TY - JOUR T1 - Effect of Citrullus Colocynthis on diabetic rats plasma glucose TT - بررسی اثر گرد میوه حنظل بر قند خون موش صحرایی دیابتی شده JF - KAUMS JO - KAUMS VL - 12 IS - 4 UR - http://feyz.kaums.ac.ir/article-1-678-en.html Y1 - 2009 SP - 1 EP - 6 KW - Citrullus Colocynthis KW - Plasma glucose KW - Diabetes KW - Rat N2 - Background : Diabetes mellitus is known as a major worldwide complication. Despite numerous synthetic medicines presented for treatment of the disease, it still remains a universal health problem. Although Citrullus Colocynthis is traditionally used as an antidiabetic herbal medicine, however, scant studies describe the antidiabetic properties of the fruit. The present study was designed to investigate the probable hypoglycemic effects of this drug in diabetic rats. Materials and Methods : This work was carried out on 15 male (n=7 and n=8 in the control and test groups, respectively) Wistar rats weighed 200 – 250 g. To make the animals diabetic, they were injected by a single dose of streptozotocin. The rats in the test group were treated daily (continued for 40 days) by the herbal medicine (30 mg/kg dissolved in 0.2 cc distilled water), while those in the control group received distilled water in the same volume. Plasma glucose was measured 10, 20, 40 days following the prescription and 10 days after the termination of treatment. Results: We found a significant decline in the plasma glucose of the drug-treated rats on the 10th day of experiment (P M3 ER -