TY - JOUR JF - KAUMS JO - Feyz VL - 21 IS - 3 PY - 2017 Y1 - 2017/8/01 TI - Response of glycemic index and liver tissue damage to aerobic exercise followed by coriander seed extract in streptozotocin-induced diabetic rats TT - پاسخ شاخص های قندی و آسیب بافت کبدی به یک دوره تمرین هوازی همراه با مصرف عصاره دانه گشنیز در موش های صحرایی نر دیابتی شده با استرپتوزوتوسین N2 - Background: The aim of this study was to investigate the response of glycemic index and liver tissue damage to aerobic training along with coriander seed extract in Streptozotocin-induced diabetic rats. Materials and Methods: diabetic male Wistar rats (n=40, average age: 12 weeks; weight: 130±10 g) were randomly divided into four groups: Control, Extract, Exercise and Exercise+Extract. The diabetes model in rats was induced with a single injection of Streptozotocin-(60 mg/kg) dissolved in citrate buffer (0.05 mole). The high glucose level of 250 mg/dl is defined as the diabetic criterion. The extract was administered orally (150 mg/kg/day). The exercise program was six weeks of aerobic exercise, 5 times a week with 50-55% of maximal oxygen consumption. Results: The application of aerobic training followed by coriander seed extract in diabetic rats had a significant effect on total serum glucose (P=0.002), AST (P=0.001), ALT (P=0.005) and ALP (P=0.033); however, it had no significant effect on insulin level (P=0.656) and insulin-resistance (P=0.458). Conclusion: It seems that the combination of a regular aerobic exercise and coriander seed extract in diabetic rats had beneficial effects on liver tissue damage and possibly can prevent and improve liver tissue damage via the reduction of the of some liver tissue damage markers. SP - 247 EP - 255 AU - Abdi, Ahmad AU - Abbassi-Daloii, Asieh AU - Akbari, Iman AD - Department of Sport Physiology, Ayatollah Amoli Branch, Islamic Azad University, Amol, I. R. Iran. KW - Aerobic training KW - Diabetes KW - Coriander seed extract KW - Glycemic index KW - liver tissue damage UR - http://feyz.kaums.ac.ir/article-1-3116-en.html ER -