AU - Banitaba, Sayed Mojtaba AU - Alaei, Hojatollah TI - Surveying the effect of clonidine (α2 agonist) and idazoxan (α2 antagonist) on morphine dependency in rat PT - JOURNAL ARTICLE TA - KAUMS JN - KAUMS VO - 8 VI - 1 IP - 1 4099 - http://feyz.kaums.ac.ir/article-1-203-en.html 4100 - http://feyz.kaums.ac.ir/article-1-203-en.pdf SO - KAUMS 1 AB  - Background: It has been postulated that there is a probable relationship between opioid and adrenergic systems. In the present study we have evaluated the effect of morphine alone and together with clonidine (α2 agonist) and Idazoxan (α2 antagonist) on morphine dependency in rat.Materials and methods: For this experimental study, 32 rats were divided in 4 groups of control, morphine, morphine with clonidine and morphine with idazoxan. Having anesthesized the rats with ketamine and rammpon, jugular vein was cannulated and rats were addicted with autoinjection method. All groups were evaluated with lever pressing during 2-hour stay in autoinjection chamber. Morphine dependency was evaluated by ANOVA.Results: There was no significant difference between the active and passive lever pressing in the control rats, however, in other groups active lever pressing was significantly more than the passive pressing. Clonidine group consumed more morphine and the idozoxan group pressed lever more actively than the controls (p CP - IRAN IN - School of Medicine, Kashan Medical Science University, Kashan, Iran LG - eng PB - KAUMS PG - 26 PT - Research YR - 2004