|
The effect of eight weeks of resistance training with the consumption of Tribulus terrestris on oxidative stress markers and pro-inflammatory cytokines in heart tissue of rats exposed to anabolic steroids
|
Mojtaba Shojaeyan *    , Bahram Abedi , Sayed Ali Hosine |
| Department of Physical Education and Sports Sciences, Mahallat Branch, Islamic Azad University, Mahallat, Iran , sahinshojaei2843@gmail.com |
|
|
Abstract: (53 Views) |
Background and Objective: Today, energizing substances pose a complex issue in sports. Meanwhile, resistance training and Tribulus Terrestris greatly impact oxidative stress and inflammation. However, the combined effect of resistance training and milk thistle on these capacities has been less studied. This study aimed to investigate their effect on oxidative stress and pro-inflammatory cytokines in male rats' heart tissue exposed to stanazol.
Materials and Methods: In this experimental study, 48 large male rats with a weight range of 150 to 200 grams and an average age of 8 weeks were selected and randomly divided into 8 groups of 6 series including 1) control (C), 2). sham (Sh), 3) use of stanazol (S), 4) use of stanazol with 100 mg/kg of Tribulus Terrestris (ST100), 5) use of Stanazol with 50 mg/kg of Tribulus Terrestris (ST50), 6) use of Stanazol with resistance training (SRT), 7) use of Stanazol with resistance training and 100 mg/kg of Tribulus Terrestris (SRTT100) and 8) use of Stanazol with training Resistance and 50 mg/kg of Tribulus Terrestris (SRTT50). For eight weeks, the 3-8 groups received 5 mg/kg daily of stanazole peritoneally; Groups 6-8 performed resistance training three sessions per week, and groups 4, 5, 7, and 8 received certain doses of Tribulus Terrestris daily. The amount of TNF-α, IL-10, and the ratio of TNF-α/IL-10 were measured by the Real-Time PCR method in the hearts of rats. To analyze the findings, a one-way analysis of variance was used with Tukey's post hoc test (p<0.05).
Findings: S consumption significantly affected the increase of AOPP, MDA, and the decrease of IL-10 in the heart tissue of rats (P<0.05). However, SRT significantly increased IL-10 and decreased AOPP and MDA (P<0.05). Also, SRTT100 and SRTT50 significantly affected the increase of IL-10 and the decrease of MDA and AOPP (P<0.05). In SRTT100 groups, IL-10 levels were higher and MDA was lower than in SRT, and SRTT50 groups, but there was no significant difference in AOPP.
Conclusion: It seems that resistance training and consumption of Tribulus Terrestris extract with a higher dose separately affect the improvement of stress and heart tissue parameters. However, to draw better conclusions in connection with performing resistance exercises and consuming Tribulus Terrestris extract, more research is needed on the expression of the gene indicators in heart tissue from stanazol poisoning.
|
|
| Keywords: Resistance training, Heart, Stanazol, Tribulus terrestris MDA, AOPP, IL-10 |
|
|
|
Type of Study: Research |
Subject:
General
Received: 2024/04/22 | Revised: 2024/11/10 | Accepted: 2024/11/10
|
|
|
|
|
|
|
| Send email to the article author |
|
|
|
| Add your comments about this article |
|
|
|
.png)
.png){kind=logo}
