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Showing 6 results for Yahyaei
Asieh Abbassi-Daloii , Ahmad Abdi, Hoda Yazdani-Tapesari , Mojtaba Salehpour, Zahra Rostami-Angasi , Behroz Yahyaei ,
Volume 20, Issue 2 (Bimonthly 2016)
Abstract
Background: Evidence supports the systemic inflammation in obesity and insulin resistance. Apelin is secreted by adipose tissue and plays an important role in the inflammation process. The present study aimed to examine the effect of 8 weeks aerobic training on plasma Apelin in male rats treated with Nitro-L-Arginine-Methyl Ester (L-NAME).
Materials and Methods: In this experimental study male Wistar rats (n=24, age 20 months) were randomly assigned into four groups: Control, Training, TrainingS+L-NAME and L-NAME. An aerobic training protocol was performed for eight weeks, 5 times a week with an intensity of 75-80% of maximal oxygen consumption. The rats were sacrificed 72 hours after the last exercise session and blood samples were collected. Data were analyzed by ANOVA and Tukey post hoc test at P<0.05 significancy level.
Results: The results showed that plasma Apelin level did not change significantly after eight weeks of aerobic training compared to the Control group. However, the results showed that there was a significant difference in plasma Apelin between L-NAME and Control group (P<0.003). In addition, the results showed no significant difference between the insulin level and glucose in four groups.
Conclusion: It seems that with increasing age plasma Apelin level is not affected by aerobic exercise. However, nitric oxide inhibitors can reduce the plasma Apelin level.
Monireh Amerian, Mohammad Bagher Sohrabi, Poneh Zolfaghari , Mohammad Sadeghi , Elaheh Yahyaei, Mahmoud Zangeneh,
Volume 20, Issue 4 (Bimonthly 2016)
Abstract
Background: Control of the phosphorus in hemodialysis patients is very important and can be done in many ways. The purpose of the study was to compare the effects of Nicotinic acid and Lanthanum carbonate on hyperphosphatemia in the hemodialysis patients.
Materials and Methods: This double-blind randomized clinical trial was done in Imam Hossein hospital (Shahroud, Iran) in 2014. The participants (n=60) were divided into two groups: Control (Lanthanum carbonate) and Intervention group (Nicotinic acid). The tapering doses of Nicotinic acid and lanthanum carbonate were completed monthly in three steps from 200 to 600 mg and from 250 to 750 mg, respectively. Serum phosphorus and calcium were measured in both groups and the results were compared using the paired t-test and ANOVA.
Results: The comparison of Mean for age in Intervention (51.5±21.3 years) and Control groups (50.7±22.5 years) showed no significant differences. Comparing the phosphors level before the intervention in Intervention (6.67±1.37 mg/dl) and Control group (6.69±0.28 mg/dl) showed no significant difference. Nicotinic acid significantly decreased the blood phosphorus level (P<0.001) in a dose-dependent manner.
Conclusion: Similar to Lanthanum carbonate, Nicotinic acid can decrease the serum phosphorous level. However, for determining the most effective dose of the Nicotinic acid, more studies are required.
Mozhgan Ahmadi, Asieh Abbassi-Daloii, Seyed Javad Ziaolhagh, Behrooz Yahyaei,
Volume 21, Issue 6 (Bimonthly 2017)
Abstract
Background: Abuse of anabolic androgenic steroids has been linked to a variety of different cardiovascular side effects. The use of medicinal herbs has been shown to reduce disease and cardiovascular disorders. This study aimed at examining the structural changes of the cardiac tissue in response to boldenone supplementation along with the alcoholic extract of jujuba during resistance training in male Wistar rats.
Materials and Methods: In this experimental study, 30 male Wistar rats aged 8-12 weeks (weight 202±9.34 g) were randomly divided into five groups: control, boldenone, extract of iujuba+boldenone, boldenone+resistance training and boldenone+resistance training+extract of jujuba. The resistance training program included climbing the ladder for 8 weeks, 3 days a week, 1 session training in a day and each session consisted of the 3 sets and 5 repetitions. Injection was conducted in depth in the hamstring once a week, on an appointed day. After anesthesia, autopsy was performed and the cardiac tissue was isolated.
Results: The results showed that boldenone caused tissue damage, hyperemia, abnormal cytoplasm and unclear and dispersed nuclei. In the boldenone+resistance training group, the heart tissue had high levels of hyperemia and the muscle cells were a little abnormal. In the boldenone+jujube group, appearance of the tissue was normal and a restorative effect was evident in the tissue.
Conclusion: It seems that boldenone can cause structural damage to the heart tissue and the resistance training along with the jujube extract can reduce some of the cardiovascular disorders (necrosis and inflammation) caused by the use of anabolic steroids.
