fa اثر 8 هفته مصرف عصاره هیدروالکلی دارچین و تمرین هوازی بر سطوح SPARC، AMPK و GLUT4 عضله نعلی موش‌های دارای دیابت نوع 2 عمومى General كاربردي Applicable <div style="text-align: justify;"><span style="font-size:11pt"><span style="line-height:normal"><span style="tab-stops:right 411.3pt"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><strong><span lang="FA" style="font-size:9.0pt"><span b="" style="font-family:" zar="">سابقه و هدف:</span></span> </strong><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">با توجه به نقش هیپوگلیسمی پروتئین ترشح اسیدی و غنی از سیستئن (</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPARC</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">)<i> </i>و تأثیر آن بر فسفوریلاسیون </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">AMPK</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و بیان </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">GLUT4</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، هدف پژوهش حاضر، بررسی تأثیر تمرین هوازی همراه با مکمل عصاره دارچین بر سطوح </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPARC</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">AMPK</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">GLUT4</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> در موش‌های دارای دیابت نوع 2 بود.</span></span><span dir="LTR" style="font-size:9.0pt"></span></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><strong><span lang="FA" style="font-size:9.0pt"><span b="" style="font-family:" zar="">مواد و روش‌ها:</span></span></strong> <span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">35 موش صحرایی نر هشت‌هفته‌ای ویستار به‌طور تصادفی و مساوی به پنج گروه کنترل (</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">C</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">)، دیابت (</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">D</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">)، دیابت -‌ مکمل (</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DS</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">)، دیابت - ورزش (</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DE</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">) و دیابت - مکمل ورزش (</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DES</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">) تقسیم شدند. برنامه تمرینی 5 جلسه در هفته به‌مدت 8 هفته انجام شد. موش‌های گروه‌های </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DS</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DES</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> روزانه 200 میلی‌گرم بر کیلوگرم </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">CE</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> از طریق گاواژ و موش‌های گروه‌های </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">C</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DE</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> در این مدت آب دریافت کردند.</span></span><span dir="LTR" style="font-size:9.0pt"></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><strong><span lang="FA" style="font-size:9.0pt"><span b="" style="font-family:" zar="">نتایج:</span></span></strong> <span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">گلوکز خون در گروه‌های </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DS</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DE</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DES</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> کاهش یافت. وزن و سطوح پروتئین </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPARC</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">AMPK</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">GLUT4</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> در گروه </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">D</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> به‌طور معناداری کاهش یافت. همچنین، سطح </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">GLUT4</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> در گروه </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DS</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> به‌طور معناداری افزایش یافت. با این‌حال، سطح پروتئین </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPARC</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">AMPK</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">GLUT4</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> در هر دو گروه </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DE</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">DES</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> به‌طور معناداری افزایش یافت.</span></span><span dir="LTR" style="font-size:9.0pt"></span></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><strong><span lang="FA" style="font-size:9.0pt"><span b="" style="font-family:" zar="">نتیجه‌گیری:</span></span></strong> <span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">CE</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، فقط </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">GLUT4</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و ورزش، </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPARC</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">AMPK</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">GLUT4</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> را در موش‌های دیابتی افزایش می‌دهند. با این‌حال، ورزش با </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">CE</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> اثرات معناداری بر </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPARC</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">AMPK</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> و </span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">GLUT4</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> در موش‌های دیابتی دارند و می‌توانند در درمان هیپرگلیسمی در بیماران دیابتی بسیار مفید باشند.</span></span><span dir="LTR" style="font-size:9.0pt"></span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="font-family:Times New Roman;"><span style="color:#000000;"><span style="font-size:11pt"><span style="line-height:normal"><span arial=""><strong><span style="font-size:12.0pt"><span new="" roman="" times="">Background:</span></span> </strong><span style="font-size:12.0pt"><span new="" roman="" times="">Considering the hypoglycemic role of cysteine-rich acidic secreted protein (SPARC) and its effect on AMPK phosphorylation and GLUT4 expression, the present study aimed to investigate the effect of aerobic exercise with cinnamon extract supplementation on SPARC, AMPK and GLUT4 levels in type 2 diabetic rats.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span arial=""><strong><span style="font-size:12.0pt"><span new="" roman="" times="">Materials and Methods: </span></span></strong><span style="font-size:12.0pt"><span new="" roman="" times="">35 eight-week-old male Wistar rats were randomly and equally divided into five groups: control (C), diabetes (D), diabetes-supplement (DS), diabetes-exercise (DE), and diabetes-exercise-supplement (DES). The training program was performed 5 sessions per week for 8 weeks. Rats in DS and DES groups received 200 mg/kg of CE daily by gavage, and rats in C and DE groups received water during this period.</span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span arial=""><strong><span style="font-size:12.0pt"><span new="" roman="" times="">Results: </span></span></strong><span style="font-size:12.0pt"><span new="" roman="" times="">Blood glucose was decreased in the DS, DE, and DES groups. SPARC, AMPK, and GLUT4 protein levels and weight significantly reduced in the D group. Also, GLUT4 levels in the DS group increased significantly. However, the SPARC, AMPK, and GLUT4 protein levels were significantly increased in both the DE and DES groups.</span></span><span style="font-size:12.0pt"><span style="font-family:"Times New Roman",serif"></span></span></span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" times=""><strong>Conclusion:</strong> CE only increases GLUT4 but exercise increases the SPARC, AMPK, and GLUT4 in diabetic rats. However, exercise with CE have significantly greater effects on the SPARC, AMPK, and GLUT4 in diabetic rats and can be very useful in the treatment of hyperglycemia in diabetic patients.</span></span></span></span></span></div> تمرین هوازی, عصاره دارچین, AMPK, GLUT4, SPARK, دیابت نوع 2 Aerobic exercise, Cinnamon extract, SPARC, AMPK, GLUT4, Type 2 diabetes 657 665 http://feyz.kaums.ac.ir/browse.php?a_code=A-10-3224-10&slc_lang=fa&sid=1 Mehdi Abbasi-Moghadam مهدی عباسی مقدم valipour114@yahoo.com 2900319475328460039931 2900319475328460039931 No Department of Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, I.R. Iran. گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه لرستان، خرم‌آباد، ایران Vahid Valipour-Dehnou وحید ولی پور ده نو valipour.v@lu.ac.ir 2900319475328460039932 2900319475328460039932 Yes Department of Sport Sciences, Faculty of Literature and Human Sciences, Lorestan University, Khorramabad, I.R. Iran. گروه علوم ورزشی، دانشکده ادبیات و علوم انسانی، دانشگاه لرستان، خرم‌آباد، ایران Mahdieh Molanouri Shamsi مهدیه ملانوری شمسی vahidvalipourdehnou@gmail.com 2900319475328460039933 2900319475328460039933 No Department of Physical Education and Sport Sciences, Faculty of Humanities, Tarbiat Modares University, Tehran, I.R. Iran. گروه تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، دانشگاه تربیت مدرس، تهران، ایران