RT - Journal Article T1 - Correlation between the serum level of IL-17 and rheumatoid arthritis JF - KAUMS YR - 2015 JO - KAUMS VO - 19 IS - 1 UR - http://feyz.kaums.ac.ir/article-1-2518-en.html SP - 47 EP - 53 K1 - Rheumatoid arthritis K1 - Serum IL-17 K1 - Disease activity score (DAS28-ESR) AB - Background: Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease. Interleukin-17 (IL-17) has an important role in the pathogenesis of RA. This study aimed to evaluate the correlation between the serum level of IL-17 and the disease activity. Materials and Methods: In this cross-sectional study, 60 patients fulfilled the American college of rheumatology criteria for RA were recruited. Demographic data of patients including age, gender, and disease duration were recorded and then the serum was taken and analyzed for IL-17 level. The disease activity score (DAS28-ESR) was calculated for all patients and the scores lower than 2.6 were considered as inactive 2.6 to 3.1 as mild, 3.2 to 5 as moderate and higher than 5 were considered as the severely active. Results: Of 60 patients studied, 23 cases had controlled RA with mean disease duration of 75.37 months and mean IL-17serum level of 144.81±47.83 ng/l and 37 cases had active RA with mean disease duration of 101.78 months and the mean serum level of 237±93.8 ng/l. There was a significant correlation between the serum IL-17 level and disease activity (P LA eng UL http://feyz.kaums.ac.ir/article-1-2518-en.html M3 ER -