RT - Journal Article T1 - Effect of eight weeks of high-intensity intermittent training (HIIT) and low- intensity endurance training (LIET) with a high-fat diet on the expression of PPARĪ± and PLIN5 of skeletal tissue in overweight male rats JF - KAUMS YR - 2022 JO - KAUMS VO - 26 IS - 4 UR - http://feyz.kaums.ac.ir/article-1-4524-en.html SP - 407 EP - 415 K1 - High-intensity intermittent exercise K1 - Low-intensity exercise K1 - Peroxisome alpha proliferator active receptor K1 - PLIN5 AB - Background: Obesity is a metabolic disorder in which proteins involved in fat metabolism are altered. Because obesity is a growing disease among people living in today's societies, the purpose of this study was to compare the effects of 8 weeks of high-intensity intermittent training and low- intensity endurance training on PPARα and PLIN5 gene expression in skeletal muscle of overweight rats. Materials and Methods: Forty male Wistar rats, 5 weeks old, weighing 148.4 ±22.8 g were randomly divided into four equal groups (n=10): control, LIET, HIIT which fed high fat diet, and sham group which fed standard diet. Forty-eight hours after the end of the training program (eight weeks of intense intermittent exercise or HIIT and continued low-intensity exercise or (LIET) the rat adipose tissue was isolated under sterile conditions. Finally, expression levels of PPARα and PLIN5 of skeletal tissue were measured by the Real-time PCR method. Results: The data indicated that the expression level of the PPARα and PLIN5 was significantly increased in HIIT and LIET groups compared to the control group (P= 0.001). Conclusion: HIIT and LIET exercises increased the expression of the PLINS gene in skeletal muscle by increasing the expression of the PPARα gene in lipid droplets of skeletal muscle. LA eng UL http://feyz.kaums.ac.ir/article-1-4524-en.html M3 10.48307/FMSJ.2022.26.4.407 ER -