History and Objectives: Since several reports of this rare disease has been published and it has limited and benign characteristics and after one or two months it reverts into normality and frequently is mistaken on the basis of pathologic and clinical findings with malignant lymphoma and infectious mononucleosis, the present case is reported from department of internal medicine of Shaheed Beheshti hospital in Kashan in 1995. First report of this disease was given by Kikuchi 26 year ago and since then 23 other papers had been published and 74 cases for 1980 to 1998 has been recorded in Medline and etiological basis of the disease and diagnosis have been offered. Five years ago a similar report was publish in Journal of Babol Medical University. An 11-year-old girl from Aran with complains and sign of malignant lymphoma was admitted. Infectious mononucleosis, toxoplasmosis and SLE was considered in the differential diagnosis of the disease. However final diagnosis of Kikuchi was offered on the basis of excisional biopsy of lymphatic nodes of neck and its pathological characteristics.

Results: Although kikuchi disease is benign and is due to rare incidence of FLO, however, early diagnosis will reduce unnecessary examination and false treatments.