:: Volume 24, Issue 5 (Bimonthly 2020) ::
Feyz 2020, 24(5): 473-480 Back to browse issues page
Investigating the effects of Crocin on pituitary-adrenal axis and thyroid hormones in streptozotocin-induced diabetic male rats
Raheleh Rahbarian , Ghazal Ataei
Department of Biology, Faculty of Science, Payame Noor University of Tehran, Tehran, I.R. Iran. , ra_rahbarian@yahoo.com
Abstract:   (1921 Views)
Background: Due to the antioxidant effects of saffron in improving diabetes, this study was conducted in order to investigate the effects of crocin on pituitary-adrenal axis and thyroid hormones in diabetic rats.
Materials and Methods: In this experimental study, which was performed at Payame Noor University, 28 male rats were divided into 4 groups: control, untreatment diabetic, 2 crocin (50, 100 mg/ml, 25 days intraperitoneal injection)-treated diabetic groups. The diabetic groups obtained with intraperitoneal injection of streptozotocin. Blood sampled from the heart of the rats 25 days after the start of the experimental. Then, pituitary-adrenal axis hormones (cortisol, aldosterone, adrenocorticotropin, and thyroid hormones (TSH, T3, and T4)) were evaluated. The results were analyzed by Kruskal Wallis and LSD tests.
Results: Crocin at concentrations of 50 and 100 mg/ml has led to a significant increase in cortisol, aldosterone, and adrenocorticotropin compared to the diabetic rats. Diabetes causes a significant decrease in the levels of thyroid hormones (TSH, T3, and T4). Prescribing crocin at concentrations of 50 and 100 mg/ml has significantly increased the level of thyroid hormones compared to the untreatment diabetic group (P<0.05). Comparing the two concentrations of crocin, the group treated with the concentration of 100 mg/ml has showed a significant increase in the studied indices compared to the group treated with 50 mg/ml of crocin. Also, crosin significantly reduced the level of glucose in diabetic rats.
Conclusion: Crocin can increase the level of pituitary-adrenal and thyroid hormones in diabetic male rats.
 
