The effect of a resistance training program and olive oil consumption on the expression of caspase-9, -8, and -3 genes in the hippocampal tissue of male rats with induced Alzheimer’s disease

Haghshenas, Mostafa; Elmiyeh, Alireza; Fadaei chafi, Mohammadreza

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The effect of a resistance training program and olive oil consumption on the expression of caspase-9, -8, and -3 genes in the hippocampal tissue of male rats with induced Alzheimer’s disease

Mostafa Haghshenas

, Alireza Elmiyeh ^*

, Mohammadreza Fadaei chafi

Department of Physical Education and Sports Sciences, Faculty of Humanities, Rasht Branch, Islamic Azad University, Rasht, Iran , elmieh@iaurasht.ac.ir

Abstract: (376 Views)

Background and Aim: The hallmark pathological features of Alzheimer’s disease include the formation of extracellular beta-amyloid plaques and intracellular neurofibrillary tangles. The present study aimed to investigate the effects of resistance training combined with olive oil consumption on the expression of caspase-3, -8, and -9 genes in male rats with experimentally induced Alzheimer’s disease.
Methods: In this experimental study, 32 adult male rats were randomly divided into four groups of Alzheimer’s-induced rats. The Alzheimer’s model was established via intrahippocampal injection of beta-amyloid 1–42. Resistance training consisted of three sessions per week for eight weeks. Gene expression levels were measured using real-time PCR. Data were analyzed using one-way ANOVA, followed by Tukey’s post hoc test.
Results: After eight weeks of resistance training, the expression of caspase-9, -8, and -3 genes in the intervention groups showed a significant reduction compared to the Alzheimer’s group (P<0.05). Moreover, the Alzheimer’s + resistance training group and the Alzheimer’s + resistance training + olive oil group exhibited a significant decrease in gene expression compared to the Alzheimer’s + olive oil group (P<0.05).
Conclusion: Resistance training combined with olive oil consumption appears to improve apoptotic factors in male rats with induced Alzheimer’s disease. Further research in this area is warranted.

Keywords: Resistance training, Olive oil, Caspase, Alzheimer’s disease

Type of Study: Research | Subject: medicine, paraclinic
Received: 2025/01/16 | Revised: 2025/06/29 | Accepted: 2025/04/21

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