1. Gnoth C, Godehardt E, Frank-Herrmann P, Friol K, Tigges J, Freundl G. Definition and prevalence of subfertility and infertility. Hum Reprod 2005; 20(5): 1144-7.

2. Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol 2009; 181(2): 741-51.

3. Aflakseir A, Mahdiyar M. The Role of Religious Coping Strategies in Predicting Depression among a Sample of Women with Fertility Problems in Shiraz. J Reprod Infertil 2016; 17(2): 117-22.

4. Parsanezhad ME, Jahromi BN, Zare N, Keramati P, Khalili A, Parsa-Nezhad M. Epidemiology and etiology of infertility in Iran, systematicreview and meta-analysis. Womens Health Issues 2013; 2:6.

5. Mendiola J, Torres-Cantero AM, Vioque J, Moreno-Grau JM, Ten J, Roca M, et al. A low intake of antioxidant nutrients is associated with poor semen quality in patients attending fertility clinics. Fertil steril 2010; 93(4): 1128-33.

6. Nakae D, Akai H, Kishida H, Kusuoka O, Tsutsumi M, Konishi Y. Age and Organ Dependent Spontaneous Generation of Nuclear 8-Hydroxydeoxyguanosine in Male Fischer 344 Rats. Lab Invest 2000; 80(2): 249-61.

7. Valko M, Leibfritz D, Moncol J, Cronin MT, Mazur M, Telser J. Free radicals and antioxidants in normal physiological functions and human disease. Int J Biochem Cell 2007; 39(1): 44-84.

8. Manna SK, Zhang HJ, Yan T, Oberley LW, Aggarwal BB. Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1. J Biol Chem 1998; 273(21): 13245-54.

9. Irvine DS. Glutathione as a treatment for male infertility. Rev Reprod 1996; 1(1): 6-12.

10. Costabile RA, Spevak M. Cancer and male factor infertility. Oncology (Williston Park) 1998; 12(4): 557-62.

11. Filho DW, Torres MA, Bordin AL, Crezcynski-Pasa TB, Boveris A. Spermatic cord torsion, reactive oxygen and nitrogen species and ischemia-reperfusion injury. Mol Aspects Med 2004; 25(1-2): 199-210.

12. De Flora S, Grassi C, Carati L. Attenuation of influenza-like symptomatology and improvement of cell-mediated immunity with long-term N-acetylcysteine treatment. Eur Respir J 1997; 10(7): 1535-41.

13. Clement SL, Hellier BC, Elberson LR, Staska RT, Evans MA. Flies (Diptera: Muscidae: Calliphoridae) are efficient pollinators of Allium ampeloprasum L. (Alliaceae) in field cages. J Econ Entomol 2007; 100(1): 131-5.

14. Cobo J, Castiñeira M. Oxidative stress, mitochondrial respiration, and glycemic control: clues from chronic supplementation with Cr3+ or As3+ to male Wistar rats. Nutrition 1997;13(11-12): 965-70.

15. Barekat F, Tavalaee M, Deemeh MR, Bahreinian M, Azadi L, Abbasi H, et al. A Preliminary Study: N-acetyl-L-cysteine Improves Semen Quality following Varicocelectomy. Int J Fertil 2016; 10(1): 120-6.

16. Reddy PS, Rani GP, Sainath SB, Meena R, Supriya C. Protective effects of N-acetylcysteine against arsenic-induced oxidative stress and reprotoxicity in male mice. J Trace Tlem Med Biol 2011; 25(4): 247-53.

17. Ciftci H, Verit A, Savas M, Yeni E, Erel O. Effects of N-acetylcysteine on semen parameters and oxidative/antioxidant status. J Urolo 2009; 74(1): 73-6.

18. Kunle-Alabi OT, Akindele OO, Odoh MI, Oghenetega BO, Raji Y. Comparative effects of coconut water and N-Acetyl cysteine on the hypothalamo-pituitary-gonadal axis of male rats. Songklanakarin J Sci Technol 2017; 39(6).

19. Feng D, Huang H, Yang Y, Yan T, Jin Y, Cheng X, et al. Ameliorative effects of N-acetylcysteine on fluoride-induced oxidative stress and DNA damage in male rats' testis. Mutation Research 2015; 792: 35-45.

