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Showing 5 results for Sharafi
Akbar Ali Asgharzadeh, Ali Akbar Sharafi, Hossein Nikzad, Hasan Hashemi, Volume 2, Issue 1 (Quaterly 1998)
Abstract
History and Objectives: With popularity of MRI procedures as a diagnostics tool and various reports on its biological effects and in order to determine its effect in the range. 1.5 Tesla on mouse embryonic growth, the present study was conducted in Tarbiat Modares University and Diagnostic Imaging of Imam Khomeini hospital in 1997-1998. Materials and Methods: An experimental study was carried out on 100 pregnant Balb/c mice. They were divided into 2 groups. Each (50 pregnant mice) group was divided into five subgroups. To one group MRI radiation (1.5 Tesla) was given at the 3, 6, 9, 12 and 15 day of pregnancy. To the second group no radiation was given. The effect of radiation as to numbers of live embryo, dead embryo, absorbed and abnormal embryo was recorded. Other criteria as to the weight, length of embryo, length of right and left femur, bone volume of Tibia with Alizarin Red and Alcian Blue staining were analyzed. Determination of bone volume one day before delivery was determined. T-test and other statistical analysis was conducted on 2 groups. Results: No apparent abnormality was observed in two groups. The number of dead and absorbed embryos at the 9 and 12 embryonic day was higher in radiated group compared to the control group however the difference was statistically insignificant. At the 9 and 12 embryonic day, the weight of embryo was 30.2% and 18.1%, height of embryo 17.6% and 12.7% length of right femur 24.9% and 14% and the left femur 25.4% and 16.9% and volume of left Tibia was 32% and 23.8% of the control group. These differences were statistically significant (P<0.05), whereas for other days no significant difference was observed. Conclusion: MRI has an effect at the 9 and 12 day of mice embryonic life. Further study on the effect of MRI on human models is recommended.
Meysam Yasrebi, Ali Esteki, Ali Akbar Sharafi, Giti Torkaman, Azade Shadmehr, Volume 10, Issue 4 (Quarterly 2007)
Abstract
Background: In this experimental study, the radiographic and biomechanical characteristics of osteoperforated rabbit tibia during bone repair period were investigated. Materials and Methods: Using dental drills, 2 mm holes were drilled at the mid-shaft of right tibia in 12 New Zealand white rabbits. The left tibia was intact and selected as the control. X-rays of the left and right tibias were taken right after surgery and then every two weeks up to six weeks. Radiographic densities of the medial, central and lateral sites of the holes were measured. Every two weeks from the surgery, four of the animals were sacrificed. Tibias were removed and ultimate loads, elongations at ultimate loads, and stiffness of both right and left bones were measured. Results: Results revealed that during repair process, radiographic density of the test leg at lateral and medial sites, in contrast to the control, changed significantly (p<0.05) and reached the controls’ levels after six weeks (p>0.05). Radiographic density in the medial site of right tibia was significantly different (p<0.05) from the same site in the control leg. But, it approached the same density as that of the control leg after four weeks (p>0.05). Ultimate load, elongation at ultimate load, and stiffness were not significantly different from those of the control leg (p>0.05). Conclusion: Cancellus bone repairs faster than compact bone. Radiographic density characteristic was more sensitive to repair compared to mechanical characteristics.
Akram Ansar, Pedram Alirezaei, Sajjad Daneshyar, Bita Sharafi, Saadat Torabian, Volume 22, Issue 1 (Bimonthly 2018)
Abstract
Background: Acne vulgaris is an inflammatory skin disease. Topical retinoids with significant anti-inflammatory properties are used for treatment of acne. The common side effect of topical retinoids is local irritation. The aim of this study was to compare the efficacy and tolerability of tretinoin 0.05% and adapalene 0.1% in patients with mild to moderate acne vulgaris.
Materials and Methods: This randomized double-blind clinical trial was conducted on 50 patients referred to the dermatology clinic of Farshchian hospital in Hamadan city with mild to moderate facial acne. The patients were divided into two groups; the first group received tretinoin gel 0.05% and the second group adapalene gel 0.1%. The severity of acne was measured by Global Acne Grading System (GAGS) and tolerability was evaluated at the beginning of the trial, and 4 and 12 weeks thereafter in both groups.
