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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
1
6
article
Administration of Kanamycin in urinary tract infections
Mohsen Adib Haj Bagheri
adibhajbagheri_m@kaums.ac.ir
1
Ali Reza Sharif
2
Sayed Gholam Abbas Mousavi
3
Ghasem Chavoshi
4
History and Objectives: Kanamycin is an amino glycoside that was widely administered in the treatment of urinary tract infections in the past, but it is no longer used at present because of resistance to it. After several years the Kanamycin has not been used, this study was performed to determine sensitivity of bacterial agents urinary tract infections to Kanamycin and other commonly used antibiotics. Materials and Methods: A descriptive study was performed on patients with urinary tract infection hospitalized in the ward of infections diseases. A urine culture on blood agar and EMB was performed for all patients. Differential culture media were used to diagnose bacterial type. Then transfer on TSB liquid culture media has been done and Mueller Hinton culture medium was used for antibiogram and discs of ampicillin, co-trimoxazole, cephalothin, ceftizoxime, tobramycin and Kanamycin were applied. Results of antibiogram were reported as sensitive or resistant and then data were analyzed. Results: In 157 patients with positive urine cultures and mean age of 53.6 years, bacterial sensitivity to ampicillin, co-trimoxazole, cephalothin, tobramycin and Kanamycin was 17.27, 38.77, 47.17, 61.97 and 71.27 respectively. Conclusion: Sensitivity of etiologic bacterial agents of urinary tract infection is most to kanamycin. A clinical trial experimental study to compare the therapeutic effects of this antibiotic is recommended.
http://feyz.kaums.ac.ir/article-1-504-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
7
10
article
Effect of injection of Atropine-Promethazine on the duration of active phase of labor
Zahra Sooki
soki_z@kaums.ac.ir
1
Narjes Seddighpoor
2
Ahmad Ershadi
3
Mohammad Hossein Karbaschi
4
History and Objectives: Due to importance of reducing the duration of the active phase of labor and controversies about effect of injection of Atropine-Promethazine combination on the duration of the active phase of labor, this study was performed on multiparous women referring to Shaheed Dr. Shabihkhani maternity hospital in Kashan in the second half of 1374 to evaluate the effects of injection of Atropine-Promethazine on the duration of active phase of labor. Materials and Methods: A single-blinded clinical trial was performed on 2 experimental and control groups with intramuscular injection of 0.5mg Atropine and 25mg Promethazine and 2 milliliter distilled water respectively at the beginning of the active phase of labor. Onset of the active phase was characterized by 3 centimeters dilation and 50% effacement. The previous delivery was normal in all samples and rupture of amniotic sac occurred after the onset of the active phase of labor. Women with history of abortion, hypertension, diabetes cardiac disease twin pregnancy, abnormal fetal presentation and pelvic stricture were excluded from the study. Then duration of the active phase, i.e. the time from 3 centimeters to 10 centimeters dilation, was evaluated by repeated vaginal examinations and recorded. Results: 200 multiparous women aged 18-35 years were studied. They were para 2 to para 4. Experimental and control groups each contained 100 patients that were age and para-matched. The duration of active phase of labor was 190±100 and 149±81 minutes in the experimental and control groups respectively. Injection of Atropine and Promethazine combination reduces the duration of the active phase of labor by 23.7% (P<0.001). Conclusion: Considering the effect of Atropine-Promethazine combination in reducing the duration of the active phase of labor, its administration is recommended during labor.
