TY - JOUR JF - KAUMS JO - Feyz VL - 23 IS - 2 PY - 2019 Y1 - 2019/5/01 TI - The effect of aqua-ethanolic extract of yellow horned poppy (Glaucium flavum Crantz) on serum activity of hepatic enzymes and insulin concentration in diabetic male rats induced by alloxan TT - تأثیر عصاره آبی- اتانولی شقایق شاخ‌دار زرد (Glaucium flavum Crantz) بر فعالیت آنزیم‌های کبدی و غلظت انسولین سرمی موش‌های صحرایی نر دیابتی شده با آلوکسان N2 - Background: Glaucium flavum Crantz (Yellow Horned Poppy, YPH) is used to reduce complications of diabetes in Iranian folk medicine. This study was conducted to compare the effect of aqua-ethanolic extract of Yellow Horned Poppy and Glibenclamide on serum levels of AST, ALT, ALP and insulin in diabetic rats induced by alloxan. Materials and Methods: In this experimental study, 40 adult male Wistar rats were randomly divided into five groups of eight: healthy control, healthy treated with 500mg/kg body weight (BW) of the YPH extract (healthy+YPH), diabetic control, diabetic treated with 500mg/kg BW of the extract (diabetic+YPH), diabetic treated with 5μg/kg BW of Glibenclamide (diabetic+ medicine). Diabetes was induced by injection of alloxan. After a month, blood samples were collected and serum levels of liver enzymes and insulin were also measured. Finally, the data were analyzed by one-way ANOVA and Tukey's post-hoc test. Results: The activity of AST and ALP enzymes in the diabetic+YPH group was significantly higher than that in the diabetic+drug group (P=0.04). Also, ALT activity and insulin concentration in diabetic+YPH group significantly increased compared to diabetic control group (P<0.001). Conclusion: The findings of this study reveal that oral administration of the YHP extract in addition to its hepatoprotective activity against diabetes-induced stress, can enhance serum insulin level. SP - 117 EP - 124 AU - Khoshvaghti, Ameneh AU - Darya, Gholam Hossein AU - Bkaran-Nejad, Pouria AU - Zarghami, Fatemeh AD - Young Researchers and Elite Club, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, I. R. Iran. KW - Diabetes mellitus KW - Glaucium flavum Crantz KW - Liver functional enzymes KW - Insulin KW - Rat KW - Alloxan UR - http://feyz.kaums.ac.ir/article-1-3756-en.html ER -