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:: Volume 24, Issue 3 (Bimonthly 2020) ::
Feyz 2020, 24(3): 253-245 Back to browse issues page
Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats
Sadri Saeedipour , Maryam Rafieirad *
Department of Biology, Izeh Branch, Islamic Azad University, Izeh, I.R. Iran. , Rafieirad.m@gmail.com
Abstract:   (1179 Views)
Background: Considering the side effects of anti- anxiety drugs, this study investigated the effect of alpha-pinene on anxiety behaviors compared with Diazepam in rats.
Materials and Methods In this study, 40 male Wistar rats were divided into 5 groups: control, sham (received alphapinene solvent), the groups received 2 and 4 mg/kg alphapinene, and the group that received diazepam 10 mg/kg. At the end of this period, anxiety was measured using elevated plus maze and concentrations of malondialdehyde, thiol and glutathione peroxidase, in hippocampal tissue. The results were analyzed using one-way ANOVA and Tukey tests.
Results: In the groups receiving 2 and 4 mg/kg doses of alpha-pinene significantly increased the percentage of open arm entry (P<0.001) and percentage of time spent in the open arm (P<0.05) (P<0.05). Compared to the control and diazepam groups, administration of alpha-pinene significantly decreased MDA concentration (P<0.001) and significant increase in thiol (P<0.01) (P<0.05) and glutathione peroxidase enzyme activity was evident (P<0.001).
Conclusion: Alpha-pinene showed a downward effect on anxiety responses in male rats, similar to anxiolytic effects of diazepam. Alpha-pinene may be potentiated by binding to the position of benzodiazepines in GABA A receptors and exerted its anti-anxiety effect with antioxidant properties.
Keywords: Anxiety, Alpha-pinene, Diazepam, Rat
Full-Text [PDF 320 kb]   (273 Downloads)    
Type of Study: Research | Subject: General
Received: 2019/05/9 | Accepted: 2020/07/7 | Published: 2020/08/19
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Saeedipour S, Rafieirad M. Anti-anxiety effect of Alpha-pinene in comparison with Diazepam in adult male rats. Feyz. 2020; 24 (3) :253-245
URL: http://feyz.kaums.ac.ir/article-1-3863-en.html

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Volume 24, Issue 3 (Bimonthly 2020) Back to browse issues page
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