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:: Volume 24, Issue 3 (Bimonthly 2020) ::
Feyz 2020, 24(3): 342-349 Back to browse issues page
The in vitro survey of cytotoxic activities extracts of garlic and green tea
Ali Sharifzadeh , Faranak Aali , Milad Heidari , Neda Kowsari
Department of Microbiology, Faculty of Veterinary Medicine, Shahrekord Branch, Islamic Azad University, Shahrekord, I.R. Iran. , alisharifzadeh98@yahoo.com
Abstract:   (2025 Views)
Background: Garlic (Allium sativum) belongs to the Liliaceae family and green tea (Camellia sinensis) belongs to the Theaceae family are widely used in folk medicine. Antibacterial, anticancer and antioxidant activity of these plants have been previously reported. This study aimed to investigate the cytotoxic activity of the extracts of garlic and green tea on breath cancer cell line (MCF-7) and HDF.
Materials and Methods: Cytotoxicity of different concentrations (250,500,750 μg/ml) of garlic and green tea ethanolic extracts on MCF-7 and HDF cell lines were examined. The cell lines were grown in RPMI supplemented with 10% FBS, 1% penicillin and streptomycin. The cells were allowed to incubate at 37ºC in an atmosphere that contained 5% CO2 and 95% humidity. The standard MTT assay was performed to estimate cell viability after treatment garlic and green tea extracts.
Results: The results of the MTT assay showed that garlic extract had time and concentration dependent anticancer activities on the MCF- 7 cell line (P<0.01). But, any effect of green tea extract on MCF-7 and HDF cell lines showed.
Conclusion: Results of this survey suggested that garlic extract has a good potential to control of cancer cells.

 
Keywords: Garlic, Green tea, Breast cancer, Cytotoxicity
Full-Text [PDF 1278 kb]   (910 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/05/17 | Revised: 2020/09/9 | Accepted: 2020/07/20 | Published: 2020/08/19
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Sharifzadeh A, Aali F, Heidari M, Kowsari N. The in vitro survey of cytotoxic activities extracts of garlic and green tea. Feyz 2020; 24 (3) :342-349
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Volume 24, Issue 3 (Bimonthly 2020) Back to browse issues page
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