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:: Volume 14, Issue 2 (Quaterly 2010) ::
Feyz 2010, 14(2): 99-106 Back to browse issues page
Effect of Arnebia leaf on the healing process of rat's second degree burn
Hosain Nikzad, Mohammad Ali Atlasi *, Amir Hosain Naseri Esfahani, Homayon Naderian, Mohsen Nikzad
, ma_atlasi@yahoo.com
Abstract:   (8136 Views)

Background: Regarding the current trend of turning attention towards the clinical application of herbal drugs in the healing of burn wounds, the present study was designed to evaluate the effect of Arnebia leaf on the healing process of second degree burn wounds in rat.

Materials & Methods: After the production of a second degree burn covering 10% of total body surface area on 40 adult albino rats (weighing 220±30 g.) animals were divided into 4 groups: treatment group using herbs containing Arnebia leaf treatment group using herbs containing no Arnebia leaf silver sulphadiazine (SSD) treatment group and normal saline treated group. All groups were treated and controlled once a day up to the 30th day that they decapitated for histological study of healing process (e.g. epidermal area density, blood vessel density and number in the area). Data analyses were done using one-way ANOVA and post-hoc Tukey tests.

Results: Morphometric studies showed that herbal treatment group containing Arnebia leaf compared to herbal treatment group with no Arnebia leaf and SSD group for epidermal area density had a significant lower (P<0.0001 and P<0.002, respectively) and compared to no Arnebia leaf group a significane higher number and density of blood vessels (P<0.001 and P=0.004, respectively).

Conclusion: This study shows that Arnebia leaf did not have any effect on healing of second degree burn wounds in rat's. More study were recommended for evaluating the effects of other parts of the plant on burn healing.

Keywords: Burn, Wound healing, Arnebia, Rat
Full-Text [PDF 196 kb]   (2035 Downloads)    
Type of Study: Research | Subject: General
Received: 2010/07/6 | Published: 2010/07/15
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Nikzad H, Atlasi M A, Naseri Esfahani A H, Naderian H, Nikzad M. Effect of Arnebia leaf on the healing process of rat's second degree burn . Feyz. 2010; 14 (2) :99-106
URL: http://feyz.kaums.ac.ir/article-1-912-en.html


Volume 14, Issue 2 (Quaterly 2010) Back to browse issues page
مجله علمی پژوهشی فیض ::: دانشگاه علوم پزشکی کاشان KAUMS Journal ( FEYZ )
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