@ARTICLE{Peeri, author = {shirkhani, Yousef and peeri, maghsoud and Azarbayjani, mohammad ali and matinhomaee, hassan and }, title = {The effect of resistance training with vitamin C consumption on TRF1 and CDK1 expression in skeletal muscle of elderly male Wistar rats}, volume = {25}, number = {5}, abstract ={Background: Telomere shortening causes intracellular signals that trigger programmed cell death. This study aimed to investigate the effect of resistance training with vitamin C consumption on Telomere Repeat-binding Factor 1 (TRF1) and Cyclin-Dependent Kinase 1 (CDK1) expression in skeletal muscle of elderly male Wistar rats. Methods: The present study was an experimental study with a control group. Twenty-five male rats (Wistar) aged 24 weeks (280-320 g) were randomly divided into 5 group; young control group, elderly group + resistance training, elderly group + liposomal vitamin C, elderly group + resistance training + liposomal vitamin C and old age control group. The duration of taking vitamins and doing exercise was eight weeks. Data analysis was performed at a significance level of α <0.05. Results: Aging significantly reduced CDK1 and TRF1 expression in skeletal muscle of rats (P = 0.001). Resistance training with vitamin C had a significant effect on CDK1 expression (P = 0.001). There was no significant change in TRF1 expression due to resistance training and vitamin C intake. Conclusion: Eight weeks of resistance training with vitamin C supplementation consumption in elderly rats significantly increases CDK1 in skeletal muscle but it did not have a significant effect on TRF1. Therefore, it is recommended to use a higher dose of vitamin C. }, URL = {http://feyz.kaums.ac.ir/article-1-4345-en.html}, eprint = {http://feyz.kaums.ac.ir/article-1-4345-en.pdf}, journal = {Feyz Medical Sciences Journal}, doi = {10.48307/FMSJ.2021.25.5.1176}, year = {2021} }