Effect of zinc supplement on the complications of gestational diabetes
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Mitra Behrashi * , Fateme Froozanfard , Akbar Aliasgharzade , Sayed gholam Abbas Mousavi  |
, dr_behrashi2006@yahoo.com |
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Abstract: (11690 Views) |
Background: Diabetes, especially the gestational diabetes with its special fetal and maternal disorders, is the most common complication of pregnancy. Both gestational and type II diabetes mellitus are along with a disturbances to insulin secretion as well as insulin resistance. Considering the significant role of zinc in insulin function, the deficiency and importance of this element in gestational diabetes is a matter of consideration. Materials and Methods: This clinical trial was carried out on 60 pregnants suffering from gestational diabetes, and needing insulin injection from 32nd week to full-term. The patients were divided into two groups the case group (n=30), received daily zinc sulfate (25mg or 5cc) plus insulin and control group (n=30) received daily placebo (5 cc as syrup) plus insulin until the time of delivery. The required insulin dose was regulated through monitoring fasting blood sugar and blood sugar, 2 h postprandial, every two weeks in both groups. These groups were compared in terms of required insulin dose and maternal/fetal complications. Data were analyzed using t-test, OR, CI, Fisher Exact test, Kolmogorov-Smirnov and Chi-Square tests. Results: The required dose of insulin had a significant decrease in the case group compared to the control one (p<0.001). However, the mean change in insulin dose in the case and control group compared to the beginning of study was 8.766 (SD:9.63) and 17.533 (SD: 10.54), respectively. The incidence of macrosomia in the case and control groups was significant (P<0.01). The odds ratio of control group compared to the case group was 7. The preeclampsia prevalence in both groups was not significant. Conclusion: Zinc supplementation in gestational diabetes may lead to the reduction of required insulin dose, incidence of macrosomia and the related complications (e.g., caesarian and delivery dystocia). |
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Keywords: Gestational diabetes, Zinc supplement, Macrosomia |
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Full-Text [PDF 229 kb]
(2459 Downloads)
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Type of Study: Research |
Subject:
General Received: 2009/05/5 | Revised: 2009/05/9 | Published: 2009/01/15
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