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:: Volume 24, Issue 3 (Bimonthly 2020) ::
Feyz 2020, 24(3): 261-269 Back to browse issues page
Clinical effects of toxic and non-toxic doses of biological and chemical silver nanoparticles on rats' neonate kidney
Behrooz Yahyaei , Parastoo Pourali , Tana Heidari
Department of Medical Sciences, Biological Nanoparticles in Medicine Research Center, Shahrood Branch, Islamic Azad University, Shahrood, I.R. Iran. , behroozyahyaei@yahoo.com
Abstract:   (1886 Views)
Background: Silver has long been known for its antibacterial properties. With the increasing use of silver nanoparticles in various consumer and medical products, it is necessary to check the toxicity of silver nanoparticles for the safety of users.
Materials and Methods: This study was done on the female Wistar rats. These rats were divided to 5 groups such as the control and four treatment groups. Toxic dose was determined based on IC50. For the biological nanoparticles, the non-toxic dose was 3-4 ml and the toxic dose was 6-8 ml. For the chemical nanoparticles, the non-toxic dose was 2.5 ml and the toxic dose was 5 ml. Injections were performed in the last two weeks of gestation and sampling was performed two weeks after birth. Then histological study of renal changes in the cortical and medulla and details of each area were performed by two incisions.
Results: This test was showed that the nonpoisonous of chemical nanoparticles slightly caused the hyperemia and inflammation in renal cells. Injection of poisonous chemical nanoparticles caused serious change renal tissue. In injection of poisonous and nonpoisonous biological didn't changes tubular cells but caused little changes in renal tissue.
Conclusion: The facing with the chemical silver nanoparticles during the pregnancy related to the different dosage of silver nanoparticles induced the poison in the kidney of offspring rats. Biological nanoparticles have the less effect on the renal tissue despite of the chemical ones.
Keywords: Biological silver nanoparticles, Toxic and non-toxic doses, Kidney, Chemical nanoparticles, Neonate
Full-Text [PDF 436 kb]   (884 Downloads)    
Type of Study: Research | Subject: medicine, paraclinic
Received: 2019/05/29 | Revised: 2020/09/9 | Accepted: 2020/06/1 | Published: 2020/08/19
References
1. Vikas S, Krishan KS, Manjit KS. Nanosilver: Potent antimicrobial agent and its biosynthesis. African J Biotechnol 2014; 13(4): 546–54.
2. Hansch C, Mc karns SC, Smith C, Dodittle D. Comparative Q SAR evidence for a free- radical mechanism of phenal in duced texicity. Chem Psiol 2000; 127: 61-72.
3. Horikoshi S, Serpone N. Introduction to Nanoparticles. En Microwaves in Nanoparticle Synthesis. 1st ed. Edited by Satoshi Horikoshi and Nick Serpone. 2013 Wiley-VCH Verlag GmbH & Co. KGaA.
4. Zhang L, Jiany Y, Ding Y, Daskalakis N, Jeuken L, Povey M. Mechanistic investigation in to antibacterial behaviour of suspensions of Zno nanoparticles against E. Coli. J Nano Particle Res 2010; 12: 1625-36.
5. Salari-Joo H.R, Kalbassi, MR Johari, SA. Effect of water salinity on acute toxicity of colloidal silver nanoparticles in rainbow trout (Oncorhynchus mykiss) larvae. Iran J Health Environ 2012; 5: 121-132. [in Persian]
6. Hansch C, Mc karns SC, Smith C, Dodittle D. Comparative Q SAR evidence for a free-radical mechanism of phenol-induced toxicity. Chem Psiol 2000; 127: 61-72.
7. Irvani S, Korbekandi H, Mirmohammadi SV, Zolfaghari B. Synthesis of silver nanoparticles: chemical, physical and biological methods. Res Pharm Sci 2014; 9(6): 385-406.
8. Sadowski Z, Maliszewska IH, Grochowalska B, Polowczyk I, Kozlecki T. Synthesis of silver nanoparticles using microorganisms. Materials Science-Poland 2008; 26(2): 419-24.
9. AshaRani PV, Low Kah Mun G, Hande MP, Valiyaveettil S. Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells. ACS Nano 2009; 3(2): 279-90.
10. Yanamala N, Kagan VE, Shvedova AA. Molecular modeling in structural nano-toxicology: interactions of nano-particles with nano-machinery of cells. Adv Drug Deliv Rev 2013; 65(15): 2070-7.
11. Ruparelia JP, Kumar A, Duttagupta SP, Dia M, Yaom. Use of zero valent iron nanoponticles in inactivating microbes. Water Res 2009; 43: 5243-51.
12. Moyano DF, Rotello VM. Nano meets biology: structure and function at the nanoparticle interface. Langmuir 2011; 27(17): 10376-85.
13. Lee Ye, Choi J, Kim P, Choi K, Kim S, Shon W, et al. A transfer of silver nanoparticles from pregnant rat to offspring. Toxicological Res 2012; 28(3): 139-41.
14. Yu WJ, Son JM, Lee J, Kim SH, Lee IC, Baek HS, et al. Effects of silver nanoparticles on pregnant dams and embryo-fetal development in rats. Nanotoxicology 2014; 8(1): 85-91.
15. Heydarnejad MS, Jafarzadeh R, Kabiri M. A survey ofacute histopathological effects of silver nanoparticles on liver, kidney with blood cells during oral administration in male mice (Mus musculus. J Shahrekord Univ Med Sci 2015; 17(4): 97-107. [in Persian]
16. Pourali P, Nouri M, Ameri F, Heidari T, Kheirkhahan N, arabzadeh S, et al. Histopathological study of the maternal exposure to the biologically produced silver nanoparticles on different organs of the offspring. Naunyn-Schmiedeberg's Arch Pharmacol 2020; 393(5): 867-878.
17. Collins P, Bradley K, Ishigami M. Extreme oxygen sensitivity of electronic properties of carbone nanotubes. Sciencemag. Res Pharm Sci 2000; 9(6): 385-406.
18. Irvani S, Korbekandi H, Mirmohammadi SV, Zolfaghari B. Synthesis of silver nanoparticles: chemical, physical and biological methods. Res Pharm Sci 2014; 9(6): 385-406.
19. Kumar S, Abyaneh M, Gosavi S, Kulkarni S, Ahmad A, Khan M. Sulfite reductase-mediated synthesis of gold nanoparticles capped with phytochelatin. Biotechnol Appl Biochem 2007; 47: 191-5.
20. Seyedalipour B, Arefifar A, Khanbabaee R, Hoseini SM. Cytotoxic assessment of silver nanoparticles in embryonic development and kidney tissue in pregnant mice . J Birjand Univ Med Sci 2015; 22(3): 218-28. [in Persian]
21. Yahyaei B, Pourali P, Bakherad S. Study of the possible effects of the biologically produced gold nanoparticles by Bacillus cereus on the function and structure of the rat`s liver. J Knowledge Health 2019; 13(4): 3-10. [in Persian]
22. Yarmohammadi-Samani P, Arabi M, Yarmohammadi-Samani P. Evaluation of Dermal Absorption of Nanosilver Particles on the Renal Function Parameters in Male Mice. Iran South Med J 2015; 18(2): 260-9. [in Persian]
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Yahyaei B, Pourali P, Heidari T. Clinical effects of toxic and non-toxic doses of biological and chemical silver nanoparticles on rats' neonate kidney. Feyz 2020; 24 (3) :261-269
URL: http://feyz.kaums.ac.ir/article-1-3882-en.html


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Volume 24, Issue 3 (Bimonthly 2020) Back to browse issues page
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