|
|
|
 |
Search published articles |
 |
|
Showing 103 results for Diabetes
Raheleh Rahbarian, Jalal Shegofte,
Volume 0, Issue 0 (1-2025)
Abstract
Background: Plant phenolic compounds act as antioxidants, affecting hormonal disorders caused by diabetes through the activity of the pituitary-testicular axis and reducing fertility disorders. The present study aimed to determine the effect of the antioxidant properties of the Launaea acanthous plant on hormonal changes of testosterone in diabetic rats.
Materials and methods: In the present study, 36 male rats were divided into four groups: control, diabetic control, and two diabetic groups treated with 100 and 300 mg/kg. The diabetic groups were injected with alloxan, and the treatment groups received the aqueous extract of Launaea acanthous for 30 days. Post-treatment, serum levels of insulin, glucose, and testosterone were measured and evaluated.
Results: The findings indicated that the diabetic group treated with a dose of 100 mg/kg on day 15 and with a dose of 300 mg/kg of Launaea acanthous extract on days 15 and 30 had a significant decrease and increase in serum glucose and insulin levels, respectively, compared to the diabetic control group. Also, a dose of 300 mg/kg on days 15 and 30 resulted in a significant increase in testosterone levels compared to the diabetic control group (p<0.05).
Conclusions: It seems that the aqueous extract of the L. acanthous, with its antioxidant properties due to the phenolic compounds present in it, leads to the prevention of chronic diabetes by reducing glucose levels and increasing insulin levels, which ultimately leads to an increase in testosterone levels in the cells of diabetic mice by reducing oxidative stress and improving fertility disorders.
Dr Mansoureh Karimi, Dr Masome Nobahar,
Volume 0, Issue 0 (1-2025)
Abstract
The aim of this article is to investigate the relationship between obesity and adipose tissue accumulation and the pathways involved in the development of muscle atrophy, where aberrant lipid accumulation in organs may affect peripheral insulin sensitivity and decrease muscle mass. Insulin resistance (IR) and muscle mass loss often occur concomitantly in individuals with type 2 diabetes (T2D). Most patients with type 2 diabetes are overweight, and it is well established that obesity and impaired lipid metabolism play an important role in the development of IR in these individuals. In particular, increased adipose tissue mass and dysfunction in adipose tissue lead to fat accumulation and systemic inflammation through altered adipose secretions and factors and cytokines. In addition, increased fatty acid flow from adipose tissue may lead to increased fat storage in the liver and skeletal muscle, thus resulting in altered hepatic secretions, mitochondrial function, and impaired insulin signaling in skeletal muscle. Therefore, obesity and adipose tissue disorders can lead to muscle atrophy, which causes IR and are two sides of the same coin with muscle atrophy. However, the exact relationship between lipid accumulation, T2D, and muscle atrophy is largely unknown and requires further investigation in this area.
Shokouh Sarbolouki, Forough Azam Taleban, Naser Valai,
Volume 4, Issue 4 (1-2001)
Abstract
| History and Objectives: Dietary soluble fiber had beneficial effects on serum glucose and lipid levels. Sugar beet is one of the dietary soluble fibers. Contradictory results have been associated with the effect of its consumption on serum glucose and lipid levels. Therefore, the present study was performed to assess their effect on type II diabetic patients admitted to Diabetic Clinic in Kashan in 1997-98. Materials and Methods: A cross-over, sequential and single blind clinical trial was carried out on 30 type II diabetic patients with FBS>7.8 mmol/L and HbA1C 5-9% who were treated with 2 tablets of Glibenclamide per day. Sugar fiber beet was refined, dried, ground and packed into 10 gram samples. The individuals were randomly divided into two groups: One receiving 20 grams of sugar beet fiber, blended with yogurt at lunch and dinner for 4 weeks, while the other group receiving 20 grams of starch powder instead. The individuals in each group had another 4 weeks of crossover followed by 2 weeks of wash out. Blood samples were taken for FBS and serum lipids at the beginning of the study and 5 additional samples at 2 week intervals. Paired t-test and t-test were used for statistical analysis. Results: Consumption of beet sugar fiber caused a reduction of 33% (P<0.001), 13% (P<0.01), 11% (P<0.05), 30% (P<0.02) and 15% (P<0.05) in FBS, total cholesterol, LDL-C triglyceride and total cholesterol/HDL-C ratio respectively. Furthermore, the results indicated that sugar beet fiber consumption did not have any statistically significant effect of HDL-C levels during the period of study. Conclusion: Consumption of sugar beet fiber, as a glucose and lipid-lowering agent is recommended for type II diabetic patients. |
