RT - Journal Article T1 - Comparing the effects of the aqueous extract of Aloe vera and Na+ Nitroprusside on the contraction of rat isolated thoracic aorta JF - KAUMS YR - 2015 JO - KAUMS VO - 18 IS - 6 UR - http://feyz.kaums.ac.ir/article-1-2467-en.html SP - 539 EP - 545 K1 - Thoracic aorta K1 - Isolated tissue K1 - Rat K1 - Aqueous extract K1 - Aloe vera K1 - Na+ nitroprusside AB - Background: Aloe vera is used in traditional medicine to treat hypertension. The purpose of this study was to examine the effect of the aqueous extract of Aloe vera (compared to Na+ nitroprusside) on the contraction of the rat isolated thoracic aorta precontracted with 20 mM potassium chloride. Materials and Methods: In this study, 18 rings isolated from the thoracic aorta of 9 Wistar rats (250-300g) were divided into three groups. On the loaded tissue, a tension less than 2 g was applied which then was precontracted with potassium chloride (20mM) in organ bath containing the carbogen-Krebs solution. Changes in aorta contractility in response to cumulative application of vehicle (group I), extract (group II: 5-50 mg/ml) and Na+ Nitroprusside (group III: 0.0001-10 μM) were measured isometrically.Results: The results showed that although Aloe vera has a decreasing effect on the contraction induced by potassium chloride (20mM), this effect was less than the cumulative effect of Na+ nitroprusside (P LA eng UL http://feyz.kaums.ac.ir/article-1-2467-en.html M3 ER -