of diabetic male Wistar rats}, abstract ={Background: Diabetes mellitus exacerbates oxidative stress and reduces the antioxidant defense system activity. As the brain has a high sensitivity to oxidative stress due to physiological and biochemical reasons and scientific evidence suggests the effect of regular exercise on reducing brain sensitivity to brain damage under pathophysiological conditions. Therefore, this study aimed at investigating the effect of moderate intensity exercise training on the activity of catalase enzyme and malondialdehyde in hippocampus area of diabetic male Wistar rats. Materials and Methods: Twenty-four male rats (245±9.4 g) aged 10 weeks were divided into four groups (diabetic training, diabetic control, healthy training and healthy control). The rats of the diabetic group were diabetic by intraperitoneal injection of streptozotocin (STZ). The exercise program included 6 weeks of moderate intensity exercise. At the end of six weeks, the hippocampal tissue samples were extracted 24 hours after the last training session and the activity of catalase enzyme and malondialdehyde was evaluated. Results: After the endurance training, the catalase levels in both diabetic training group (161.24±7.74) compared to the diabetic control group (148.55±8.05) and healthy training group (408.85±2.3) compared to the healthy control group (283.44±9.33) were significantly increased (P<0.05). Also, the level of malondialdehyde in the diabetic training group (9.65±1.75) was significantly decreased compared to the control diabetic group (13.23±1.01) (P>0.05). Conclusion: It can be concluded that endurance training may be effective to increase the antioxidant role of catalase enzyme and reduce the amount of malondialdehyde in the hippocampus tissue of diabetic rats.   }, Keywords = {Exercise, Catalase, Malondialdehyde, Hippocampus}, volume = {22}, Number = {6}, pages = {555-563}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3633-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3633-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rafiei, Samaneh and Edalatmanesh, Mohammad Ami}, title = {The effect of swimming training, Gallic acid and high-fat diet on the serum levels of sex hormones in rats with polycystic ovary syndrome}, abstract ={Background: Polycystic ovary syndrome (PCOS) is characterized by hormonal-metabolic disorders, obesity, oxidative stress and ovulatory dysfunction. The aim of this study was to investigate the effect of four weeks of swimming training and Gallic acid (GA) administration on the serum level of sex hormones in rats with a polycystic ovary syndrome (PCOS) under the standard and high-fat diet. Materials and Methods: In this experimental study, 72 virgin female Sprague-Dawley rats were randomly divided into the nine groups: Control, PCOS,  PCOS+HF (high fat diet), PCOS+EX (swimming training), PCOS+EX+HF (swimming training and high fat dietary), PCOS+GA (GA treatment), PCOS+GA+HF (GA treatment with high fat diet), PCOS+EX+GA (GA treatment and swimming training), PCOS+EX+GA+HF (GA treatment and swimming training with a high-fat diet). PCOS was induced with 1mg/kg letrozole and GA (100mg/kg, 4weeks) was administrated orally for 28 days. Then, the serum levels of LH, FSH, β-estradiol, progesterone and testosterone were measured using the ELISA method. Results: In the PCOS group, the progesterone level decreased and LH, FSH, β-estradiol and testosterone levels significantly increased compared to the control group (P<0.05). Treatment with GA or swimming training ameliorated the serum levels of these hormones. However, high fat diets reduced the ameliorative effect of GA and swimming training on the sex hormones in different groups. Conclusion: Gallic acid administration and swimming training can reduce dysregulation of sex hormones due to the PCOS in rats, but a high-fat diet increases PCOS pathogenesis.}, Keywords = {Polycystic ovary syndrome, Exercise training, Gallic acid, high-fat diet, Sex hormones}, volume = {22}, Number = {6}, pages = {564-572}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3533-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3533-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mousavi, Smatalsadat and Fallahmohammadi, Ziya and HajizadehMoghaddam, Akbar}, title = {Evaluating the protective effect of 6 weeks resistance training and vitamin D intake on brain neuro-inflammatory factors in female rats with experimental autoimmune encephalomyelitis}, abstract ={Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease and is associated with reduced physical capacity. The aim of this study was to examine the protective effect of a 6-week resistance training program and vitamin D intake on the brain neuro-inflammatory factors in female Lewis rats with experimental autoimmune encephalomyelitis (EAE). Materials and Methods: In this experimental study, four-week-old female Lewis rats (n=48) were randomly divided into 8 groups. Resistance training protocol was performed for 6 weeks and 5 days a week. A training program was started with a load equal to 50% of the body weight of the rat. Animals in the first two sessions performed 8 to 10 repetitions (climbing the ladder) at 2-minute breaks. The rats were immunized with the guinea pig's spit and complete adjuvant. The EAE model was induced at the end of the sixth week of the exercise. Rats received 5 μg of vitamin D3 in 150 μl of sesame oil per kilogram of their body weight via intraperitoneal injection once every two days for 2 weeks. Results: The results showed that six weeks of resistance training with vitamin D had no significant effect on granulocyte-monocyte growth factor, nuclear transcription factor kB and transforming growth factor beta (P>0.05). However, Interleukin-17 values showed a significant difference in all three levels of training (P=0.000), supplements (P=0.045), and interactive training and supplementation (P=0.043). Conclusion: The inadequacy of the training period (frequency and intensity of exercise) and the dose rate of vitamin D3 can be one of the possible causes of ineffectiveness of the present intervention.