[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Indexing Sources::
Guide for Authors::
Online Submission::
Ethics::
Articles archive::
For Reviewers::
Contact us::
::
Basic and Clinical Biochemistry and Nutrition
..
DOAJ
..
CINAHL
..
EBSCO
..
IMEMR
..
ISC
..
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
enamad
..
:: Volume 26, Issue 3 (Bimonthly 2022) ::
Feyz 2022, 26(3): 256-263 Back to browse issues page
The effect of eight weeks of moderate intensity aerobic exercise with Resveratrol supplementation on vascular adhesion molecules (VCAM-1 and ICAM-1) and tumor necrosis factor alpha (TNF-α) in the heart tissue of male rats with type 2 diabetes
Zahra Mahzoon , Sanaz Mirzayan Shanjani , Yaser Kazemzadeh
Department of Exercise Physiology, Islamshahr Branch, Islamic Azad University, Islamshahr, I.R. Iran. , san_mir2000@yahoo.com
Abstract:   (768 Views)
Background: this study aimed to evaluate the effect of eight weeks of moderate intensity aerobic exercise with Resveratrol supplementation on vascular adhesion molecules (VCAM-1 and ICAM-1) and tumor necrosis factor alpha (TNF-α) in the heart tissue of male rats with type 2 diabetes.
Materials and Methods: The present study was experimental. Statistical samples included 2-month-old male rats weighing 270-230 g. Rats were divided into 5 groups of 6 after familiarity with training protocols; Healthy control, diabetic control (Streptozocin), diabetes supplement, diabetic exercise and exercise + diabetic supplement. 9 mg / kg Resveratrol was given daily to each rat. The study lasted eight weeks.
Results: The amount of TNF-α in the exercise + diabetic supplement group was significantly reduced compared to the diabetic control group (P=0.001), and in the exercise + diabetic supplement group was significantly reduced compared to the diabetic exercise group (P= 0.001). The levels of ICAM-1 and VCAM-1 in the exercise + diabetic supplement group were significantly reduced compared to the diabetic control group (P=0.001). The level of ICAM-1 in the diabetic exercise + diabetic supplement group was significantly reduced compared to the diabetic supplement group and the diabetic exercise group, and the level of VCAM-1 in the exercise + diabetic supplement group was significantly reduced compared to the diabetic supplement group (P=0.001).
Conclusion: The results showed that diabetes increases TNF-α, ICAM-1 and VCAM-1, but exercise and Resveratrol reduce it. Also, a combination of exercise and Resveratrol can lead to better effects.
Keywords: Resveratrol, Exercise, TNF-α, ICAM-1 and VCAM-1
Full-Text [PDF 402 kb]   (454 Downloads)    
Type of Study: Research | Subject: General
Received: 2022/04/27 | Revised: 2022/07/30 | Accepted: 2022/07/11 | Published: 2022/07/30
References
1. Liu C, Feng X, Li Q, Wang Y, Li Q, Hua M. Adiponectin, TNF-α and inflammatory cytokines and risk of type 2 diabetes: a systematic review and meta-analysis. cytokine 2016; 86: 100-9.
2. Jang DI, Lee AH, Shin HY, Song HR, Park JH, Kang T-B, et al. The role of tumor necrosis factor alpha (TNF-α) in autoimmune disease and current TNF-α inhibitors in therapeutics. Int J Mol Sci 2021; 22(5): 2719.
3. Higuchi Y, Niidome T, Miyamoto Y, Komohara Y, Tokunou T, Kubota T, et al. Accumulation of gold nano-rods in the failing heart of transgenic mice with the cardiac-specific expression of TNF-α. Heart Vessels 2019;34(3):538-44.
4. Lorenzo O, Picatoste B, Ares-Carrasco S, Ramírez E, Egido J, Tuñón J. Potential role of nuclear factor κB in diabetic cardiomyopathy. Mediators Inflamm 2011; 2011.
5. Ailuno G, Zuccari G, Baldassari S, Lai F, Caviglioli G. Anti-Vascular Cell Adhesion Molecule-1 nanosystems: A promising strategy against inflammatory based diseases. J Nanosci Nanotechnol 2021; 21(5): 2793-807.
6. Ramos TN, Bullard DC, Barnum SR. ICAM-1: isoforms and phenotypes. J Immunol 2014; 192(10): 4469-74.
7. Zhang Y, Liu H, Tang W, Qiu Q, Peng J. Resveratrol prevents TNF-α-induced VCAM-1 and ICAM-1 upregulation in endothelial progenitor cells via reduction of NF-κ B activation. J Int Med Res 2020; 48(9): 0300060520945131.
