1. Galicia-Garcia U, Benito-Vicente A, Jebari S, Larrea-Sebal A, Siddiqi H, Uribe KB, et al. Pathophysiology of type 2 diabetes mellitus. Int J Mol Sci. 2020; 21(17):6275. doi:10.3390/ijms21176275 PMid:32872570 PMCid:PMC7503727

2. Padhi S, Nayak AK, Behera A. Type II diabetes mellitus: a review on recent drug based therapeutics. Biomed Pharmacother. 2020;131:110708.doi:10.1016/j.biopha.2020.110708 PMid:32927252

3. Artasensi A, Pedretti A, Vistoli G, Fumagalli L. Type 2 diabetes mellitus: a review of multi-target drugs. Molecules. 2020;25(8):1987 doi:10.3390/molecules25081987 PMid:32340373 PMCid:PMC7221535

4. Aitken N, Smith S, Schwarz C, Morin PA. Single nucleotide polymorphism (SNP) discovery in mammals: a targeted‐gene approach. Mol Ecol. 2004; 13(6):1423-31. doi:10.1111/j.1365-294X.2004.02159.x PMid:15140087

5. Humphries AD, Streimann IC, Stojanovski D, Johnston AJ, Yano M, Hoogenraad NJ, et al. Dissection of the mitochondrial import and assembly pathway for human Tom40. J Biol Chem. 2005; 280(12):11535-43. doi:10.1074/jbc.M413816200 PMid:15644312

6. Valant V, Keenan BT, Anderson CD, Shulman JM, Devan WJ, Ayres AM, et al. TOMM40 in cerebral amyloid angiopathy related intracerebral hemorrhage: comparative genetic analysis with Alzheimer's disease. Translational stroke res. 2012;3: 102-12. doi:10.1007/s12975-012-0161-1 PMid:24323865 PMCid:PMC4054941

7. Ferencz B, Karlsson S, Kalpouzos G. Promising genetic biomarkers of preclinical Alzheimer's disease: the influence of APOE and TOMM40 on brain integrity. Int J Alzheimer's Dis. 2012;2012 doi:10.1155/2012/421452 PMid:22550605 PMCid:PMC3328927

8. Cui B, Zhu X, Xu M, Guo T, Zhu D, Chen G, et al. A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese. PloS one. 2011;6(7):e22353. doi:10.1371/journal.pone.0022353 PMid:21799836 PMCid:PMC3142153

9. Peuget S, Bonacci T, Soubeyran P, Iovanna J, Dusetti N. Oxidative stress-induced p53 activity is enhanced by a redox-sensitive TP53INP1 SUMOylation. Cell Death Differentiation. 2014;21(7):1107-18 doi:10.1038/cdd.2014.28 PMid:24608790 PMCid:PMC4207477

10. MWer S, Dykes D, Polesky H. A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic acids Res. 1988;16(3):1215 doi:10.1093/nar/16.3.1215 PMid:3344216 PMCid:PMC334765

11. Linjawi S, Al-Gaithy Z, Sindi S, Hamdi N, Linjawi A, Alrofidi A. Tetra-primer ARMS PCR as an efficient alternative for SNPs detection in molecular diagnostic: A comparison study. Eur J Pharm Med Res. 2019;6:91-6.

12. Mesrian Tanha H, Mojtabavi Naeini M, Rahgozar S, Rasa SMM, Vallian S. Modified tetra-primer ARMS PCR as a single-nucleotide polymorphism genotyping tool. Genet testing mol biomarkers. 2015; 19(3):156-61 doi:10.1089/gtmb.2014.0289 PMid:25658900

13. Linjawi S, Al-Gaithy Z, Sindi S, Hamdi N, Linjawi A, Alrofidi A. Tetra-primer ARMS PCR as an efficient alternative for SNPs detection in molecular diagnostic: a comparison study. EJPMR. 2019;6:91-6.

14. Karki R, Pandya D, Elston RC, Ferlini C. Defining "mutation" and "polymorphism" in the era of personal genomics. BMC med genomics. 2015;8 (1):1-7 doi:10.1186/s12920-015-0115-z PMid:26173390 PMCid:PMC4502642

15. 15. Tian XP, Ma SY, Young KH, Ong CK, Liu YH, Li ZH, et al. A composite single-nucleotide polymorphism prediction signature for extranodal natural killer/T-cell lymphoma. Blood. 2021; 138 (6):452-63 doi:10.1182/blood.2020010637 PMid:33728448

16. Radovica I, Fridmanis D, Silamikelis I, Nikitina-Zake L, Klovins J. Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population. Meta Gene. 2014;2:565-78 doi:10.1016/j.mgene.2014.07.006 PMid:25606439 PMCid:PMC4287865