}, Keywords = {Resistance training, Neuro-inflammatory factors, Vitamin D, Multiple sclerosis}, volume = {22}, Number = {6}, pages = {573-580}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3658-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3658-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Golfam, Leila and Heydari, Azhdar and Ardjmand, Abolfazl}, title = {The effect of pre- and post-natal nitrate exposure on inhibitory avoidance memory in mice}, abstract ={Background: Nitric oxide (NO) is directly involved in mechanisms responsible for fetal neurogenesis and development. It has also been shown that NO can impair or improve learning and memory in different models. There is evidence that administration of nitrate can produce NO. This study aimed at examining the effect of pre- and post-natal nitrate exposure on inhibitory avoidance memory in mice and measuring the NO metabolites herein. Materials and Methods: In this experimental study, 28 pregnant mice were divided into 4 groups: 1) Control group (whose mothers received only drinking water during the pregnancy and post-natal), 2) Treatment Group (whose mothers received sodium nitrate (100 mg / l) in drinking water during the pregnancy and post-natal until the 6th and 11th day after birth). During a two-day session (training and test) the learning and memory of animals (30 days after receiving sodium nitrate) were studied in a step down apparatus. The latency time for coming down from the platform in the test day (S) was used as a criterion for memory. The nitrate oxide metabolites in brain tissue were measured by Miranda method. The nitrite to nitrate recovery and total nitrite measurements were performed using Griess reagents with a spectrophotometer. Results: The oral administration of sodium nitrate (100 mg/L) during pregnancy and lactation until 11 days after birth improved the avoidance memory compared to the control group (P<0.05). Also, sodium nitrate did not change the NO metabolites during those time periods. Conclusion: The oral sodium nitrate in pregnancy and lactation period improves mice avoidance memory without an alternation in nitric oxide metabolites.}, Keywords = { Nitrate, Avoidance memory, Mice, Nitric oxide, Pregnancy, Lactation}, volume = {22}, Number = {6}, pages = {581-588}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3673-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3673-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Ghodratpour, Fatemeh and Baghbani-Arani, Fahimeh and SadatShandiz, Seyed Ataolah}, title = {Cytotoxic effects of Zn oxide nanoparticles against breast cancer T47D cells and NM23 gene expression}, abstract ={Background: Breast cancer is the second leading cause of cancer-related death worldwide among women. Nowadays, nanoparticles are interested as anti-cancer factors in studies related to cancer therapy. Therefore, the present study aimed to explore cytotoxic effects of zinc oxide nanoparticles (ZnONPs) and to evaluate NM23 gene expression in T47D breast cancer cells. Materials and Methods: The cancerous T47D and normal HEK293 cell lines were treated with different concentration of ZnONPs for 24 hours and the cytotoxicity activity of ZnONPs was analyzed by the MTT assay. Then, the NM23 gene expression was evaluated using the real-time PCR method. Results: According to MTT results, the ZnONPs significantly decreased the viability of T47D cells in dose-dependent manner. Also, the results revealed that the mRNA level of NM23 was up-regulated (7.8-fold) in cells treated with ZnONPs. Conclusion: ZnONPs can destroy cancerous T47D cells compared to normal HEK293 cells. Furthermore, it seems that ZnONPs can modulate metastasis by enhancing the NM23 gene expression level in breast cancer T47D cells. Thus, ZnONPs can be considered as a promising strategy for the treatment of breast cancer.}, Keywords = {Breast cancer, ZnONPs, T47D, NM23}, volume = {22}, Number = {6}, pages = {589-594}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3663-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3663-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Pourvatan, Neda and Khazaei-Koohpar, Zeinab}, title = {Investigation of exon 4 mutations of phenylalanine hydroxylase gene in phenylketonuria patients in Guilan Province using PCR-sequencing}, abstract ={Background: Phenylketonuria (PKU) is a heterogeneous and autosomal recessive metabolic disorder that is mainly caused by mutations in the hepatic phenylalanine hydroxylase (PAH) gene. Distribution pattern of mutations in the PAH gene are specific to each population. To date, no reports of phenylketonuria molecular analysis have been found in this population. The aim of this study was to identify PAH mutations within exon 4 in PKU patients in Guilan Province and compare it with the studies in other parts of Iran. Materials and Methods: In this cross-sectional and descriptive study, 25 unrelated PKU patients (age range, 1-21 years) were identified from different regions of Guilan Province during a one-year period. After collecting blood samples and DNA extraction, the DNA fragments containing the exon 4 of the PAH gene and its flanking intronic sequences were amplified and sequenced. Results: In this study, IVS4+5G>T mutation (10%) was identified. This mutation was found in two homozygous PKU patients and one heterozygous patient; they had mPKU and cPKU phenotypes, respectively and their parents were third degree relatives. In addition, IVS4+47C>T (28%) and IVS3-22C>T (8%) polymorphisms were also detected. Conclusion: Investigation of mutations in the PAH gene can be a useful tool for molecular detection of the PKU disease and carrier detection in this population. Moreover, the other 12 remaining exons need to be analyzed to obtain the full spectrum of mutations of this gene among the PKU patients in Guilan Province.