Results: The mean GAGS score at the beginning of the study was 49.56 (SD=12.24) in the adapalene group and 47.76 (SD=11.34) in the tretinoin group (P=0.592). This score dropped to 35.00 (SD=11.13) in the adapalene and 25.28 (SD=8.17) in the tretinoin group in week 4 (P= 0.001). A further GAGS score decline was observed in week 12 (25.08±9.00 in the adapalene and 12.12±4.71 in the tretinoin group (P<0.001)). Regarding tolerability, there was no significant difference between the two groups at the end of weeks 4 and 12 (P=1.00 and P=0.747, respectively).
Conclusions: Adapalene 0.1% and tretinoin 0.05% are both effective and safe in treatment of mild to moderate acne vulgaris, although the tretinoin gel shows more efficacy in reducing the GAGS score. Both treatments are equally tolerated.
Samaneh Faraji, Leila Rashki Ghaleno, Mohsen Sharafi, Maryam Hezavehei, Mehdi Totonchi, Abdolhossein Shahverdi, Rouhollah Fathi, Volume 24, Issue 5 (Bimonthly 2020)
Abstract
Background: Sperm associated antigens (SPAGs) play an important role in the incidence of various cancers including breast, lung, liver, and bladder. SPAGs are also important in sperm functions, such as motility. However, it seems that sperm cryopreservation as one of the assisted reproductive techniques (ART), can affect the expression of these genes. This study aimed to evaluate the effect of freezing on the expression of human SPAG 5 and 9 in human spermatozoa.
Materials and Methods: In the present experimental study, twelve semen samples in terms of normozoospermic parameters were collected from individuals referred to the Royan Institute, and progressive motile sperms were isolated by density gradient centrifugation (DGC). Each sample was divided into two, non-frozen (control) and frozen groups. After rapid freezing and three-day storage in liquid nitrogen, samples were thawed in tap water and incubated for 2 hours of recovery-time in a CO2 incubator. RNA extraction in both groups was performed using TRIzol; and SPAG5 and 9 were evaluated by Real-time PCR technique.
Results: Based on statistical analysis, the expression of SPAG5 decreased significantly in the frozen group compared to the control group (P≤0.05); In contrast, there was no significant difference in the expression of SPAG9 between the control and frozen groups.
Conclusion: Considering the cold shock in the future of cell, a significant reduction in SPAG5 expression in the frozen group may indicate probable influences in the derived fetus.
Fatemeh Kazeminasab, Ali Bahrami Kerchi, Fatemeh Sharafifard, Nafiseh Hasanpour, Volume 28, Issue 4 (Bimothly 2024)
Abstract
Background and Aim: Vitamin D has been shown to reduce exercise-induced muscle damage and muscle soreness; however, further research is needed to establish definitive conclusions. The aim of this study was to investigate the effect of vitamin D supplementation on muscle soreness and recovery after exercise.
Methods: A systematic review and meta-analysis was conducted to evaluate the effects of vitamin D intake on muscle soreness and biochemical markers of muscle damage, including myoglobin (MB), creatine kinase (CK), lactate dehydrogenase (LDH), and inflammatory factors such as TNFα and IL-6. Data were sourced from PubMed, Scopus, and Web of Science databases up to February 2024. Analyses were performed to compare vitamin D with placebo, and weighted mean differences (WMD) were calculated.
Results: A total of 11 studies involving 358 athletes and non-athletes were examined. Changes in muscle soreness immediately after exercise due to vitamin D intake were not statistically significant [P=0.70, WMD=-0.07]. However, vitamin D significantly reduced muscle soreness 24 hours after exercise [P=0.04, WMD=-0.40]. No significant changes were observed in CK [P=0.30, WMD=-3.22 U/L], LDH [P=0.30, WMD=-11.86 U/L], or MB [P=0.50, WMD=10.66 ng/ml] immediately after exercise.
Conclusion: Vitamin D may be effective in reducing muscle soreness 24 hours post-exercise, but it does not appear to significantly affect markers of muscle damage, including CK, MB, and LDH, in the timeframes studied. Further research in this area is recommended.
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