Sayyed Javad Ziaolhagh, Leila Khojasteh, Sayyed Saeid Ziaolhagh, Behrooz Yahyaei,
Volume 22, Issue 2 (Bimonthly 2018)
Abstract
Background: This study aimed at investigating the effect of boldenone, and endurance and resistance training on liver damage in rats.
Materials and Methods: In this study, 70 male Wistar rats aged 12 weeks (weight, 228±7 g) were randomly divided into 10 equal groups: control, sham, boldenone (2 mg/kg), boldenone (5 mg/kg), resistance training, resistance training-boldenone (2 mg/kg), resistance training-boldenone (5 mg/kg), endurance training, endurance training-boldenone (2 mg/kg) and endurance training-boldenone (5 mg/kg) groups. The resistance training program included an 8-week climb from the ladder, three times a week and each session 3 sets with 5 repetitions and the endurance training program was 8-week running on treadmills, 3 days a week, every day 30 minutes at a speed of 12 meters per minute. The injection was performed in the biceps femoris muscle once a week. After anesthesia, autopsy was performed and the liver tissue was isolated for histological studies.
Results: The most liver tissue damage was observed in the boldenone group without training; so that the vacuolar degeneration more than 66% and the presence of 1-3 necrotic cells was very important. In resistance training and high-dose boldenone resistance training, liver damage was also observed as vacuolar degeneration. In the endurance training-boldenone inflammation group, increased kupffer cells and mild vacuolar degeneration were observed. Histological studies showed that endurance training reduced the vacuolar degeneration and inflammation and did not increase kupffer cells.
Conclusion: It seems that boldenone can cause damage to liver and endurance training compared with resistance training may cause more reduction in liver damage, especially reduction in the vacuolar degeneration and inflammation induced by boldenone.
Saeedeh Shadmehri, Mozhgan Ahmadi, Asieh Abbassi-Daloii, Seyed Javad Ziaolhagh, Behrooz Yahyaei,
Volume 22, Issue 5 (Bimonthly 2018)
Abstract
Background: Changes in the structure of the hippocampus play a role in the development of attention deficit hyperactivity disorder (ADHD). The aim of this study was to evaluate the motor coordination and structural changes of the hippocampus tissue in response to an 8-week aerobic training program and Ritalin consumption in hyperactive rats.
Materials and Methods: In this experimental study, 33 Wistar rats weighing 180-220g were randomly divided into 5 groups: 1) healthy control, 2) hyperactivity, 3) hyperactivity-aerobic training, 4) hyperactivity- Ritalin, and 5) hyperactivity-aerobic training-Ritalin and respond positively to the open field test. To induce ADHD in the rats, they were injected 10 mg/kg of L-NAME for 8 weeks (6 days per week) based on the weight of the rats. The drug group received 1 mg oral Ritalin per kg weight of rats daily for 8 weeks. The rats performed aerobic training 30 minutes a day and 7 days a week for 8 weeks.
Results: The results showed that aerobic training and Ritalin consumption had no significant effect on weight (P=0.877) but had a significant effect on motor coordination (P=0.001) in hyperactive rats. In rats with the hyperactivity disorder, there was a slight change in the tissue and cellular structure, necrosis and tissue hyperemia as well as piconosis of the hippocampus tissue. Treadmill training along with Ritalin consumption reduced the tissue and cellular damage, necrosis, and also piconosis of the hippocampus tissue.
Conclusion: Attention deficit hyperactivity disorder can cause the structural damage of the hippocampus tissue and treadmill exercises with Ritalin consumption may improve the damage to the hippocampal structure.
Behrooz Yahyaei, Parastoo Pourali, Tana Heidari,
Volume 24, Issue 3 (Bimonthly 2020)
Abstract
Background: Silver has long been known for its antibacterial properties. With the increasing use of silver nanoparticles in various consumer and medical products, it is necessary to check the toxicity of silver nanoparticles for the safety of users.
Materials and Methods: This study was done on the female Wistar rats. These rats were divided to 5 groups such as the control and four treatment groups. Toxic dose was determined based on IC50. For the biological nanoparticles, the non-toxic dose was 3-4 ml and the toxic dose was 6-8 ml. For the chemical nanoparticles, the non-toxic dose was 2.5 ml and the toxic dose was 5 ml. Injections were performed in the last two weeks of gestation and sampling was performed two weeks after birth. Then histological study of renal changes in the cortical and medulla and details of each area were performed by two incisions.
Results: This test was showed that the nonpoisonous of chemical nanoparticles slightly caused the hyperemia and inflammation in renal cells. Injection of poisonous chemical nanoparticles caused serious change renal tissue. In injection of poisonous and nonpoisonous biological didn't changes tubular cells but caused little changes in renal tissue.
Conclusion: The facing with the chemical silver nanoparticles during the pregnancy related to the different dosage of silver nanoparticles induced the poison in the kidney of offspring rats. Biological nanoparticles have the less effect on the renal tissue despite of the chemical ones.
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