TY - JOUR JF - KAUMS JO - Feyz VL - 18 IS - 4 PY - 2014 Y1 - 2014/8/01 TI - The effect of intrathecal administration of Genipin on rat paw inflammatory edema in the presence and absence of morphine TT - اثر تجویز نخاعی Genipin بر ادم التهابی پای موش صحرایی در حضور و عدم حضور مرفین N2 - Background: Uncoupling protein 2 (UCP2) is an intramembranous mitochondrial protein that the knocking down of its gene causes an induction of the pro-inflammatory responses. However, genipin, as a pharmacological inhibitor of UCP2, has anti-inflammatory effects. In this study the effect of genipin on rat paw inflammatory edema induced by formalin in the presence and absence of morphine was investigated. Materials and Methods: In this research, male Wistar rats (200-250g) were assigned to seven groups: Saline(i.p)-Saline(i.t), Saline(i.p)-DMSO(i.t), Saline(i.p)-genipin(i.t), Morphine (10mg/kg,i.p)-DMSO(i.t), Morphine(10mg/kg,i.p)-genipin(i.t), Morphine(1μg/kg,i.p)-DMSO(i.t) and Morphine(1μg/kg,i.p)-genipin(i.t). Inflammation was induced in the rat’s hind paw by the injection of 50 µl of formalin 2.5% and paw volume was measured using plethysmometer method before and after the injection. Results: Results revealed an anti-inflammatory effect for genipin against the formalin-induced paw edema (P SP - 345 EP - 353 AU - Abbasi, Zohreh AU - Fereidoni, Masoud AU - Behnam-Rasouli, Morteza AD - Ferdowsi University of Mashhad KW - UCP2 KW - Genipin KW - Inflammation KW - Morphine UR - http://feyz.kaums.ac.ir/article-1-2330-en.html ER -