20. da Silva RF, Borges CdS, Villela e Silva P, Missassi G, Kiguti LRA, Pupo AS, et al. The coadministration of N-acetylcysteine ameliorates the effects of arsenic trioxide on the male mouse genital system. Oxid Med Cell longev 2016; 201(6).

21. Ji YL, Wang H, Zhang C, Zhang Y, Zhao M, Chen YH, et al. N-acetylcysteine protects against cadmium-induced germ cell apoptosis by inhibiting endoplasmic reticulum stress in testes. Asian J Androl 2013; 15(2): 290-6.

22. Kumar BA, ReddyAG, Kumar PR, Reddy YR, Rao TM, Haritha C. Protective role of N-Acetyl L-Cysteine against reproductive toxicity due to interaction of lead and cadmium in male Wistar rats. J Nat Sci Biol Med 2013; 4(2): 414-9.

23. Anand H, Misro M, Sharma S, Prakash S. Protective effects of Eugenia jambolana extract versus N‐acetyl cysteine against cisplatin‐induced damage in rat testis. Andrologia 2015; 47(2): 194-208.

24. Asadpour R, Azari M, Hejazi M, Tayefi H, Zaboli N, editors. Protective effects of garlic aquous extract (Allium sativum), vitamin E, and N-acetylcysteine on reproductive quality of male rats exposed to lead. Vet Res Forum 2013; 4(4): 251-7.

25. Maheshwari A, Misro M, Aggarwal A, Sharma RK. N-acetyl-L-cysteine modulates multiple signaling pathways to rescue male germ cells from apoptosis induced by chronic hCG administration to rats. Apoptosis 2012; 17(6): 551-65.

26. Oksay T, Nazıroğlu M, Ergün O, Doğan S, Özatik O, Armağan A, et al. N‐acetyl cysteine attenuates diazinon exposure‐induced oxidative stress in rat testis. Andrologia 2013; 45(3): 171-7.

27. Duarte F, Blaya R, Telöken PE, Becker D, Fernandes M, Rhoden EL. The effects of N-acetylcysteine on spermatogenesis and degree of testicular germ cell apoptosis in an experimental model of varicocele in rats. Int Urol Nephrol 2010; 42(3): 603-8.

28. Farombi EO, Ugwuezunmba MC, Ezenwadu TT, Oyeyemi MO, Ekor M. Tetracycline-induced reproductive toxicity in male rats: effects of vitamin C and N-acetylcysteine. Exp Toxicol Pathol 2008; 60(1): 77-85.

29. Payabvash S, Salmasi AH, Kiumehr S, Tavangar SM, Nourbakhsh B, Faghihi SH, et al. Salutary effects of N-acetylcysteine on apoptotic damage in a rat model of testicular torsion. Urol Int 2007; 79(3): 248-54.

30. Çay A, Alver A, Küçük M, Işik O, Eminağaoğlu MS, Karahan SC, et al. The effects of N-acetylcysteine on antioxidant enzymeactivities in experimental testicular torsion. J Surg Res 2006; 131(2): 199-203.

31. Zafarullah M, Li W, Sylvester J, Ahmad M. Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 2003; 60(1): 6-20.

32. Roberfroid M, Calderon P. Free radicals and oxidation phenomena in biological systems. 1995. New York: Marcel Dekker, Inc.

33. Sundaresan M, Yu ZX, Ferrans VJ, Irani K, Finkel T. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 1995; 270(5234): 296-9.

34. Braga PC. Drugs in bronchial mucology: Raven Press (ID); 1989.

35. Stohs SJ, Bagchi D, Hassoun E, Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol 2001; 20(2).

36. Clement SL, Hellier BC, Elberson LR, Staska RT, Evans MA. Flies (Diptera: Muscidae: Calliphoridae) are efficient pollinators of Allium ampeloprasum L.(Alliaceae) in field cages. J Economic Entomol 2007; 100(1): 131-5.

37. Sakamoto H, Ogawa Y, Yoshida H. Relationship between testicular volume and varicocele in patients with infertility. J Urol 2008; 71(1): 104-9.

38. Jung A, Schuppe HC. Influence of genital heat stress on semen quality in human. Andrologia 2007; 39(6): 203-15.

39. Cam K, Simsek F, Yuksel M, Turker L, Haklar G, Yalcin S, et al. The role of reactive oxygen species and apoptosis in the pathogenesis of varicocele in a rat model and efficiency of vitamin E treatment. Int J Androl 2004; 27(4): 228-33.