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The effect of resistance training with vitamin C consumption on TRF1 and CDK1 expression in skeletal muscle of elderly male Wistar rats
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Yousef Shirkhani    , Maghsoud Peeri , Mohammad ali Azarbayjani , Hassan Matinhomaee |
| , m.peeri@gmail.com |
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Abstract: (1199 Views) |
Background: Telomere shortening causes intracellular signals that trigger programmed cell death. This study aimed to investigate the effect of resistance training with vitamin C consumption on Telomere Repeat-binding Factor 1 (TRF1) and Cyclin-Dependent Kinase 1 (CDK1) expression in skeletal muscle of elderly male Wistar rats.
Methods: The present study was an experimental study with a control group. Twenty-five male rats (Wistar) aged 24 weeks (280-320 g) were randomly divided into 5 group; young control group, elderly group + resistance training, elderly group + liposomal vitamin C, elderly group + resistance training + liposomal vitamin C and old age control group. The duration of taking vitamins and doing exercise was eight weeks. Data analysis was performed at a significance level of α <0.05.
Results: Aging significantly reduced CDK1 and TRF1 expression in skeletal muscle of rats (P = 0.001). Resistance training with vitamin C had a significant effect on CDK1 expression (P = 0.001). There was no significant change in TRF1 expression due to resistance training and vitamin C intake.
Conclusion: Eight weeks of resistance training with vitamin C supplementation consumption in elderly rats significantly increases CDK1 in skeletal muscle but it did not have a significant effect on TRF1. Therefore, it is recommended to use a higher dose of vitamin C. |
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| Keywords: Resistance training, Vitamin C, CDK1 protein, TRF1 protein |
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Full-Text [PDF 1040 kb]
(709 Downloads)
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Type of Study: Research |
Subject:
General
Received: 2021/02/16 | Revised: 2021/12/26 | Accepted: 2021/09/15 | Published: 2021/11/28
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