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Showing 5 results for Valipour-Dehnou
Mohammad Fathizadeh, Vahid Valipour-Dehnou, Mohammad Fathi,
Volume 23, Issue 5 (Bimonthly 2019)
Abstract
Background: Physical Activity has a beneficial effect on blood lipids. In patients with subclinical hypothyroidism the levels of blood lipids increase. Therefore, the aim of this study was to investigate the effect of 5 month aerobic exercise training on serum lipids profile in women with subclinical hypothyroidism.
Materials and Methods: In this semi-experimental study, after obtaining written consent, 25 subclinical hypothyroidism women (age: 35.59±3.83) were divided into three groups: drug-exercise (n=8), exercise (n=7), and drug (n=10). Aerobic exercise training consisted of 3 sessions (60 min) per week for 5 months. In order to increase the intensity of training, rhythmic movements were performed with different and more complex combinations. The drug group was inactive persons who took only LT4 tablets. Serum levels of cholesterol, LDL, HDL, TG and VLDL were measured in three groups after 5 months. Data were analyzed using analysis of variance.
Results: Results showed that aerobic exercise training resulted in non-significant changes in serum levels of cholesterol (P=0.539), LDL (P=0.537), HDL (P=0.676), TG (P=0.531), VLDL (P=0.529) in subclinical hypothyroidism women.
Conclusion: According to the findings of the present study, it can be concluded that 5 months of Aerobics exercise leads to non-significant changes in serum lipid profiles in subclinical hypothyroidism women. Thus, 5 months of Aerobic exercise does not affect the improvement of serum lipid profiles in subclinical hypothyroidism women.
Saeed Kouhgardzadeh, Vahid Valipour-Dehnou, Mahdieh Molanouri-Shamsi,
Volume 26, Issue 2 (Bimonthly 2022)
Abstract
Background: High-intensity functional training is a group- and individual-based exercise which increase physical fitness, and it seems to be useful for improving the health of the elderly. Therefore, this study aimed to investigate the effect of high-intensity functional training on serum levels of cholesterol, triglyceride, HDL, LDL, ApoA-I and ApoB in elderly men and women.
Materials and Methods: In this quasi-experimental research, 23 subjects (7 males and 16 females, aged 60-88 yrs) were divided into experimental (n=16) and control (n=7) groups. The experimental group performed a high-intensity functional training protocol consisting of six exercises three sessions per week for eight weeks. The exercises were performed at all-out intensity for 30 seconds and there was 15 seconds between each set and 2 minutes rest between each exercises. To analyze the data, paired samples t-test and ANCOVA were used and the level of significance was considered as P<0.05.
Results: The results showed that in the experimental group, serum levels of LDL, cholesterol and triglyceride significantly decreased and HDL and apoA-I significantly increased (P<0.05), but in the control group, no significant change was observed in the serum levels of the variables (P>0.05). Also, the results showed a significant difference between the two groups in all variables (P<0.05) except for cholesterol (P=0.093) and ApoB (P=0.251).
Conclusion: Eight weeks of high-intensity functional training in elderly men and women improve serum levels of cardiovascular health-related factors. Therefore, high-intensity functional training is recommended at least to improve cardiovascular function in elderly men and women.
Mehrzad Shabani, Vahid Valipour-Dehnou, Mohammad Reza Tabandeh, Mahdieh Molanouri-Shamsi,
Volume 26, Issue 3 (Bimonthly 2022)
Abstract
Background: Heat shock protein 60 (HSP60) is considered as an indicator of mitochondrial stress and plays a role in modulating mitochondrial dysfunction. This study aimed to investigate the effect of aerobic endurance exercise on changes in heat shock protein 60 and insulin resistance in mice with type 2 diabetes.
Materials and Methods: Thirty adult mice were randomly and equally divided into three groups: control (C), diabetic (D) and diabetic-exercise (DE). Diabetes was induced by intraperitoneal injection of Streptozotocin. Aerobic endurance training was performed five sessions per week for eight weeks. 48 hours after the last training session, glucose, insulin and HSP60 levels and insulin resistance index were measured.
