History and Objectives: Considering the prevalence of thyroid cancer in nodular goiter patients and the prevalence of goiter in Kashan’s region specially in the mountain area and various reports about cancer in this type of patients, this investigation was conducted to determine the prevalence of thyroid cancer in nodular goiter patients operated in at Kashan Naghavi hospital during 1983 to 1987.
Materials and Methods: This research was conducted by using the existing data about all the patients who were diagnosed with nodular goiter and went under surgery. The characteristics of the patients such as age, sex, duration of having goiter, kind of goiter, types of surgery and pathological diagnosis were extracted from the patients, files and were recorded of analysis.
Results: From total of 130 patients identified with nodular goiter and surgery operation, 12 patients (9.2%) had cancer. The prevalence of thyroid cancer for women was five times more than men. The types of cancer included 91.7% papillar and 8.3% follicular type, consecutively.
Conclusion: Considering the noticeable prevalence of thyroid cancer among the nodular goiter, proper diagnosis and prompt treatment this disease plays an important role in survival and life condition of the patients. In addition, FNA is definitely recommended and in cases that there is certainly or even suspicion about cancer, surgery must be performed. Decrement of a cold single nodule treated by thyroxin necessarily is no indication of absence of cancer. In addition, since papillar type cancer has various cystic form, consequently not all thyroid cysts are always benign. All the cysts that recur immediately after FNA even with the negative cytology report and also any nodule with the negative FNA, which is clinically suspect, must undergo surgery.