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:: Volume 27, Issue 1 (Bimonthly 2023) ::
Feyz 2023, 27(1): 61-66 Back to browse issues page
Investigation the concentration of interleukin-6, interleukin-10, and vitamin D in diabetic patients with covid-19 hospitalized in the intensive care unit
Farnaz Seifi-Skishahr , Maghsoud Nabilpour
Department of Sports Physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh Ardabili, Ardabil, I.R. Iran. , f.seify@yahoo.com
Abstract:   (773 Views)
Background: Anti-cytokine considerations and other treatments in covid-19 patients with a history of diabetes can play an important role in preventing mortality. Therefore, the aim of this study was to investigation the concentration of IL-6, IL-10, and vitamin D in diabetic patients with covid-19 hospitalized in the intensive care unit.
Materials and Methods: The statistical population of this research was all diabetic patients with covid-19 hospitalized in the special care department. 16 of them were selected as a statistical sample by the census. Cytokines were measured using a special kit for IL-6 and IL-10 based on the manufacturer's instructions, using the ELISA method. A level above 30 ng/dL of vitamin D was considered as a sufficient level, and a level below that was considered as an insufficient and deficient level. Independent t-test was used to compare two groups. In addition, to reveal the effect size in the independent test, Cohen's D effect sizes were calculated for each group. The significance level of all statistical operations was determined by SPSS at the P≤0.05 level. Graphs were drawn using Graph Pad Prism 9.
Results: All diabetic patients infected with covid-19 suffered from vitamin D deficiency levels so, the level of vitamin D was between 10 and 20 ng/dl in all of them. Also, the results showed that the levels of both IL-6, IL-10 increased significantly in patients admitted to the intensive care unit compared to healthy individuals (P≤0.05).
Conclusion: It seems that measuring the level of IL-6, IL-10, and their ratio along with vitamin D can be used as a useful predictor to diagnosing special care measures in diabetic patients with covid-19.
Keywords: Diabetes, Coronavirus, Cytokine, Interleukin, Vitamin D
Full-Text [PDF 329 kb]   (509 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2022/08/3 | Revised: 2023/07/25 | Accepted: 2023/01/2 | Published: 2023/04/5
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Seifi-Skishahr F, Nabilpour M. Investigation the concentration of interleukin-6, interleukin-10, and vitamin D in diabetic patients with covid-19 hospitalized in the intensive care unit. Feyz 2023; 27 (1) :61-66
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Volume 27, Issue 1 (Bimonthly 2023) Back to browse issues page
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