Results: Insulin and blood glucose levels and insulin resistance in group DE decreased significantly compared to group D (P<0.05). Also, HSP60 protein levels in group DE increased significantly compared to group D (P<0.05) and decreased significantly in group D compared to group C (P<0.05). Also, the results showed that there was a negative correlation between HSP60 and insulin resistance in all three groups (P= 0.001, r= 0.930).
Conclusion: Diabetes lowers HSP60 levels and aerobic endurance exercise increases its levels. Also, endurance exercise can enhance mitochondrial function in diabetes by increasing HSP60 protein expression. It improves the insulin resistance index, also.
Mehrzad Shabani, Vahid Valipour-Dehnou, Mohammad Reza Tabandeh, Mahdieh Molanouri-Shamsi,
Volume 26, Issue 4 (Bimonthly 2022)
Abstract
Background: Heat shock protein 70 (HSP70) and lon protease 1 (LONP1) are thought to be indicators of mitochondrial stress, which is essential for cell survival. This study aimed to investigate the effect of endurance exercise on changes in HSP70 and LONP1 in diabetic mice.
Materials and Methods: This study was experimental and thirty adult mice were randomly and equally divided into three groups: control (C; n=10), diabetic (D; n=10) and diabetic-exercise (DE; n=10). Diabetes was induced by intraperitoneal injection of streptozotocin. Aerobic endurance training was performed for eight weeks. 48 hours after the last training session, glucose, insulin, HSP70 levels, LONP1 levels and insulin resistance index were measured.
Results: Insulin, blood glucose levels and insulin resistance in group DE decreased significantly compared to group D (P<0.05). Also, HSP70 protein levels in group DE increased significantly compared to group D (P<0.05) and in group D compared to group C decreased significantly (P<0.05). A period of endurance training significantly increased the expression of LONP1 protein levels in DE group compared to group D (P<0.05). LONP1 protein levels in group D increased significantly compared to group C (P<0.05), also.
Conclusion: Reports show that diabetes can decreases the levels of HSP70 and increases LONP1. Also, endurance exercise can enhance impaired mitochondrial function in diabetes by increasing the expression of HSP70 and LONP1 proteins. It also improves the insulin resistance index.
Mehdi Abbasi-Moghadam, Vahid Valipour-Dehnou, Mahdieh Molanouri Shamsi,
Volume 26, Issue 6 (Bimonthly 2022)
Abstract
Background: Considering the hypoglycemic role of cysteine-rich acidic secreted protein (SPARC) and its effect on AMPK phosphorylation and GLUT4 expression, the present study aimed to investigate the effect of aerobic exercise with cinnamon extract supplementation on SPARC, AMPK and GLUT4 levels in type 2 diabetic rats.
Materials and Methods: 35 eight-week-old male Wistar rats were randomly and equally divided into five groups: control (C), diabetes (D), diabetes-supplement (DS), diabetes-exercise (DE), and diabetes-exercise-supplement (DES). The training program was performed 5 sessions per week for 8 weeks. Rats in DS and DES groups received 200 mg/kg of CE daily by gavage, and rats in C and DE groups received water during this period.
Results: Blood glucose was decreased in the DS, DE, and DES groups. SPARC, AMPK, and GLUT4 protein levels and weight significantly reduced in the D group. Also, GLUT4 levels in the DS group increased significantly. However, the SPARC, AMPK, and GLUT4 protein levels were significantly increased in both the DE and DES groups.
Conclusion: CE only increases GLUT4 but exercise increases the SPARC, AMPK, and GLUT4 in diabetic rats. However, exercise with CE have significantly greater effects on the SPARC, AMPK, and GLUT4 in diabetic rats and can be very useful in the treatment of hyperglycemia in diabetic patients.
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