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:: Search published articles ::
Showing 7 results for Hajizadeh

Abbas Madani, Niloufar Hajizadeh, Bahar Madani,
Volume 7, Issue 3 (Quarterly 2003)
Abstract

Background : Nephrotic syndrome is one of the most common chronic renal diseases of childhood and for many years steroids are the first choice of treatment. Some children with nephrotic syndrome are steroid-dependant and some relapse frequently. Levamisole helps to maintain remission in some cases of steroid-dependant children.

Materials and methods : During this case series study, 41 children with the diagnosis of nephrotic syndrome who had referred to Children Medical Center during a 15-year period (1986-2001) were included. Levamisole was administered according to the standard protocol and its effect on number of relapses, steroid usage, remission, and also its side-effects were all determined.

Results : The study population included 28 boys and 13 girls. The mean number of relapses before levamisole was 2.48 relapse per year per patient, however, one year following levamisole administration it was significantly dropped to 0.78 (p=0.008). 19 patients remained in remission after cessation of levamisole course. We have found no drug side effects.

Conclusion : Levamisole has a positive effect on nephrotic syndrome. It is a safe drug that could be prescribed for affected patients.


Khadije Daneshjou, Ali Zamani, Niloufar Hajizadeh,
Volume 8, Issue 3 (Quarterly 2004)
Abstract

Bcakground: Cytomegalovirus (CMV) infection is quite common. This disease has different variations in clinical symptoms. The aim of this study was to identify the symptoms, diagnosis pathway and clinical variations of cytomegalovirus infection. Therefore, in a 10-year period children who were hospitalized or referred to pediatric hospitals of Tehran city were selected.

Materials and methods : This is descriptive study was performed on 41 consecutive cases. Diagnostic criteria were rising of CMV IgG-Ab titer in two separated time with two weeks interval. Tittering methods for this specific antibody was Elisa. Demographic features such as age, sex, onset of symptoms, clinical symptoms and laboratory findings were evaluated.

Results : Of 41 infected children, 71% were boys, 58.5% aged less than one year, and 92.7% had experienced the disease during their first year of life. The most common symptoms were neurological (83%), developing defect (76%), seizure (54%) and microcephalus (39%). 24.4% had positive urine culture for CMV (active disease). Hepatomegaly and splenomegaly were the most common non-neurological symptoms (29.3% and 17.1%, respectively).

Conclusions : CMV infection is a congenital infection which transmits from mother to children, so it is better that pregnant women in first trimester period and immature neonate wouldn’t been exposed to suspicious patient with CMV infection.


Tahereh Mazoochi, Mogdeh Salehnia, Mojtaba Rezazadeh Valojerdi, Sayed Javad Mowla, Ibrahim Hajizadeh,
Volume 11, Issue 1 (Quarterly 2007)
Abstract

Background: Vitrification is a simple and ultra rapid technique for the conservation of fertility. In this study, we compare the in vitro development of preantral follicles obtained from fresh specimens with vitrified- warmed mouse ovaries.

Materials and Methods: This experimental study was carried out on 20, 14-day-old female mice (NMRI). Ovaries were vitrified with a solution containing ethylene glycol, ficoll 70 and sucrose in PB1 (EGFS40) for 5 min, and transferred directly into liquid nitrogen and stored for one week. Fast warming was done by descending sucrose at room temperature. Preantral follicles with 100-130 µm in diameter were mechanically isolated from fresh and vitrified-warmed ovaries and cultured in α-minimum essential medium (α-MEM) supplemented with 5% fetal bovine serum (FBS), 100 mIU/ml rFSH, 1% ITS, and 20ng/ml mrEGF in vitro for 10 days. Diameter of follicle, and, survival rate and number of antral follicles in both groups were compared using t-test and chi-square test, respectively.

Results: Isolated follicles from the vitrified and nonvitrified groups survived and grew in vitro culture. On the day 6 survival rates in the vitrified and fresh control groups were 72.1% and 78.6%, and, on the day 10, they were 66.9% and 72.6%, respectively. Follicle antrum formation was 37.5% in the vitrified group while it was 43.5% in the fresh group in the 10th day. On the day 2, the mean diameters of fresh and vitrified follicles were 158.11 ± 11.23 and 155.48 ± 8.35 and on the day 4, they were 201.56 ± 9.87 and 193.42 ± 8.46, respectively. There was no significant difference between the control and vitrified groups in these variables (p>0.05).

Conclusion: Taken together, cryopreservation of the ovary by vitrification seems to be a promising method to preserve ovarian follicles.


Mahdi Moshki, Fazlollah Ghofranipoor, Parviz Azad Fallah, Ebrahim Hajizadeh,
Volume 12, Issue 4 (Quaterly 2009)
Abstract

Background: Mental health refers to the feeling of well-being, self-confidence, self-trust and competition capacity or having the ability to cope with adversity, intergeneration attachment and fulfilling the emotional and potential abilities. Mental health is something beyond the absence of mental disorders. The present study describes a planned program to promote mental health status among university students using self-esteem and health control beliefs from 2004 to 2007 .

Materials and Methods: The quasi experimental study was carried out on 144 students of Gonabad and Birjand Medical Universities. They were randomly divided into case (n=71) and control (n=73) groups. Data were collected through demographic questionnaires, multidimensional health locus of control (HLC) scales, Rosenberg's self-esteem and general health questionnaire-28 (GHQ-28). The educational program was based on using the self-concept, self-confidence, health locus of control and self-esteem as a focus group in which discussion method was used for 11 sessions. The questionnaires were collected and evaluated before, immediately after and 3 months after the intervention.

