History and Objective: Due to the variety of pathologic lesions of appendix and its unknown status is Kashan and in order to define the types of the pathologic lesions and their relationship with sex and age and detecting the positive cases, this study was performed on the specimens received by the word of pathology of Kashan University of Medical Sciences from 1372 to 1374.

Materials and Methods: The present study was performed by existing data method on all of the received specimens. Patient’s records were drawn out from the archive of the ward and those with the clinical diagnosis of appendicitis were enrolled into the study if their sex ad age were also recorded. The lesions were classified into seven independent groups and their relationship with age and sex were evaluated and presented by descriptive statistics.

Results: From the 522 patients, 506 had complete information. 281 cases (55.5%) were female and 225 (44.5%) were male with the age of 27.2±13.6 years. From the 449 patients undergone surgery with the clinical diagnosis of appendicitis, 332 (79.2%) had positive results on pathological examination and 87 cases (20.8%) had negative results. The most common lesions were acute suppurative appendicitis (31.2%) and acute appendicitis (32%). Follicular hyperplasia was observed in 25% of cases. Appendix was normal in 10% of subjects.

Conclusion: Appendectomy is more commonly performed in women than men. Appendicitis is more common in the third decade of life. Acute suppurative appendicitis, which was the most common pathological diagnosis, was more frequently observed among men. Correct diagnosis was observed in 79.2% of the patients with the clinical diagnosis of appendicitis. Negative results on pathological examination are more commonly observed among women, which are due to the special diseases that are mistaken with acute appendicitis.