http://feyz.kaums.ac.ir/article-1-505-en.html
per
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
11
16
article
Effect of education of breast-feeding method on nutritional patterns of neonates of cesarean sectioned primiparous women
Simin Khalili
1
Sousan Parsay
2
Mohammad Gharegozloo
3
Naser Valai
4
History and Objectives: Since breast-feeding problems are more commonly observed in cesarean-sectioned primiparous women and failure of breast feed is more in these mothers, this study was performed to evaluate the effect of education of breast-feeding method on nutritional patterns in up to 2 months infants born from cesarean-sectioned primiparous mothers in Shabihkhani maternity hospital in Kashan in 1374. Materials and Methods: A clinical trial study case group was educated immediately was performed on 60 mothers in 2 case and control groups by random sampling. Mothers in the after recovery up to the time of discharge, while the control group was not educated. The effects of education of breast-feeding method on the time of the first infant feeding, type of the first nutritional material that was given to the infant and nutritional patterns of the infant within 2 months after birth were studied by referring to their houses in both case and control groups. Using statistical X² and Fisher’s exact tests correlation among variables were evaluated, RR and AR of non-education of breast-feeding method on the appropriate nutritional pattern in the infant (Exclusive breast feeding) were calculated. Results: This study showed that the 2 groups were similar from the point of age, occupational status, maternal educational level and the level of knowledge in their husbands and there was no statistically meaningful difference in this regard. The first episode of breast-feeding within four hours after birth was 20% more in the educated mothers than non-educated mothers in the control group (P<0.05). This study also revealed that colostrum was fed as the first nutritional agent 20% more in the educated group of mothers than their control counterparts (P<0.05). Nutritional patterns during the last 24-hours at 2 mothers of age was 66.7% breast milk alone, 6.7% breast milk and formula, 26.6% breast milk, dextrose water and herbal medications in the case group and 23.3% breast milk alone, 10% breast milk and formula, 66.7% breast milk, dextrose water and herbal medications in the control group (P<0.05). Conclusion: Regarding the positive effect of education of breast-feeding method on nutritional patterns of the infant particularly exclusive breast-feeding and considering the simplicity of education, it is recommended that the nutritional patterns in the infants be improved by education and further study and evaluation be carried out in this field.
http://feyz.kaums.ac.ir/article-1-506-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
17
22
article
Effect of Glucantime on blood parameters in patients with cutaneous Leishmaniasis
Safar Ali Talari
1
Zarichehr Vakili
2
Amir Hossein Emami
3
History and Objectives: Due to the possibility of side effects of Glucantime on blood parameters and in order to determine its effect on blood parameters, this study was performed on patients with cutaneous Leishmaniasis referred to central laboratory in Kashan in 1375. Materials and Methods: A clinical trial with comparison of peripheral blood smear before and after treatment in 70 patients with cutaneous Leishmaniasis, considering age, occupation and residential place of the patients complete blood count with RBC indices and platelet count were performed. Then Glucantime was administered 50 mg/kg day for 21 days by intramuscular injection and on the last day of treatment all the above examinations were repeated under the same conditions. Results were recorded and changes in blood parameters were compared by paired t-test. Results: This study revealed that treatment with Glucantime results in decrease in the number platelets (4.6%), red blood cells (2.5%), white blood cells (10.4%), monocytes (12.7%) and increase in ESR (50.4%), lymphocytes (8.5%), eosinophils (3.4%), basophils (0.2%), MCH (0.17%), MCV (2.4%), MCHC (0.23%) while the average neutrophil and monocyte count, HCT, Hb and absolute WBC, RBC and platelet counts were decreased. Conclusion: Due to resulting changes following Glucantime administration, it is recommended to perform CBC and ESR in patients with cutaneous Leishmaniasis before treatment with Glucantime in order to use other therapeutic options in the presence of a hematologic disease.
http://feyz.kaums.ac.ir/article-1-507-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
23
29
article
Analysis of generations in genetics of life span in Drosophila Melanogaster
Morteza Hemmat
1
History and Objectives: Life span and its increasing in human and its decreasing in pathogenic and harmful organisms has attracted many scientists including genetic. Not enough effort has been made in clarifying the genetics of life span, in some of the previous studies and not enough attention has been made in controlling the environmental effects in others. A different method was performed in this study, focusing on genetics of life span in Drosophila melanogaster at university of Shahrekord (1997-1998). Materials and Methods: This study in Drosophila melanogaster involved parental, F1, F2 and backcross generations (B1 and B2), derived from crosses between 2 long lived (Mean, 39.5 days) and short lived (Mean, 30.8 days) inbred lines. By performing the variance weighted least square method, the genetic parameters were calculated and the results were tested by using T-test and Chi-Square test. Results: From 6 genetic parameters employed in experimental model, 5 were significant (PP>0.25. Conclusion: It was concluded that genetic parameters such as [d], [h], [i] and [l], resulted from nuclear genes actions are involved in controlling the life span. The trigenic interaction and similar complex factors such as extra-nuclear control does not make any significant contribution in genetics of the character. Further studies are needed in clarifying the nuclear genes controlling the character.
