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Showing 2 results for Kafi
Sedighe Amini Kafiabad, Ali Talebian, Zahra Ataii, Fahime Ranjbar Karmani,
Volume 9, Issue 1 (Quarterly 2005)
Abstract
Background: Hepatitis C virus (HCV) is the predominant cause of nonA-nonB and post transfusion hepatitis. This study was conducted to evaluate the efficacy of third generation Recombinant Immunoblot Assay (RIBA-3) especially structural and non-structural bands compared with Reverse Transcripatase Polymerase Chain Reactions (RT-PCR) for the diagnosis of hepatitis C infection. Materials and Methods: Sera of 80 patients with ELIAS-3 positive were analyzed by RIBA-3 and RT-PCR. Results: Forty-eight out of 80 patients were positive in RIBA-3. Of them 92% was RT-PCR positive and only 4 patients were RN negative. Among 20 samples with 4 bands, 18 (90%) were RNA positive. Among the 18, 3-bands positive, 16(88%) were RNA positive, whereas all of 11(100%) of RIBA-3 positive with anti-capsid and anti-NS3 reactivity are RNA positive. Among the RIBA-3 indeterminate cases (13 patients), HCV-RNA was positive only in 31 % (4 patients). Sera of these four patients were reactive with the core (C22) region in RIBA-3. All samples reacted to NS-4 regions were RT-PCR negative. So samples with indeterminate results in RIBA-3 should be evaluated by RT-PCR for HCV RNA. All samples without any reaction in RIBA-3 were RT-PCR negative. Conclusion: There were not absolute correlations between the results of RIBA-3 and PCR but all of RIBA-3 positvie with anti-capsid and anti-NS3 reactivity were PCR positive, but other profiles were associated with HCV viremia in about 88%-90% of cases.
Neda Kafi, Amene Barjaste Yazdi, Rambod Khajei, Mohammadreza Hoseinabadi,
Volume 27, Issue 6 (Bimonthly 2023)
Abstract
Background and Aim: Primary dysmenorrhea significantly affects the daily lives and performance of girls. This study aimed to investigate the effects of resistance training and melatonin consumption on sex hormone levels, PGF2α, FSH, LH, pain intensity, and sleep quality in girls with primary dysmenorrhea.
Methods: This semi-experimental study included 60 girls with moderate primary dysmenorrhea randomly assigned to four groups: exercise + melatonin, exercise + placebo, melatonin, and control (15 girls in each group). Participants in the exercise + melatonin group received 10 mg of melatonin daily, while the placebo group received an equivalent amount of carbohydrates. The resistance training program involved 50-60 minutes of weight training daily, three days a week for eight weeks. Pain intensity was evaluated using the McGill questionnaire, and sleep quality was assessed using the Pittsburgh questionnaire. Serum levels of sex hormones, PGF2α, FSH, and LH were also measured.
Results: The exercise + melatonin group exhibited a significant increase in estrogen (P<0.001), progesterone (P<0.001), LH (P<0.001), and FSH (P<0.001) levels compared to all other groups. Additionally, both the exercise + placebo group and the melatonin group showed higher levels of these hormones compared to the placebo group. The melatonin group demonstrated reductions in PGF2α (P<0.001), pain intensity (P<0.001), and sleep quality (P<0.001) compared to all other groups. Similar improvements were observed in the exercise + placebo group and the exercise + melatonin group compared to the placebo group.
Conclusion: The findings reveal that hypothalamic and corticotropin hormone release may play a role in primary dysmenorrhea. Melatonin appears to modulate sex hormone fluctuations associated with primary dysmenorrhea, leading to improved sleep quality and reduced pain intensity by decreasing PGF2α levels.
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