RT - Journal Article T1 - Histopathological study of the effects of ibuprofen on gastric surgical trauma in rats JF - KAUMS YR - 2009 JO - KAUMS VO - 12 IS - 4 UR - http://feyz.kaums.ac.ir/article-1-680-en.html SP - 13 EP - 21 K1 - Ibuprofen K1 - Wound healing K1 - Stomach K1 - Rat K1 - Histopathology AB - Background : Nowadays faster healing of surgical wounds to decrease wound complications, especially pain, is a matter of challenge for researchers. Synthetic drugs are more effective for the improvement of wound healing. The main objective of the present study was to evaluate the healing effects of ibuprofen, as a non-selective COX-1 and COX-2 inhibitor, on surgical trauma of stomach in rats. Materials and Methods : In this experimental study fifteen Wistar rats were randomly assigned into three groups of five animals . To induce trauma, a gastrotomy incision with a width of 1 cm was made in the grater curvature of rat stomach. Thereafter, it was sutured in 2 layers. After the surgery, the experimental group was treated with daily oral ibuprofen for 15 days in a dose of 30 mg/kg (dissolved in 10 ml/kg of DMSO 5%). The placebo and control groups received DMSO (5%) and saline (10 ml/kg), respectively, in the same manner. Histopathologi cal studies for the evaluation of healing were carried out in experimental rats, which were euthanized 15 days after the experiment using hematoxylin-eosin (H&E) and Masson's trichrome staining methods. Wound healing within the groups was compared with the consideration of more effective agents on wound healing (e.g., proliferation of fibroblasts, angiogenesis , re-epithelialization and collagen synthesis ). Significant differences (p LA eng UL http://feyz.kaums.ac.ir/article-1-680-en.html M3 ER -