TY - JOUR JF - KAUMS JO - Feyz VL - 9 IS - 1 PY - 2005 Y1 - 2005/4/01 TI - Effect of Stress Resulting from Independent and Synergic Morphine Use on Serum Cortisol Level in Rat TT - بررسی تاثیر طولانی مدت مورفین به تنهایی و توام با کربوهیدارت بر میزان کورتیزول سرم در رات N2 - Background: In this study effects of stress resulted from using independent and co-administration morphine and carbohydrate on serum cortisol levels in rat were investigated to determine the possible causal link between morphine, carbohydrate and serum cortisol level. Materials and Methods: This experimental study was performed on 24 male Wistar rats (200-250 gr) divided to 3 groups (n=8). Morphine dependency was induced by increasing doses of morphine through intraperitioneal (IP) injection. Animals were injected 10,20,30,40,50,60 mg/kg morphine sulfate on days 1,2,3,4,5,6 respectively and dose of 60 mg/kg was repeated for 20 extra days (Mo group). Another group of animals received the same dose of morphine plus l gr/kg glucose per day through intraperitoneal (IP) injection (Mo+Glu group). Duration of experiment was 26 days.Results: Significant increase in serum cortisol level was observed after long-term use of both morphine and co-administration of morphine and carbohydrate. However, this increase was higher in Mo+Glu group than morphine group. (16.57% vs. 11.55%, P SP - 26 EP - 29 AU - Rad Ahmadi, Maryam AU - Amini, Masoud AU - Fesharaki, Mehrafarin AU - Sharifi, Mohammad Reza AD - KW - Morphine KW - Carbohydrate KW - Cortisol UR - http://feyz.kaums.ac.ir/article-1-158-en.html ER -