Hossein Sharifi, Mohamamd Afshar, Hossein Akbari, Sayed Mohamamd Matini,
Volume 6, Issue 1 (4-2002)
Abstract
Background: With respect to the prevalence of diabetes mellitus, its known complications, the impact of epidemiological features on prognosis and in order to determine the acute complications of diabetes mellitus and its related mortality and morbidity, the present study was conducted in Shaheed Beheshti University hospital in Kashan, during an 8-year period (1991-99). Materials and Methods: It was an existing data type study. Demographic characteristics as well disease profile were all recorded. Then descriptive statistics was used. Results: 114 patients with 144 acute complications were included. Diabetic ketoacidosis, hyperosmolar syndrome and hypoglycemia were reported in 54 (37.5%), 9 (6.3%) and 81 (56.2%), respectively. Diabetic ketoacidosis was more obvious in 12-20-year-old individuals (21 cases). The mortality rare was 11.1%, 66.6% and 6.2%, respectively. Conclusion: Hypoglycemia was by far the most common complication. Diabetic ketoacidosis was found more common among 12-20-year-old individuals. Whereas hyperosmolar syndrome and hypoglycemia were more prevalent after 60. Mortality had occurred among these patients. Thus an experimental study is strongly recommended.
Zahra Sepehrmanesh, Hossein Sarmast, Sayed Fakhroddin Sadr, Shokouh Sarbolouki,
Volume 7, Issue 3 (10-2003)
Abstract
Background : Depression is quite a common finding in patients suffering from chronic illness specially diabetics. The present study was carried out on diabetics referring to Akhavan hospital in Kashan to determine the prevalence of depression. Materials and methods : 300 randomly selected diabetics entered this descriptive study. Initial data including sex, age, level of education, marital status, depression in family, type of diabetes, late complications of diabetes, blood sugar to be under control or not, level of triglyceride and cholesterol, blood pressure, and duration of diabetes were all recorded. Beck test was used to determine the depression and the score of 16 was set as the cut off point. The prevalence and severity of depression was determined and its related factors were analysed. Results : The study population included 78 males and 222 females. Depression was observed in 53.3% of males and 57.7% of females (p<0.05). Depression was more common among individual aged more than 40 years (p<0.0001). Meanwhile, the prevalence of depression was significantly higher among the following subjects: illiterates, with insulin-dependant diabetes, with positive family history of depression, with late complications of diabetes, insulin that was not under control, hypertriglycemics, and hypertensive subjects (p<0.0001). During the interview it was revealed that 32% of male diabetics and 47.3% of female diabetics had major depression. Conclusion : Depression, especially major depression is a common problem of diabetics. Psychological consultation is strongly suggested for at least diabetics with longer period of disease
Negin Masoudi Alavi, Fazlollah Ghofranipour, Fazlollah Ahmadi, Asadollah Rajab, Gholam Reza Babeie,
Volume 7, Issue 4 (1-2004)
Abstract
Background: Diabetes mellitus is a common and dangerous disease. Current methods in our country are not effective in the management of diabetes mellitus. The main object of our study is to design and test an effective model in the management of diabetes mellitus. Materials and methods : Grounded theory research used for designing the heory, 30 adults patients with their families, physicians, nurses, and dietitians were interviewed. The data were analyzed according to the Straus and Corbin method. The effect of designed theory on glycemic control was assessed during a randomized clinical trial on 104 diabetics referring to the Iranian Diabetes Association in 1382. Results : In qualitative part, 395 open codes were clustered in 27 subcategories and 9 main categories. Later on, the model shaped with defining the process and relationships between the categories. Personal system cure, care, and support system as well as social system are the main 3 systems that their interaction will determine the outcomes like glycemic control which is the most important indicator of diabetics. 3 months followed by model-based interventions, the mean of HbA1c was reduced form 8.22±2 to 6.7±1.6 in the intervention group. (p<0.02) Conclusion : Outcome based management revealed to control effectively the blood glucose level.
