Background: Active metabolites are formed during the metabolism of toxins that can damage the liver. Using plants in treatment of the liver diseases has a long history. Ginger (Zingiber officinale) and Camphor have antioxidant and disinfectant properties that in combination with nano-silver can be more effective in the prevention and treatment of the diseases.

Materials and Methods: In this study, the effects of Ginger, Camphor and Silver nanoparticles on the liver toxicity of thioacetamide was examined. Rats were divided into six groups (n=10), then the control group was treated with saline and the treatment groups with Ginger and Camphor extracts, 3000ppm dose of Silver nanoparticles and the combination of the three materials. Five mice in each group were sampled from the heart and their liver tissues isolated. The thioacetamide 50mg / kg was injected for the remaining 5 mice in each group during the two consecutive days. Blood samples were taken 48 hours after the last injection and then the liver tissues isolated. Finally, SGPT and SGOT enzymes were measured.

Results: The combination of the three materials significantly decreased the SGOT enzyme after the liver toxicity. Hepatocytes and liver tissue in this group had suffered less damage than other groups (P<0.001).

Conclusion: Ginger can have a protective effect on liver, but combination of the substances can have more protective effect.