http://feyz.kaums.ac.ir/article-1-508-en.html
per
Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
30
37
article
Bacterial and fungal agents producing cutaneous ulcers and their drug resistance in children younger than 10 years old in Golestan province in 1377
Jamile Noroozi
1
Mehraban Falahati
2
Ebrahim Taji
3
History and Objectives: Due to prevalence of cutaneous ulcers, different reports about their etiologic and drug resistance and worriment about contagiousness of the infectious cutaneous ulcers in warm and wet weather of Golestan province, this study was conducted to identify the bacterial and fungal microorganisms that produce cutaneous ulcers and their drug resistance in children younger than 10 years old referring to outpatient clinics to physicians in three cities in 1377. Materials and Methods: A descriptive study was performed. After definitive diagnosis of cutaneous ulcers, specimens were collected by the physicians and cultured on specific culture media and the bacteria and fungal type was recognized through standard examinations. Then their resistance and sensitivity to the usual antibiotics were determined. Results: Specimens were provided from 270 children less than 10 years old during a 6-month period. Bacteria were grown in 98 patients (36.6%) and in 105 children (59.6%) fungi were the etiologic agents. In 11 cases (4.1%) no microorganism was grown. Gram-positive bacteria were most resistant to penicillin, ampicillin and amoxicillin and least resistant to vancomycin and erythromycin. Gram-negative bacteria were most resistant to ampicillin and cephalexin and least resistant to kanamycin. The most common bacteria, dermatophyte and Candida were Staphylococcus, Microsporum canis and Candida albicans respectively. Conclusion: The predominant bacterial and fungal pathogens were not observed in this study. Most of the bacteria were normal body flora and the prevalence of Microsporum canis is due to the presence of animal host in rural areas.
http://feyz.kaums.ac.ir/article-1-509-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
38
43
article
Prevalence of Beta hemolytic group A Streptococcal carriers and its role in the ASO titer in students of Kashan in 1375
Mahmoud Saffari
saffari_m@kaums.ac.ir
1
Ahmad Pirouzmand
2
Gholam Reza Vali
3
Ahmad Khorshidi
4
History and Objectives: Due to prevalence of Streptococcal infections in children and adolescents and their complications and in order to determine the prevalence of carriers of these bacteria and their role in the ASO titer, this study was performed on 7-15 years old students in Kashan in 1375. Materials and Methods: In the first stage a descriptive study was performed on 960 cases by random sampling and then a cohort study in 170 cases was carried out in the second stage. Sample from throat was obtained by means of a sterile swab and transferred to selective culture media containing crystal violet and blood agar. The plates were transferred to laboratory of medical faculty and incubated at 37° centigrade. After 24 hours bacteria were recognized by colonial morphology, B-hemolysis, catalase test, sensitivity to bacitracin disc and resistance to sulfamethoxazole trimethoprim. After 15 days, 5cc blood was obtained from the students and 5cc blood was obtained from the same numbers of normal children. The samples were immediately transferred to the laboratory. ASO titer was measured by Macro method. Results: Bacterial isolation from selective culture media and blood agar was completely similar. Carrier state was defected in 8.85% of patients, 9.5% of boys and 7.96% of girls. Carrier state was most common (23.7%) in 13 years old and least common (1.2%) in 11 years old students. The prevalence of the carrier state was different in various areas of Kashan. The prevalence of the carrier state was also dependent on the number of children of the family. Comparing ASO titer in carriers and control group shows that 17.6% of carrier have abnormally high (>1/250) titers, while abnormal titer was detected in only 1.1% of the control group (P<0.001). The conclusion is that the bacteria can increase the ASO titer. Conclusion: Due to prevalence of this bacterium among students and considering its late and irreversible complications, it is recommended essential therapeutic and hygienic measures be considered in this regard and also regarding the high prevalence of abnormally high ASO titer among carriers, interpretation of this test should be done with caution particularly in children and adolescents.