Hamdollah Karamifar, Gholam Hossein Amirhakimi,
Volume 7, Issue 4 (1-2004)
Abstract
Background: Diabetes mellitus is the most common endocrine disorder in children. Chronic lymphocytic thyroiditis is frequently associated with type I diabetes in children. With respect to the unknown prevalence of goiter and hypothyroidism in the region, the present study was performed to determine the prevalence of goiter and hypothyroidism in children with insulin dependent diabetes mellitus. Materials and methods : For this cross sectional study, 72 children with insulin dependent diabetes mellitus were enrolled. A complete history was obtained and physical examination was performed. They had no other systemic disease and all of them were on NPH insulin. Goiter was evaluated according to the EHO criteria, meanwhile, T4 and TSH were checked by radioimmunoassay. Results : Goiter was reported in 69.4%, among whom 7% had hypothyroidism. Hyperthyroidism was also reported in 1.3%. Of 5 children with hypothyroidism, 4 had height below the 5th percentile (p<0.05). Conclusion : Goiter and hypothyroidism may be found in diabetics, on the other hand, deceleration of growth may also be associated with thyroid failure, thus, we recommend routine screening of hypothyroidism in diabetic children annually.
Mohamamd Afshar, Fateme Sadat Izadi,
Volume 8, Issue 4 (1-2005)
Abstract
Backgraound: Regarding the growing rate of hyperglycemia in Iran and some of its known complications, we attempted to assess the effect of teaching this matter on diabetic patients at kashan in 1380. Materials and Methods: This experimental research was conducted on 60 patients suffering from diabetes mellitus for at least on year. A Checklist including demographic and disease-related data were filled out for each patient. Then FBS (Fasting Blood Sugar) and Bs (5 PM) were evaluated in three consecutive days. The characteristics and complications of diabetes and the ways of its control were taught via face to face interview during two weeks. After 3 months, again the checklist was filled out and FBS and BS (5 PM) were evaluated in three consecutive days. Data analysis was performed by McNemar's test. Results: 60 patients including 41.6% male and 58.3% female, aged between 22 and 60 years were studied. Duration of disease was between 1 and 15 years. The frequency of abnormal FBS and BS decreased from 95% to 48.3% (P< 0.0001) and from 91% to 71.6% (P< 0.0001), respectively. Conclusion: It seems that teaching diabetic patients about their illness is useful in control of disease. Further studies are recommended to find out more detailed results
Davoud Aghadoost, Sayed Fakhroddin Sadr,
Volume 9, Issue 1 (4-2005)
Abstract
Background: Diabetes mellitus has a high prevalence in our country. It is usually complicated with diabetic retinopathy. The aim of the present study was to determine the prevalence and risk factors of diabetic retinopathy in patients referring to Kashan Diabetic Center in 2002-2003. Materials and Methods: In this descriptive study, a thorough ocular examination was performed on 200 randomly selected patients from Kashan Diabetic Center. Stage of retinopathy was determined in patients. The risk factors such as age, sex, duration of disease and type of diabetes were considered. Results: Diabetic retinopathy was found in 72 patients (36%). Sixty-two patients (31% of examined patients) were in non-proliferative phase. There was a significant association between diabetic retinopathy and duration of disease (P=0.00006), creatinin level (P=0.002), blood urea (P=0.002), fasting glucose (P=0.05) and sex (P=0.044). Other risk factors such as blood cholesterol and triglyceride level, hypertension, type of diabetes, and ischemic heart disease did not show a significant association with diabetic retinopathy. Conclusion: With respect to the high prevalence of diabetic retinopathy, controlling the blood sugar, urea, creatinin, blood pressure, and fat level can influence the occurrence of diabetic retinopathy.
