History and Objectives: Kawasaki disease is the most common vasculitis in childhood and its most serious manifestation is cardiac. Considering the progressive number of patients with Kawasaki disease and in order to define the characteristics of 21 patients with Kawasaki, this study was performed on the referrers to the pediatric ward of Shaheed Beheshti hospital of Kashan during the years 1375 to 1377.

Material and Methods: This study was performed by descriptive method on the hospitalized patients and the diagnosis was established in the presence of 5 criteria from the 6 clinical criteria. Age, sex, clinical and paraclinical changes of the patients and the seasonal prevalence of the disease were evaluated and recorded.

Results: From the 21 patients, 7 cases were female and 14 were male, aged 38.9±24 months and male to female ratio was 2 to 1. Clinical manifestations such as fever and oral mucosal changes were present in 100%, conjunctivitis in 95%, rashes in 91%, changes in hands and feet in 71%, lymphadenopathy in 67% and diarrhea in 43% of cases. Laboratory findings such as abnormal ESR in 91%, leukocytosis in 81%, thrombocytosis in 71%, pyuria in 43% and increased SGPT in 14% of the studied patients. One third of patients were affected in the winter.

Conclusion: The disease is present in our country and diagnostic work up is especially suggested in cases with prolonged fever unresponsive to antibiotics or children with sterile pyuria or unexplained increase in liver enzymes, since the findings of Kawasaki disease particularly its clinical manifestations are in common with many other diseases.