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:: دوره 27، شماره 5 - ( دوماه نامه 1402 ) ::
جلد 27 شماره 5 صفحات 578-566 برگشت به فهرست نسخه ها
اندومتریوز و نقش بالقوه بیومارکرها در تشخیص و درمان آن: مطالعه مروری روایتی
سید علیرضا میرابوطالبی ، محمود دهقانی اشکذری* ، سید مرتضی سیفتی
گروه زیست شناسی، مرکز تحقیقات زیست فناوری پزشکی، واحد اشکذر، دانشگاه آزاد اسلامی، اشکذر، یزد، ایران ، mdashkezary@yahoo.com
چکیده:   (939 مشاهده)
ضایعاتی که از بافت آندومتر در اندام‌های خارج رحمی مانند صفاق لگن، تخمدان‌ها و روده‌ها منشأ می‌گیرد، اندومتریوز نامیده می‌شود. این شرایط که در ارتباط با ناباروری است، در بیشتر خانم‌ها با درد مزمن همراه است. اگرچه علت دقیق این عارضه هنوز بطور کامل مشخص نشده اما عوامل ایمونولوژیکی، هورمونی و نورولوژیکی در مکانیسم های ایجادکننده علائم آن دخیل هستند. روش استاندارد طلایی برای تشخیص این بیماری، لاپاروسکوپی است که به‌دلیل تهاجمی بودن آن، تشخیص این بیماری را به‌طور متوسط 11-7 سال به‌تاخیر می‌اندازد که ممکن است عواقب جبران ناپذیری را به دنبال داشته باشد. بنابراین، همواره نیاز به بیومارکرهای غیرتهاجمی برای تشخیص زودهنگام بیماری وجود دارد. در مطالعه مروری حاضر به ارزش تشخیصی miR ها در اندومتریوز پرداخته شد. بیان تعدادی از miR ها در بافت و سرم بیماران مبتلا به آندومتریوز به دلایل مختلفی افزایش می‌یابد، که بررسی سریع این بیومارکرها می‌تواند با جلوگیری از عوارض آسیب زا، به تشخیص زودهنگام و غیرتهاجمی این بیماری کمک کند. در مجموع، شناسایی ژن‌هایی که با بیماری اندومتریوز در ارتباط هستند اگرچه دشوار است اما می‌تواند در تشخیص و پیش‌آگهی و مدیریت درمان این بیماری بسیار کمک کننده باشد.
در این مطالعه مروری روایتی، در ابتدا، طبقه‌بندی و بررسی علائم بالینی و همچنین فرضیه‌های موجود در مورد علت آندومتریوز بررسی می‌شود و در نهایت انواع بیومارکرهایی که دارای حساسیت و ویژگی‌های قابل قبولی برای تشخیص آندومتریوز هستند، معرفی می‌گردند.
واژه‌های کلیدی: آندومتریوز، بیومارکرها، ژنتیک، تخمدان‌، هورمون‌
متن کامل [PDF 568 kb]   (613 دریافت)    
نوع مطالعه: مروري | موضوع مقاله: medicine, paraclinic
دریافت: 1401/10/16 | ویرایش نهایی: 1402/9/28 | پذیرش: 1402/8/27 | انتشار: 1402/9/19
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Miraboutalebi S A, Dehghani Ashkezari M, Seifati S M. Endometriosis and the potential role of biomarkers in its diagnosis and treatment: A narrative review. Feyz Med Sci J 2023; 27 (5) :566-578
URL: http://feyz.kaums.ac.ir/article-1-4786-fa.html

میرابوطالبی سید علیرضا، دهقانی اشکذری محمود، سیفتی سید مرتضی. اندومتریوز و نقش بالقوه بیومارکرها در تشخیص و درمان آن: مطالعه مروری روایتی. مجله علوم پزشکی فيض. 1402; 27 (5) :566-578

URL: http://feyz.kaums.ac.ir/article-1-4786-fa.html



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