Karim Parastouei, Shahnaz Ravanshad, Habiballah Mostaphavi, Esfandiyar Setoudehmaram,
Volume 9, Issue 3 (10-2005)
Abstract
Background: Diabetes, hypercholesterolemia and hypertension are three major risk factors that lead to the increased incidence of cardiovascular disease. Historically, there has been great interest in the role of garlic in reducing cardiovascular risk factors. In this study we evaluated effects of garlic tablet in type 2 diabetic patients with hyperlipidemia. Materials and method: A clinical trial (before and after) was performed in a group of 50 type 2 diabetic patients with hyperlipidemia (including 39 women, 11 men with serum cholesterol concentration greater than or equal to 220 mg/dl) to assess the effect of garlic powder tablet on blood glucose, lipid profiles and blood pressure. Each subject received tablets containing 300 mg of garlic powder (Garcin) 3 times per day for 6 weeks. Before and after the treatment, blood pressure, fasting blood glucose, glycated hemoglobin and lipid profiles were measured. 24 hr dietary recalls were used to evaluate nutritional status of the patients. Results: Our results indicate that 6 weeks supplementation with garlic powder tablets give rise to a significant decrease in total cholesterol (p < 0.01) and LDL-C (p < 0.001) but increase in HDL-C (p < 0.02). We observed a considerable decreased in systolic blood pressure (p < 0.03). There were no significant changes in diastolic blood pressure, fasting blood sugar, serum triglycerides and HbAıc. Also there were no significant changes in diet composition. Conclusion: 6 weeks treatment with garlic powder tablets significantly decreased total cholesterol, LDL-C, systolic blood pressure and increased HDL-C in type II diabetic patients with hyperlipidemia. Further studies are required to assess quality, efficacy and safety of this product.
Nadia Rezaei, Faride Tahbaz, Masoud Kimiagar, Hamid Alavi Majd,
Volume 9, Issue 4 (1-2006)
Abstract
Background: Medical-nutritional management can reduce the risk of progression of complications. Therefore the aim of this study was to evaluate the effect of nutrition education on metabolic control of patients with type 1 diabetes in Aligoodarz in year 2001. Methods and Materials: Firstly , Patients with type 1 diabetes were traced and recruited from medical centers. Then the study was performed with a semi experimental (self-control) design. Anthropometric measurements, diet survey and KAP study were conducted on patients with type 1 diabetes by a nutritionist. Biochemical indices were measured on blood and urine samples. The comparisons were made by paired t-test and MacNemar test. P values less than 0.05 were considered as significant. Results: In total, for 30 patients FBS (239.84 ±12.61 vs 183.74±91.02) and TC (224.23±60.86 vs 163.86±34.08) decreased significantly (p<0.001). Also HbA1c%, LDL-C, and 24 hr urinary protein (for all p<0.001) and serum creatinine (p<0.008) decreased significantly. Cholesterol intake decreased (p<0.01) and dietary fibre, vitamin C and folate increased significantly (for all p<0.001). Both Knowledge and Practice scores increased significantly (for both p<0.001), while Attitude was not significantly changed. Conclusion: Findings of this project highlights the importance of nutrition education of patients with type 1 diabetes for better metabolic control. Thus setting up a diabetes unit in cities like Aligoodarz is recommended, to register patients and monitor their metabolic control regularly.
Sayed Alireza Ebadi, Elham Rahimi Lenji, Mohsen Taghadosi, Ahmad Khorshidi, Hossein Akbari,
Volume 11, Issue 1 (4-2007)
Abstract
Background: Type 2 diabetes mellitus is one of the most common health problems. Garlic (Allium sativum) has been the focus of serious clinical attention because of its beneficial effects on the reduction of serum blood glucose. This study was designed to evaluate the effects of garlic on serum glucose level in patients with type 2 diabetes mellitus. Materials and Methods: This 3-month randomized and double blind clinical trial was conducted on 60 new cases of type 2 diabetes referred to diabetes center of Kashan. The effect of garlic on their blood sugar and HbA1C. was assessed Thirty patients were given 2 tablets of garlic 3 times per day (each tablet containing 400 mg dry garlic powder and over 1000 m g Allicin) and 30 patients (controls) received vitamin B1 tablets. Both groups were given the same diet and exercise programs. Before and after the treatment fasting blood sugar (FBS) and gelycated hemoglobin were measured and analyzed with t-test, Results: The mean age in the garlic and control groups was 46.3 ± 3 and 45.7 ± 10 years, respectively. There was no significant difference in age, sex, and other diseases between the two groups. After 3 months, the garlic-treated group showed a significant reduction (49.5 mg/dl) in FBS (P<0.001) when compared with the control group. The garlic-treated group also had a significant reduction (1.5%) in gelycated hemoglobin (P<0.003) compared with the control group. Conclusion: Garlic significantly reduced FBS and HbA1C in type 2 diabetic patients. Hence, it may be a candidate drug in the treatment of diabetes mellitus.