http://feyz.kaums.ac.ir/article-1-510-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
44
51
article
Prevalence and causes of hysterectomy among women referring to Dr. Shabikhani Maternity Hospital in Kashan, 1374-75
Mitra Behrashi
behrashy_m@kaums.ac.ir
1
Hossein Nikzad
2
Sayed Gholam Abbas Moosavi
3
Davoud Mazloomi
4
History and Objectives: Hysterectomy (Removal of uterus) is one of the common surgical operations in females. Due to the importance of determination of its prevalence and causes in health care and therapeutic programs and lack of corresponding data in Kashan, this study was conducted to establish the prevalence and causes of hysterectomy among patients referring to Dr. Shabihkhani maternity hospital in Kashan in 1374-1375. Materials and Methods: A descriptive study was performed on 150 women referring Dr. Shabihkhani maternity hospital for hysterectomy. Data including age, job, marital status, educational level, parity, menopausal status, technique of operation, preoperative diagnosis on the basis of physical examination, laboratory examinations and pathologic reports were recorded in corresponding questionnaires. Finally, after extraction and classification of the information, they were statistically described. Results: This study showed that hysterectomy accounts for 5.9% of all surgical operations in women in this center. 44.7% of patients were 45-55 years old. 56.6% of women had history of one of 5 childbirths, which comprised the largest group among patients. Abdominal hysterectomy was performed in 90.6% of patients and the remainder undergone vaginal hysterectomy. The most common causes of hysterectomy were leiomyoma (49.3%) abnormal uterine bleeding (28.6%) and pelvic laxation (12.6%). Abnormal pelvic examination was reported in 117 patients (78%) and in 33 women (22%) pelvic examination failed to detect the involved site. 71.3% of patients had laboratory examination and the remaining 28.7% did not have. Pathologic report was abnormal in 60% and normal in 40% of patients. Conclusion: Leiomyoma, abnormal uterine bleeding and pelvic laxity constitute the common causes of hysterectomy. Analytical studies are recommended to determine the contribution of different factors in order to prevent unnecessary hysterectomies.
http://feyz.kaums.ac.ir/article-1-511-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
52
56
article
Comparison of subcutaneous versus intravenous Heparin among patients with unstable Angina pectoris
Sayed Mahmoud Seyyedi
seiediniasar_m@kaums.ac.ir
1
History and Objectives: Due to prevalence of cardiovascular diseases particularly unstable angina pectoris and its known and controllable prognosis and considering the present controversies about the route of administration of heparin, this study was performed on patients with unstable angina pectoris referred to Shaheed Beheshti hospital in Kashan in 1374 to compare the effects of subcutaneous versus intravenous administration of heparin. Materials and Methods: A clinical trial was performed on 100 patients in 2 groups of subcutaneous versus intravenous heparin administration. Patients, selected by random and matching, were divided into 2 experimental (Subcutaneous) and control (Intravenous) groups. The effects on number of pain attacks, occult ischemia and complications such as mortality, myocardial infarction and severe bleeding in a minimum of 5 days follow-up were evaluated and statistical analysis was performed by X² test. Results: This study was performed on 50 patients in 2 experimental and age, sex and risk factors (Hypertension, diabetes, hyperlipidemia and cigarette smoking) matched control group. Pain attacks in the different days following treatment were similar in both groups, 15.6% and 14% in intravenous and subcutaneous groups respectively. Occult ischemia was less commonly observed in the subcutaneous heparin group than intravenous one, but the difference was not statistically meaningful. There was no mortality. 2 patients had myocardial infarction in each group and one had severe hemorrhage in the intravenous group. Conclusion: subcutaneous heparin has therapeutic effects similar to intravenous heparin. Further studies especially complemented by angiography and scan are recommended.
