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:: Volume 24, Issue 2 (Bimonthly 2020) ::
Feyz 2020, 24(2): 142-150 Back to browse issues page
The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus
Mehrnoosh Bahmani , Maghsoud Peeri , Mohammad Ali Azarbayjani , Hasan Matinhomaee
Department of Exercise Physiology, Central Tehran Branch, Islamic Azad University, Tehran, I.R. Iran. , m.peeri@iauctb.acir
Abstract:   (1882 Views)
Background: Physical activity has been recognized, as an effective way to prevent and treat diabetes. This study aimed to determine the effect of the continuous aerobic - versus high -intensity interval training on IRS1 gene expression and its correlation with insulin resistance index in liver tissue with type 2 diabetic rats.
Materials and Methods: In an experimental study, 24 male Wistar rats aged 6-5 weeks weighed 160 to 180 g. The rats were randomly divided into three groups of 8 controls, aerobic continuity, and severe periodicity. Each group performed their protocol five days a week for eight weeks. 24 hours after the last training session, blood samples were collected directly from heart of rats. The liver tissue was immediately extracted. Pearson correlation, one-way ANOVA and Tukey post hoc test were used to analyze the data.
Results: The results of this research showed that both trainings had a significant effect on the expression of IRS1 gene in the liver of type 2 diabetes mellitus than in the control group (P=0.011), but no difference was observed in the two training groups (P=0.874). There was a significant correlation between IRS1 gene expression and insulin resistance index in the liver of type 2 diabetic rats after a HIIT and continuous exercise (P=-0.634). Increasing the IRS1 gene, reduced the insulin resistance index (r= -0.634, P=0.005).
Conclusion: It seems that both intensive and continuous aerobic exercises could be used to improve the indices studied in subjects with type 2 diabetes.
Keywords: Aerobic continuous exercise, HIIT, Type 2 diabetes, IRS1 gene
Full-Text [PDF 319 kb]   (719 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/11/5 | Revised: 2020/07/26 | Accepted: 2020/02/3 | Published: 2020/04/29
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Bahmani M, Peeri M, Azarbayjani M A, Matinhomaee H. The effect of the continuous aerobic and high-intensity interval training on IRS1 gene expression and its correlation with insulin resistance index of liver tissue in rats with type 2 diabetes mellitus. Feyz 2020; 24 (2) :142-150
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Volume 24, Issue 2 (Bimonthly 2020) Back to browse issues page
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