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:: Volume 23, Issue 2 (Bimonthly 2019) ::
Feyz 2019, 23(2): 117-124 Back to browse issues page
The effect of aqua-ethanolic extract of yellow horned poppy (Glaucium flavum Crantz) on serum activity of hepatic enzymes and insulin concentration in diabetic male rats induced by alloxan
Ameneh Khoshvaghti , Gholam Hossein Darya * , Pouria Bkaran-Nejad , Fatemeh Zarghami
Young Researchers and Elite Club, Faculty of Veterinary Medicine, Kazerun Branch, Islamic Azad University, Kazerun, I. R. Iran. , ghdarya88@gmail.com
Abstract:   (253 Views)
Background: Glaucium flavum Crantz (Yellow Horned Poppy, YPH) is used to reduce complications of diabetes in Iranian folk medicine. This study was conducted to compare the effect of aqua-ethanolic extract of Yellow Horned Poppy and Glibenclamide on serum levels of AST, ALT, ALP and insulin in diabetic rats induced by alloxan.
Materials and Methods: In this experimental study, 40 adult male Wistar rats were randomly divided into five groups of eight: healthy control, healthy treated with 500mg/kg body weight (BW) of the YPH extract (healthy+YPH), diabetic control, diabetic treated with 500mg/kg BW of the extract (diabetic+YPH), diabetic treated with 5μg/kg BW of Glibenclamide (diabetic+ medicine). Diabetes was induced by injection of alloxan. After a month, blood samples were collected and serum levels of liver enzymes and insulin were also measured. Finally, the data were analyzed by one-way ANOVA and Tukey's post-hoc test.
Results: The activity of AST and ALP enzymes in the diabetic+YPH group was significantly higher than that in the diabetic+drug group (P=0.04). Also, ALT activity and insulin concentration in diabetic+YPH group significantly increased compared to diabetic control group (P<0.001).
Conclusion: The findings of this study reveal that oral administration of the YHP extract in addition to its hepatoprotective activity against diabetes-induced stress, can enhance serum insulin level.
Keywords: Diabetes mellitus, Glaucium flavum Crantz, Liver functional enzymes, Insulin, Rat, Alloxan
Full-Text [PDF 374 kb]   (74 Downloads)    
Type of Study: Research | Subject: General
Received: 2018/11/29 | Accepted: 2019/03/5 | Published: 2019/06/10
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Khoshvaghti A, Darya G H, Bkaran-Nejad P, Zarghami F. The effect of aqua-ethanolic extract of yellow horned poppy (Glaucium flavum Crantz) on serum activity of hepatic enzymes and insulin concentration in diabetic male rats induced by alloxan. Feyz. 2019; 23 (2) :117-124
URL: http://feyz.kaums.ac.ir/article-1-3756-en.html

Volume 23, Issue 2 (Bimonthly 2019) Back to browse issues page
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