}, Keywords = {Guilan Province, PKU, PAH, mutation, exon4. .PCR-Sequencing.}, volume = {22}, Number = {6}, pages = {595-601}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3666-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3666-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Rezaei, Zeinab and RasoliAzad, Mourad and Mehrzad, Fatemeh and Farhad, Majid and Azad-Miveh, Zahr}, title = {The effect of dialectical behavioral therapy on craving and depression in methadone patients}, abstract ={Background: Methadone maintenance treatment (MMT) is a common medication for opioid dependence disorder. Despite the positive results, this therapy has many physical and psychological effects. The aim of this study was to determine the effectiveness of a dialectical behavioral therapy (DBT) on craving and depression in people under the methadone maintenance therapy. Materials and Methods: This is a randomized, controlled clinical trial with intervention (DBT) and control (MMT) groups. Initial diagnostic evaluations were performed by psychiatrist and clinician at a clinical interview. Fifty men referred to methadone treatment clinic were randomly assigned to the two groups (intervention and control). Data were collected through demographic information questionnaire, craving scale, depression questionnaire, treatment validity questionnaire, and treatment alliance questionnaire for pre-test, post-test and follow up. Results: The results showed that the scores of the intervention group were significantly reduced in comparison with the control group in craving and depression after 4 months of intervention and 2 months follow-up (P<0.01). Conclusion: The combination of the methadone therapy and dialectical behavior therapy can be useful in reducing craving and psychological problems of opiate dependent people. Considering the emphasis on a dialectical behavioral therapy on emotional regulation as the main mechanism for change, this treatment can be a useful therapy for other psychological disorders that are involved with emotional problems.}, Keywords = {Methadone maintenance therapy, Dialectical behavior therapy, Craving, Depression}, volume = {22}, Number = {6}, pages = {602-609}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3723-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3723-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Afshar, Mohammad and Sabbagi, Ensieh}, title = {The effect of educational package on recurrence and severity of bleeding in patients with epistaxis}, abstract ={Background: Epitasis is a disorder that affects about 60% of the population, and the lack of treatment of this disorder causes a lot of problems for the patient. Therefore, this study aimed at examining the effect of the educational package on reducing the recurrence and severity of bleeding in patients with epistaxis. Materials and Methods: This clinical trial study was performed on 60 patients with epistaxis referred to Matini Hospital, Kashan, Iran. Patients were randomly assigned into two equal groups of intervention and control (n=30, each group). In addition to routine care services, patients in the intervention group received an educational package including face to face education and educational pamphlets. Patients in the control group only received routine care services. After one month of training, at the end of the 4th, 8th and 12th weeks, the intensity and recurrence of epistaxis were evaluated. Results: Sixty percent of the patients in the intervention group and 66.7% of the control group were female and the rest were male. The mean age of the subjects in the intervention group was 50.8±19.39 and in the control group was 47.51±19.19 years. The frequency rates of recurrence of nasal bleeding during the first four weeks in the intervention and control groups were 20% and 46.7%, respectively (P=0.03), whereas in the 8th week, 6.7 and 16.7 percent (P=0.43) and in the 12th week were 0 and 6.7 in intervention and control groups (P=0.49). Also, the severity of bleeding was lower in the first week (P=0.07) than in the eighth week (P=0.37) and twelfth (P=0.35). Conclusion: A short-time education through face-to-face and pamphlet can reduce recurrence of epistaxis while having a modest effect on severity of bleeding.  }, Keywords = {Severity of bleeding, Recurrence of bleeding, Educational package, Epistaxis}, volume = {22}, Number = {6}, pages = {610-616}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3684-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3684-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Mirzaii-Fini, Fatemeh and Dowlati, Mohammad Ali and DehghaniAshkezari, Mahmood and Kouchaki, Ebrahim}, title = {Investigating the association of Val/Met polymorphism of the BDNF gene with the incidence of disease in patients with Alzheimer and comparison with healthy elderly people in Iran}, abstract ={Background: Alzheimer's disease is the most common cause of dementia in the elderly and the genetic and environmental factors interfere with its creation. The BDNF gene is responsible for producing a brain-derived neuronal factor. In this disease, the valine66methionine polymorphism and nucleotide changes of 196 (G>A) BDNF are genetic risk factors .This polymorphism has not been investigated in patients with Alzheimer's disease in Iran. This study aimed to provide appropriate information on the prognosis of the disease and the ability to get it. Materials and Methods: In this case-control study, 73 patients with Alzheimer's disease and 100 healthy controls were evaluated. Blood samples were taken from the subjects and DNA was extracted. After quantitative and qualitative DNA analysis, PCR-RFLP was performed and the results of both groups were analyzed and compared. Results: Fourteen patients and seven controls had polymorphisms of BDNF gene. Fifty-nine patients had normal allele, 8 patients with heterozygote allele and 6 patients had methionine/methionine allele. In the controls, 93 patients had normal allele, 5 with heterozygote allele and 2 had methionine/methionine allele. Conclusion: The findings of this study indicate that the increase in valine/methionine polymorphism in the BDNF gene in Alzheimer's patients compared to the control group can express the role of this polymorphism in this disease. Also, patients with this polymorphism had a worse clinical status than patients without this polymorphism. Therefore, evaluation of this polymorphism can provide appropriate information about the patient's condition.}, Keywords = {Alzheimer's disease, BDNF gene, Polymorphism, Valine/methionine}, volume = {22}, Number = {6}, pages = {617-623}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3672-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3672-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Sattari, ُShiva and Ahmadizadeh, Changiz}, title = {The study of expression of PTEN and AKT1 genes in co-culturing of HT29 colon cancer cell line with Streptococcus thermophilus}, abstract ={Background: Colon cancer is one of the most common cancers in the world. Probiotics are viable and useful microorganisms that have an effective role in controlling cancer by influencing the digestive enzymes of animals and humans, inhibition of cancerous agents in the body and in vitro conditions, suppression of lotions, and cancer-inducing compounds and tumors in experimental animals. The present study was conducted to investigate the PTEN/ AKT1 cellular signaling pathway in adjacent cultures of Streptococcus thermophilus with HT29 colon cancer cells. Materials and Methods: Bacterial culture, supernatant and bacterial extract were prepared and the cells were treated with these materials. Cell necrosis was evaluated by the MTT method. Also, the expression of PTEN and AKT1 genes in HT29 cell line was investigated using the real-time PCR. Results: The results showed that the thermophiles bacterium reduced the expression of AKT1 genes, and increased the expression of PTEN and led the cancerous cells toward apoptosis. The MTT test showed that the concentration of OD=0.05 had the highest mortality in 4 hours. Conclusion: Thermophiles bacteria can be used to create a novel therapeutic effect with high impact, low side effects, harmless biological effect and lower costs. Also, it can be used as an extra treatment appropriate to the body's natural flora for the treatment and prevention of colon cancer.}, Keywords = {Probiotic, Colon cancer, HT29 cell}, volume = {22}, Number = {6}, pages = {624-631}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3648-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3648-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} } @article{ author = {Afshari, Behrooz and Zanjani, Zahr}, title = {Evaluation of executive and cognitive functions in bipolar patients and their family members}, abstract ={Background:  Bipolar disorder is a debilitating psychiatric disorder characterized by recurrent depression, manic, and hypomanic episodes. Examination and comparison of executive and cognitive functions in bipolar patients and their family members has not been addressed in Iran so far. The aim of the present study was to examine executive and cognitive functions in bipolar patients and their family members. Materials and Methods: In this cross-sectional study, 50 patients with bipolar disorder, 50 of their family members, and 50 healthy controls were included. The Young Mania Rating Scale, Beck Depression Inventory, Tower of London task, Wisconsin Card Sorting Task, Trail Making Test, Ruler Drop method, Four- Choice task, and general intelligence test were used to examine executive and cognitive functions of the participants. Results: Executive and cognitive functions in patients with a bipolar disorder were significantly lower than those in the other groups (P<0.01), but there was no significant difference in executive and cognitive functions between family members of the patients and healthy controls. Conclusion: According to the results of the present study, executive and cognitive functions have been destroyed in patients with bipolar disorder, but their family members have normal executive and cognitive functions.}, Keywords = {Executive function, Cognitive function, Bipolar disorder}, volume = {22}, Number = {6}, pages = {632-639}, publisher = {Kashan University of Medical Sciences}, url = {http://feyz.kaums.ac.ir/article-1-3652-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-3652-en.pdf}, journal = {Feyz Medical Sciences Journal}, issn = {1029-7855}, eissn = {2008-9821}, year = {2018} }