8. Szkudelski T, Szkudelska K. Resveratrol and diabetes: from animal to human studies. Biochim Biophys Acta 2015; 1852(6): 1145-54.
9. Meng T, Xiao D, Muhammed A, Deng J, Chen L, He J. Anti-inflammatory action and mechanisms of resveratrol. Molecules 2021; 26(1): 229.
10. Pedersen BK. Anti‐inflammatory effects of exercise: role in diabetes and cardiovascular disease. Eur J Clin Invest 2017; 47(8): 600-11.
11. Rajabi A, Siahkouhian M, Akbarnejad A. Comparison of the effect of a therapeutic exercise program and oral administration of saffron on the levels of IL-6, TNF-a and glycemic control in type 2 diabetic women. Razi J Med Sci 2018; 25(1): 20-33. [in Persian]
12. Mohammadi R, Matin Homaee H, Azerbaijani, Mohammad Ali, Baesi K. Effect of 12 Week Resistance training on gene expressions rage, icam, vcam in the heart of diabetic rats with stz. IJDM 2017; 16(1): 1-8. [in Persian]
13. Hashemi HS, Hosseini SA. The effect of moderate intensity endurance training and lipid lowering genistein in Streptozotocin induced diabetic rats. JSUMD 2017;19(1):10-23. [in Persian]
14. Riyahi Malayeri S, Azadniya A, Rasaee MJ. Effect of eight-week high intensity interval training and Resveratrol intake on serum Adiponectib AND Re in type 2 diabetIic rats. IJDM 2019;18(1):8-1. [in Persian]
15. Wang M, Weng X, Chen H, Chen Z, Liu X. Resveratrol inhibits TNF-α-induced inflammation to protect against renal ischemia/reperfusion injury in diabetic rats 1. Acta Cir Bras 2020;35.
16. Guo R, Liu B, Wang K, Zhou S, Li W, Xu Y. Resveratrol ameliorates diabetic vascular inflammation and macrophage infiltration in db/db mice by inhibiting the NF-κB pathway. Diab Vasc Dis Res 2014; 11(2): 92-102
17. Asad M, Sistani M, Barzegari A. The effect of eight weeks of continuous endurance training on ICAM-1 and VCAM-1 expression in the heart tissue of rats. JBUMS 2019; 21(1): 230-6. [in Persian]
18. Mohammad Shirazi R, Ghazaliyan F, Soori R, Abednazari H, Gholami M. Comparing the Effect of a 10-Week High-and Moderate-Intensity Aerobic Exercise on Plasma ICAM-I and VCAM-I Levels in Obese boys. SJRM 2021;10(2):274-83. [in Persian]
19. Barzegari A, Asad MR, Ranjbar H. Effect of one bout continuous versus intermittent aerobic exercise on plasma levels of intercellular adhesion molecules 1 and vascular cell adhesion molecules 1 in patients with coronary heart disease. JSSUMS 2020; 27(11): 2052-62. [in Persian]
20. Hocaoglu-Emre FS, Saribal D, Yenmis G, Guvenen G. Vascular cell adhesion molecule 1, intercellular adhesion molecule 1, and cluster of differentiation 146 levels in patients with Type 2 diabetes with complications. Endocrinol Metab (Seoul) 2017; 32(1): 99-105.
21. Etienne-Manneville S, Manneville J-B, Adamson P, Wilbourn B, Greenwood J, Couraud P-O. ICAM-1-coupled cytoskeletal rearrangements and transendothelial lymphocyte migration involve intracellular calcium signaling in brain endothelial cell lines. J Immunol 2000; 165(6): 3375-83.
22. Mruk DD, Xiao X, Lydka M, Li MW, Bilinska B, Cheng CY. Intercellular adhesion molecule 1: recent findings and new concepts involved in mammalian spermatogenesis. Sem Cell Deve Bio 2014; 29: 43-54.
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mahzoon Z, Mirzayan Shanjani S, Kazemzadeh Y. The effect of eight weeks of moderate intensity aerobic exercise with Resveratrol supplementation on vascular adhesion molecules (VCAM-1 and ICAM-1) and tumor necrosis factor alpha (TNF-α) in the heart tissue of male rats with type 2 diabetes. Feyz 2022; 26 (3) :256-263
URL: http://feyz.kaums.ac.ir/article-1-4601-en.html


Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 26, Issue 3 (Bimonthly 2022) Back to browse issues page
مجله علوم پزشکی فیض Feyz Medical Sciences Journal
Persian site map - English site map - Created in 0.06 seconds with 46 queries by YEKTAWEB 4645