Mohammad Nassaji-Zavareh, Ramin Taheri, Raheb Ghorbani, Maryam Aminian,
Volume 11, Issue 4 (1-2008)
Abstract
Background: Herpes Zoster (HZ) is the reactivation of latent varicella-zoster virus due to such risk factors as aging and immunosupression. Diabetes Mellitus (DM) causes immunosupression and can activate HZ. This study focuses on the relationship between Herpes Zoster and Diabetes Mellitus. Materials and Methods: In this cross-sectional study 103 patients referred to the dermatology and infectious disease clinics with HZ (cases) and 142 with other diseases (control) were enrolled to the study. They had no history of DM. Both groups were matched for age, gender and family history of DM. FBS was checked for all participants and FBS ³ 126mg/dl was defined as DM. Results: 35.9% of patients with HZ and 19.7% of control group had DM. There was a significant relationship between HZ and undiagnosed DM (OR=2.28, 95% CI: 1.28-4.06, p=0.0046). On the other hand, DM was 2.28 times more common in HZ patients than in normal population. Conclusion: Undiagnosed DM can cause HZ so the patients suffering from HZ but have no history of DM should be monitored for diabetes.
Mina Khabaz, Maryam Rashidi, Fatemeh Kaseb, Mohammad Afkhami-Ardekani,
Volume 11, Issue 4 (1-2008)
Abstract
Background: Type 2 diabetes is associated with elevated oxidative stress and decline in antioxidant defense. Vitamin E supplementation reduces oxidative stress level in diabetic patients. Also some studies showed that vitamin E enhances insulin sensitivity and improves lipid profile. The aim of this study was to evaluate the effect of vitamin E supplementation on glycemic control and lipid profile in type 2 diabetic patients. Materials and Methods: In this study 31 type 2 diabetic subject who referred to Yazd Diabetes Research Center with Fasting blood suger:140-200 mg/dl,2-hour postprandial BS <250 md/dl, Triglyceride <400mg/dl, Total Cholesterol ≤300 mg/dl and mild hypertension (systolic blood pressure: 140-160mmHg,diastolic BP:90-100mmHg) were selected. Subjects received vitamin E 800 IU/day for 3 months. At first and end of treatment period FBS, TC, TG, LDL, HDL, Glycated hemoglobin and fasting insulin level were measured. Results: In this study 31 type 2 diabetic patients (19 female, 12 male) with mean age 53.03 ± 8.87 years and mean duration of diabetes 2.16 ± 0.89 years were studied. Vitamin E supplementation for 3 months had no positive effect on type 2 diabetic patients. As FBS, TG and fasting insulin decreased but this decline was not significant. Also TC levels, systolic and diastolic BP changes was not remarkable. Conclusion: Results of this study showed that 800 IU vitamin E administration for 3 months could not improve blood glucose, lipids, HbA1C, fasting insulin, systolic and diastolic BP in type 2 diabetic patients.
Parvin Baghaei, Mitra Zandi, Zoherh Vares, Negin Masoudi Alavi, Mohsen Adib-Hajbaghery,
Volume 12, Issue 1 (4-2008)
Abstract
Background: Self care in diabetic patients is very important not only from hygienic views, but also from society’s economical aspects. The goal of this study is assessment of knowledge of diabetic patients about self-care, in those referring to Kashan Diabetes Center. Materials and Methods: This descriptive- analytic study is conducted on 300 of 1400 diabetic patients who had medical records in Kashan Diabetes Center, with the use of random sampling method. Data were collected by completion of questionnaire containing demographic information, patients’ self care (considering three aspects: observation, function and family function), Foot care and patient knowledge level. To determine the relationship between self care and studied variants statistical tests x2, T test, sideway analytic variance test, OR, and CI were used. Results: Out of 300 patients, 214 (71.3%) were women and 86 (28.7%) were men, with a diabetes duration of 10.6 ± 6.5 years. Self care situation had a meaningful relationship with the patients’ education and diabetes duration. The longer the diabetes duration, the better was the level of self care. So, even the uneducated people had a well self-care. The type of treatment and marital status had relationship only with legs self care. Conclusion: Based on the results of this study and the discrepancy in some demographic characteristics of patients with different dimension of self-care and knowledge, it is recommended that the education in diabetes center should be more practical and emphasize on behavioral changes, altering attitude, and feeling of self sufficiency.