http://feyz.kaums.ac.ir/article-1-512-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
57
63
article
Knowledge and insight to menopause in 40-45 years old females referring to hospitals of Shahid Beheshti University of Medical Sciences in 1377
Shayeste Eftekhari Tavakoli
1
Naser Valai
2
Zonoobi
3
History and Objectives: Due to importance of women’s knowledge about menopause in their psychomotor health and considering various reports of ignorance on this topic and its unknown status in our country, this study was performed to determine the level of Knowledge and insight of 40-45 years old women referring to outpatient clinics of hospital of Shaheed Beheshti university of medical sciences in the second half of 1377. Materials and Methods: A descriptive study was carried out on 400 women referring to gynecologic clinics of hospitals of Shaheed Beheshti University of Medical Sciences in the second half of 1377. Patient selection was based on accurate statistical calculations and random sampling. Age, literacy and number of children were evaluated among the samples. Level of knowledge was determined by 12 questions each having one score and type of insight with 4 positive and 4 negative phrases about menopause. Scores below 6 was considered ignorance and scores below 12 was regarded as negative attitude. The prevalence of complications among samples was determined and complications in the society were estimated and the role of economical and social factors on the type of insight and level of Knowledge was determined. Results: 50% of the 400 women aged 40-45 years, were illiterate or at primary school level. Ignorance was found in 55% with a 95% confidence interval and negative attitude in 53.7% number of children and level of literacy contributed to level of knowledge but the age of samples had no role. Conclusion: Knowledge and insight were low in these critical years and further studies to find out the best educational methods for women and more research in this field are recommended.
http://feyz.kaums.ac.ir/article-1-513-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
64
71
article
Evaluation of surgery of thoracic Tuberculosis in patients referred to Imam Khomeini Hospital in 1367-76
Abdolhossein Davoodabadi
davoodabadi_ab@kaums.ac.ir
1
Mohamamd Bagher Rahim
2
Ebrahim Razi
3
History and Objectives: Due to epidemiology of Tuberculosis in Iran and the consequent mortality and diagnostic therapeutic surgical measures and in order to determine the status of patients and the various diagnostic and surgical techniques, this study was carried out in patients referring to Imam Khomeini hospital in Tehran in the years 1367-1376. Materials and Methods: This study was performed by existing data recorded in the records of patients undergone surgical pulmonary resection and/or diagnostic procedures. Tuberculosis was diagnosed by sputum culture and tissue pathology. Age, sex, occupation residential place during these ten years, clinical manifestations and paraclinical examinations type of resection and complication of the surgery were evaluated. Results: During 10 years a total of 500 patients with pulmonary and thoracic Tuberculosis were studied 44% of patients were female and the other 56% were male. The patients were 15-20 years old. Complications of Tuberculosis were 5 times more common in males as females and pericardial involvement was twice in men than women. The most common occupations were house-keeping and workers. The most common clinical manifestations were pleuritic chest pain (82%), dyspnea (80%) and cough (78%). PPD was negative in 50% of patients. The differential leukocyte count was neutrophils 73%, lymphocytes 24% and the remainder were eosinophils and basophiles. ESK was abnormally elevated in 88% of the patients. Pulmonary resection was done in 34% of patients. Total pericardiectomy and pericardial window were performed in 18% and 6% of patients respectively. Limited diagnostic thoracotomy for hilar lymphadenopathy and SPN was performed in 24% of the cases. All paraclinical examinations were negative in these patients despite the presence of pulmonary Tuberculosis. Clavicular resection was performed in 6% of patients. Eloesser flap in 6% and superior vena cave obstruction in 2% diagnostic thoracotomy was performed in these cases. Conclusion: complication in men aged 15-20 years were five times the women. Pericardial involvement was also twice more common in men than women. The patients were often housekeeper or workers. In 24% of patients who were suspicious to have Tuberculosis all paraclinical examinations were negative but limited thoracotomy confirmed Tuberculosis. One patient in this group had upper lobe Tuberculosis accompanied by squamous cell carcinoma of the lung. Therefore thoracotomy is recommended in these cases and lung cancer should be considered whenever Tuberculous involvement of the upper lobe especially its anterior segment is present. In our series mortality and morbidity were 4% and 12% respectively that are compatible with foreign reports.