Results: The results showed significant differences between selected variables in the case group compared to those in the control one, before and after the intervention (p<0.05).The external components of HLC showed a significant decrease, while the internal HLC and self-esteem revealed a significant increase immediately after the intervention (P<0.0001). Besides, the students' mental health significantly increased three months after the intervention (P<0.0001).

Conclusion: The findings emphasized on enforcing, participating and improving the HLC beliefs, self-esteem and the promotion of mental health in the students following the program.
Gholam Reza Bayat, Sohrab Hajizadeh, Mohammad Javan, Fatemeh Safari, Mahdi Goodarzvand, Saeed Shokri, Khalil Pourkhalili , Firozeh Alavian ,
Volume 16, Issue 2 (Bimonthly 2012)
Abstract

Background: The anabolic androgenic steroids are known to stimulate muscle protein synthesis and hypertrophy. Cardiomyocytes have two types of ATP-sensitive potassium channels in sarcolemma (sarcKATP) and in mitochondria (mitKATP). Activation of the sarcKATP channels has been proposed to protect against ischemia-reperfusion injury. This study aimed to investigate the effect of nandrolone decanoate on the expression of sarcKATP channels in the presence and absence of exercise in rat heart.

Materials and Methods: In this experimental study, 40 adult male rats were divided into five groups: control, vehicle, ND, exercise and exercise-ND group. Rats in the exercise group were submitted to a running program on a treadmill, 5 days a week for 10 weeks. In addition, rats in the ND and exercise-ND groups received a weekly intramuscular injection of ND (10 mg/kg) for 10 weeks. Expression of the KATP channel subunits (Kir6.2 and SUR2) was determined using the Western blotting method.

Results: ND administration had no effect on the expression of sarcKATP channel subunits in the sedentary group, while the chronic exercise significantly increased the expression of KATP channel subunits (P=0.01). Moreover, the ND administration significantly decreased the Kir6.2 (P=0.001) and SUR2 (P=0.05) subunits in the exercised animals.

Conclusion: Chronic exercise and ND increases and decreases the expression of sarcKATP channels, respectively. The ND-induced expression decrement of channels is probably one of the mechanisms involved in the impairment of exercise-induced cardioprotection in rat heart.


Vahid Sobhani , Behzad Hajizadeh, Behzad Bazgir, Maryam Kazemipour , Alireza Shamsoddini, Abolfazl Shakibaey,
Volume 17, Issue 6 (Bimonthly 2014)
Abstract

Background: Omega (ω)-3 fatty acids have positive effects on different body systems such as cardiovascular, respiratory, nervous, and skeletal systems. The purpose of this study was to examine the effect of ω-3 supplementation on pulmonary function in cadets participated in army ranger training.

Materials and Methods: In this study, 41 army cadets (mean age, 18.6±‌0.9 years) were randomly allocated to the supplement (S, n=21) and placebo (P, n=20) groups. The two groups participated in army classic military training 4-5 days/week for 8 consecutive weeks. The S and P groups were asked to consume 1000 mg/day ω-3 and placebo per day for 8 weeks, respectively. Pulmonary function was assessed at the first and end of the training.

Results: Results indicated a significant difference in FEV1, FVC, MVV, FEF25-75%, FIV1 at the end of the training compared to those obtained at the beginning in both groups however, the changes were markedly greater in the S group (P≤0.05).

Conclusion: It can be concluded that the supplementation of ω-3 (1000 mg/d) can induce positive alteration in different pulmonary function indices.


Smatalsadat Mousavi, Ziya Fallahmohammadi, Akbar Hajizadeh Moghaddam,
Volume 22, Issue 6 (Bimonthly 2018)
Abstract

Background: Multiple sclerosis (MS) is a chronic inflammatory autoimmune disease and is associated with reduced physical capacity. The aim of this study was to examine the protective effect of a 6-week resistance training program and vitamin D intake on the brain neuro-inflammatory factors in female Lewis rats with experimental autoimmune encephalomyelitis (EAE).
Materials and Methods: In this experimental study, four-week-old female Lewis rats (n=48) were randomly divided into 8 groups. Resistance training protocol was performed for 6 weeks and 5 days a week. A training program was started with a load equal to 50% of the body weight of the rat. Animals in the first two sessions performed 8 to 10 repetitions (climbing the ladder) at 2-minute breaks. The rats were immunized with the guinea pig's spit and complete adjuvant. The EAE model was induced at the end of the sixth week of the exercise. Rats received 5 μg of vitamin D3 in 150 μl of sesame oil per kilogram of their body weight via intraperitoneal injection once every two days for 2 weeks.
Results: The results showed that six weeks of resistance training with vitamin D had no significant effect on granulocyte-monocyte growth factor, nuclear transcription factor kB and transforming growth factor beta (P>0.05). However, Interleukin-17 values showed a significant difference in all three levels of training (P=0.000), supplements (P=0.045), and interactive training and supplementation (P=0.043).
Conclusion: The inadequacy of the training period (frequency and intensity of exercise) and the dose rate of vitamin D3 can be one of the possible causes of ineffectiveness of the present intervention.


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