 
Keywords: Diabetes mellitus, Crocin, Pituitary gland, Adrenal gland, Thyroid hormones, Rat
Full-Text [PDF 1040 kb]   (537 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2020/04/19 | Revised: 2020/12/15 | Accepted: 2020/10/26 | Published: 2020/12/15
References
1. Ataei Gh, Rahbarian R, Rajabian Noghondar M. Effect of Crocin on Bax, Bcl-2, and Oxidative Stress Markers in the Testis Tissue of Streptozotocin-Induced Diabetic Rats. Horizon Med Sci 2019; 25 (4): 340-51. [in Persian]
2. Shahraki MR, Mirshekari H, Khamar Moghadam S. Effect of shorttime consumption of oral magnesium sulfate on blood glucose and serum lipids in streptozotocin-induced diabetic male rats. Horizon Med Sci 2013; 19(2): 67-70. [in Persian]
3. Sharifi H, Afshar M, Akbari H, Matini SM. Acute complications of diabetes mellitus in patients hospitalized in Shahid Beheshti Hospital Kashan, 1991-99. Feyz 2002; 6(1): 56-60. [in Persian]
4. Neves C. Thyroid diseases, dyslipidemia and cardiovascular pathology Revista portuguesa de cardiologia: orgao oficial da Sociedade Portuguesa de Cardiologia. Rev Port Cardiol 2008; 27(10): 1211-36.
5. Soltani S, Taghian F. Compare the effect of 8 Weeks of Aerobic Interval Traning and Glycogen Consumption on Serum Apelin and Insulin Resistance in Women with Type2 Diabetes. Iran J Diabetes Metabol 2019; 18(3): 147-55. [in Persian]
6. Tsatsaris A. The Impact of TRH-TSH-T3 System on Sexual Offenders Thyroid Function: A Theoretical Chaotic Model. Annals Thyroid Res 2018; 4(1): 136- 40
7. Rudolf H, Edward J. Dietrich Recent Advances in Thyroid Hormone Regulation: Toward a New Paradigm for Optimal Diagnosis and Treatment. Frontiersin Endocrinol 2017; 8(364): 1-8.
8. Dastrange S, Shaban Sarvestani F. Effect of 15-day Supplementation of Aqueous Saffron Extract on Cortisol Response in an Aerobic Training Session. The First National Conference on Physical Education and Sport Sciences, 2016 March 1-5, Larestan, Iran [in Persian]
9. Sokhandani M, Zareie A, Naderzadeh E. The effect of alcoholic extract of aerial parts of Salvia officinalis, Golestanica and Glibenclamide. Hyperglycemia and Pituitary-Thyroid Axis Activity in Streptozotocin-Induced Diabetic Rats. 6th International Conference on Applied Research in Agriculture Science, 2019 Februery 1-8, Tehran, Iran [in Persian]
10. Karamifar H, Amirhakimi GH. Goiter and hypothyroidism in children with insulin dependent diabetes mellitus. Feyz 2004; 7(4): 95-100. [in Persian]
11. Strojek K. Features of Macro vascular Complications in Type 2 Diabetic Patients. Acta Diabetolo 2003; 10(40): 334–37.
12. Samarghandian S, Borji A, Delkhosh MB, Samini F. Safranal treatment improves hyperglycemia, hyperlipidemia and oxidative stress in streptozotocin-induced diabetic rats. J Pharm Pharm Sci 2013; 16(2): 352-62.
13. Shirali S, Bathaie SZ, Nakhjavani M. Effect of crocin on the insulin resistance and lipid profile of streptozotocin‐induced diabetic rats. Phytotherapy Research 2013; 27(7): 1042-47.
14. Kianbakht S, Hajiaghaee R. Anti-hyperglycemic effects of saffron and its active constituents, crocin and safranal, in alloxan-induced diabetic rats. J Med Plants 2011; 3(39): 82-9.
15. Rahbarian R, Sepehri Moghadam H, Sadoughi SD. Effect of aqueous extract of Launaea acanthodes on open skin wound in diabetic rats. Horizon Med Sci 2016; 22(1): 1-11 [in Persian]
16. Struck MB, Andrutis KA, Ramirez HE, Battles AH. Effect of a short-term fast on ketamine–xylazine anesthesia in rats. J Am Association Laboratory Animal Sci 2011; 50(3): 344-8.
17. Rotondi M, Magri F, Chivato L. Thyroid and obesity: not a one way interaction. J Clin Endocrinol 2011; 96(2): 344-46.
18. Marzullo P, Minocci A, Tagliaferri MA, Guzzaloni G, Diblasio A, De Medici C et al. Investigation of thyroid hormones and antibodies in obesity. J Clin Endocrinol Metab 2010; 95(1): 3965-72.
19. Kijin K. Change of body composition, blood concentrations of lipid profiles and thyroid bormon after exercise training in ypothyroid rat. Jomes 2012; 21(1): 65-71.
20. Bizheh N, Ebrahimi Atri A, Jaafari M. Effect of three-month aerobic training on hscrp levels, serum homocysteine and lipids, and aerobic power in middle and middle-aged men. DMed 2012; 19(1): 43-50. [in Persian]
21. Kalantari S. The Prevalence of Autoimmune Thyroid Disease in Diabetic Patients. J Guilan Univ Med Sci 2006; 15(59): 106-11. [in Persian]
22. Ghare S, Latifian G, Pooresmaeel V. Frequency of thyroid dysfunction in type 2 diabetic patients referred to internal clinic of 22 Bahman hospital, Mashhad, between 2013 and 2014. J Med Sci Islamic Azad Univ Mashhad 2016; 6(2): 1-13. [in Persian]
23. Kashi Z, Akha O, Boroumand M, Bahar A, Mobini M. The Correlation between Type 2 Diabetes Mellitus and Hypothyroidism. J Mazand Univ Med Sci 2010; 20(79): 9-14. [in Persian]
24. Smithson MJ. Screening for thyroid dysfunction in a community population of diabetic patients. Diabet Med 1998; 15(2): 148-50.
25. Modaghegh M, Shahsbian, M, Rajbai O. Saffron (CrousSativus) tablets in healthy volunteers. Phytomedicine 2008; 15(12): 1032- 37.
26. Xu GL, Yu SQ, Gong ZN, Zhang SQ. Study of the effect of crocin on rat experimental hyperlipemia and the underlying mechanisms. Zhongguo Zhong Yao Za Zhi 2005; 30(5): 369-72.

XML   Persian Abstract   Print

Creative Commons License
This open access journal is licensed under a Creative Commons Attribution-NonCommercial ۴.۰ International License. CC BY-NC ۴. Design and publishing by Kashan University of Medical Sciences.
Copyright ۲۰۲۳© Feyz Medical Sciences Journal. All rights reserved.
Volume 24, Issue 5 (Bimonthly 2020) Back to browse issues page