:: Volume 10, Issue 4 (Quarterly 2007) ::
Feyz 2007, 10(4): 31-36 Back to browse issues page
Effect of fluvoxamine on concentration of testosterone, FSH, LH and histological changes in testis in adult male rat
Mokhtar Mokhtari *, Mehrdad Shariatie, Farnaz Tavakoli
, Mokhtar_Mokhtary@yahoo.com
Abstract:   (40521 Views)

Background: Fluvoxamine is a serotonin reuptake inhibitor,considering the importance of this drug in treating nervous disease such as obsessive-compulsive disorder, bulimia nervousa,panic disorders and depression, lts side effect on the endocrine axis are very importante. In the present research the effect of fluvoxamine on the concentrations of LH,FSH, testosterone and spermatogenesis was studied.

Materials and Methods: The experiments were done on 50 male wistar rats. The control group received nothing while the sham groups were given 0.05ml of ethanol dissolved in 0.15 ml of distilled water. The experimental group was injected 15, 30, 60mg/kg of drug intraperitoneally for 14 days. Blood samples were taken at 14th day and concentrations of lutein hormone (LH), follicle stimulating hormone (FSH) and testosterone were measured by RIA method. In addition, at the 14th day the testis was separated and histological changes were studied among experimental, control and sham groups. The results were evaluated using ANOVA and Duncan test.

Results: The results indicated that the concentration of testosterone significantly decreas at high doses of fluvoxamine in comparison to the control group. No significant change was observed in the concentration of LH and FSH in experimental groups. Spermatogenesis chain did not show significant difference in the experimental group compared with the control group.

Conclusion: According to our findin's fluvoxamine may decreases the concentration of testosterone through lowering LH receptors in leydig cells.

Keywords: Fluvoxamine, Testosterone, FSH, LH, Testes, Rat
Full-Text [PDF 376 kb]   (42786 Downloads)    
Type of Study: Research | Subject: General
Received: 2008/10/27 | Published: 2007/01/15

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Volume 10, Issue 4 (Quarterly 2007) Back to browse issues page