Ali Reza Soleimani, Elahe Mianesaz, Mohammad Reza Tamadon, Sayed Gholam Abbas Mousavi,
Volume 12, Issue 3 (10-2008)
Abstract
Background: Best choice for end stage renal disease (ESRD) is replacement therapy and kidney transplantation. Pre/post transplantation diabetes mellitus (DM) has adverse effects on both the patient and new kidney. In this study the effects of DM before and after the transplantation were compared with complications and outcomes of the procedure in kidney transplanted patients during 2002- 2007. Materials and Methods: In this historical cohort study patients were divided into 3 groups: group I with DM before graft, group II with DM after the transplantation and group III left non diabetic. All information were evaluated based on the delayed function of graft (DGF), rejection possibility, systemic infections, cancer, relapse of renal disease, cardiovascular disease and subsequent death. Results: One hundred five patients were included in this study (35 in each group). Mean age of the group I, II and III were 47, 47.3, and 47.1 respectively. Also, the incidence of outcomes and complications was 82.9%, 57.1% and 22.9% respectively. The one year survival of transplanted kidneys in each group was 68.5%, 77.1% and 91.4% and the one year survival of patients was 82.8%, 88.5% and 97.1% respectively. Conclusion: The prevalence of post transplantation diabetes mellitus (PTDM) in this research was 21%. The rate of complications and death in pre transplantation DM patients was higher than that in PTDM patients. Also, this rate was the lowest in non diabetic patients. In conclusion, due to the adverse effects of DM or PTDM, the accurate follow up of patients in terms of blood sugar monitoring and complications is suggested.
Zahra Aghanouri, Mahdi Noureddini, Mahmoud Salami,
Volume 12, Issue 4 (1-2009)
Abstract
Background : Diabetes mellitus is known as a major worldwide complication. Despite numerous synthetic medicines presented for treatment of the disease, it still remains a universal health problem. Although Citrullus Colocynthis is traditionally used as an antidiabetic herbal medicine, however, scant studies describe the antidiabetic properties of the fruit. The present study was designed to investigate the probable hypoglycemic effects of this drug in diabetic rats. Materials and Methods : This work was carried out on 15 male (n=7 and n=8 in the control and test groups, respectively) Wistar rats weighed 200 – 250 g. To make the animals diabetic, they were injected by a single dose of streptozotocin. The rats in the test group were treated daily (continued for 40 days) by the herbal medicine (30 mg/kg dissolved in 0.2 cc distilled water), while those in the control group received distilled water in the same volume. Plasma glucose was measured 10, 20, 40 days following the prescription and 10 days after the termination of treatment. Results: We found a significant decline in the plasma glucose of the drug-treated rats on the 10th day of experiment (P<0.05). In contrast to the control group, the number of diabetic rats decreased in the drug-treated group with passing the time (P<0.018). While the mortality rate decreased in the rats treated with the medicine, it considerably increased in the controls as the experiment proceeded (P<0.05). Conclusion : Citrullus Colocynthis has a moderate hypoglycemic effect in adult diabetic rats. Decreased number of diabetic animals and increased mortality in the test animals indicate that the herbal medicine has a potential effect in treating diabetes.
