fa بررسی شیوع سرطان پروستات در MRI-TRUS fusion biopsy بیماران دارای ضایعه مشکوک در Multi-Parametric MRI با PI-RADS ٢ و٣ که قبلاً تحت بیوپسی پروستات قرار گرفته‌اند medicine, paraclinic medicine, paraclinic كاربردي Applicable <div style="text-align: justify;"><span style="color:#000000;"><span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="FA" style="font-size:9.0pt"><span b="" style="font-family:" zar="">سابقه</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" style="font-family:" zar=""> و هدف:</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> سرطان پروستات، شایع‌ترین سرطان </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">میان </span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">مردان بالای هفتاد سال </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">است.</span></span></b><b> </b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">در مطالعات قبلی شیوع سرطان پروستات در گروه‌های </span></span></b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PIRADS 2,3</span></span><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> در</span></span></b><b> </b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">Multi-parametric MRI<b> </b></span></span><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">متفاوت گزارش شده </span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">و </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">مطالعه مشابهی در ایران صورت نگرفته است</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">. </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">در این پژوهش، برای نخستین‌بار در ایرانیان شیوع سرطان پروستات در این دسته از بیماران به‌صورت گذشته‌نگر بررسی می‌شود.</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="font-family:"B Lotus""></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" style="font-family:" zar="">مواد و روش‌ها:</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> مطالعه </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">مقطعی</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> در سال 1398 برروی 159 بیمار مشکوک به سرطان پروستات </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">در</span></span></b><b> </b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">بیمارستان رسول اکرم (ص) صورت گرفت. سـن، مقـادیر</span></span></b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PSA </span></span><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">، نتایج </span></span></b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">MRI</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> <b>مولتی پارامتریک و نتایج پاتولوژیک </b></span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">MRI /TRUS Fusion Biopsy</span></span> <b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">مـشخص و</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> تجزیه‌وتحلیل اطلاعات با استفاده از آزمون‌های آماری در نرم‌افزار</span></span></b> <span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">SPSS</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> <b>ویرایش 22 انجام شد.</b></span></span><b><span dir="LTR" style="font-size:9.0pt"></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" style="font-family:" zar="">نتایج:</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> میانگین سنی </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">بیماران</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> 49/8</span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">&plusmn;</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">96/61 سال بود. میانگین حجم پروستات این افراد 09/31</span></span></b><span lang="AR-SA" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">&plusmn;</span></span><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">57/59 بود، براساس نتایج </span></span></b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">MRI</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> <b>6/61 درصد دارای </b></span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">3</span></span> <span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PI-RADS</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> <b>و </b></span></span><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">4</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">/38% دارای </span></span></b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PI-RADS</span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times=""> 2</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> <b>بودند. بین سن، حجم پروستات و </b></span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PI-RADS</span></span><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">،</span></span> <b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">رابطه معنی‌داری وجود نداشت (05/0<</span></span></b><i><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">P</span></span></i><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">). با افزایش سن، حجم پروستات افزایش معنی‌داری داشت. براساس نتایج بیوپسی 3/23 درصد سرطان و 7/76 درصد دارای </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">هایپرپلازی خوش‌خیم پروستات</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> بودند. شیوع سرطان باتوجه به نتایج آسیب‌شناسی، در </span></span></b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PI-RADS2</span></span><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> برابر <b>7/19 درصد و در</b></span></span><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PI-RADS3 </span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:">&nbsp;<b>برابر 5/25 درصد بود.</b></span></span><b><span lang="FA" style="font-size:9.0pt"><span style="font-family:"B Lotus""></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:normal"><span style="direction:rtl"><span style="unicode-bidi:embed"><span calibri="" style="font-family:"><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" style="font-family:" zar="">نتیجه‌گیری:</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> شیوع سرطان در بیماران با ضایعات </span></span></b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PI-RADS2,3</span></span><span style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> <b>درمجموع، 3/23</b></span></span><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">% </span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">بود که </span></span></b><b><span lang="FA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:">بخش</span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> قابل‌توجهی از بیماران را تشکیل می‌داد. به‌نظر می‌رسد با درنظرگرفتن شرایط بیمار، بیوپسی در موارد </span></span></b><span dir="LTR" style="font-size:9.0pt"><span new="" roman="" style="font-family:" times="">PI-RADS2,3</span></span><b><span lang="AR-SA" style="font-size:9.0pt"><span b="" lotus="" style="font-family:"> به تشخیص تعداد قابل‌توجهی از موارد سرطان می‌انجامد.</span></span></b></span></span></span></span></span></span></div> <div style="text-align: justify;"><span style="color:#000000;"><span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Background:</b> Prostate cancer is the most common cancer among men over seventy years. Prevalence of prostate cancer is reported diversely in PIRADS2,3 group in Multi-parametric MRI in previous studies and there is no similar examinations in Iran. The present study was investigated to prevalence of prostate cancer in these patients in Iranians for the first time, retrospectively.</span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Materials and Methods:</b> This cross-sectional study was performed in 2019 on 159 patients with suspected prostate cancer in Hazrat Rasoul Hospital. After obtaining informed consent, age and PSA levels, multi-parametric MRI results and MRI/TRUS Fusion Biopsy pathologic results was determined. Data analysis was performed using Statistical tests in SPSS 22 software.</span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Results:</b> The mean age of the patients was 61.96&plusmn;8.49 years. The mean prostate volume of these patients was 59.57&plusmn;31.09 with a range of (178-208). According to MRI results 61.6% had PI-RADS3, and 38.4% had PI-RADS2. There was no significant relationship between age, prostate volume, and PI-RADS (<i>P</i>>0.05). Prostate volume increased significantly with age. According to biopsy results, 23.3% had cancer and 76.7% had benign prostatic hyperplasia. The prevalence of cancer was 19.7% in PI-RADS2, and 25.5% in PI-RADS3.</span></span></span><br> <span style="font-size:12pt"><span style="unicode-bidi:embed"><span new="" roman="" style="font-family:" times=""><b>Conclusion:</b> The prevalence of cancer in patients with PI-RADS2,3 lesions was 23.3%, which comprises a significant portion of patients. Biopsy in PI-RADS2,3 cases, considering the patient&#39;s condition, seems to lead to the diagnosis of a significant number of cancer cases.</span></span></span></span></div> پروستات, تصویربرداری تشدید مغناطیسی مولتی‌پارامتریک, نئوپلاسم, نمونه‌برداری Biopsy, Multiparametric magnetic resonance imaging, Neoplasms, Prostate 220 227 http://feyz.kaums.ac.ir/browse.php?a_code=A-10-4087-1&slc_lang=fa&sid=1 Kimiya Katebi کیمیا کاتبی kimiakatebi91@yahoo.com 2900319475328460037050 2900319475328460037050 No Department of Radiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, I.R. Iran. گروه رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران Mohammadreza Khaleghi محمدرضا خالقی mkh712003@yahoo.com 2900319475328460037051 2900319475328460037051 No Department of Radiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, I.R. Iran. گروه رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران Hooman Bakhshandeh هومن بخشنده bakhshandeh@rhc.ac.ir 2900319475328460037052 2900319475328460037052 No Department of Epidemiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, I.R. Iran. گروه اپیدمیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران Mahyar Ghafoori مهیار غفوری ghafoori.m@iums.ac.ir 2900319475328460037053 2900319475328460037053 Yes Department of Radiology, Faculty of Medicine, Iran University of Medical Sciences, Tehran, I.R. Iran. گروه رادیولوژی، دانشکده پزشکی، دانشگاه علوم پزشکی ایران، تهران، ایران