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Showing 3 results for Forouzanfar
Anahita Ebrahimian, Vahid Hemayatkhah-Jahromi , Mohsen Forouzanfar,
Volume 17, Issue 6 (Bimonthly 2014)
Abstract
Background: Fluoxetine is frequently used to treat depression. There has not been any report for the effect of fluoxetine on hormonal axis of pituitary-gonad in rats. Several studies have also shown that antidepressants have interaction with sex hormones in both sexes and women are more likely to take antidepressants than men. This study aimed to examine the effect of fluoxetine on sexual hormones in female rats. Materials and Methods: In this experimental study, 40 female rats (180-200 g and 100-120 days of age) were divided into the five groups including control, sham and three experimental (fluoxetine 5, 10 and 20 mg/kg) groups. Fluoxetine was intraperitoneally injected during four weeks. Control group did not receive any drug, but the sham group was injected with distilled water (0.18-0.2 ml/kg body weight). Levels of FSH, LH, estrogen and progesterone were measured using a blood test. Results: Results of this study showed that fluoxetine (10 or 20mg/kg) considerably reduced the estrogen and FSH levels and also fluoxetine (20mg/kg) reduced the progesterone level. However, different doses of fluoxetine did not change the LH level. Conclusion: Fluoxetine can decrease the estrogen, progesterone, FSH levels and cause oogenic defects in rats.
Zohreh Talebi-Yazdabadi, Kianoush Dormiani, Mahboobeh Forouzanfar, Liana Lachinani, Marzieh Tavalaee, Mohammad Hossein Nasr- Esfahani,
Volume 23, Issue 3 (Bimonthly 2019)
Abstract
Background: Inactivation of transcription occurs during two phases of spermatogenesis. First, in spermatocytes entering the primary meiosis and the second in round and elongating spermatids. These stages of inactivated transcription demand extensive regulation of translation. Therefore, presence of the control on gene expression during spermatogenesis seems essential. In the cases that post-transcription controlling mechanisms show an abnormal function, spermatogenesis will be impaired. RNA-binding proteins have an important effect in this phenomenon. One group of these proteins is Musashi family that plays a critical role during spermatogenesis and this study aimed to examine the role of this protein family during spermatogenesis.
Materials and Methods: This study was a review article and the selection of the papers was done using Google scholar, PubMed and Scopus databases and special key words. Then, all related English-language papers between 1994 and 2018 were considered.
Results: Several studies showed that Musashi 1 had an important role in the early stage of spermatogenesis in which spermatogonia and gonocytes proliferate, while Musashi 2 had a central role during the late stage of spermatogenesis for differentiation of spermatocytes and spermatids.
Conclusion: Musashi proteins have a critical role during spermatogenesis. Severe pathological defects were detected in transgenic models with knockdown or knockout Musashi, including sperm abnormal morphology, DNA fragmentation and low fertilization potential.
Hamed Abdollahi, Mohammad Amin Edalatmanesh, Seyed Ebrahim Hosseini, Mohsen Forouzanfar,
Volume 25, Issue 1 (Bimonthly 2021)
Abstract
Background: Utreoplacental Insufficiency (UPI) causes impaired fetal brain development and induces oxidative stress, which ultimately leads to intrauterine growth restriction. Due to the antioxidant properties of Hesperidin (HES), the study aimed to outcome this compound on cognitive impairment and serum level of catalase, antioxidant capacity of total and malondialdehyde following uterine-placental insufficiency in rats.
Materials and Methods: Thirty pregnant Wistar rats were randomly divided into 5 groups: control group, UPI+NS (Utreoplacental insufficiency+normal saline), UPI+HES25 (Utreoplacental insufficiency+Hesperidin 25 mg/kg), and UPI+HES50 (Utreoplacental insufficiency+Hesperidin 50mg/kg), UPI+HES100 (Utreoplacental insufficiency+ Hesperidin 100mg/kg). UPI was induced by obstruction of the anterior uterine arteries on day 18 of gestation. Hesperidin or normal saline gavage was performed from day 12 to 18 of gestation. Evaluation of working memory, avoidant learning and anxiety-like behaviors and then evaluation of serum levels of catalase, total antioxidant capacity and malondialdehyde content were performed in one-month-old pups.
Results: There was a significant decrease in working and avoidance memory, catalase levels, total antioxidants capacity with increased levels of anxiety and malondialdehyde in the UPI+ NS group compared to the control group (P<0.05). While in the HES-treated groups, there was a significant increase in working and avoidance memory, catalase level and total antioxidant capacity with a decrease in anxiety and malondialdehyde levels compared to the UPI+NS group (P<0.05(.
Conclusion: Hesperidin can improve memory and cognitive impairments in the model of uterine-placental insufficiency of rats by reducing oxidative stress damage.
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