Mitra Behrashi, Fateme Froozanfard, Akbar Aliasgharzade, Sayed Gholam Abbas Mousavi,
Volume 12, Issue 4 (1-2009)
Abstract
Background: Diabetes, especially the gestational diabetes with its special fetal and maternal disorders, is the most common complication of pregnancy. Both gestational and type II diabetes mellitus are along with a disturbances to insulin secretion as well as insulin resistance. Considering the significant role of zinc in insulin function, the deficiency and importance of this element in gestational diabetes is a matter of consideration. Materials and Methods: This clinical trial was carried out on 60 pregnants suffering from gestational diabetes, and needing insulin injection from 32nd week to full-term. The patients were divided into two groups the case group (n=30), received daily zinc sulfate (25mg or 5cc) plus insulin and control group (n=30) received daily placebo (5 cc as syrup) plus insulin until the time of delivery. The required insulin dose was regulated through monitoring fasting blood sugar and blood sugar, 2 h postprandial, every two weeks in both groups. These groups were compared in terms of required insulin dose and maternal/fetal complications. Data were analyzed using t-test, OR, CI, Fisher Exact test, Kolmogorov-Smirnov and Chi-Square tests. Results: The required dose of insulin had a significant decrease in the case group compared to the control one (p<0.001). However, the mean change in insulin dose in the case and control group compared to the beginning of study was 8.766 (SD:9.63) and 17.533 (SD: 10.54), respectively. The incidence of macrosomia in the case and control groups was significant (P<0.01). The odds ratio of control group compared to the case group was 7. The preeclampsia prevalence in both groups was not significant. Conclusion: Zinc supplementation in gestational diabetes may lead to the reduction of required insulin dose, incidence of macrosomia and the related complications (e.g., caesarian and delivery dystocia).
Abolfazl Mohamadbeigi, Hamid Reza Tabatabaee, Narges Mohamadsalehi,
Volume 13, Issue 1 (4-2009)
Abstract
Background: Diabetes mellitus (DM) is a metabolic disorder and the 5th cause of death in developed countries. Gestational diabetes mellitus (GDM) is an impaired glucose tolerance in pregnancy period. Fourteen-eighteen percent of pregnant women are at risk of GDM, 3-4 percent of whom suffer from it. The present study was conducted to determine the most important causes of DM in a regression model. Materials and Methods : In a case control study 70 GDM patients were compared with 350 non-GDM pregnant women referring to Shiraz hospital for delivery. The data were gathered and analyzed using Fisher exact test, in univariate t-test method and binary logistic regression at multivariate model. Results : The mean age in cases and controls was 31.2 ± 6.03 and 26.32 ± 5.03, respectively. All of variables showed significant difference between two groups, except history of infertility malformation of twine pregnancy, toxemia and previous preterm delivery having no relation with GDM. In final regression model, GD history (OR=21.93), glocosuria in three trimester (OR=10.34), age older 35 years (OR=9.57), family history of GD (OR=8.13) and preeclampsia (OR=3.81) were the most important predictors of GDM, respectively. Conclusion : To prevent diabetes and its unpleasant outcomes in pregnant women it is suggested that they should avoid creating factors of glocosuria, especially in older mothers with family history of GD and GDM history.
Robab Sheikhpour , Bemanali Jalali Khanabadi , Parichehr Yaghmaei , Mohammad Afkhamiardekani ,
Volume 13, Issue 2 (7-2009)
Abstract
Background: Chronic complications (e.g. cardiovascular failure) are among the most common problems in diabetics. It is suggested that oxidative stress and lipid peroxidation play a key role in chronic diabetic complications. Supplementation with agents containing antioxidant properties can suppress lipid peroxidation. Many studies confirmed the antioxidant properties of zinc in biological systems. The aim of the present study was to evaluate the effect of zinc supplements on serum lipid oxidizability in diabetic patients. Materials and Methods: In this clinical trial study, 60 diabetic patients were chosen and randomly divided into two groups. Serum lipid oxidizability and serum zinc level were evaluated in each group before and after zinc supplementation (25.50 mg/day for 2 month). Lipid oxidizability was followed through monitoring the change of conjugated compounds in diluted serum after adding Cu2+ by spectrophotometric method. S erum zinc level was measured by atomic absorbance spectrophotometer. Results: While there was no significant change in the post- supplementation zinc level (25 mg) in the first group, zinc serum level was increased significantly (p<0.002) in the second group. No significant change was seen in serum lipid oxidizability parameters before and after supplementation in two groups. SPSS software (V.11.5) and Wilcoxon test were used for statistical analysis. Conclusion: Our results indicate that zinc supplementation (25.50 mg) in short period of time has no favorable effect on serum lipid oxidizability in diabetic patients. It seems that zinc dose, duration of treatment and also the patients' condition may affect their response to supplementation.
|
|
_-_Copy.png)
.png){kind=logo}
