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The Effect of a Combined Exercise Program on Anthropometric Indices and Its Association with Serum Albumin Levels as a Marker of Muscle Atrophy in Patients with Type 2 Diabetes
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Sajjad Ramezani    , Reza Farzizadeh * , Farnaz Seifi – asgshahr , Afsaneh Talaei |
| Department of Exercise Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran , r_farzizadeh@uma.ac.ir |
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Abstract: (52 Views) |
Introduction: Serum Albumin, the most abundant protein in plasma, is synthesized by hepatic parenchymal cells and has been associated with T2DM and muscle atrophy. However, engagement in physical exercise appears to improve diabetes-related indices and body composition through various physiological pathways. Therefore, the present study aimed to investigate the effect of an 8-week combined training program on anthropometric indices and their association with serum albumin levels—as a marker of muscle atrophy—in patients with type 2 diabetes.
Methods: In this quasi-experimental study, 29 women with type 2 diabetes (mean age 47.75±3.19) participated. After reviewing their medical records and meeting inclusion criteria, they were randomly assigned to two groups: combined exercise (CT) and control (CO). The combined exercise group performed the selected exercises for 8 weeks, 3 days a week. Venous blood samples were collected by a laboratory specialist before and after the intervention period, and serum albumin concentrations were measured using human ELISA kits. Data were analyzed using the Shapiro-Wilk test, Levene’s test, and independent/paired t-tests in SPSS version 26.
Results: The results showed that combined exercises increased serum albumin levels (P<0.001) and muscle mass (SMM) (P<0.003) significantly after combined exercises. Body Fat mass (FMS) and body composition (BMI) (P<0.001) in the exercise group were significantly lower than those in the control group (P<0.01). However, no significant correlation was observed between serum albumin and SMM (P<0.05, r=0.0466), FMS (P<0.05, r=0.10), and BMI (P<0.05, r=0.0253).
Conclusion: The results of the present study showed that combined exercises improve muscle mass indices, fat percentage, and BMI, and increase serum albumin levels in patients with type 2 diabetes. However, given the lack of correlation between albumin and body composition indices, further studies are needed to diagnose muscle atrophy in patients with diabetes.
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| Keywords: Combined training, Atrophy, Serum Albumin, Body composition, Type 2 diabetes mellitus |
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Type of Study: Research |
Subject:
General
Received: 2025/12/2 | Revised: 2026/04/22 | Accepted: 2026/04/7
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