http://feyz.kaums.ac.ir/article-1-514-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
72
79
article
Evaluation of high-risk pregnancy, contributing factors, treatment and its results in Sarem clinic in 1371-74
Farahnaz Amini Nayeeni
1
History and Objectives: Due to prevalence of high-risk pregnancies and its known outcome and controversies about role of different contributing factors, method of treatment and finally its prognosis, this study was performed on patients referring to Sarem clinic in the years 1371 to determine high-risk pregnancies and the effective therapeutic factors and their results. Materials and Methods: This study was conducted by evaluating the existing data records of women at risk for high-risk pregnancy were examined and therapeutic methods and their outcome were extracted and role of contributing factors and confidence interval were determined. Results: Among 25000 records, 309 records had the including criteria for study. The patients were 32±7 years old, duration of their marriage was 8±7.6 years, 80% had completed their high-school education and a few were illiterate. 46.3% of the patients became pregnant with treatment and undersupervision. After excluding the patients who were lost of follow-up, 68.9% were pregnant with treatment and 31.1% have had no pregnancy yet and are under treatment. Conclusion: Considering the results and the risk factors in the evaluation of fetus, a treatment period of one year is necessary before a desired pregnancy. Conducting research projects in order to select the best public education increased maternal and consequently social health.
http://feyz.kaums.ac.ir/article-1-515-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
80
85
article
Diabetes mellitus and impaired Glucose tolerance in patients with major Thalassemia in Booali Sina educational and treatment center in Sari in 1375-77
Mehrnoush Kosarian
1
History and Objectives: Diabetes Mellitus (DM) and impaired glucose tolerance (IGT) are of known complications in patients with Thalassemia major. In order to diagnose asymptomatic cases and trial of oral hypoglycemic agents and adhering to dietary regimen, this study was carried out on the referrers to pediatric endocrinologic clinic of Booali Sina hospital. Materials and Methods: Thalassemic patients affected by diabetes mellitus were recognized and their characteristics were recorded. After description of the project and obtaining patient’s consent, fasting blood glucose and oral glucose tolerance test were performed in the asymptomatic Thalassemic patients. The quality of response was compared with WHO protocol and American National Society of Diabetes. Descriptive statistics were used to show the findings and correlations were evaluated by means of correlation coefficient. Results: In 600 patients, 2.5% were affected by diabetes mellitus. 9 girls aged 21±7 years and 5 boys aged 17±5 years had diabetes mellitus. Age and diagnosis was 19±6 and 15±3 years in the girls and boys respectively. Standard 5-stage oral glucose tolerance test was performed (OGTT) in 70 patients. 2 cases of diabetes mellitus (One 21-year-old girl and one 18-year-old boy) and 11 patients with impaired glucose tolerance test (IGT) were detected. The IGT group consisted of 9 girls and 2 boys aged 19±3.6 years. Measuring fasting blood glucose alone has no diagnostic value for patients with IGT and diabetes mellitus. Conclusion: Asymptomatic patients with impaired glucose metabolism can be diagnosed by a two-stage OGTT and oral hypoglycemic agents can be used in the treatment of patients.
http://feyz.kaums.ac.ir/article-1-516-en.html
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Kashan University of Medical Sciences
Feyz Medical Sciences Journal
1029-7855
2008-9821
1999-07
3
2
86
89
article
Case report of a patient with paroxysmal nocturnal hemoglobinuria during pregnancy
Abolfazl Mahdizadeh
1
Abdoresool Akbarian
2
Hasan Ali Movahedi
3
Fateme Arjmand
4
Reza Alaghehbandan
5
History and Objectives: PNH is a rare nonhereditary hemolytic anemia characterized by acute and chronic intravascular hemolysis and recurrent hemoglobinuria. It often results in abortion and vascular complications such as venous thrombosis but some cases of successful and uncomplicated pregnancies have been observed in these patients. In this way, a pregnant patient with PNH, referred to Rasool Akram hospital in Tehran in winter of 1377 is reported. Case report and Findings: The patient was a 22-year-old G2P1 woman with a 34-weeks gestation fetus who has referred to hospital because of preeclampsia. Manifestations of PNH were progressively presented during her second pregnancy. After hospitalization, cesarean section was performed and a preterm female newborn was delivered. Postoperatively, the patient developed venous thrombosis in the abdominal wall vessels. After improvement she was discharged from the hospital in a satisfactory general condition. Conclusion: Venous thrombosis in pregnant PNH patients during pregnancy and postpartum period is hazardous unless treated. Monitoring of hemoglobin and hematocrit levels, timely blood transfusion and evaluation of coagulation system activity are important factors in prognosis.
http://feyz.kaums.ac.ir/article-1-517-en.html