17. Schulze MB, Rimm EB, Shai I, Rifai N, Hu FB. Relationship between adiponectin and glycemic control, blood lipids, and inflammatory markers in men with type 2 diabetes. Diabet care. 2004;27 (7):1680-7 doi:10.2337/diacare.27.7.1680 PMid:15220246

18. Kulminski AM, Loika Y, Culminskaya I, Huang J, Arbeev KG, Bagley O, et al. Independent associations of TOMM40 and APOE variants with body mass index. Aging Cell. 2019;18(1):e12869 doi:10.1111/acel.12869 PMid:30462377 PMCid:PMC6351823

19. Middelberg RP, Ferreira MA, Henders AK, Heath AC, Madden PA, Montgomery GW, et al. Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits. BMC Med Genetics. 2011;12:1-9 doi:10.1186/1471-2350-12-123 PMid:21943158 PMCid:PMC3189113

20. Soyal SM, Kwik M, Kalev O, Lenz S, Zara G, Strasser P, et al. A TOMM40/APOE allele encoding APOE‐E3 predicts high likelihood of late‐onset Alzheimer's disease in autopsy cases. Mol Genetics Genomic Med. 2020;8(8):e1317 doi:10.1002/mgg3.1317 PMid:32472747 PMCid:PMC7434743

21. Wang XF, Lin X, Li DY, Zhou R, Greenbaum J, Chen YC, et al. Linking Alzheimer's disease and type 2 diabetes: Novel shared susceptibility genes detected by cFDR approach. J neurol sci. 2017; 380: 262-72. doi:10.1016/j.jns.2017.07.044 PMid:28870582 PMCid:PMC6693589

22. Gui W, Qiu C, Shao Q, Li J. Associations of vascular risk factors, APOE and TOMM40 polymorphisms with cognitive function in dementia-free Chinese older adults: a community-based study. Frontiers in Psychiatry. 2021; 12: 617773. doi:10.3389/fpsyt.2021.617773 PMid:33790814 PMCid:PMC8005534

23. Chen S, Sarasua SM, Davis NJ, DeLuca JM, Boccuto L, Thielke SM, et al. TOMM40 genetic variants associated with healthy aging and longevity: a systematic review. BMC Geriatrics. 2022;22(1): 667 doi:10.1186/s12877-022-03337-4 PMid:35964003 PMCid:PMC9375314

24. Yamase Y, Horibe H, Ueyama C, Fujimaki T, Oguri M, Kato K, et al. Association of TOMM40 and SLC22A4 polymorphisms with ischemic stroke. Biomed Reports. 2015;3(4):491-8. doi:10.3892/br.2015.457 PMid:26171154 PMCid:PMC4487021

25. Omoumi A, Fok A, Greenwood T, Sadovnick AD, Feldman HH, Hsiung G-YR. Evaluation of late-onset Alzheimer disease genetic susceptibility risks in a Canadian population. Neurobiol Aging. 2014;35(4): 936. e5e12. doi:10.1016/j.neurobiolaging.2013.09.025 PMid:24176626

26. Liu X, Yue C, Xu Z, Shu H, Pu M, Yu H, et al. Association study of candidate gene polymorphisms with amnestic mild cognitive impairment in a Chinese population. PLoS One. 2012;7(7):e41198. doi:10.1371/journal.pone.0041198 PMid:22911757 PMCid:PMC3401144

27. Bocharova A, Vagaitseva K, Marusin A, Zhukova N, Zhukova I, Minaycheva L, et al. Association and Gene-Gene Interactions Study of Late-Onset Alzheimer's Disease in the Russian Population. Genes. 2021;12(10):1647 doi:10.3390/genes12101647 PMid:34681041 PMCid:PMC8535278

28. Bao J, Wang XJ, Mao ZF. Associations between genetic variants in 19p13 and 19q13 regions and susceptibility to Alzheimer disease: A meta-analysis. Medical science monitor: Int Med J Exp Clin Res. 2016; 22:234 doi:10.12659/MSM.895622 PMid:26795201 PMCid:PMC4727495

29. Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ, et al. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003;348(12):1170-5.doi:10.1056/NEJMsb025007 PMid:12646676

30. Bendlin BB. Antidiabetic therapies and Alzheimer disease. Dialogues in clinical neuroscience. 2022.

31. Roses A, Sundseth S, Saunders A, Gottschalk W, Burns D, Lutz M. Understanding the genetics of APOE and TOMM40 and role of mitochondrial structure and function in clinical pharmacology of Alzheimer's disease. Alzheimer's Dementia. 2016;12 (6):687-94 doi:10.1016/j.jalz.2016.03.015 PMid:27154058

32. Su M, Naderi K, Samson N, Youssef I, Fülöp L, Bozso Z, et al. Mechanisms associated with type 2 diabetes as a risk factor for Alzheimer-related pathology. Mol Neurobiol 2019;56:5815-34 doi:10.1007/s12035-019-1475-8 PMid:30684218